Microbiology and Immunology 712 by gcpCOvQ


									                                 Advanced Virology (VTMB 503)
                                      Course Director: William Halford
         Time: MWF 8:00 - 8:50 a.m.        Location: Molecular Biosciences Building, Seminar Room

Week                     Topic                                       Instructor       Reading
     M Aug 28     Principles of Virology-1                                            Ch. 1
1    W Aug 30     Principles of Virology-2                            Halford         Ch. 1
     F Sep 1      Virion structure-1                                                  Ch. 2
     M Sep 4      No class (Labor Day)
2    W Sep 6      Virion structure-2                                  Bothner         Ch. 2
     F Sep 8      Literature Review                                               Primary literature
     M Sep 11     + ssRNA viruses (picorna)                                           Ch. 3
3    W Sep 13     + ssRNA viruses (picorna)                           Halford         Ch. 3
     F Sep 15     Quiz 1 + Literature Review                                      Primary literature
     M Sep 18     + ssRNA viruses (other + ssRNA)                                     Ch. 3
4    W Sep 20     Replication of RNA viruses                          Halford         Ch. 3
     F Sep 22     Quiz 2 + Literature Review                                      Primary literature
     M Sep 25     dsRNA viruses (reo)                                                 Ch. 3
5    W Sep 27     dsRNA viruses (reo)                                 Hardy           Ch. 3
     F Sep 29     Literature Review                                               Primary literature
     M Oct 2      -ssRNA viruses (paramyxo)                                         Ch. 4
6    W Oct 4      -ssRNA viruses (orthomyxo)                          Halford       Ch. 4
     F Oct 6      Exam 1 (Weeks 1 - 5)                                      7:30 - 9:30 am
     M Oct 9      Retroviruses-1 (simple)                                             Ch. 5
7    W Oct 11     Retroviruses-2 (complex)                            Halford         Ch. 5
     F Oct 13     Literature Review                                               Primary literature
     M Oct 16     DNA viruses-1 (herpes)                                              Ch. 6
8    W Oct 18     DNA viruses-2 (adeno)                               Halford         Ch. 6
     F Oct 20     Literature Review on Antiviral drugs                            Assigned reading
     M Oct 23     Oncogenic viruses-1                                             Assigned reading
9    W Oct 25     Oncogenic viruses-2                                 Halford     Assigned reading
     F Oct 27     Quiz 3 + Literature Review                                      Primary literature
     M Oct 30     Abstracts / Subviral agents and retrotransposons                    Ch. 7
10   W Nov 1      Evolution of viruses                                Halford     Assigned reading
     F Nov 3      Quiz 4 + Literature Review                                      Primary literature
     M Nov 6      Host defense and viral counterdefense-1                             Ch. 8
11   W Nov 8      Host defense and viral counterdefense-2             Halford         Ch. 8
     F Nov 10     No class (Veteran's Day)
     M Nov 13     Prions                                                            Ch. 7
12   W Nov 15     Literature Review                                   Bessen    Primary literature
     F Nov 17     Exam 2 (Weeks 1 - 10)                                    7:30 - 9:30 am
     M Nov 20     Literature Review                                   Halford     Primary literature
13   W Nov 22     Essays Due / No class (Thanksgiving )
     F Nov 24     No class (Thanksgiving)
     M Nov 27     Viral vectors for gene delivery                                     Ch. 9
14   W Nov 29     Gene therapy: uses and limitations                  Halford         Ch. 9
     F Dec 1      Literature Review                                               Primary literature
     M Dec 4      Student presentations
15   W Dec 6      Student presentations
     F Dec 8      Student presentations
     F   Dec 15   Final Exam (Comprehensive)                         8:00 - 9:50 am
Textbook:       Viruses and Human Disease, 2002, Strauss and Strauss
Attendance:     Students are expected to attend all classes, unless prevented by sickness.
                In the event of an absence, students will be held responsible for the
                materials covered in that class on the exam.
Quizzes:        Four quizzes will be administered in the first 15 minutes of class during
                the semester. Each quiz will focus on molecular details and/or a major
                concept in the reading or specific assigned goals since the previous quiz
                (e.g. biochemical structures of phosphorylated amino acids, antiviral
                drugs, 7-methylguanosine caps, glycosylation sites, etc.). There will be
                no make-ups for quizzes. Failure to attend will result in a score of 0 of 15
                possible points. Those who show up late will only have until 8:15 am to
                complete the quiz.
Essays and Class Presentations: Each student is required to write an original 2500-
              to 3000-word essay (10 to 12 double-spaced pages) on a relevant current
              topic in virology, and distill the relevant literature on this topic down into
              a cohesive review-type article that summarizes what is known and what
              remains to be done to advance this area of scientific inquiry. The format
              of these reviews will be a Title, Abstract (does not count against word
              limit), Summary of what is known (1000 - 2000 words), Questions that
              remain to be addressed (500 - 1000 words), and a Conclusion (<250
              words). A complete list of References must be provided.
              The initial proposal for the essay must be submitted to the Course
              Director in the form of an e-mail draft containing the Title and an
              Abstract (250 - 400 words) by no later than October 30th. Earlier
              submission of Abstracts are encouraged. Students will be notified by e-
              mail within a few days regarding the suitability of their Abstract for an
              essay topic. Students whose Abstracts are not approved will meet with
              the Course Director to discuss alternative topics or how to modify the
              current Abstract to shift the focus more towards the intended goal of the
              essay…a cohesive review on an important topic in virology.
              Essays must be completed by Nov. 22nd and an oral summary of the essay
              topic must be presented in class during the week of December 4-8. The
              grading breakdown for the “Student Essay / Presentation” component of
              the course will be 5% for the quality of the first Abstract, 15% for the
              essay, and 5% for the oral presentation of the essay topic in class (25% of
              the course grade).
Grading:           Quizzes                            60 points (15%)
                   Student Essay / Presentation      100 points (25%)
                   Exam I                             60 points (15%)
                   Exam II                            60 points (15%)
                   Final Exam                        120 points (30%)
                   Total Possible                    400 points
               Scores on each component will be fitted to a bell curve, and letter grades
               will be assigned, as follows: A = 93-100; B = 85-92; C=75-84; D= 66-74;
               F = 65 or below.
Honor Code: All graded work must be done by the individual receiving the grade.
            Academic misconduct on any assignments or tests, as defined by University
            policies, will result in a grade of ‘F’ in the course.
Instructor:   William Halford
              Room 231, Molecular Biosciences Building 994-9355
              Department of Microbiology       halford@montana.edu
Office Hours: Monday and Wednesday, 9:00 - 10:30 am, or by appointment
Objectives:   The goals of Advanced Virology are to (1) emphasize basic principles of
              molecular virology, (2) illustrate the ubiquity of viruses in nature through
              discussion of viruses that infect humans, plants, insects, and bacteria, and
              (3) to discuss the relationship between viruses and the mobile genetic
              elements that are present in the genomes of all living organisms. Specific
              viruses that are representative of a group of viruses will be discussed in
              depth. Viruses that possess single-stranded RNA genomes face different
              hurdles to the completion of their replication cycle as opposed to DNA
              viruses. Likewise, plant viruses face different physical barriers to their
              dissemination than animal viruses because of the different architecture of
              plant and animal tissues. Such principles will be highlighted in class,
              emphasized through readings from the primary literature, and tested in
              three written examinations.

To top