Program final by 70eaO6

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									Sunday, Sept. 25

14:00-17:00 Registration
18:00 Arrival coffee
19:00 – 19:05 Welcome: Madalena Tarsounas
      19:05 – 19:55 Keynote lecture: Elizabeth Blackburn, Telomeres and
      telomerase regulation in humans under adverse conditions.
19:55-20:45 Session 1 - Telomere structure and function, Chair: Thanos
Halazonetis
      Eric Gilson: How telomere topology determines chromosome stability
      and replicative senescence?
      Peter Baumann: Telomerase RNA Biogenesis.
20:45 Dinner
Monday, Sept. 26
9:00-10:35 Session 2 – Cellular responses to dysfunctional telomeres,
Chair: E. Blackburn
       Frank Buchholz: Harnessing high throughput biology for novel insights
       into DNA repair and telomere length regulation
       Sandy Chang: Single strand telomere binding protein Pot1b is essential
       for hematopoietic stem cell survival and function
Short talks - Madalena Tarsounas: Checkpoint responses emanating from
       uncapped telomeres
                Jacqueline Jacobs: A functional genetic screen identifies factors
       critical for DNA damage response signaling and repair activities at
       uncapped telomeres.
                Sara Sandin - Structure of active, dimeric human telomerase in
       complex with telomeric DNA
10:35-11:15 Coffee break
11:15-12:45 Session 3 - Mechanisms and regulation of DSB repair and
DSB signaling, Chair: Tony Carr
       The Gray Institute Lecture, Daniel Durocher: Orchestration of DNA
       damage signaling by regulatory ubiquitylation
       Yoshi Shiloh: The ATM-mediated DNA damage response: from specific
       pathways to system – and back
       George Iliakis: The role of DNA ligase III in DNA replication and DNA
       double strand break repair
Short talk - Vassilis Gorgoulis: ATM downregulates oncogene-induced ARF
       expression through a Protein Phosphatase 1–mediated pathway
13:00-15:00 Lunch
15:00-17:00 Poster session (posters no. 1-30)
17:00-17:45 Coffee
17:45-19:30 Session 4 - Chromatin structure and DNA repair, Chair: Daniel
Durocher
       Dimitris Thanos: Stochastic inter-chromosomal interactions coordinate
       the antiviral transcriptional program
       Tim Richmond: Structure and mechanism of the chromatin remodeling
       factor ISW1a
       Anna Friedl: Double-strand break-induced transcriptional silencing
  Short talks -        Steve Jackson: Assembly and disassembly of proteins at
       sites of DNA damage
                Batsheva Kerem: Failure of origin activation in response to fork
       stalling leads to chromosomal instability at fragile sites.
19:30-21:00 Dinner
21:00-21:55 Outdoors session – DNA damage repair and ageing, Chair:
Vassilis Gorgoulis
       Jan Hoeijmakers: Genome maintenance: impact on aging and disease
  Short talks – Paula Martinez: In vivo synthetic lethality of 53BP1 and TRF1
deficiencies.
              Douglas Oliveira: FACT-dependent recruitment of RNF20 during
              DNA repair.
Tuesday, Sept. 27

9:00-10:30 Session 5 - Responses to replicative stress 1, Chair: Oskar
Fernandez-Capetillo
      Tony Carr: Replication forks restarted by homologous recombination
      display a high frequency of errors at inverted repeats
      Philippe Pasero: Spontaneous replication stress regulates replication
      timing in budding yeast
      Vincenzo Costanzo: Understanding the role of DNA repair and
      chromatin remodelling factors in vertebrate DNA replication
  Short talk -     Thanos Halazonetis: DNA replication stress in human
cancers
10:30-11:10 Coffee break
11:10-12:55 Session 6 - Responses to replicative stress 2, Chair: Kim
      Nasmyth
      John Tainer: FEN1 and the MRN complex at the replication-repair
      interface
      Sarantis Gagos: Chromosome instability in replication stress and
      telomere dysfunction
     Camilla Sjogren: Replication-induced topological tension and the
     Smc5/6 complex
 Short talks -   Jo Murray: Smc5/6 regulates recombination and
     chromosome segregation.
              Bekker-Jensen Simon: Rapid deubiquitylation of p15(PAF) in
      cellular responses to replication stress

