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					              Identifier: BioRP-SOP                   BioRepository (BioRP)
                                                      Malaysia Genome Institute (MGI)
Effective Date:      Update:          No. of pages:   Jalan Bangi, 43000 Kajang, Selangor
   APR 2010        August 2012             25
                                                      Phone: 03-8926 7446 ext. 1435; Fax: 03-8926 7972
                                                      E-mail: biorp@genomemalaysia.gov.my



    Standard Operating Procedure (SOP)
          BioRepository (BioRP)
                                                 APPROVAL


AUTHOR:
Mohamad Ridzuan bin Kamarudin                                           Signature                  Date

CONTENT/QUALITY APPROVAL :
Prof Dr Sheila Nathan                                                   Signature                  Date




                                         AMENDMENT RECORD

ISSUE NUMBER                 DATE                                       CHANGE




            This procedure is a mandatory requirement and forms part of the BioRP Quality System

            UNAUTHORISED COPIES OF THIS DOCUMENT ARE NOT PERMITTED
                             Visit Our Website at www.genomemalaysia.gov.my
Table of Contents
1.0 INTRODUCTION ...................................................................................................................... 3

2.0 PURPOSE ................................................................................................................................ 3

3.0 SCOPE ..................................................................................................................................... 3

4.0 RESPONSIBILITIES ................................................................................................................... 3

5.0 DEFINITIONS........................................................................................................................... 4

6.0 TRAINING ............................................................................................................................... 4

7.0 HEALTH AND SAFETY.............................................................................................................. 4

8.0 HOW TO DEPOSIT BIOSPECIMENS ......................................................................................... 4

9.0 PROCEDURE

    9.1 BioSpecimens Receiving

      9.1.1 BioSpecimens Transfer Agreement .............................................................................. 5

      9.1.2 Receiving....................................................................................................................... 5

    9.2 BioSpecimens Processing

      9.2.1 Transfer of Glycerol Stock from 96-Well Plate to 384-Well Plate ................................ 5

    9.3 BioSpecimens Storage and Inventory

      9.3.1 Storage.......................................................................................................................... 7

      9.3.2 Creating a Barcode Label .............................................................................................. 8

      9.3.3 Enable Barcode Scanners ............................................................................................. 9




                                                                      1
10.0 RELATED DOCUMENT

    10.1 Freezer

     10.1.1 Use of the Freezer ........................................................................................................ 9

     10.1.2 Routine Maintenance

       10.1.2.1 Cleaning of Cabinet ................................................................................................ 10

       10.1.2.2 Cleaning of Condenser Filter ................................................................................. 10

       10.1.2.3 Defrosting of Inside Wall ....................................................................................... 11

    10.2 Computer Server

     10.2.1 Routine Maintenance of Computer Server ................................................................ 12

    10.3 Emergency Response Procedure

     10.3.1 Emergency Procedure for -20oC & -80oC Freezer Failure .......................................... 13

     10.3.2 Biohazardous Spills ..................................................................................................... 13

11.0 APPENDICES

    11.1 BioSpecimens Transfer Agreement 15

    11.2 Freezer: Routine Maintenance

     11.2.1 Cleaning of Cabinet ..................................................................................................17

     11.2.2 Cleaning of Condenser Filter ....................................................................................18

     11.2.3 Defrosting of Inside Wall ............................................................................................ 19

    11.3 Routine Maintenance of Computer Server .............................................................. 20

    11.4 Accident Reporting Form ........................................................................................... 21

12.0 REFERENCES ......................................................................................................................... 24




                                                                     2
1.0    INTRODUCTION

The Biorepository (BioRP) is a core depository facility was designed to collect, process and track a

large numbers of high quality research BioSpecimensvery quickly and efficiently. This is a long-

term project aim at building a comprehensive depository and resource information for

depository. The BioRP is more than a storage facility just tracking specimen’s inventory, but most

of the operation are performed using laboratory automation including the integrated monitoring

system and inventory system to avoid processing errors inherent in the handling a larger numbers

of BioSpecimens. The BioRP will provide a biological specimen documentation using robust

centralized data management system.



