Curriculum Vitae

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					                             Curriculum Vitae

                   Joshua John Gamsby, Ph.D.

                         Department of Genetics,
                        Geisel School of Medicine
                            Dartmouth College
                                   HB 7400
                            Hanover, NH 03755
                 Email: Joshua.Gamsby@dartmouth.edu
                           Tel #: (603) 650-1120
                          Fax #: (603) 650-1188

Education

   Bachelor of Science, Microbiology and Molecular Biology, University of
    Central Florida, Orlando, FL, 1998-2001

   PhD., Biochemistry and Molecular Biology, University of South Florida,
    Tampa, FL, 2001 – 2005

   Postdoctoral Fellow, Department of Genetics, Geisel School of
    Medicine at Dartmouth, 2005 - Present

Grants and Financial Awards

• Hitchcock Foundation Pilot Grant, PI ($28,750) Investigating the role of
the circadian period genes in modulating the effects of the      atypical
antipsychotic clozapine on the alcohol drinking and preference in
alcohol-preferring mouse strains.

• Travel Award, Society for Research on Biological Rhythms Biennial
Meeting, Sandestin, FL 2008

• Graduate Student Travel Award, FASEB, San Diego, 2003

• Undergraduate Research Stipend, University of Central Florida, Orlando,
FL, 1999 – 2001
Academic Awards and Honors

• Dean’s List, Spring Term, 1999
• Dean’s List, Fall Term, 1999
• Dean’s List, Spring Term, 2000



Other Activities

      Ad Hoc reviewer, Journal of Biological Rhythms, Nucleic Acids
       Research, Molecular Cell Biology, and PLoS One.

      Officer and founding member of               the   Dartmouth     College
       Postdoctoral Association 2008-2010.

Publications

      Gamsby, JJ, Templeton, EL, Bonvini, LA, Wang, W, Loros, JJ, Dunlap, JC,
       and Green, AI, Gulick, D. The Circadian Per1 and Per2 Genes Influence
       Alcohol Intake, Preference, and Response to Alcohol Addiction
       Treatments in Mice. In preparation. 2012

      Grant GD, Gamsby J.J, Martyanov V, Brooks L 3rd, George LK, Mahoney
       JM, Loros JJ, Dunlap JC, Whitfield ML. Live cell monitoring of periodic
       gene expression in synchronous human cells identifies forkhead genes
       involved in cell cycle control. Mol Biol Cell. 2012

      Poliandri A.H., Gamsby J.J., Christian M., Spinella M.J., Loros
       J.J., Dunlap J.C., Parker M.G. Modulation of Clock Gene Expression
       by the Transcriptional Coregulator Receptor Interacting Protein
       (RIP140). Journal of Biological Rhythms. 26: 187. 2011

    Heim, K.C., Gamsby, J.J.*, Hever M., Freemantle S. J., Loros, J.J.,
     Dunlap, J.C., and Spinella, M.C. (2009) Retinoic Acid Mediates
     Long-Paced Oscillations in Retinoid Receptor Activity: Evidence for
     a Potential Role for RIP140. PLoS One. 4(10):e7639. 2009 (* indicates
     shared first authorship)

      Gamsby, J.J., Loros, J. J., and Dunlap, J. C. A Phylogenetically
       Conserved DNA Damage Response Resets the Circadian Clock.
       Journal of Biological Rhythms. (3):193-202. 2009
     Dunlap, J. C., Loros, J. J., Colot, H. V., Mehra, A., Belden, W. J., Shi,
      M., Hong, C. I., Larrondo, L. F., Baker, C. L., Chen, C. H.,
      Schwerdtfeger, C., Collopy, P. D., Gamsby, J. J. and Lambreghts, R.
      A Circadian Clock in Neurospora: How Genes and Proteins
      Cooperate to Produce a Sustained, Entrainable, and Compensated
      Biological Oscillator with a Period of about a Day. Cold Spring Harb
      Symp Quant Biol. 72, 57-68. 2007

     Loros, J. J., Dunlap, J. C., Larrondo, L. F., Shi, M., Belden, W. J.,
      Gooch, V. D., Chen, C. H., Baker, C. L., Mehra, A., Colot, H. V.,
      Schwerdtfeger, C., Lambreghts, R., Collopy, P. D., Gamsby, J. J. and
      Hong, C. I. Circadian output, input, and intracellular oscillators:
      insights into the circadian systems of single cells. Cold Spring Harb
      Symp Quant Biol. 72, 201-214. 2007