13:00-15:00 Lunch

15:30-17:00 Session 7 - Chromosomal alignment and segregation, Chair:
Steve Jackson
      The KuDOS Lecture, Kim Nasmyth: Running rings around
  chromosomes
      Andrea Musacchio: Dissecting mitotic progression with small molecule
      inhibitors
      Steve Doxsey: Cilia assembly machinery is required for chromosome
      alignment and spindle orientation
  Short talks - Joanna Morris: The 19S proteasomal de-ubiquitinating enzyme
      POH1 co-ordinates the mammalian DNA damage response.
17:00-17:40 Coffee
17:45 Trip to Sounio (sunset 19:14)
20:00 Dinner with poster viewing (posters no. 31-65)
Wednesday, Sept. 28

9:00-10:30 Session 8 - The DNA damage response in tumorigenesis and
cancer therapy, Chair: Sandy Chang
   Ruth Muschel: Strategies for radiosensitization of tumours: implications for
        therapy
   Jiri Bartek: DNA damage response: Mechanistic insights and impact on
        cancer treatment
   Gillies McKenna: High-throughput screening for genes determining
        radiosensitivity
Short talk - Dimitris Kletsas: DNA damage, cellular senescence and role in
tissue homeostasis

10:30-11:10 Coffee break

11:10-12:25 Session 9 - Mouse models for genome instability, Chair: Jos
Jonkers
  The MicroLeman Lecture, Andre Nussenzweig: Functional connection
      between FA, NHEJ and HR in repair of DNA interstrand crosslinks.
  Jos Jonkers: Studying therapy response and resistance in genetically
      engineered mouse models of BRCA-associated breast cancer
  EMBO YIP Lecture, Oskar Fernandez Capetillo: Exploiting oncogene-
      induced replicative stress for cancer therapy

12:30-14:00 Lunch and airport departure

End of the meeting

Talks: 20+10 min
Short talks: 10+5 min (TOTAL: 8; J Jacobs, Jo Murray, B. Kerem, J. Tainer,
Jo Morris, P. Martinez, D. Oliviera, S. Bekker-Jensen) Lobrich, N., Lowndes, E
Soutoglouwoudl be good to give Evi a talk


Sunday, Sept. 25
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14:00-17:00 Registration                                                          Formatted: Indent: Left: 0.5"
                                                                                  Formatted: Font: Bold, Italic
17:00 Welcome coffee
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      18:30 – 19:30 Keynote lecture: Elizabeth Blackburn, San Francisco –         Formatted: English (United States)
      “New Looks at Cellular Responses to Perturbing Telomere Maintenance”        Formatted: Font: Bold
                                                                                  Formatted: Font: Helvetica
19:30-20:30 25+25+15 minutes does not equal 50 minutes                            Formatted: Font: Helvetica, Bold, Italic
Session 1, Chair: E. Blackburn – Telomere structure and function                  Formatted: Indent: Left: 0", Hanging: 0.5"
Eric Gilson – “Telomeres under topological strain”
 Peter Baumann – “End protection – not just for telomeres”                       Formatted: Font: Helvetica
                                                                                  Formatted: Font: Bold, Italic
20:30 Dinner
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Monday, Sept. 26
                                                                                  Formatted: Font: Italic
      9:00-11:00 Session 2, Chair: Steve Jackson – Mechanisms and regulation       Formatted: Font: Bold
            of DSB repair and DSB signaling                                        Formatted: Indent: Left: 0", Hanging: 0.5"

