RESEARCH TRAINING AND CAREER DEVELOPMENT AWARDS by ay5aByO

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									   Training and
Career Development
                            Charlotte A. Pratt, PhD
                                  Program Director
              Division of Prevention and Population
                                           Science
           National Heart, Lung, and Blood Institute
              Overview
• Career Timeline
• Grant mechanisms
   – Training
   – Career Development
• Success Rates
• Loan Repayment Program
• Summary
• Additional Resources
                    Spectrum of Training/Career Development
                          Opportunities through NHLBI
 HS     Graduate                                       Transition to   Established
  &        &                     Post graduate         Established     Investigator
College Medical                   Fellowships          Investigator
         School                                        (Jr. Faculty)
MARC          BRTPUG                                        K08
U*STAR        Program
                                                                          K24
Undergrads                    F32 Individual award          K23           K25
              T32
BRTPUG                       T32 Institutional award        K25            R-
Program       T32                                           K22        mechanisms
Undergrads,   Minority
                                  T32 Minority
post-bac, &   institutions      institution award      K01 Minority       F33
graduates                                                 faculty
              F31
                                                       K01 Minority
T35           Minority
Undergrads    students &                                institution
              individuals
              with
              disabilities                               K99/R00
              T35                                      R mechanisms
              Minority
              students
    Awards for Individuals with a Health-Professional Doctorate

           Institutional
    Training Grants (T32)                                                      Senior Fellowships
Short-Term                                        Postdoctoral
Training Grant                                                                         (F33)
                                               Fellowships (F32)
(T35)




 Medical                                                                 Independent
                 Internship/Residency         Specialty
 School                                                                  Investigator

                                                                           Career Enhancement
                                                                           Award Stem Cells (K18)
                               Scientist Development         Midcareer Investigator
                                   Program (K12)              in Patient-Oriented
                                                                Research (K24)
                           Mentored Clinical Scientist
                           Development Award (K08)         Mentored Patient-Oriented
                                                             Research CDA (K23)
                  Awards for Individuals with a Research Doctorate
                                Institutional
             Predoctoral
                            Training Grants (T32)
        Fellowships (F31)                                                       Senior Fellowships
MARC                                                    Postdoctoral
                                                                                       (F33)
COR (T34)                                            Fellowships (F32)




                                                                          Independent
Coll.           Graduate School &         Postdoctoral
                                                                          Investigator
                Medical School
BRTPUG
Program                                                                     Career Enhancement
Undergrads,                                 Career
                                           Transition                       Award Stem Cells (K18)
post-bac, &
                                                                 Independent
graduates                                 Award (K22)
                                                                 Scientist Award (K02)
T35
Undergrads                                      Mentored Research Scientist
                                                 Development Award (K01)
    NHLBI Early Career Development Awards
           (Individual K Awards)
                        Overall goal:
To transition junior faculty into successful R01 investigators

                      Individual awards
  Provides salary support to 75% for protected research time
   Support for research expenses, coursework, books, travel
    Evaluated based on the qualifications of the applicant,
    mentoring team, institutional resources, education &
                       research plan
              Mentoring team critical to success
       Awardee encouraged to apply for R01 in year 4-5
         Awards For New Researchers

• Mentored Clinical Scientist Development Award (K08)
• Mentored Patient-Oriented Research Career Development
  Award (K23)
• NIH Pathway to Independence (PI) Award
  (K99/R00)
• Independent Scientist Award (K02)
• Career Transition Award (K22)
• Mentored Quantitative Research Career Development
  Award (K25)
          Mentored Clinical Scientist
          Development Award (K08)

• Applicants: Clinicians who are interested in
  developing independent research careers.
• Application deadlines: February 1, June 1, and
  October 1.
• Requirements: at least 75% effort.
• Support: 3-5 years.
• Salary: Up to $75,000 per year plus benefits and up to
  $25,000 per year for research development support.
       Mentored Patient-Oriented Research
        Career Development Award (K23)

• Applicants: Scientists who are committed to
  developing careers in patient-oriented research.
• Application deadlines: February 1, June 1, and
  October 1.
• Requirements: at least 75% effort.
• Support: 3-5 years.
• Salary: Up to $75,000 per year plus benefits and up to
  $50,000 per year for research development support.
  Facts About K08 and K23