2.0    PURPOSE

The purpose of this document is to detail the correct method for laboratory staff to store the

BioSpecimens the freezer (-20oC & -80oC) at the BioRP room in a safe manner.



3.0    SCOPE

This document covers the procedures for receiving, processing, storage and inventory of

BioSpecimens.



4.0    RESPONSIBILITIES

All laboratory staff will be responsible for carrying out procedures as detailed out in this

document. The Principle Investigator will oversee that all laboratory staff will work in accordance

to this document.




                                                 3
5.0   DEFINITIONS
Terminology                           Definition
BioRP                                 Biorepository
SOP                                   Standard Operating Procedure
CR3                                   Code Reader 3.0 Scanner

6.0       HEALTH AND SAFETY
          •     A lab coat must be worn all the times at the facilitiy.
          •     Special gloves and goggles must always be worn when handling samples to be
                stored in the freezers.
          •     All microbiologically contaminated media in the laboratory shall be autoclaved
                prior to disposal.
          •     Mouth pipetting is prohibited
          •     All accidents, particularly those which may result in infection, shall be reported to
                the Principle Investigator. The Accident Reporting Form (page 21) must be
                completed also.

7.0       HOW TO DEPOSIT BIOSPECIMENS




                                                       Transferring BioSpesimens to
                                                             a 384-well plate



                                                                   No


                                                                   Sent                       Freeze the plate
                     Contact           Login
  START                                          Yes          BioSpecimens            Yes        at Freezer      END
                   BioRP Staff      BioRP-DAT
                                                             in 384-well plate                  -80oC/-20oC


                                        No


                                     Create an
                                      account




Figure 1: Schematic outline of deposit BioSpecimens work flow.



8.0       LIST OF EQUIPMENT

         Equipment                    Type                                                   Model
Freezer -20oC                         Sanyo                                                 MDF-U537
Freezer -80oC                         Sanyo                                                 MDF-U73V
Barcode printer                       Brady                                                 BP-IP600



                                                       4
9.0    PROCEDURE

       9.1 BioSpecimens Receiving

             9.1.1 BioSpecimens Transfer Agreement Form

STEP       ACTION
1          Check that the BioSpecimens Transfer Agreement Form (page 15) is complete.
           To protect the depositor’s right and to promote the utilization of biological resource in
           field of research and development, the BioSpecimens Transfer Agreement should be
           concluded between the depositor and BioRP.

2          Depositor is request to send the BioSpecimens when the BioSpecimens Transfer
           Agreement has been finalized between Depositor and BioRP and one copy has been
           returned to the depositor. Although a culture in glycerol is preferable for deposit, a
           living culture can be considered.


             9.1.2 Receiving

STEP       ACTION
1          Verify the information on repository form and BioSpecimens Transfer Agreement match
           that on the BioSpecimens labels on the containers.

2          Check the BioSpecimens is accommodated in the form of 1.5 ml vial, 96-wells plate or
           384-wells plate.

3          Ensure the BioSpecimens is in the frozen condition and the container is defective free.



       9.2 BioSpecimens Processing

             9.2.1 Transfer of Glycerol Stock from 96-Well Plate to 384-Well Plate

STEP       ACTION
1          Place the 96-well plates-glycerol stock (source plate) in a laminar flow / biosafety
           cabinet to thaw about 30 minutes.
           To avoid cross-contamination among neighboring wells, un-foiling plates while they are
           frozen rather than after they have thawed.

2          During the thawing process, turn on Biomex NXP robots
3          Check the waste reservoir and make sure it is empty

4          After the thawing process, put all the glycerol stock plates on ice before the transferring
           procedure.
5          Glycerol stock plates are visually inspected to see if there any holes or irregularities such

                                                5
        as contamination.
        If there any holes or irregularities, return the glycerol stock plates to the depositor, so
        that the plate may be fixed or replaced.

