HIV AIDS RESEARCH INSTITUTE - DOC

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					HIV AIDS RESEARCH INSTITUTE

SUMMARY SHEET                                                 COMPLETED


TITLE:       A randomised control study to assess the role of post-exposure
             prophylaxis in reducing mother to child transmission of HIV-1 in
             infants born to mothers without access to anti-retroviral therapy

PROPOSAL NUMBER: RES057-02

INVESTIGATOR: Dr. Glenda Gray

LOCATION: Johannesburg, South Africa

CONTACT DETAILS: (tel) +27 11 989 9700
                 (fax) +27 11 938 3973
                 (E-mail) gray@pixie.co.za

GRANT AWARDED: US$ 42,000

ROLEPLAYERS: University of Witwatersrand, Perinatal HIV Research Unit

AIM OF STUDY: To compare the efficacy of AZT and Nevirapine at delivery
in reducing the transmission of HIV from positive, untreated mothers to their
infants

OBJECTIVES: (Primary)
(a) Compare the efficacy of Nevirapine versus Zidovudine in reducing mother
    to child transmission of HIV-1 when administered postnatally to the infant.

OBJECTIVES: (Secondary)
(a) Assess the efficacy of postpartum Nevirapine versus Zidovusine
   administered to premature infants born to HIV-infected women.
(b) To assess the efficacy of postpartum Nevirapine versus Zidovudine
   administered to full-term infants born to HIV-infected women
(c) To assess the efficacy of post-exposure prophylaxis in infants who are
    breastfed.

TIME LINE: 6 months

PROTOCOL: Extension of original trail to include additional site

				
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posted:9/15/2012
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