     Wang, J. W., Gamsby, J. J.*, Highfill, S. L., Mora, L. B., Bloom, G. C.,
      Yeatman, T. J., Pan, T. C., Ramne, A. L., Chodosh, L. A., Cress, W. D.,
      Chen, J. and Kerr, W. G. (2004) Deregulated expression of LRBA
      facilitates cancer cell growth. Oncogene. 23, 4089-4097. 2004 (*
      indicates shared first authorship)

   Gamsby, J. J., Wang, J. W., Highfill, S. L., Mora, L. B., Bloom, G. C.,
      Yeatman, T. J., Pan, T. C., Ramne, A. L., Chodosh, L. A., Cress, W. D.,
      Chen, J. and Kerr, W. G., WD, (2003) The Lipopolysaccharide Beige-
      like Anchor Gene (LRBA) is down-regulated by p53 and up-
      regulated by E2F. FASEB JOURNAL. Volume: 17 Issue: 4 Pages:
      A576-A576

Teaching and Mentoring Experience:

Teaching:

     Lecturer in Genetics142/Bio79, a graduate level course titled,
      “Genetics and Physiology of Behavior” at Dartmouth College. Topic:
      “The Genetics of the Mammalian Circadian Oscillator”.

Graduate Student Supervision:

     Alec Crowell, Dartmouth graduate student 2012 - present.
      Mentored during his rotation in our lab. Alec has begun training in
      Cell Culture, Genetics, and Molecular Biological techniques.
      Yufei Chen, Dartmouth graduate student, Fall Term 2010. Mentored
       during her lab rotation. She was trained in Cell Culture and
       Molecular Biological techniques.

      Arko Dasgupta, Dartmouth graduate student 2009-2010. Mentored
       during his rotation in our lab. Arko was trained in Cell Culture,
       Genetics, and Molecular Biological techniques. He presented his
       data at a lab meeting and has since joined the Dunlap and Loros
       labs.

Undergraduate Student Supervision:

      Kyle Lenz, Dartmouth undergraduate, Fall 2010 – Spring 2012. Kyle
       was a Howard Hughes research fellowship student. He was trained
       in Genetics, Cell Culture, and Molecular Biological techniques and
       presented his work at two lab meeting sessions as well as at the
       annual Dartmouth undergraduate poster presentation. He has
       since left the lab to focus on enrolling in medical school.

      Laura Bond, SURF undergraduate, Summer 2010. Mentored for the
       Summer Undergraduate Research Program (SURF). Laura was
       trained in Cell Culture, Genetics, and Molecular Biology techniques.
       She presented her data during a lab meeting, and at two poster
       sessions: SURF meeting (Woods Hole SURF Retreat) and at the
       Dartmouth SURF poster session. Laura is now a graduate student in
       the Integrated Program in Biochemistry at the University of
       Wisconsin-Madison and works in the Ntambi lab.

      Adam Hill, SURF undergraduate, Summer 2009. Mentored for the
       Summer Undergraduate Research Program (SURF). Adam was
       trained in Cell Culture, Genetics, and Molecular Biology techniques.
       He presented his data during a lab meeting, and at two poster
       sessions: SURF meeting (Woods Hole SURF Retreat) and at the
       Dartmouth SURF poster session. Adam is now a graduate student in
       the Yale Neuroscience program.

Technician Supervision and Training:

      Wei Wang, technician, 2007-present. Trained in techniques such as
       cell culture, genotyping, and mouse husbandry. Wei maintains our
       mouse colony and performs experiments under my direction.

