Update on the National Marrow Donor Program and the

HHS Advisory Council Meeting Assessment of the Healthcare System Capacity to Support Blood and Marrow Stem Cell Transplantation Jeffrey Chell, M.D. Chief Executive Officer National Marrow Donor Program® September 2009 Entrusted to operate the CW Bill Young Cell Transplantation Program Goal for this Presentation Acquaint you with a Summit planned by the NMDP and ASBMT – Assess the capacity of the US Healthcare System to support a significant increase in unrelated Allogeneic transplants 10,000 Transplants by 2015 – Identify most likely barriers in the system that would inhibit growth – Recommend solutions 2 Overarching Goal • 10,000 Transplants by 2015 – Why 10,000? • Studies performed separately by NMDP and CIBMTR identified the need in the U.S. to be in this range based on current indications aged 0 to 60. • Causes an organization like NMDP to think outside of our current activities and business model to influence others to prepare for supporting this degree of growth Slide 3 Overarching Goal • 10,000 Transplants by 2015 – Why 10,000? • Effective Communication Tool to Key Stakeholders who would have to have advance notice to prepare for a 2 to 3 fold increase in their activity. • Effective Tool within NMDP to focus on high priority activities to support the achievement of the goal. Slide 4 Overarching Goal • 10,000 Transplants by 2015 – Why 2015? • Gives a sense of urgency to the goal. The need is 10,000 per year today. If you know that, then you don’t want to waste anytime getting there! • Increases realization that key initiatives and investments need to start today to achieve the goal. Slide 5 Impact of Overarching Goal at NMDP • Significant increase in the number and diversity of Cord Blood Units • Significant increase in adult donor recruitment – 350k in 2006 to 500k in 2010 • Increase in International Partnerships – NetCord, several countries • Improved matching algorithm • Increased Patient Advocacy and Assistance • New project in re-engineering the donor management process – Phoenix Initiative Slide 6 10,000 Transplants by 2015 • Major factors threatening this target are – Lack of suitable donors for all patients – Non-HLA barriers to access. • Insurance, timely referral, attitudes – Mortality and morbidity • Research, which is translated into changes in clinical practice, is essential for improving access, survival and quality of life following transplantation Slide 7 “System” Issues • Money – Financing of transplant - Insurance – Capital investment in space and technology • People – Transplant physicians – Nurses – Allied Health personnel • Attitude – Transplant works – It’s a cost effective health care strategy Slide 8 HSC Summit • Bringing together of ASBMT, NMDP and Key Stakeholders to identify healthcare system capacity issues and formulate “upstream” solutions • Examples of organization that have members that would be part of the response to growth include: UHC, AAMC, ONS, ASCO. AMA, AHA, etc. Slide 9 HSC Summit • Examples – How and when does one influence someone in training to consider transplant as a career? – What would cause a healthcare center to invest in transplant services? • Combination of mission, profit, prestige • Timing of investment to increase capacity and ROI Slide 10 HSC Summit - Process • Core Committee develops case statement, plans working groups, selects working group chairs • Core Committee plus Working Group Chairs charter each working group, select working group members • Broad group of individuals and organizations will be invited to the summit to hear the deliberations of the Working Groups and give comments Slide 11 HSC Summit - Process • A “white paper” will be generated from the proceedings and distributed to participants for comment. • Final product should be suitable for publication. • Ultimate goal will be that invited organizations will transform recommendations from the summit into priority initiatives for the organization and its members. Slide 12 HSC Summit • Thank you • Questions? Slide 13 Be The Match Many coming together for the benefit of one Health care Professionals Donors PATIENT Contributors Volunteers 14

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