6       Open the Biomex®software operating system on the computer, allow the robot for
        homing procedure and set the protocol as follows.

6.1     Drag and drop an Instrument Setup step from the Basic Palette into the Method View.

6.1.1   To load the labware, highlight the Instrument Setup and the configuration area will be
        appeared.

6.1.2   Select an ALP_50ul tips from the configuration area and drop to TL1, P1, P4 and P7.

6.1.3   Select a swap station from the configuration area and drop to P10.

6.1.4   Select a source plate (96-well plate-greiner cone PP) from the configuration area and
        drop to P2, P3, P6 and P8, double click on the plate graphic to add the volume and liquid
        type.

6.1.5   Select a destination plate (384-well plate-genetix flat bottom) from the configuration
        area and drop to P5, double click on the graphic to name it.

6.2     Drag and drop a Transfer step from the Step Palette into the Method View just below
        the Instrument Setup step.

6.2.1   In Tip Handling, make sure Load is checked.

6.2.2   Click on the AP96_50ul tip box on TL1 in the Current Deck Display to load AP96_50ul tips
        as part of the Transfer step.

6.2.3   Select unload them in the next field.

6.2.4   Select Change tips between sources.

6.2.5   To configure the 96-well plate as a source plate, clicks on ‘Click here to add source’, then
        click on the plate graphic on the deck display.

6.2.6   Set the aspirate height for the depth of the tip descends into the source plate by place
        the mouse cursor over the tip illustration and hold down the left mouse button and
        move up and down until the depth is as close to 1.00 mm from bottom.

        The other way to set the aspirate height by right-click on the graphic, then select the
        height from the menu that appears.

6.2.7   Configure the 384-well plate as a destination plate, click on ‘Click here to add
        destination’, then click on destination graphic on the deck display.
                                             6
6.2.8       Transfer liquid into specific well columns or rows, double click on the selected well
            graphic then add the transfer volume and set the aspirate height. Repeat this procedure
            to all columns and rows.

6.3         Click on Finish step to end the method, check the status bar at the bottom for any error.
            The error message will be highlighted in red. Use the displayed message to correct the
            error and reconfigure the step.

6.4         To run the method, click on the green arrow button on the toolbar and the deck
            confirmation will appears on the top of the main editor.

6.5         If the physical deck layout matches to the expected deck layout shown in the deck
            confirmation, choose ok. The prompt will continues.

7           When the run is finished, remove the 384-well plate (glycerol stock) from P5 and put the
            plate in a laminar flow.

8           Seal the 384-well plate (glycerol stock) with adhesive plate sealer.

9           Label the glycerol plates and put all the relevant description

10          Place the glycerol plates on the designated rack in -800C freezer.

        9.3 BioSpecimens Storage and Inventory

              9.3.1 Storage

STEP        ACTION
1           Store labeled BioSpecimens according to sample type:
            BioSpecimens 1 (Glycerol stock) at -80°C freezer OR BioSpecimens 2 (DNA, RNA, cDNA
            clone and genomic clone) at -20°C freezer

3           Record BioSpecimens information according to data entry worksheet.

4           Enter stored BioSpecimens data into BioRP database system.


              9.3.2 Creating a Barcode Label

The barcode labels are depicted in Figure 2.




                                                 7
                              Figure 1: Barcode label for freezer -20oC




                              Figure 2: Barcode label for freezer -80oC

STEP          ACTION
1             Turn on the computer and the barcode printer (BRADY IP Series Printer).

2             Insert the barcode dongle to the USB port of your PC

3             Click on Start > All programs > Teklynx > CODESOFT 8 > CODESOFT 8 Enterprise

4             Click File > open > BioRP-Barcode > -20oC OR -80oC
5             Edit text (see Figure 1 & 2)

6             Print


                9.3.3 Enable Barcode Scanners

STEP          ACTION
1             Connect the USB interface cable to the host

2             To power up the reader (CR3), press and hold either of the red trigger buttons for 3
              seconds

3             The CR3 features omnidirectional decoding. Center the symbol in any orientation within
              the laser dot aiming pattern (Figure 3).