      Amy Costello, technician 2004. Trained in techniques such as cell
       culture and western blot.
Presentations and Seminars

     Poster Presentation, “The Circadian Period Genes and Time of
      Treatment Modulate the Effects of Clozapine on Alcohol Drinking in
      a Sex-dependent Manner “ Society for Research on Biological
      Rhythms Biennial Meeting, Sandestin, FL. 2012

     Poster Presentation, “The Circadian Period Genes and Time of
      Treatment Modulate the Effects of Clozapine on Alcohol Drinking in
      a Sex-dependent Manner “ Annual Society for Neuroscience
      meeting, Washington D.C. 2011

     Poster Presentation, “The Circadian Period Genes and Time of
      Treatment Modulate the Effects of Clozapine on Alcohol Drinking in
      a Sex-dependent Manner “ Neuroscience Center Day, Dartmouth
      Medical School, NH. 2011

     Poster Presentation, “RIP140 is a Conduit for Circadian Control of
      Genes Involved in Hormonal Output”, Society for Research on
      Biological Rhythms Biennial Meeting, Sandestin, FL. 2010

     Poster Presentation, “RIP140 is a Conduit for Circadian Control of
      Genes Involved in Hormonal Output”, Chronobiology Gordon
      Conference, Salve Regina University, RI. 2009.

     Poster Presentation, “DNA Damage Resets the Mammalian
      Circadian Clock in Mouse Embryonic Fibroblasts”, Society for
      Research on Biological Rhythms Biennial Meeting, Sandestin, FL.
      2008

     Poster Presentation, “DNA Damage Resets the Mammalian
      Circadian Clock,” Department of Molecular and Cellular Biology
      Retreat, Dartmouth College. 2007

     Seminar, “LRBA and Carcinogenesis: Gene regulation, Structure,
      and Function,” Department of Biochemistry Seminar Series,
      University of South Florida, Tampa, FL. 2004

     Seminar, “LRBA and Carcinogenesis: Gene regulation, Structure,
      and Function,” Department of Biochemistry Seminar Series,
      University of South Florida, Tampa, FL. 2004
      Poster Presentation, “Functional Regulation of the LPS-responsive
       Beige-like Anchor (LRBA) gene by p53 and E2F1,” FASEB, San Diego.
       2003

      Poster Presentation, “Functional Regulation of the LPS-responsive
       Beige-like Anchor (LRBA) gene by p53 and E2F1,” University of South
       Florida Research Day, Tampa, FL,. 2003

Research Interests

My research interests lie in the molecular underpinnings of the mammalian
circadian oscillator, with a particular focus on the interaction between the
clock and cell cycle. With the support and guidance of my advisors,
Professors Dunlap and Loros, I have published a primary paper that
describes the relation between the clock and DNA damage (Gamsby et
al, 2009) and my research using a real time luminometer to follow the cell
cycle in live cells has recently been published (Grant et al, 2012).
Additionally, I am interested in the connection between circadian
function and cellular metabolism; I have contributed to papers
characterizing the role of the metabolic regulator Rip140 in both retinoic
acid signaling (Heim et al, 2009) and circadian function (Poliandri et al,
2011). Finally, I am interested in how the circadian clock impacts animal
and human behavior and I am currently preparing a manuscript detailing
the role of the circadian Period genes in alcohol drinking behavior in
mice. Through these projects I have been fortunate to have established
collaborations within the Dartmouth Departments of Psychiatry (Dr. Alan
Green), Pharmacology and Toxicology (Dr. Michael Spinella), and
Genetics (Dr. Michael Whitfield), and abroad (Dr. Malcolm Parker,
Imperial College of London).
References
Jay C. Dunlap, Ph.D.
Professor and Chair of Genetics
Dartmouth Medical School
Hanover, NH 03755
Tel: (603) 650-1108
Fax: (603) 650-1188
Email: Jay.C.Dunlap@Dartmouth.edu

Jennifer J. Loros, Ph.D.
Professor of Biochemistry and Genetics
Dartmouth Medical School
Hanover, NH 03755
Tel: (603) 650-1154
Fax: (603) 650-1188
Email: Jennifer.Loros@Dartmouth.edu

Michael Spinella, Ph.D.
Associate Professor of Pharmacology and Toxicology
7650 Remsen
Dept. of Pharmacology and Toxicology
Dartmouth Medical School
Hanover NH 03755
Office: Remsen 620
Phone: 603-650-1920
Fax: 603-650-1129
Email: michael.spinella@dartmouth.edu

Michael Whitfield, Ph.D.
Assistant Professor of Genetics
Norris Cotton Cancer Center
Dartmouth Medical School
7400 Remsen
Hanover, NH 03755
Phone: 603-650-1109
Fax: 603-650-1188
Email Address: Michael.Whitfield at Dartmouth.edu

				
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