HERPESVIRIDAE - PowerPoint by 9N066m

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									RHABDOVIRIDAE

PETER H. RUSSELL, BVSc,
PhD, FRCPath, MRCVS
Department of Pathology and
Infectious Diseases, The Royal
Veterinary College,
     Royal College Street,
      London NW1 OTU.
  E-mail        Web site
     LEARNING OBJECTIVES
      Students should be able to:
• Describe rabies pathogenesis in mammals,
  including bats
• Relate rabies epidemiology in different
  countries to the control measures used.
• Name the four requirements in the rabies
  control strategy recently introduced as an
  alternative to quarantine in the UK.
    FAMILY
CHARACTERISTICS:


   (Rhabdo = rod )
        RABIES



Notifiable; zoonotic; rare in UK
  but several cases have been
         veterinarians!
            RABIES



 Non-fatal infections are rare but skunks
and foxes may recover; dogs can have mild
      symptoms, recover and remain as
     excretors. Recovered animals have
antibodies. These infections are important
 in spreading the virus in the environment.
        RABIES


ANTIGENICITY: only one type
     required in vaccine
         RABIES


HOST RANGE: All mammals are
   susceptible including bats
             RABIES

              CONTROL:
 The strategy depends on whether rabies
is endemic or whether the country is free
                of virus.
          Virus-free countries:
     RABIES

     CONTROL:

Virus endemic countries:
RABIES

CONTROL:

In humans:
                Summary
• Rabies targets the nervous system and brain
  causing a fatal infection; transmitted by biting as
  virus in saliva; zoonotic.
• Rabies-free countries aim to keep rabies out by
  quarantine; countries with endemic rabies in
  wildlife control rabies by reducing wildlife
  numbers +/- vaccination of wildlife.
• In the UK, the Pet Travel Scheme has been
  introduced to replace quarantine but for
      movements between specified countries only.

								
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