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Summary

Global Market Direct’s pharmaceuticals report, “Shire Plc - Product Pipeline Review
- 2012” provides data on the Shire Plc’s research and development focus. The report
includes information on current developmental pipeline, complete with latest
updates, and features on discontinued and dormant projects.

This report is built using data and information sourced from Global Markets Direct’s
proprietary databases, Shire Plc’s corporate website, SEC filings, investor
presentations and featured press releases, both from Shire Plc and industry-specific
third party sources, put together by Global Markets Direct’s team.

Scope

- Shire Plc - Brief Shire Plc overview including business description, key information
and facts, and its locations and subsidiaries.
- Review of current pipeline of Shire Plc human therapeutic division.
- Overview of pipeline therapeutics across various therapy areas.
- Coverage of current pipeline molecules in various stages of drug development,
including the combination treatment modalities, across the globe.

Table of contents:

List of Tables 8
List of Figures 10
Shire Plc Snapshot 11
Shire Plc Overview 11
Key Information 11
Key Facts 11
Shire Plc – Research and Development Overview 12
Key Therapeutic Areas 12
Shire Plc – Pipeline Review 15
Pipeline Products by Stage of Development 15
Pipeline Products – Monotherapy 16
Shire Plc – Pipeline Products Glance 17
Shire Plc – Late Stage Pipeline 17
Registration Filed Products/Combination Treatment Modalities 17
Phase III Products/Combination Treatment Modalities 18
Shire Plc Clinical Stage Pipeline Products 19
Phase II Products/Combination Treatment Modalities 19
Phase I Products/Combination Treatment Modalities 20
Shire Plc – Early Stage Pipeline Products 21
Pre-Clinical Products/Combination Treatment Modalities 21
Discovery Products/Combination Treatment Modalities 22
Shire Plc – Drug Profiles 23
Bradykinin B1 Receptor Antagonist 23
Product Description 23
Mechanism of Action 23
R&D Progress 23
Drug for Gastrointestinal & CNS 24
Product Description 24
Mechanism of Action 24
R&D Progress 24
Firazyr 25
Product Description 25
Mechanism of Action 25
R&D Progress 25
HGT 1110 27
Product Description 27
Mechanism of Action 27
R&D Progress 27
HGT 2310 28
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