Advanced Virology (VTMB 503) Course Director: William Halford Time: MWF 8:00 - 8:50 a.m. Location: Molecular Biosciences Building, Seminar Room Week Topic Instructor Reading M Aug 28 Principles of Virology-1 Ch. 1 1 W Aug 30 Principles of Virology-2 Halford Ch. 1 F Sep 1 Virion structure-1 Ch. 2 M Sep 4 No class (Labor Day) 2 W Sep 6 Virion structure-2 Bothner Ch. 2 F Sep 8 Literature Review Primary literature M Sep 11 + ssRNA viruses (picorna) Ch. 3 3 W Sep 13 + ssRNA viruses (picorna) Halford Ch. 3 F Sep 15 Quiz 1 + Literature Review Primary literature M Sep 18 + ssRNA viruses (other + ssRNA) Ch. 3 4 W Sep 20 Replication of RNA viruses Halford Ch. 3 F Sep 22 Quiz 2 + Literature Review Primary literature M Sep 25 dsRNA viruses (reo) Ch. 3 5 W Sep 27 dsRNA viruses (reo) Hardy Ch. 3 F Sep 29 Literature Review Primary literature M Oct 2 -ssRNA viruses (paramyxo) Ch. 4 6 W Oct 4 -ssRNA viruses (orthomyxo) Halford Ch. 4 F Oct 6 Exam 1 (Weeks 1 - 5) 7:30 - 9:30 am M Oct 9 Retroviruses-1 (simple) Ch. 5 7 W Oct 11 Retroviruses-2 (complex) Halford Ch. 5 F Oct 13 Literature Review Primary literature M Oct 16 DNA viruses-1 (herpes) Ch. 6 8 W Oct 18 DNA viruses-2 (adeno) Halford Ch. 6 F Oct 20 Literature Review on Antiviral drugs Assigned reading M Oct 23 Oncogenic viruses-1 Assigned reading 9 W Oct 25 Oncogenic viruses-2 Halford Assigned reading F Oct 27 Quiz 3 + Literature Review Primary literature M Oct 30 Abstracts / Subviral agents and retrotransposons Ch. 7 10 W Nov 1 Evolution of viruses Halford Assigned reading F Nov 3 Quiz 4 + Literature Review Primary literature M Nov 6 Host defense and viral counterdefense-1 Ch. 8 11 W Nov 8 Host defense and viral counterdefense-2 Halford Ch. 8 F Nov 10 No class (Veteran's Day) M Nov 13 Prions Ch. 7 12 W Nov 15 Literature Review Bessen Primary literature F Nov 17 Exam 2 (Weeks 1 - 10) 7:30 - 9:30 am M Nov 20 Literature Review Halford Primary literature 13 W Nov 22 Essays Due / No class (Thanksgiving ) F Nov 24 No class (Thanksgiving) M Nov 27 Viral vectors for gene delivery Ch. 9 14 W Nov 29 Gene therapy: uses and limitations Halford Ch. 9 F Dec 1 Literature Review Primary literature M Dec 4 Student presentations 15 W Dec 6 Student presentations F Dec 8 Student presentations F Dec 15 Final Exam (Comprehensive) 8:00 - 9:50 am Textbook: Viruses and Human Disease, 2002, Strauss and Strauss Attendance: Students are expected to attend all classes, unless prevented by sickness. In the event of an absence, students will be held responsible for the materials covered in that class on the exam. Quizzes: Four quizzes will be administered in the first 15 minutes of class during the semester. Each quiz will focus on molecular details and/or a major concept in the reading or specific assigned goals since the previous quiz (e.g. biochemical structures of phosphorylated amino acids, antiviral drugs, 7-methylguanosine caps, glycosylation sites, etc.). There will be no make-ups for quizzes. Failure to attend will result in a score of 0 of 15 possible points. Those who show up late will only have until 8:15 am to complete the quiz. Essays and Class Presentations: Each student is required to write an original 2500- to 3000-word essay (10 to 12 double-spaced pages) on a relevant current topic in virology, and distill the relevant literature on this topic down into a cohesive review-type article that summarizes what is known and what remains to be done to advance this area of scientific inquiry. The format of these reviews will be a Title, Abstract (does not count against word limit), Summary of what is known (1000 - 2000 words), Questions that remain to be addressed (500 - 1000 words), and a Conclusion (<250 words). A complete list of References must be provided. The initial proposal for the essay must be submitted to the Course Director in the form of an e-mail draft containing the Title and an Abstract (250 - 400 words) by no later than October 30th. Earlier submission of Abstracts are encouraged. Students will be notified by e- mail within a few days regarding the suitability of their Abstract for an essay topic. Students whose Abstracts are not approved will meet with the Course Director to discuss alternative topics or how to modify the current Abstract to shift the focus more towards the intended goal of the essay…a cohesive review on an important topic in virology. Essays must be completed by Nov. 22nd and an oral summary of the essay topic must be presented in class during the week of December 4-8. The grading breakdown for the “Student Essay / Presentation” component of the course will be 5% for the quality of the first Abstract, 15% for the essay, and 5% for the oral presentation of the essay topic in class (25% of the course grade). Grading: Quizzes 60 points (15%) Student Essay / Presentation 100 points (25%) Exam I 60 points (15%) Exam II 60 points (15%) Final Exam 120 points (30%) Total Possible 400 points Scores on each component will be fitted to a bell curve, and letter grades will be assigned, as follows: A = 93-100; B = 85-92; C=75-84; D= 66-74; F = 65 or below. Honor Code: All graded work must be done by the individual receiving the grade. Academic misconduct on any assignments or tests, as defined by University policies, will result in a grade of ‘F’ in the course. Instructor: William Halford Room 231, Molecular Biosciences Building 994-9355 Department of Microbiology firstname.lastname@example.org Office Hours: Monday and Wednesday, 9:00 - 10:30 am, or by appointment Objectives: The goals of Advanced Virology are to (1) emphasize basic principles of molecular virology, (2) illustrate the ubiquity of viruses in nature through discussion of viruses that infect humans, plants, insects, and bacteria, and (3) to discuss the relationship between viruses and the mobile genetic elements that are present in the genomes of all living organisms. Specific viruses that are representative of a group of viruses will be discussed in depth. Viruses that possess single-stranded RNA genomes face different hurdles to the completion of their replication cycle as opposed to DNA viruses. Likewise, plant viruses face different physical barriers to their dissemination than animal viruses because of the different architecture of plant and animal tissues. Such principles will be highlighted in class, emphasized through readings from the primary literature, and tested in three written examinations.
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