Omega 3 for Life FINAL by f8gPN2bN


									         Omega-3 For Life
    Application through Life’s Stages

    Mark Lange, PhD
Director, Quality Control
    Market America

The statements contained in the following
presentation have not been evaluated by
the Food and Drug Administration. The
ingredients discussed are not intended to
diagnose, treat, cure or prevent any
        Essential Fatty Acids
 ALA deemed “Essential” because of its
  apparent benefits in animal studies.
 Later found that DHA provides the health
  benefits to eye and brain.
 ALA is converted to DHA (<1% efficient).
 Therefore, DHA is “Conditionally Essential”
  because the body can make it – but not
       Plant and Marine Sources of
   Vegetable oils contain significant ALA, but
    no EPA/DHA.

   Fish oils have concentrated EPA/DHA and
    trace ALA.

   Typical America diet provides 2-3 g/day
    ALA and 50-80 mg/day EPA/DHA.
       Omega-3 Health Benefits

   DHA is required at high levels in the brain
    and retina for optimal learning ability and
    mental development and visual acuity.

   DHA/EPA support cardiovascular health.
          Pregnancy Stage
 Taken to support the health of the baby
  during neonatal period.
 Particularly important during last
 Consuming fish is risky because of
  mercury contamination.
 Take at least 300 mg DHA per day.
                  Pregnancy Stage
Clinical trials show that women with
higher DHA intake have infants with
higher cognitive development scores and
children with higher IQ scores.

Daniels, J.L. Fish intake during pregnancy and early cognitive development of
offspring. Epidemiology. 15:394-402, 2004

Cohen, J.T. A quantitative analysis of prenatal intake of n-3 polyunsaturated fatty
acids and cognitive development. Am. J. Prev. Med 29(4):366-374, 2005
                 Pregnancy Stage
Evidence that mothers with higher intake of DHA
give birth to infants with improved sleep

Cheruku, S.R. Higher maternal plasma DHA during pregnancy is associated with
more mature neonatal sleep-state patterning. Am. J. Clin. Nutri. 76:608-613, 2002
 Low Omega-3 Intake Linked to
   Depression in Pregnancy
Women consuming 1500 mg omega-3
from seafood per week were less likely to
have depressive symptoms than those
consuming none.

Avon Longitudinal Study of Parents and Children.
Epidemiology 2009, Jul; 20(4); 598-603
                                              Postpartum Depression and Fish Consumption
                                         Hibbeln, J.R. (2002) Journal of Affective Disorders 69(1-3) 15-29
                                                            South Africa
                                       22.5                                      New Zealand
                                                                                                                    r = - 0.76
Edinburgh Postnatal Depression Scale

                                                                      W. Germany                                    p < 0.0001
     Postpartum depreessed %

                                       17.5        Saudi                             United States
                                                  Netherlands         UK
                                       12.5                                                     France
                                                            Ireland         Israel
                                        7.5                                                                         Hong Kong

                                        2.5                                                       Singapore

                                              0             20             40            60            80     100   120         140       160

                                                                                Fish Consumption (lbs/ person/year)
                  Pregnancy Stage
Higher intakes of DHA/EPA during
pregnancy (150+ mg/day) have increased
birth weights and reduced risk of preterm

Lucas, M. Gestational age and birth weight in relation to n-3 fatty acids among Inuit.
Lipids. 39:617-626, 2004.

Olsen, S.F., Low consumption of seafood in early pregnancy as a risk factor for
preterm delivery. BMJ. 324:1-5, 2002
      Lactation/Infancy Stage
 The level of DHA in breast milk is very low
  because fish is only consumed about every
  10 days. (80 mg/day average.)
 Women consuming 11,000 mg ALA/day
  still have very low DHA in milk.
 Taking 300 mg DHA/day elevates breast
  milk levels from 0.14% of total milk fats to
       Lactation/Infancy Stage
Supplementing with 200 mg/day DHA for
four months after delivery resulted in
higher scores on the Bayley Psychomotor
Development Index at 30 months of age.