Similarities -
• Mentored awards
• Faculty appointment not required
• Require > 75% effort
• 3 – 5 years of support
• Budgets similar
   – Salary levels may vary by institute
       Facts About K08 and K23
Differences -
• Research Development Support -
      $25,000/year for K08
      up to $50,000/year for K23
• K23 candidates must take courses such as study
  design, biostatistics, epidemiology, data management,
  hypothesis development, drug development, etc., and
  legal and ethical issues associated with human subjects
  research
     What is “Patient-Oriented Research”?
For purposes of K23 award –
Research conducted with human subjects (or on material
  of human origin such as tissues, specimens, and
  cognitive phenomena) for which an investigator directly
  interacts with human subjects.
 This includes:
• mechanisms of human disease
• therapeutic and behavioral interventions
• clinical trials
• development of new technologies
 What Doesn’t Count as Patient-
      Oriented Research?
• Analysis of existing databases
• Brief interaction with human subjects (such as
  one blood draw)
• Candidate designs a questionnaire that will be
  administered by other staff
     The projects listed above would
        be appropriate for a K08
               application
      NIH “Clinical Research” Definition

Clinical research is defined in three parts as follows:
(1) Research conducted with human subjects (or on material of
   human origin such as tissues, specimens, and cognitive
   phenomena) for which an investigator (or colleague)
   directly interacts with human subjects. Excluded from this
   definition are in vitro studies that utilize human tissues that
   cannot be linked to a living individual. Patient-oriented
   research includes: (a) mechanisms of human disease, (b)
   therapeutic interventions, (c) clinical trials, and (d)
   development of new technologies,
(2) Epidemiologic and behavioral studies,
(3) Outcomes research and health services research.
                  PA-06-133
    NIH Pathway to Independence (PI) Award
                  (K99/R00)

• Release date: 1/27/2006
• Letter of Intent: Not required
• First receipt date: April 7, 2006
• Subsequent receipt dates: Standard NIH
  deadlines
• Announcement at http://grants.nih.gov/grants/guide/-a-
    files/PA-06-133.html
                 K99/R00

• Up to 5 years support, two phases
• Phase I Mentored research, 1-2 years (K00)
• Phase II Independent research support (R00) 1-
  3 years, contingent on securing an independent
  research/faculty position
• Each phase provides funds for salary & research
  costs
K99/R00 Applicant Requirements
• Outstanding postdoctoral candidates who have terminal
  clinical or research doctorates (PhD, MD, DO, DDS,
  DVM, ScD, DNS)
• No more than 5 years postdoctoral research training
• US citizens & non-US citizens
• May submit only one PI Award application
• May not simultaneously submit applications or have
  pending awards for any other PHS career development
  award (no K awards)
                   K99/R00 Award
• Salary-Phase I Mentored research (K00): up to $50,000, plus
  applicable fringe benefits; up to $20,000 for research
  support/year. Total cost up to $90,000; may engage in teaching
  and/or clinical duties up to 25% effort
• Salary-Phase II Independent research support (R00):
  Consistent with institution’s salary structure. Total cost up to
  $249,000/year.
• Requirement: minimum of 75% of full-time professional .
• Salary for mentor (K00): May also request up to 5% of
  mentor’s salary plus benefits.
• Application deadline: 12th of March, July and November
•   http://grants.nih.gov/grants/funding/submissionschedule.htm
            Independent Scientist
                Award (K02)
 Applicants: Investigators at non-federal public or
  profit U.S. institutions engaged in health-related
  research.
 Application deadlines: February 1, June 1, and
  October 1.
 Requirement: at least 75% effort.
 Support: 3-5 years
 Salary: Up to $75,000 per year plus benefits. No
  other research development support funds are
  provided.
              Career Transition Award (K22)
             • How to apply: Individuals apply to the NIH.
• Application deadlines: February 1, June 1, and October 1.


