Standard Operating Procedures

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					                           Standard Operating Procedures
                                        Laboratory Specific
                                    Chemical: Isopropyl formate

                 Please fill out the form completely. Print a copy and insert into your
                       Laboratory Safety Manual and Chemical Hygiene Plan.
                                   Refer to instructions for assistance.

_____________________________________________________________________________

Department:________________________                          Date when SOP was written:_______

Date when SOP was approved by the lab supervisor: ___________________

Principal Investigator:___________________________________________________

Internal Laboratory Safety Coordinator/Lab Manager:___________________________________

Laboratory Phone:____________________ Office Phone:_____________________

Emergency Contact:____________________________________________________
                      (Name and Phone Number)

Location(s) covered by this SOP:__________________________________________
                                     (Building/Room Number)
_____________________________________________________________________________


Type of SOP:              Process          Hazardous Chemical            Hazardous Class


Purpose

(State the procedure the specific chemical is used for in lab/the purpose of the chemical)

Physical & Chemical Properties/Definition of Chemical Group
CAS#:                     625-55-8

Class:                    Highly Flammable liquid and Irritant

Molecular formula:        C4H8O2

Form (Physical State): Colorless liquid

Melting Point:            N/A

Boiling Point:            68 °C (154 °F) - lit.

Flash Point:              -13.9 °C (7.0 °F) - closed cup

Density:                  0.884 g/cm3 at 25 °C (77 °F)




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Potential Hazards/Toxicity

Inhalation: May be harmful if inhaled. Causes respiratory tract irritation. Vapors may cause
drowsiness and dizziness.

Skin: May be harmful if absorbed through skin. Causes skin irritation.

Eyes: Causes eye irritation.

Ingestion: May be harmful if swallowed.

Personal Protective Equipment (PPE)

       Respiratory protection: Where risk assessment shows air-purifying respirators are
        appropriate use a full-face respirator with multi-purpose combination (US) or type ABEK
        (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is
        the sole means of protection, use a full-face supplied air respirator. Use respirators and
        components tested and approved under appropriate government standards such as
        NIOSH (US) or CEN (EU).

       Hand protection: PVC or other plastic material gloves

       Eye protection: Face shield and safety glasses

       Skin and body protection: Choose body protection according to the amount and
        concentration of the dangerous substance at the work place.

       Hygiene measures: Handle in accordance with good industrial hygiene and safety
        practice. Wash hands before breaks and at the end of workday.

Engineering Controls

Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety
shower. Use adequate ventilation to keep airborne concentrations low.

First Aid Procedures

       Inhalation: Move person into fresh air. If not breathing give artificial respiration Consult a
        physician.

       Ingestion: Do NOT induce vomiting. Never give anything by mouth to an unconscious
        person. Rinse mouth with water. Consult a physician.

       Skin Contact: Wash off with soap and plenty of water. Consult a physician.




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       Eye Contact: Rinse thoroughly with plenty of water for at least 15 minutes and consult a
        physician.

Special Handling and Storage Requirements

Precautions for safe handling: Avoid contact with skin and eyes. Avoid inhalation of vapor or
mist. Keep away from sources of ignition - No smoking. Take measures to prevent the build-up of
electrostatic charge.

Conditions for safe storage: Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Store in cool place.

Spill and Accident Procedure

Carbon monoxide and/or carbon dioxide may be given off in a fire. In the event of fire, evacuate
and bar further entry.

Chemical Spill Dial 911 and x59797

Spill – Help contaminated or injured persons. Evacuate the spill area. Avoid breathing vapors.
Eliminate sources of ignition if the chemical is flammable. If possible, confine the spill to a small
area using a spill kit or absorbent material. Vacuum or sweep up material and place into a
suitable disposal container. Avoid runoff into storm sewers and ditches which lead to waterways.
Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid
generating dusty conditions. Provide ventilation. Prevent spreading of vapors through sewers,
ventilation systems and confined areas. Evacuate unnecessary personnel. Keep others from
entering contaminated area (e.g., use caution tape, barriers, etc.)

Small (<1 L) – If you have training, you may assist in the clean-up effort. Use appropriate
personal protective equipment and clean-up material for chemical spilled. Double bag spill waste
in clear plastic bags, label and take to the next chemical waste pick-up.

Large (>1 L) – Dial 911 (or 310-825-1491 from cell phone) and EH&S at x59797 for
assistance.

Chemical Spill on Body or Clothes – Remove clothing and rinse body thoroughly in
emergency shower for at least 15 minutes. Seek medical attention. Notify supervisor and EH&S
at x59797 immediately.

Chemical Splash Into Eyes – Immediately rinse eyeball and inner surface of eyelid with
water for 15 minutes by forcibly holding the eye open. Seek medical attention. Notify supervisor
and EH&S at x59797 immediately.

Medical Emergency Dial 911 or x52111

Life Threatening Emergency, After Hours, Weekends And Holidays – Dial 911
(or 310-825-1491 from cell phone) or contact the Ronald Reagan UCLA Medical Center
(emergency room) directly at x52111 (located at 757 Westwood Plaza, enter from Gayley
Avenue). Note: All serious injuries must be reported to EH&S at x59797 within 8 hours.




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Non-Life Threatening Emergency – Go to the Occupational Health Facility (OHF),
                                            th       th
x56771, CHS room 67-120 (This is on the 6 floor, 7 corridor, room 120. Enter through the
School of Dentistry on Tiverton Drive and proceed to the “O” elevator to the 6th floor.)Hours: M -
F, 7:30 a.m. to 4:30 p.m. At all other times report to Ronald Regan UCLA Medical Center
(emergency room) at x52111. Note: All serious injuries must be reported to EH&S at x59797
within 8 hours.

Needle stick/puncture exposure (as applicable to chemical handling procedure) – Wash
the affected area with antiseptic soap and warm water for 15 minutes. For mucous membrane
exposure, flush the affected area for 15 minutes using an eyewash station. Page the needle stick
nurse by dialing 231 from a campus phone, enter 93333 when prompted and then enter your
extension. Hours: M – F, 8:00 a.m. to 4:00 p.m. At all other times report to Ronald Regan UCLA
Medical Center (emergency room) at x52111. Note: All needle stick/puncture exposures must be
reported to EH&S at x59797 within 8 hours.

Decontamination/Waste Disposal Procedure

Waste disposal procedures
       Once the waste container is full or 90 days have passed, dispose of according the UCLA
       EH&S hazardous waste guidelines.

Decontamination of Equipment
Equipment that needs to be decontaminated (for repair or change of location etc.) must be
washed with soapy water and rinsed with copious amounts of water.

Material Safety Data Sheet (MSDS) Location
(State the location of MSDS)

Hardcopy or electronic copy must be available.
Online MSDS can be accessed at http://msds.ehs.ucla.edu.

Protocol/Procedure
(Add specific description of procedure.)

Note: Any deviation from this SOP requires written approval from PI.

Documentation of Training (signature of all users is required)

       Prior to conducting any work with the chemical, designated personnel must provide
        training to his/her laboratory personnel specific to the hazards involved in working with
        this substance, work area decontamination, and emergency procedures.

       The Principal Investigator must provide his/her laboratory personnel with a copy of this
        SOP and a copy of the chemical’s MSDS provided by the manufacturer.

       The Principal Investigator must ensure that his/her laboratory personnel have attended
        appropriate laboratory safety training or refresher training within the year.




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I have read and understand the content of this SOP:

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