Your Federal Quarterly Tax Payments are due April 15th Get Help Now >>

Gaucher Therapeutic Goals by R6t6zU0w

VIEWS: 3 PAGES: 17

									Gaucher Disease:
Bone Imaging
DXA (Dual-Energy X-ray Absorptiometry)
DXA Spine Image and Test Results
DXA Hip Image and Test Results
Absorptiometry




                 Projection
                 Plane
DXA: Trabecular Bone Change

                              BMD ↓




                              BMD ↓




                              BMD ↓
DXA: Cortical Bone Change

                            BMD ↓




                            BMD ↓




                            BMD ↓
Computed Tomography

         Measurement
         Slice
                           1

                       2
Whole-body CT Scan With Vertebra
Close-up of Vertebra
Forearm CT Scan
Image of Radius and Ulna
Quantitative Computed Tomography
(QCT): Trabecular Bone Change


                                   TBD ↔




                                   TBD ↓




                                   TBD ↓
QCT: Cortical Bone Change


                            CBD ↔




                            CBD ↔




                            CBD ↓
Possible Conditions for Bone Loss


              Resorption ↑
              Formation ↔

              Resorption ↔          Negative
              Formation ↓           Balance

               Resorption ↑
               Formation ↓
Follow-up Measurements
                   0.8




                   0.7
     BMD [g/cm2]




                   0.6




                   0.5
                         1        2        3
                             Measurement
Significant Differences
                    0.85


                                   sd
                    0.80
                                                       D  2.8 sd
                                                       (p>95%)
                                         D
      BMD [g/cm2]




                    0.75



                    0.70



                    0.65



                    0.60
                           1                       2
                               Measurement Point

								
To top