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									Personalized Medicines for
    Aging Populations




      John Alam, MD
    Head of TSU Aging
       Sanofi R&D
    12 December, 2011
              Sanofi Aging R&D Strategy

• Treatments for age-related chronic diseases such as
  Alzheimer’s, osteoarthritis, stroke recovery, and hearing loss
• Treatment of age-related syndromes such as chronic
  disabling pain, age-related muscle loss, and frailty
• Preventive strategies for major age-related pathologic
  processes (novel dietary supplements or innovative uses of
  existing medicines)
Healthy    Known
           Specific   Acute Illness
 State
            Cause



            Target
           Specific
            Cause



          Candidate
          Medicine
Chronic Disorders of Aging
Multi-morbidity – Multi-medications
Increasing importance of social environment
                       Senescence            Disease         Disease        Disease
                                                1               2              n




                                      Geriatric Syndromes


                                           Health Issues
                                       (Disorders/ Diseases)


             Function &
                                               Activities                     Participation
              Structures
                                             (Limitations)                    (Restrictions)
            (Deficiencies)




                             Environmental                             Personal
                                Factors                                Factors
                                                                Disease    Disease
                                  Senescence       Disease1
                                                                   2          n




        Vaccines &                                                                           Physical Activities
          Drugs                                                                                 Cognitive
                                               Geriatric Syndromes                             Stimulation



                                                     Health Issues                                       Nutrition
                                                 (Disorders/ Diseases)



                 Fonctions &
                                                       Activities                    Participation
                  Structures
                                                     (Limitations)                   (Restrictions)
                (Deficiencies)



Continuity of                                                                                         Educational &
   Care                          Environmental                             Personal
                                                                                                        coaching
                                    Factors                                Factors                      programs


                                 Home Services                          Geron-
                                                                     technologies
July 2003

								
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