      Training Site         Salary
    1 NHLBI Intramural      Based on experience; 100% effort; up
      Labs                  to 3 years
    2 Extramural            Up to $75,000 per year plus benefits,
      Institution           and up to $75,000 per year for
                            research support; up to 75% effort; up
                            to 2 years
         Mentored Quantitative Research
         Career Development Award (K25)

• Applicants: Individuals with an advanced degree in a
  quantitative area of science or engineering who are
  committed to careers as independent biomedical or
  behavioral investigators.
• Application deadlines: February 1, June 1, October 1.
• Salary: Up to $75,000 per year plus benefits and up to
  $40,000 per year for research development support.
• Requirement: at least 75% effort.
• Support: 3-5 years
     Awards For Minority Scientists

              Minority Researchers
• NHLBI Mentored Career Award for Faculty at
  Minority Institutions (K01)
• NHLBI Mentored Minority Faculty Development
  Award (K01)
• Research Supplements for Underrepresented Minority
  Investigators
              Mentored Career Award for
          Faculty at Minority Institutions (K01)
• Applicants: Minority Institutions apply on behalf of faculty and
  students.
• Application deadline: Announced annually, July 19, 2005, 2006 and
  2007.
• Faculty Salary: Up to $75,000 per year plus benefits, and up to
  $36,000 per year for research support .
• Requirement: 100% effort during summer; at least 25% effort
  during academic year.
• Salary: May also request up to 5% of mentor’s salary plus benefits.
   – Student Salary: $10.00 per hour plus benefits and a summer
     housing allowance.
           NHLBI Mentored Minority Faculty
             Development Award (K01)

• Applicants: Underrepresented minority faculty members
  interested in cardiovascular, pulmonary, hematologic, or
  sleep disorders research.
• Application deadline: Announced annually, usually late
  August.
• Requirement: at least 75% effort.
• Support: 3-5 years.
• Salary: Up to $75,000 per year plus benefits, and up to
  $30,000 per year for research support.
           Minority Investigator Research
                    Supplements
• Applicants: Principal investigators with eligible NHLBI
  grants apply on behalf of the minority junior faculty
  individual.
• Application deadline: At least 3 months before the
  requested start date.
• Salary and benefits: Up to $75,000 per year plus benefits.
• Requirement: at least 75% effort.
• Support: 2-4 years.
• Supplies and travel: Up to $10,000 per year
         Established Researchers


• National Research Service Awards for Senior
  Fellows (F33)
• Mid-Career Investigator Award in Patient-
  Oriented Research Award (K24)
     National Research Service Awards for
             Senior Fellows (F33)

• Applicants: Experienced scientists with at least 7 years of
  relevant postdoctoral research or professional training who
  are interested in changing the direction of their careers.

• Application deadline: April 5, August 5, and December 5.

• Support: Full-time up to 2 years support

• Stipend: Up to $51,036 per year, plus an institutional
  allowance of $5,500 per year.
  Mid-Career Investigator Award in Patient
         Oriented Research (K24)

• Applicants: Established clinicians within 15 years of their
  specialty training.

• Application deadline: February 1, June 1, and October 1.

• Support: 3 to 5 years, 20 to 50 percent effort, with a one
  time renewal.

• Stipend: Up to $80,600 plus fringe benefits per year, and
  up to $25,000 for research development support.
NIH K Award Data
            Number of NIH K Awards
                Fiscal Years 1994 - 2004


                “Patient-Oriented
                Research”                                4,000
                awards begin
                                                         3,500

                                                         3,000

                                                         2,500

                                                         2,000

                                                         1,500
1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004
   Trends in Number of Individual K Awards by Institute or
                          Center
                 Fiscal Years 1994 - 2004




                                                                                                               600
                                                                                                               500
            I
          LB H
                                                                                                               400
        NH NIM CI
              N DK
                 D    D
               NI NIAI DA
                      NI NDS
                               A
                                                                                                               300
                        NI   NI HD
                                 C     R
                              NI N C R
                                        AM
                                          S
                                             R
                                     NI NIDC AA
                                                                                                               200
                                              A      S
                                            NI    G M NEI
                                                NI
                                                        NI
                                                            S
                                                          EH CD
                                                              D
                                                                                                               100
                                                            NI       M
                                                                  CA     NR
                                                               NC      NI       I
                                                                          NH
                                                                             GR
                                                                                  FIC
                                                                                                               0
                                                                                         HD




                                                                                                       20
                                                                                                        20
                                                                                       CM          M




                                                                                                         20



                                                                                                         04
                                                                                                          19
                                                                                   N          NL




                                                                                                          02
                                                                                                           19



                                                                                                           00
                                                                                                            19



