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					Effects of Weight Gain

There seems to be some effects that happen in the body before and after
weight gain. It may have something to do with the way that blood flows
through the body. But that is putting it simply. There was a recent study
about how substantial weight gain in people may affect certain functions
that concern the efficient blood flow in the body.

In a research report provided by the world renowned Mayo Clinic in the
US, researchers have discovered that substantial weight gain may cause
some impairment on endothelial function. The aim of the study was to
learn about the effects of weight gain and subsequent weight loss to the
endothelial function. Endothelial cells in the body can be found lining
up the blood vessels. When they are not functioning properly, these cells
can obstruct blood flow. This may eventually lead to a person suffering
from a heart attack or stroke.

According to the study, a weight gain of nine to ten pounds in lean
healthy young adults may be enough to impair endothelial function. This
is considered to be an important finding since endothelial dysfunction is
a known predictor of heart attacks and stroke. Its association with
weight gain was not previously known.

The Mayo Clinic study was the first controlled, randomized and blinded
trial that was undertaken to evaluate the effects of weight gain and the
subsequent weight loss on endothelial function. The study consisted of
getting a group of 43 lean and healthy volunteers with an average body
mass index of between 18.5 and 24.9. The body mass index is a statistical
measurement of a person's weight in relation to height. The average age
of the volunteers was 29, with 42 percent of them being women. All the
volunteers in the group were not taking any type of medication during the
study and were non-smokers.

The volunteer group went through a weight maintenance period supervised
by an experienced dietician. During this period, the volunteers were
randomly selected to either gain weight or maintain weight. 35 of the
volunteers went into the weight gaining groups while the rest made up the
weight maintaining group.

During the course of the study, the 35 volunteers gained weight for up to
nine pounds or four kilograms. Their endothelial functions were then
measured by means of ultrasound on the large vessel in the upper arm
called the brachial artery. The measurements were done at the same time
early in the morning and under various flow conditions.

For the weight gainers, measurements of the endothelial function was done
at the start of the study, eight weeks after gaining weight and then 16
weeks after weight loss. The other group was measured at the start of the
study and then eight weeks later for follow-up.

During the said study, the weight gainers put on an average of four kilos
of weight which also increased their visceral and subcutaneous fat in the
body. The flow measurements at the brachial artery from the weight
gainers showed gradual decrease with the addition of weight.
But when the subjects went through the period of losing the weight they
have gained during the study, the flow levels improved and eventually
returned to the levels measured at the start of the study. This goes to
show that endothelial function in the body may be affected before and
after weight gain.

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