4             Hold the CR3 still - DO NOT SWIPE OR MOVE THE READER. Press the trigger until the
              CR3 beeps, indicating the code has been successfully decoded




    Figure 3: Center the symbol in any orientation within the laser dot aiming pattern (red spot).

                                                  8
10.0   PROCEDURE FOR USAGE OF THE EQUIPMENT

       10.1 Freezer (-20oC and -80oC)

       10.1.1 Use of the Freezer

STEP        ACTION
1           The freezers should be checked daily to ensure it is in working order. If any problems
            occur, these should be reported immediately. All contents should be removed until the
            freezer is fully operational.

            Before open a freezer, location of the sample must be confirmed. If not, take out the
            whole rack or box and close the freezer door.

2           Open the door for as short a time as possible to prevent large temperature fluctuations.

3           If the freezer doors have been left open for more than a few minutes, allow 30 minutes
            of closed-door stabilization prior to recording temperature.


              10.1.2 Routine Maintenance

                     10.1.2.1 Cleaning of the freezer cabinet

STEP        ACTION
1           Clean the unit every sixth month (page 17). Regular cleaning keeps the freezer cabinet
            looking new.

2           Use a dry cloth to wipe off small amounts of dirt on the outside and inside of the unit
            and all accessories. If the outside panels are dirty, clean them with a diluted neutral
            dishwashing detergent. (Undiluted detergent can damage the plastic components. For
            the dilution, refer to the instruction of the detergent.)

3.          After the cleaning with the diluted detergent, always wipe it off with a wet cloth. Then
            wipe off the cabinet or accessories with a dry cloth.

4.          Never pour water onto or into the unit. Doing so can damage the electric insulation and
            cause failure.
5.          The compressor and other mechanical part are completely sealed. This unit requires
            absolutely no lubrication.

6.          There is a fan behind the compressor, so be very careful if you stick your hand into this
            part of the unit.




                                               9
                 10.1.2.2 Cleaning of Condenser Filter

STEP   ACTION
1      This unit is provided with the filter check lamp on the control panel. Clean the filter
       when this lamp lights. Clean the filter every 3 month even if the check lamp is not on
       since a clogged filter may cause shorter compressor life as well as the poor cooling (page
       18).
       WARNING: Do not touch the condenser directly when the filter is removed for cleaning.
       This may cause injury by hot surface.

2      Open the grille by pulling it to you as shown in the Figure 4.

3      Take out the condenser filter.

4      Wash the filter with water.
5      Replace the filter and the grille.

6      Check that the filter check lamp is off in the event the check lamp was ON.




                      Figure 4: Step to open the grille (front view).

                 10.1.2.3 Defrosting of Inside Wall

STEP   ACTION
1      Clean the frost every years (page 19). The frost is built at the upper portion of the
       chamber and inner door. The excessive frost possibly make some gap between the
       cabinet and door gasket, which may cause poor cooling. Remove the frost on the inner
       door with a scraper enclosed with the unit. Following shows the procedure for removing
       the chamber frost.
       Note: For removing the frost, do not use a tool with sharp edge such as a knife or a
       screw driver.

                                            10
2           Turn off the back-up system if applicable.

3.          Take out and transfer all the contents to another freezer or a container which is
            refrigerated by liquid carbon dioxide or dry ice.

4.          Turn off the power switch of the freezer.

5           Open the outer door and inner door. Remove the inner door by lifting up as shown in
            the Figure 5.

6           Leave the freezer as it is.
7           The water accumulated on the bottom of the chamber should be wiped up with a dry
            cloth.