                                                                                                            98
                                                                                                             96
                                                                                                              94
Excludes K12, K16, and K17.
              Trends in K08 Awards by Institute
                                                  Fiscal Years 1994 - 2004




                                                                                                                                                                 250
                                                                                                                                                                 200
NH
     LB
          I
            DD
                 K                                                                                                                                               150
          NI           AI
                         D
                     NI      NC
                                  I

                                      NI
                                        ND
                                             S
                                                   MH
                                                                                                                                                                 100
                                                 NI       D
                                                       CH
                                                     NI     NI
                                                              A

                                                              NI
                                                                AM
                                                                  S
                                                                      NE
                                                                        I                                                                                        50
                                                                            S
                                                                          GM       D
                                                                        NI
                                                                              NI
                                                                                DC
                                                                                       NI
                                                                                         DA
                                                                                                     R
                                                                                                                                                                 0
                                                                                                DC
                                                                                              NI




                                                                                                                                                               20
                                                                                                                 S




                                                                                                                                                        20
                                                                                                             IEH




                                                                                                                                                 20




                                                                                                                                                                 04
                                                                                                                                          19
                                                                                                                        A




                                                                                                                                                          02
                                                                                                         N                         19
                                                                                                                   AA




                                                                                                                                                   00
                                                                                                                            19




                                                                                                                                            98
                                                                                                                 NI                  96
                                                                                                                              94
       NIH Success Rates for Selected K Activities
                   Fiscal Years 1990 - 2004

                                                        Success Rate
                                                                70

                                                                60

                                                                50

                                                                40

                                                  K02           30
                                                  K08
                                                  K23           20
                                                  K24
                                                                10
                                                  K01

                                                                0
1990     1992   1994   1996     1998    2000   2002     2004
       NHLBI K08 and K23 Applications
                 Fiscal Years 1995 - 2004
                                                                            250

                                                                            200




                                                                                  # of Applications
                                 K23
                                 K08                                        150


                                                                            100


                                                                            50


                                                                            0
1995    1996   1997    1998    1999* 2000       2001   2002   2003   2004
                                Fiscal Year
*Salary Cap increase, $50K – $75K; K23 begins
Loan Repayment Program for
   Extramural Scientists



       = LRP
       Extramural NIH Loan
        Repayment Program
• Attract Health Professionals to res. Careers
• Must conduct qualified research at a non-profit
  institution
• NHLBI Programs: Pediatric; Clinical; Health
  Disparities
• Must be U.S. citizen or perm. resident
• Debt must be > 20% of annual salary
• Exchanges 2 year commitment for up to $70,000
  repayment of your qualified educational debt
• Termination by participant: $7,500/month of
  unserved time plus all amounts paid on behalf
  NHLBI Research Training Contacts

K08 – Mentored Clinical Scientist Development Award
          Ms. Lorraine Silsbee (301) 435-0707
K23 – Mentored Patient-Oriented Research Career Development
                Award
           (301) 435-0535
K02 – Independent Scientist Award
          Dr. Traci H. Mondoro (301) 435-0052
K22 - Career Transition Award
          Dr. Helena Mishoe (301) 435-5081
  NHLBI Research Training Contacts

K24 – Mid-career Investigator Award in Patient-Oriented Research
            Dr. Ellen Werner (301) 435-0077
K25 – Mentored Quantitative Research Career Development Award
            Dr. Michael Commarato (301) 435-0052
K01 – Minority Faculty Development Award
            Ms. Lorraine Silsbee (301) 435-0707
K01 – Mentored Career Award for Faculty at Minority Institutions
            Dr. Traci H. Mondoro (301) 435-0052
F33 – National Research Service Award for Senior Fellows
            Dr. Charlotte A. Pratt (301) 435-0382
                 Summary
1. Contact NIH Program Director
2. Work with mentor, collaborators
3. Prepare application
4. Solicit local reviews
5. Submit application
6. Before review, contact SRA, if necessary
7. After review, contact Program
 Additional Training Resources

             NHLBI Training & Funding
www.nhlbi.nih.gov/funding/training/training/index.htm

             NIH Training Opportunities
    http://grants1.nih.gov/training/extramural.htm

                       K Kiosk
http://grants1.nih.gov/training/careerdevelopment.htm

								
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