Jensen, C.L. Effects of maternal DHA intake on visual function and
neurodevelopment in breastfed term infants. Am. J. Clin. Nutr. 82:125-132.
       Lactation/Infancy Stage
There is a positive correlation between
mother supplementing with fish oil
EPA/DHA during lactation and their child’s
visual acuity at 4 months age.

Lauritzen, L. Maternal fish oil supplementation in lactation: effect on visual
acuity and n-3 fatty acid content of infant erythrocytes. Lipids. 38(3): 195-
206, 2004
Pregnant and Lactating Women

World Association of Perinatal Medicine, the
Early Nutrition Academy, and the Child Health
Foundation support:

– Pregnant and lactating women should get at 200 mg
  DHA per day.
– Infant formula contain 0.2 – 0.5% DHA of total fat.
– Baby should continue taking omega-3 after first 6
  months of life.

J. Perinat. Med. 2008; 36(1);5-14
                   Infancy Stage
Infant formulas containing 0.36%
DHA provided 8% improved
performance on the Mental
Development Index, a measure of
memory, problem solving,
vocalization, and math.

Birch, E.E. A randomized controlled trial of early dietary supply of long-
chain polyunsaturated fatty acids and mental development in term infants.
Dev. Med. And Child Neur. 42:174-181,2000
                      Childhood Stage
 ADHD children have low blood levels of DHA.
 A study using functional food sources of omega-
  3 providing 514 mg DHA + 100 mg EPA showed
  significant reduction in aggression.

    Hamazaki, T. The effect of DHA-containing food administration on symptoms of
    ADHD – a placebo-controlled doubled blind study. Eur. J. Clin. Nutr. 58:838,2004

    Voight, R.G. A randomized, double-blind, placebo-controlled trial of DHA
    supplementation with AD/hyperactivity disorder. J. Ped. 138(2): 189-196,2001
      Omega-3s Help Prevent All-Cause
       Adult Mortality and CVD Events

 Placebo controlled study of 563 men aged
  64 – 76 years for three years.
 Diet counseling plus 2.4 g EPA+DHA per
 Omega-3 reduced all-cause mortality by
  47% and heart attack risk by 11%.

    Einvik, G. et al. Euro. J. Cardiovas. Prev. & Rehab. 10
    April 2010 (online)
                Management of Adult
   Fish oil effective at lowering triglycerides.

   2-4 g total EPA/DHA per day lower TGs 30-50%.

   Can be used in combination with statins with doctor’s

    Bucher HC, Griffith LE, Guyatt GH. Systematic review on the risk and
    benefit of different cholesterol-lowering interventions. Arterioscler
    Thromb Vasc Biol. 1999;19:187–95.
                                         Fish Consumption and the
                                    Annual Prevalence of Major Depression

Annual prevalence, (rate /100 persons)              New Zealand (5.8%)

                                                                   Canada (5.2%)
                                                                                                               r=-  0.84
                                                                             France (4.5%)
                                                                                                               p< 0.005
                                                  W. Germany
          Major Depression,


                                                      United States        Puerto
                                                      (3.0%)               Rico (3.0%)               Korea

                                                                                         Taiwan (0.8%)
                                                                                                                  Japan (0.12%)

                                             20          40           60          80          100        120       140       160

                                                   Apparent Fish Consumption (lbs./ person/year)
                                                                       Hibbeln, The Lancet, 1998
Age Related Eye Disease Study
An average intake of 64 mg/day DHA and
42 mg/day EPA associated with 27%
reduction in age-related macular
      Omega-3s and Inflammation

   The application of omega-3 FA’s for long-
    term pain relief and management of
    inflammation is warranted.

   Dose for analgesia effect is 3 grams or
    more daily of EPA plus DHA.

Nutrition & Dietetics. 2009:66;4-6
 DHA is essential for the growth and functional
  development of the brain in infants.
 The visual acuity of healthy, full-term, formula-
  fed infants is increased when their formula
  includes DHA.
 Decreases in DHA in the brain are associated
  with cognitive decline during aging.
 Strong correlation between fish consumption
  and reduction in sudden death from myocardial

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