8           After cleaning the chamber and inner door, replace the inner door and start up the unit

9           Put back the articles into the sufficiently cooled freezer compartment.

10          Turn on the back-up system if it is provided.




              Figure 5: Step to open the outer door and inner door of the freezer

       10.2 Computer Server (Part of the monitoring system).

              10.2.1 Routine Maintenance of the Computer Server

STEP        ACTION
1           Restart the computer every 2-3 days (page 20)

2           Keep a normal data back-up path

3.          Check if the connection of hardware connecting lines is good periodically


                                               11
10.3 Emergency Response Procedure


       10.3.1 Emergency Procedure for -20oC & -80oC Freezer Failure

STEP        ACTION
1           The freezer is set to operate at -20oC and -80oC, will result in the alarm sounding, this
            alarm will be audible in the Freezer room and in the corridor outside the room. The
            alarm can be silenced by pressing Buzzer stop key (BUZZER). If the alarm condition
            continues, the audible alarm will sound again after 30 minutes.

2           The CO2 Back-Up system is set to inject liquid CO2 gas into the freezer if the temperature
            rises above –65oC. One full CO2 tank will provide cooling to the Freezer for
            approximately 8 hours, depending on ambient temperature of the Freezer room.


10.3.2 Biohazardous Spills

STEP        ACTION
1           Warn personnel in the area, evacuate the lab, and close all doors into the area.

2           Get the laboratory spill cleanup kit. Wear appropriate personal protective equipment
            (PPE) whenever contacting or working with biohazardous materials. Always remove PPE
            when leaving laboratory or area of spill.

3           Pour an appropriate disinfectant solution around, but not on the spill. Mix the
            disinfectant with the spilled materials cautiously from the outside of the spill towards
            the centre.

4           Leave the area for a minimum of 30 minutes to allow the disinfectant to react with the
            spilled materials.

5           Carefully soak up the liquid with absorbent paper and place in an autoclave bag or other
            container for immediate autoclaving.

6           Apply additional disinfectant to the area for 10 minutes then absorb with paper towels

7           Wash the area with a detergent and rinse with clean water
8           Report the spill to the Principal Investigator and complete an incident report using
            Accident Reporting Form (page 21).




                                               12
11.0 APPENDICES




      13
    BioSpecimens Transfer Agreement Form
DEPOSITOR INFORMATION
Project leader :                                                              For Office Use only
Organization :
Tel            :                                                   Date received:………/…………/20.….
Fax            :                                                   Approved:           Yes      No
Email            :                                                 Freezer:      -20 C -80oC
                                                                                         o

Address          :                                                 Accession No:……………………………….

                                                                   Barcode No:………………………..……….


PROJECT INFORMATION
Title         :
Grant No      :
Grant Start / :
End Date

BIOSPECIMENSTS INFORMATION
Pathogenicity:           The strain is pathogenic for
                                   Man               Yes Risk class ____          No          Unknown
                                   Animal
                                   Plant
Type of sample                     Bacteria glycerol stock                 Genomic clone
                                   cDNA Library                            Mixture of microorganisms
                                   cDNA clone                              Others…………………..……..…..……
Storage format                     384 wells plate
Number of plate(s)
Cloning vector/host cell
Is the BioSpecimens                No                                  Yes, patent ………………………….
patented?

Additional Information/comments:




                                             14
                             Terms and Regulations
  1. The BioSpecimens(s) will be deposited to BioRP without any fees or charges.
  2. All the BioSpecimens(s) had been deposited will be entitlement to BioRP but depositor still
     retain ownership of intellectual property. Please note that the BioSpecimens(s) belong to
     the depositor will not be obtain or acquire without any strong excuses.
  3. The depositor are acquired to keep a backup of their BioSpecimens(s) and data. Failing
     which, BioRP will not be held responsible for any loss of BioSpecimens(s) and data as a
     result of not functional BioSpecimens, human error or any other events which lead to a
     partial or total loss of the BioSpecimens.
  4. All the information associated with the BioSpecimens(s) is treated as a confidential and
     the depositor still retain ownership of intellectual property.
  5. BioRP will only receive one replicate of each BioSpecimens which keep at -20oC and -800C.


I declare that all the information I have submitted is true and does not
            infringe intellectual property agreement or law.

