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					Application Pack

Research Associate

Cardiovascular Division

School of Medicine

Reference Number: R6/MKJ/922/12-JE

1. Explanatory notes including application procedure

2. Further particulars, including:

       a. Information about King’s College London, and the post

       b. Job description and person specification

       c. Summary of the terms and conditions of service
Explanatory notes

Please read carefully before completing the application form
Thank you for your enquiry regarding a post at King’s College London. Enclosed is a set of further particulars
for this post. These comprise: a job description and person specification; general information about the
College, School and Department; as well as the main terms and conditions of the post.

Application procedure
Should you wish to apply for this position, please send the following:

      Please complete a Personal details form and Equal opportunities monitoring form.

      a copy of a short statement setting out your reasons for applying for the post and highlighting the
       particular skill and experience which you feel you would bring to the role

      a copy of a current curriculum vitae which should include inter alia:
           o your full name with title
           o details of your present post with date of appointment
           o education
                    degrees (subject, class, institution, date of award)
                    other academic/professional qualifications (subject, level, institution, date of award)
                    distinctions other than degrees
           o membership of professional and learned societies
           o teaching and research experience
           o administrative and management experience
           o grants obtained
           o publications

To email:

Applications should be made electronically in Word (doc, not docx) or PDF format.

Please ensure you quote reference number R6/MKJ/922/12-JE on all correspondence.

Informal enquiries should be made to Prof. Mathias Gautel.

Closing date: 5 October 2012

Please advise your referees that they may be contacted and asked to provide a reference at short notice.
Equal opportunities
King's College London recognises that equality of opportunity and the recognition and promotion of diversity
are integral to its academic and economic strengths.

The following principles apply in respect of the College’s commitment to equality and diversity:
    To provide and promote equality of opportunity in all areas of its work and activity;
    To recognise and develop the diversity of skills and talent within its current and potential community;
    To ensure that all College members and prospective members are treated solely on the basis of their
        merits, abilities and potential without receiving any unjustified discrimination or unfavourable
        treatment on grounds such as age, disability, marital status, pregnancy or maternity, race, religion or
        belief, sex, sexual orientation, trans status, socio-economic status or any other irrelevant distinction;
    To provide and promote a positive working, learning, and social environment which is free from
        prejudice, discrimination and any forms of harassment, bullying or victimisation;
    To promote good relations between individuals from different groups.

Applicants with disabilities
King's College London is keen to increase the number of disabled people it employs. We therefore encourage
applications from individuals with a disability who are able to carry out the duties of the post. If you have
special needs in relation to your application please contact the Human Resources Advisor responsible for the
administration of the post.

Travel expenses
The College normally reimburses reasonable travel costs to and from interview within the United Kingdom.
Regrettably, only limited contribution to travel costs for applicants from outside the UK may be available.
Please contact the Head of Department before making your reservation.

We very much regret that due to limited resources and the large number of applications we currently receive,
we are only able to inform short listed candidates of the outcome of their application.

If you do not hear from us within four weeks of the closing date, please assume that you have been
unsuccessful on this occasion. We would like to assure you, however, that every application we receive is
considered in detail and a shortlist only drawn up after careful reference to a detailed person specification.

If therefore, your application is not successful, we hope that you will not be discouraged and will still apply for
other suitable vacancies at King’s College London as and when they are advertised.

Thank you for your interest in King’s College London.
Further particulars
The College
King's College London is one of the top 30 universities in the world (2011/12 QS World University Rankings),
and the fourth oldest in England. A research-led university based in the heart of London, King's has nearly
23,500 students (of whom more than 9,000 are graduate students) from nearly 140 countries, and
approximately 9,000 employees. It offers an intellectually rigorous environment supported by welcoming and
caring traditions. King's is in the second phase of a £1 billion redevelopment programme which is transforming
its estate.

King's has an outstanding reputation for providing world-class teaching and cutting-edge research. In the
2008 Research Assessment Exercise for British universities, 23 departments were ranked in the top quartile of
British universities; over half of our academic staff work in departments that are in the top 10 per cent in the
UK in their field and can thus be classed as world leading. The College is in the top seven UK universities for
research earnings and has an overall annual income of nearly £450 million.

There are nine Schools of Study:
    Arts & Humanities
    Biomedical Sciences
    Dental Institute
    Institute of Psychiatry
    Law
    Medicine
    Natural and Mathematical Sciences
    Florence Nightingale School of Nursing & Midwifery
    Social Science & Public Policy

King's has a particularly distinguished reputation in the humanities, law, the sciences (including a wide range
of health areas such as psychiatry, medicine, nursing and dentistry) and social sciences including international
affairs. It has played a major role in many of the advances that have shaped modern life, such as the discovery
of the structure of DNA and research that led to the development of radio, television, mobile phones and radar.
It is the largest centre for the education of healthcare professionals in Europe; no university has more Medical
Research Council Centres.