      The Gray Institute Lecture: Daniel Durocher – “Exploring the role of         Formatted: Font: Bold, Font color: Auto
            ubiquitin as a DNA double-strand break signalling molecule”            Formatted: Indent: Left: 0", Hanging: 0.5"
      Yoshi Shiloh – “ATM dependence and independence in the DNA damage
            response”                                                              Formatted: Font: Bold, Italic
      George Iliakis – “Functions of DNA ligase III in DNA replication and the     Formatted: Font: Bold, Italic
            repair of DNA double strand breaks”                                    Formatted: Font: Not Bold
      2 Short talks selected from poster abstracts
                                                                                   Formatted: English (United Kingdom)

      11:00-11:30 Coffee break                                                     Formatted: Font: Bold, Italic


      11:30-13:30 Session 3, Chair: Oskar Fernandez-Capetillo – Responses to
      replicative stress
                                                                                   Formatted: Font: Italic
      Tony Carr - “Replication fork collapse and restart by homologous             Formatted: Font: Bold, Italic
             recombination”                                                        Formatted: Indent: Left: 0", Hanging: 0.5"
      Philippe Pasero – “Cellular responses to spontaneous replication stress”
      Vincenzo Costanzo – “Understanding vertebrate DNA replication under normal   Formatted: Font: Not Bold
      and stressful conditions”                                                    Formatted: Font: Bold, Italic
      Thanos Halazonetis – “Structure and function of proteins involved in the
                                                                                   Formatted: Font: Bold, Italic
      response to DNA replication stress”
                                                                                   Formatted: Font: Not Bold


      13:30-15:30 Lunch

      15:30-17:30 Poster session

      17:30-18:00 Coffee break

      18:00-20:00 Session 4, Chair: Daniel Durocher– Chromatin structure and       Formatted: Font: Bold
      DNA repair
                                                                                   Formatted: Font: Italic
                                                                                   Formatted: Font: Bold, Italic
       Steve Jackson – “Assembly and disassembly of proteins at sites of DNA
       damage”                                                                     Formatted: Font: Not Bold
Daniela Rhodes – TBA????????? I think that we could do with making this just       Formatted: Font: Not Bold
three speakers                                                                     Formatted: Font: Bold, Italic
       Dimitris Thanos – “Stochastic mechanisms of gene expression”                Formatted: Indent: Left: -0.5"
       Tim Richmond – TBA
                                                                                   Formatted: Font: Italic
                                                                                   Formatted: Font: Bold, Italic
      20:00 Dinner and poster viewing
      1 hour for Hoeijmakers? + his name is mispelled                              Formatted: Font: Bold, Italic, Font color:
                                                                                   Auto
      move some talks here to reduce the number of talks on the other
      daysTuesday, Sept. 27                                                        Formatted: Indent: Left: 0", Hanging: 0.5"

                                                                                   Formatted: Font: Not Bold
      25+25+25+15+15 minutes is not 100 minutes9:00-11:00 Session 5, Chair:
      Tony Carr – Chromosomal alignment and segregation                            Formatted: Font: Bold, Italic
                                                                                   Formatted: Font color: Custom
                                                                                   Color(RGB(255,39,18))
The Steve Jackson/KuDOS Lecture. Kim Nasmyth - “How are sister                    Formatted: Font: Italic
chromatids held together?”                                                        Formatted: Font: Bold, Italic
Andrea Musacchio – “Creation and destruction of the MCC, the spindle              Formatted: Font: Not Bold
checkpoint effector complex”
                                                                                  Formatted: Font: Bold, Italic
Steve Doxsey – “Cilia assembly machinery is required for chromosome
                                                                                  Formatted: Font: Not Bold
alignment and spindle orientation”
2 Short talks selected from posters                                               Formatted: Font: Bold, Italic
                                                                                  Formatted: Font: Not Bold
11:00-11:30 Coffee break