  I have read and hereby agree to the terms and regulations are state
                                above.

Depositor



          Name                        Designation               Signature               Date




Scientist Receiving BioSpecimens



          Name                        Designation               Signature               Date




                                             15
           Room Temperature Record Form
Month / Year: _________ / _______                 Target Temperature: 16oC – 25 oC
 Day     Temperature (oC)      Initials                 Notes /Comments
  1
  2
  3
  4
  5
  6
  7
  8
  9
 10
 11
 12
 13
 14
 15
 16
 17
 18
 19
 20
 21
 22
 23
 24
 25
 26
 27
 28
 29
 30
 31




      Signature of                         Name                              Date
   Authorized Official




                                          16
17
           Cleaning of the Freezer Cabinet
Year         Date      Initials           Comments

2010       January


             July


2011       January


             July


2012       January


             July


2013       January


             July




    Signature of                   Name              Date
 Authorized Official




                                  18
              Cleaning of Condenser Filter
Year                   Date   Initial   Comment
2010        March
             June
          September
          December
2011        March
             June
          September
          December
2012        March
             June
          September
          December
2013        March
             June
          September
          December
2014        March
             June
          September
          December
2015        March
             June
          September
          December




    Signature of                Name              Date
 Authorized Official




                              19
   Defrosting of Inside Wall of the Freezer
Year         Date      Initials           Comments

2010



2011



2012



2013



2014



2015




    Signature of                   Name              Date
 Authorized Official




                                  20
  Routine Maintenance of Computer Server
Year: ……….……..

                 JAN     FEB   MAR      APR   MAY      JUN
   Mon
   Wed
    Fri
   Mon
   Wed
    Fri
   Mon
   Wed
    Fri
   Mon
   Wed
    Fri
   Mon
   Wed
    Fri

                 JUL     AUG   SEP      OCT   NOV      DEC
   Mon
   Wed
    Fri
   Mon
   Wed
    Fri
   Mon
   Wed
    Fri
   Mon
   Wed
    Fri
   Mon
   Wed
    Fri



      Signature of               Name               Date
   Authorized Official




                               21
22
                     Accident Reporting Form
Name:________________________ Date of Incident:____________________________________
(One person’s name only)                       (If not known, write date report was started)

Where Occurred:_________________________ Time Occurred:___________________________
(Address or location, as appropriate)       (If not known, write time report was started)

Others Involved:__________________________________________________________________
(All persons served are to be referred to by initials only. A separate report must be completed for
each person.)

Others Who Witnessed Incident:_____________________________________________________
(Initials only for persons served. Any employees and members of community should be listed by
name.)

Describe What Preceded Incident, If Known (Give factual and objective details of what had been
happening in the person’s life the preceding few hours and/or prior events which may have had
impact on the incident):




Describe Incident (Use concise, factual details. Be specific. Ask who, what, where and how. Give
exact quotes, if possible. If injuries were detected, describe what they look like and indicate
location on the person’s body, in detail):




                                                23
Initial Follow-up (Staff will document their immediate response to the incident. Examples may
include, but are not limited to: first aid administered in case of injury, interventions followed in
an approved plan, report filed with Protective Services):




Management Follow-up (A management follow-up response is required on all incident reports.
Further management follow-up may include initiating other service involvement, e.g., medical,
services coordination):




 The individual whose name appears in the “Name” section of this report has been informed this
      information may be shared with others who need to know about it and only necessary
                                 information will be shared.