King's College London and Guy's and St Thomas', King's College Hospital and South London and Maudsley
NHS Foundation Trusts are part of King's Health Partners. King's Health Partners Academic Health Sciences
Centre (AHSC) is a pioneering global collaboration between one of the world's leading research-led universities
and three of London's most successful NHS Foundation Trusts, including leading teaching hospitals and
comprehensive mental health services. For more information, visit:

The School of Medicine
The School of Medicine is one of the largest medical schools in the UK and is committed to pursuing excellence
in research and teaching. The School of Medicine has a population of over 2000 undergraduate and
postgraduate students. The School consists of 9 cross-School research divisions populated by over 600 staff,
with a research income of over £32M.

The School is located across four hospital campuses in South London. Each campus has its own distinctive
character and this diversity is an attractive feature of the School for our staff and students, particularly
undergraduates. The School’s two major partner trusts, Guy’s and St Thomas’ NHS Foundation Trust (GST)
and King’s College Hospital NHS Foundation Trust (KCH) have 1,000,000 patient contacts a year combined.
Their specialist services include cancer, cardiothoracic, renal, haematology, children’s services, liver disease
and transplantation, foetal medicine and neuroscience.

Based on UCAS application figures, King’s College London continues to be the most popular choice for
undergraduate medicine in the UK. The School also has a vibrant postgraduate community encompassing
taught and research degrees, with around 400 students.

The School’s research profile has benefited from significant investment since 2001, in staff and infrastructure,
further enhancing King’s international reputation in biomedical research. King’s is ranked fourth nationally in
terms of MRC application success rate by percentage of grants awarded, and in 2006 was one of six
universities selected by the MRC to sign a Strategic Partnership Agreement. King's has also been successful in
joint bids with its partner NHS Trusts for Department of Health Research Centres of Excellence, and the
College joined the global elite in medical research as part of a Global Medical Excellence Cluster.

The investment programme has included the £7M committed to laboratories to support the School’s infection
and immunity programme, and significant investment at St Thomas’ in newly refurbished laboratories for the
integrated, cross-disciplinary Imaging Sciences Division. The £30m James Black Centre opened in 2007 at the
Denmark Hill Campus provides an international centre focussed on cardiovascular research, organ
transplantation and neurodegenerative disease. An Institute of Clinical Neurosciences has also been
established on the campus, to co-exist alongside the Trust neuroscience clinical service.

The Cardiovascular Division
The Cardiovascular Division is one of the largest Research Divisions within the Health Schools of King's
College London and comprises ~ 160 research workers (including 35 Principal Investigators, ~ 70 post-
doctoral and support staff and 50 PhD/MD students and >60 PhD/MD students) whose work is focused on the
mechanisms and treatment of cardiovascular disease. The Division is headed by Professor Ajay Shah, who
holds the British Heart Foundation (BHF) Chair of Cardiology at King’s College Hospital. The overall strategy
of the Division is to (a) pursue internationally leading laboratory-to-bedside research programmes that
address fundamental molecular, cellular and physiological mechanisms underlying normal and abnormal
cardiovascular function; (b) link these to translational research that improves the prevention, diagnosis and
treatment of human cardiovascular disease; and (c) undertake high-quality research training of non-clinical
and clinical scientists.

King’s College London has recently been established as a BHF Centre of Research Excellence following a
national competition in which 4 centres were established. King’s received the largest award of £9 million. The
BHF Centre, directed by Professor Ajay Shah, brings together a wide range of scientists and clinicians in a
multi-disciplinary effort to use leading-edge basic science and translational expertise and technologies to
ultimately develop new methods for early diagnosis of heart disease and new drugs and stem-cell based
therapies for treatment and prevention. The BHF Centre also has a major focus on world-class research
training for clinical and non-clinical scientists.

Current Divisional research income is approximately £29 million, including £3.8million from research
councils and £22.4 million from major charities. This includes 3 BHF Chairs (Mathias Gautel, Ajay Shah,
Qingbo Xu), 1 MRC Programme Grant ((Mathias Gautel), 2 Leducq Foundadtion Programme awards (Mathias
Gautel, Ajay Shah), 4 BHF Programme Grants, 1 ARC Programme Grant, an MRC Cooperative Group award, 2
BHF Cardiovascular Initiative awards, an Oak Foundation infrastructure award and several MRC and BHF
career award holders. The Division has a major contribution to the NIHR Comprehensive Biomedical Centre
awarded to King’s College London and its partner NHS Foundation Trusts. It hosts 2 prestigious 4-year PhD
training schemes (a BHF 4-year programme in Cardiovascular Biology and a BBSRC programme in Integrative
Biomedicine) and a novel inter-disciplinary PhD training programme to attract engineers, mathematicians and
biophysicists into the cardiovascular field.