11:30-13:30 Session 6, Chair: Kim Nasmyth – DNA damage responses and              Formatted: Font: Bold
chromosome segregation not a great title this but I could not think of a better
one.
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Tainer should have a full slot, this is what we told him                          Formatted: Font color: Custom
Camilla Sjogren – “Resolution of replication-induced topological stress“          Color(RGB(217,11,0))
Anna Friedl –                                                                     Formatted: Font: Bold, Italic
TBA                                                                               Formatted: Font: Not Bold, English
Dimitris Kletsas – “DNA damage, cellular senescence and role in tissue            (United States)
homeostasis”                                                                      Formatted: Font: Helvetica, English
2 Short talks selected from posters                                               (United States)
                                                                                  Formatted: Font: Bold, Italic
13:30-15:30 Lunch                                                                 Formatted: Font: Not Bold
                                                                                  Formatted: Font: Bold, Italic
15:30-17:30 Session 7, Chair: Thanos Halazonetis - The DNA damage
                                                                                  Formatted: Font: Bold, Italic
response in tumorigenesis and cancer therapy
                                                                                  Formatted: Font: Not Bold

Ruth Muschel – “Strategies for radiosensitization of tumours: implications for    Formatted: Font: Italic
therapy”                                                                          Formatted: Font: Bold
Vassilis Gorgoulis – “Crosstalk between DDR and tumour suppressor                 Formatted: Font: Bold, Italic
ARF”                                                                              Formatted: Font: Not Bold
Jiri Bartek – “DNA damage response: Mechanistic insights and impact on            Formatted: Font: Helvetica, Bold, Italic
cancer treatment”
                                                                                  Formatted: Font: Italic
Gillies McKenna – “High-throughput screening for radiosensitivity targets”
                                                                                  Formatted: Font: Bold, Italic
17:30-18:00 Coffee break                                                          Formatted: Font: Not Bold
                                                                                  Formatted: Font: Bold, Italic
18:00 Trip to Sounio – sunset 19:14                                               Formatted: Font: Not Bold

20:00 Dinner with poster presentations


Wednesday, Sept. 28

9:00-11:00 Session 8, Chair: Sandy Chang – DNA damage responses: links to
telomeres and disease
                                                                                  Formatted: Font: Bold, Italic
Madalena Tarsounas - “Checkpoint responses emanating from uncapped                Formatted: Font: Not Bold
telomeres”
                                                                                  Formatted: Font: Bold, Italic
Frank Buchholz – “Harnessing high throughput biology for novel insights into
                                                                                  Formatted: Font: Not Bold
DNA repair and telomere length regulation”
Sarantis Gagos – “Chromosome instability in replication stress and telomere   Formatted: Font: Bold, Italic
dysfunction”                                                                  Formatted: Font: Not Bold
2 Short talks selected from poster abstracts

11:00-11:30 Coffee break

11:30-13:30 Session 9, Chair: Jos Jonkers – Mouse models for genome
instability
make Kletsas short talk?
Jan Hoijimakers – “The DNA damage problem in the context of ageing,           Formatted: Font: Helvetica, Bold, Italic
cancer and longevity”                                                         Formatted: Font: Bold, Italic, English
Jos Jonkers - “Studying therapy response and resistance in genetically        (United States)
engineered mouse models of BRCA-associated breast cancer”                     Formatted: Font: Bold, Italic
Sandy Chang – TBA                                                             Formatted: Font: Not Bold
EMBO YIP Lecture: Oskar Fernandez Capetillo - “Exploring the role of          Formatted: Font: Bold, Italic
replicative stress in cancer and ageing”
                                                                              Formatted: Font: Not Italic, English
                                                                              (United States)
13:30-15:00 Lunch and airport departure                                       Formatted: Font: Bold, Italic
                                                                              Formatted: Font: Not Bold
End of the meeting
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Did we tell them they will give talks?                                        No widow/orphan control, Tab stops:
                                                                              0.15", Left + 0.5", Left

								
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