    Person Writing Report                   Position                Initials               Date



            Witness                         Position                Initials               Date



         Signature of                       Position                Initials               Date
      Authorized Official




                                                24
         Instructions for Completion of Incident Report
The Incident Report form will be completed as follows:
   1. Name: document one person’s name only
   2. Date Of Incident: document the date the incident occurred; if not known, write date
       report was started
   3. Where Occurred: document the address or location where the incident occurred, as
       appropriate
   4. Time Occurred: document the time the incident occurred; if not known, write time report
       was started
   5. Others Involved: document others who were involved in the incident (all persons served
       are to be referred to by initials only); a separate report must be completed for each
       person
   6. Others Who Witnessed Incident: document others who witnessed the incident (using
       initials only for persons served); any employees and members of community should be
       listed by name
   7. Describe What Preceded Incident, if Known: give factual and objective details of what had
       been happening in the person’s life the preceding few hours and/or prior events which
       may have had impact on the incident
   8. Describe Incident: use concise, factual details and be specific; ask who, what, where and
       how and give exact quotes, if possible; if injuries were detected, describe what they look
       like and indicate location on the person’s body, in detail
   9. Initial Follow-up: staff will document their follow-up to the incident; examples may
       include but are not limited to:
            • staff’s immediate response to the incident
            • first aid administered in case of injury
            • interventions followed in an approved plan
   10. Management follow-up: management staff will document their response to the incident;
       this is mandatory in all situations; examples may include, but are not limited to:
            • if an injury was found and it is not known how the injury occurred, the
                management reviewer must attempt to determine the circumstances that led to
                the injury (at a minimum, talk to staff who worked during the past 24 hours);
                documentation of all staff interviewed must be completed and whether a cause
                can be determined
            • if restraint was used, the management reviewer must verify whether it was done
                in accordance with any applicable program
            • the initiation of other service involvement, e.g., medical, services coordination




                                               25
11.0   REFERENCESS

   1. (2008). Biopreservation and Biobanking, 6(4), 289-296.

   2. Anchordoquy, T. J., & Molina, M. C. (2007). Preservation of DNA. Cell Preservation Technology,
      5(4), 180-188.

   3. Animal Care Unit. Use and Cleaning of Refrigerators and Freezers. SOP: ACU/020/01, The
      University of Western Australia.

   4. Australasian BioSpecimens Network. (2006). Guidelines on collection of BioSpecimens. Guidelines
      for Biorepository Protocols. 12-15.

   5. Baust, J. G. (2007). BioSpecimens Research: Enabling Translational Medicine. Cell Preservation
      Technology, 5(4), 177-177.

   6. Best Practices for Repositories I: Collection, Storage, and Retrieval of Human Biological Materials
      for Research. (2005). Cell Preservation Technology, 3(1), 5-48.

   7. Chair, J.M. (2009). Standard Operating Procedures. Australia’s Healthy Ageing Biobank. Version#2

   8. Collection, Storage, Retrieval and Distribution of Biological Materials for Research. (2008). Cell
      Preservation Technology, 6(1), 3-58.

   9. Division of Comparative Medicine, Refrigerator and Freezer Unit Use and Monitoring.
      SOP#:1114.1. University of South Florida.

   10. Eder, J., Dabringer, C., Schicho, M., & Stark, K. (2009). Information Systems for Federated
       Biobanks. In Transactions on Large-Scale Data- and Knowledge-Centered Systems I (pp. 156-190).

   11. Eiseman E, Bloom G, Brower J, Clancy N, Olmsted SS. (2003). Case studies of existing human tissue
       repositories. “Best practices” for a BioSpecimens resource for the genomic and proteomic era.
       Santa Monica (CA): RAND Corporation.

   12. Faircloth, J.M. (2008). Temperature Monitoring of Walk-in Refrigerator and Freezer and of
       Precision Scientific and Percival Scientific®Incubator. SOP#TA-06.01: Florida DEP Biology Section.

   13. Groover, K., Drew, K., & Franke, J. (2007). The Use of Compressor Cycle Patterns: The Ability to
       Predict Freezer Failure. Cell Preservation Technology, 5(4), 225-228.

   14. Hede, K. (2006). New Biorepository Guidelines Raise Concerns. J. Natl. Cancer Inst., 98(14), 952-
       954.

   15. Holland, N. T., M. T. Smith, B. Eskenazi, and M. Bastaki. (2003). Biological samples collection,
       processing for molecular epidemiological studies. Mutation Research. 543: 217-234.



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