Research activities within the Division are focussed in 2 main thematic areas, namely Cardiac biomedicine
(which ranges from studies in isolated cardiac myocytes investigating sarcomeric structure, assembly, function
and signalling to experimental studies in cardiac hypertrophy and cardioprotection to proof-of-concept and
translational studies in patients) and Vascular biomedicine (which includes work on mechanisms of
endothelial dysfunction, oxidative stress, vascular calcification, stem cells and vascular repair remodelling, and
microvascular inflammation and thrombosis). There is a major focus on cellular and molecular signalling,
which cuts across and integrates these two themes. In addition, an important goal is to pursue translational
research in both thematic areas.
Divisional staff and research laboratories are based on the King’s College Hospital, St Thomas’ Hospital, Guy’s
Hospital and Waterloo campuses. At the Guy’s Campus, staff are housed in New Hunt’s House, a state-of-the-
art research building that opened in January 2000. The Division has outstanding facilities and expertise in
various areas, including molecular and cellular biology, tissue culture, cardiovascular histology,
microepifluorescence, cell physiology, integrative physiology, genomics, proteomics, confocal super-resolution
microscopy, biophysical experimentation on the cellular and single-molecule level, flow cytometry, stem cell
research and murine surgery and cardiovascular phenotyping (including experimental MRI).

Further information about the division can be found at:

The Post
A post-doctoral molecular biologist is required to join a dynamic BHF funded cardiovascular research grouping, for 28
months. The post holder will join the Section of Muscle Cell Biology in the Cardiovascular Division at the King’s
College London BHF Centre of Research Excellence at the Guy’s Campus, and will be a senior scientist with extensive
experience in cellular and molecular biology, biochemistry and animal physiology and ideally with an established track
record of work in muscle biology. The post is funded by the BHF. He/she will contribute to the research programme in
this area, and will also develop links and interactions with ongoing research into cardiac development and signalling - in
particular, the potential role of sarcomere-associated ubiquitin ligases and interacting proteins that may be involved in the
interplay of morphological development, muscle remodelling and hypertrophic signalling by regulated protein turnover
via the autophagy-lysosomal and the ubiquitin-proteasomal pathways. In vivo and cellular models of protein turnover and
proteotoxicity (including in vivo transfection models and transgenic approaches) will complement biochemical and
cellular studies. Experience in several of these areas is essential.
Job description
Post title:                            Research Associate

Department/Division/Directorate: Cardiovascular Division

Grade:                                 6

Responsible for:                       Research on MURF2 within BHF project grant

Responsible to:                        Head of Division

Reports to:                            Head of Section

Role purpose
        To participate in the study of MURF2 in cardiac development and remodelling within a BHF research

Role outline – main responsibilities
Key objectives:
      Key outputs (results) and responsibilities of the job. The headings below are to help define the
      competence levels and abilities of a suitable applicant for the post.

        Develop and undertake research of high quality consistent with making a full active research
         contribution in line Department/Division/School research strategy
        Manage specific pieces of activity to an agreed timeline and within a specific budget including literature
         reviews, data collection and analysis, report writing.
        Attend and, as appropriate, present research findings and papers at internal academic meetings and
         external professional conferences, and to contribute to the internal and external visibility of the
        Work as a conscientious and committed member of the team in order to achieve the aims of the
         projects and the primary care group.
        Facilitate collaboration and networking which engages and supports the activities of Prof. M. Gautel
        Participate in educational activities as appropriate to the stage of your career.
        Undertake such specific departmental roles and functions as may be reasonably required e.g. rotation
         of lab duties.
        To be committed to your own personal career development.
        Liaise with the administrative team for the support of the project
        Contribute to publications arising from this project
        Play a key role in the coordination of the design, testing and implementation of the range of qualitative
         and quantitative data collection instruments required in the evaluation of the study intervention
        Undertake any other reasonable duties that may be relevant to the role outline.
Communication & networking:
   Deal with routine communication using a range of media
   Communicate complex information orally and in writing
   Prepare reports to external bodies for funding or contractual purposes
   Communicate material of a specialist or highly technical nature
   Liaise with colleagues and students
   Build internal contacts and participate in internal networks for the exchange of information and to
    form relationships for future collaboration
   Join external networks to share information and identify potential sources of funds
Decision making, planning & problem solving:
   Use new research techniques and methods
   Identify areas for research, develop new research methods and extend the research portfolio
   Contribute to collaborative decision making with colleagues in area of research

Service delivery:
    Responsible for identifying needs in the scientific network (e.g. students, colleagues, external bodies)
      and ensuring these are met.
    Provide expert advice in subject area
      Set the standards of service and ensure overall quality is maintained.

Analysis & research:
   Develop research objectives and proposals for own or joint research, with the assistance of a mentor
   Conduct individual and collaborative research projects
   Write up research work for publication
   Continually update knowledge and understanding in field
   Translate knowledge of advances in the subject area into research activity
   Analyse and interpret research data and draw conclusions on the outcomes

Team work, teaching & learning support:
    Work with colleagues on joint projects as required
    Collaborate with academic colleagues on areas of shared research interest
    Attend and contribute to relevant meetings
    Be involved in the assessment of student knowledge and supervision of projects
    Assist in the development of student research skills

Sensory/physical demands & work environment:
    Balance the pressures of research and administrative demands and competing deadlines
    Conduct risk assessments and take responsibility for one’s own health and safety and that of others

Specific Aspects: indicate frequency D (daily), W (weekly), M (monthly) where applicable:

 Intensive DSE work (eg. data entry or         D           Direct patient contact involving exposure       -
 digital microscopy):                                      prone procedures (EPP):
 Heavy manual handling:                        -           Direct patient contact, no EPP                  -
 Highly repetitive tasks (eg. pipetting or     W           Work with patient specimens (eg. blood          -
 re-shelving books):                                       or tissue samples):
 Shift work, night work or call-out            -           Work with GM organisms or biological            W
 duties:                                                   agents that may pose a hazard to human
 Work involving risk of exposure to            -           Hazards which require health surveillance       -
 environmental or human pathogens (eg                      eg. respiratory sensitisers (allergens,
 in waste streams or soils):                               substances with risk phrase R42, wood
                                                           dust etc) or loud noise :
 Driving vehicles on College business:         -           Food handling or preparation:                   -
 Work at height (eg. ladders, scaffolds        -           Work in confined spaces (eg. sump               -
 etc)                                                      rooms, etc)
Pastoral care:
    Show consideration to others
    Respect confidentiality
Organisational chart

Special requirements
      You will be required to work irregular hours in accordance with the needs of the role;
      Information of a confidential nature must be kept strictly confidential and should never be disclosed
       either inside or outside work. It should be noted that breach of confidentiality is a serious offence which
       may lead to dismissal;
      This appointment is subject to Occupational Health clearance. Should you be offered this post you will
       be sent an Occupational Health Questionnaire along with your contract of employment. When the
       Occupational Health Department have evaluated your questionnaire and declared that you are fit for
       appointment, your appointment will be formally confirmed.

All staff are expected to adhere to King’s policies and procedures.

Add date on which JD was agreed.

Please note
This job description reflects the core activities of the role and as the College and the post-holder develop there
will inevitably be changes in the emphasis of duties. It is expected that the post-holder recognise this and adopt
a flexible approach to work and be willing to participate in training.

If changes to the job become significant, the job description should be reviewed formally by the post-holder
and line manger. The Human Resources department should then be consulted as to the implications of the
proposed changes.
Person specification
Eligibility to work in the United Kingdom
International applications will be considered for this position. If you do not have permission to enter, remain and work in
the United Kingdom you will need to pass a points-based immigration assessment. Before you apply for this job you must
ascertain whether you have sufficient points to qualify under Tier 1 (Post study work) and/or Tier 2(General) schemes . If
you do not have sufficient points please do not apply as you will not be granted permission to enter the United Kingdom.
Click on the following link to the points calculator: Border & Immigration Agency Points-based calculator.
   At the interview you will be asked to furnish the panel with the details of the route (Tier 1 (Post study work) and/or Tier 2
(General) you would be eligible to follow. Please note that should you have sufficient points this does not mean your
application will be successful. In the event your application is successful there is no guarantee that your application for a
visa will be granted, in which event the offer will be withdrawn.

                                                                                         E       D
Criteria                                                                                 S
                                                                                                        HOW IDENTIFIED
                                                                                                        AND ASSESSED
                                                                                         E       I
                                                                                         N       R      AP         Application
                                                                                         T       A
                                                                                                        AS         Assessment
                                                                                         I       B
                                                                                         A       L      I          Interview
                                                                                         L       E      P          Presentation
                                                                                                        R          References

Education/qualification and training
A PhD in a biological/life sciences                                                                    AP
Research training and background in cell/molecular biology                                             AP, I, P, R

Experience in the analysis of protein turnover systems (ubiquitin-proteasome                           AP, I, P, R
system, autophagy)
Previous experience in muscle biology                                                                  AP, I, P, R
Experience with the culture, transfection, and analysis of myocytes                                    AP, I, P, R
Experience with analysis of protein ubiquitylation                                                     AP, I, P, R
Use of transgenic models and common interventions, animal husbandry                                    AP, I, P, R
Skills in protein expression in bacterial and/or eukaryotic systems                                    AP, I, P, R
Experience with confocal imaging techniques                                                            AP, I, P, R
Skilled in the use of web tools and programs for DNA and protein sequence                              AP, I, P, R
Skills in immunological methods                                                                        AP, I, P, R

Personal Characteristics/Other requirements
Ability to work in an international environment                                                        AP, I, R
Proven ability to work independently and in a team.                                                    AP, I, R
Strong organisational and communication skills.                                                        AP, I, P, R
Commitment to high quality research.                                                                   AP, I, P, R
 There are two classifications – Tier 1 (Post study work) and Tier 2 (General). Highly skilled migrants are
encouraged to apply under the Tier 2 route, however this is dependent on King’s College London at its sole
discretion issuing you with a Certificate of Sponsorship.
Summary of terms and conditions of service
This appointment is made under the King’s College London Terms and Conditions of Service for Non-Clinical
Research staff, a copy of which is available from the Human Resources department on request.

Period of Appointment                 Fixed-term contract for 28 months

Probation                             6 months

Salary                                £31,020 - £37,012 per annum, plus £2323 London allowance per annum

Annual leave                          27 working days

Staff receive four additional closure days. Notification as to how these days are taken is circulated at the start
of the academic year.


This appointment is superannuable under the USS pension scheme. Staff already superannuated under the
NHS Superannuation Scheme may opt to remain in that scheme provided an application to do so is received by
the NHS scheme trustees within three months of appointment to King’s College London. Alternatively staff
may opt to participate in SERPS or take out a personal pension. Please note that the College does not provide
an employer's contribution towards a private pension plan.

The College operates PensionsPlus by which individuals increase their take home pay by reducing their NI
contributions. Staff who join the USS pension scheme will automatically be entered into PensionsPlus
(provided you would benefit from doing so). As a result your salary will be reduced so that you receive the
PensionsPlus salary and a payment is made into your pension scheme instead.

NB - NHS Superannuation Scheme: Medical Schools are classed as “Direction Employers” and some benefits
of the NHS Scheme are not available to Direction members.

For further information please contact Ms Pauline Job, Payroll & Pensions Manager, King’s College London,
James Clerk Maxwell Building, 57 Waterloo Road, London SE1 8WA.


All appointments to King’s are subject to Occupational Health clearance. Should you be offered this post you
will be sent an Occupational Health Questionnaire along with your contract of employment. When the
Occupational Health Department have evaluated your questionnaire and declared that you are fit for
appointment, your appointment will be formally confirmed.


In the course of your work you may have access to personal or confidential information which must not be
disclosed or made available to any other person unless in the performance of your duties or with specific
permission from your Head of School/Department/Division. (In particular if your work involves the handling
of clinical samples and/or patient data, NHS policies for the maintenance of security and confidentiality of
NHS systems and data must be observed). Breaches in confidentiality may lead to disciplinary action.
Training and Education

King’s College London recognises the importance of training in achieving its objective of pursuing excellence in
teaching, research and clinical practice through the activities of its staff. We are committed to providing
training for all members of staff so that they can perform their jobs effectively and offering them opportunities
for further development. Most training and development will occur "on the job" and formal training
opportunities are also available within King’s College London associated hospitals trusts and through other
external organisations.

All members of staff with teaching responsibilities are encouraged to obtain formal recognition of their
professional expertise in teaching. It is the normal expectation that staff new to teaching in higher education
will register for the Post Graduate Certificate in Academic Practice (PGCAP) unless they already possess a
teaching qualification in higher education. The PGCAP is taught and managed by the King's Learning Institute
(KLI); information about the certificate and other programmes run by KLI can be found in their web site –

No Smoking Policy

King’s College London is committed to maintaining a healthy environment for staff, students and visitors.
Therefore, please note that smoking is not permitted in any of the College buildings or in College vehicles.
Smoking is also not permitted immediately outside the entrances to College buildings or near to windows and
air intake units. Staff working at associated NHS trust sites or other premises should adhere to whatever policy
is in place at these locations.

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