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					                                         Online Appendix for the following JACC article

TITLE: Clinical Outcomes Following Stent Thrombosis Occurring In-Hospital

Versus Out-of-Hospital: Results From the <CASE>HORIZONS-AMI</CASE> Trial



AUTHORS: George D. Dangas, MD, PHD, Bimmer E. Claessen, MD, PHD, Roxana Mehran, MD, Sorin Brener, MD, Bruce R.

Brodie, MD, Dariusz Dudek, MD, Bernhard Witzenbichler, MD, Jan Z. Peruga, MD, Giulio Guagliumi, MD, PHD, Jeffrey W. Moses,

MD, Ke Xu, PHD, Gregg W. Stone, MD




APPENDIX
Supplementary Table 1. Odds ratios for variables included in the multivariate logistic regression
model used to calculate the propensity score
               Variable              Estimate          StdErr          P value          Odds Ratio
 Intercept                           -0.6739           1.9498          0.7296
 Bivalirudin vs. UFH +GPI             1.0895           0.4717          0.0209         2.97 [1.18, 7.49]
 Baseline Platelet Count              0.0004           0.0023          0.8526         1.00 [1.00, 1.00]
 Baseline TIMI 0/1 vs. 2/3            2.1282           0.8122          0.0088        8.40 [1.71,41.27]
 Diabetes                            -1.5275           0.6630          0.0212         0.22 [0.06, 0.80]
 Final TIMI 3 vs. 0/1/2              -0.2984           0.5942          0.6155         0.74 [0.23, 2.38]
 Pre-randomization Heparin           -1.0417           0.4492          0.0204         0.35 [0.15, 0.85]
 Current Smoker                      -0.9958           0.5447          0.0675         0.37 [0.13, 1.07]
 Age (10 Years Increment)            -0.1272           0.2291          0.5788         0.88 [0.56, 1.38]
               Supplementary Table 2. Baseline clinical, angiographic, and procedural characteristics, and 1-year clinical outcomes in patients with
               in-hospital and out-of-hospital ST according to the Academic Research Consortium ST timing definitions

Variable Description                                                       In-Hospital ST                                                  Out-of-Hospital ST                               P-value
                                                                                                                                                                            (e)
                                                                  (a)                          (b)                       (c)                        (d)
                                                                                                                                                                   Out of Hospital Very
                                                      Acute In Hospital Def/Prob       Subacute In Hospital       Subacute Out of          Out of Hospital Late
                                                                                                                                                                     Late (1Y to 3Y)
                                                                  ST                      Def/Prob ST           Hospital Def/Prob ST     (30d to 1Y) Def/Prob ST
                                                                                                                                                                       Def/Prob ST
                                                                (N=28)                       (N=26)                    (N=22)                     (N=30)
                                                                                                                                                                          (N=50)
Clinical characteristics
Age                                                      54.66 (48.06, 60.85)          59.18 (50.68, 68.36)     61.42 (53.22, 70.92)      58.15 (49.48, 64.97)      58.41 (52.48, 68.71)     0.09
Male                                                        71.4% (20/28)                   65.4% (17/26)          77.3% (17/22)             86.7% (26/30)             78.0% (39/50)         0.63
Body Mass Index                                          28.52 (26.00, 31.37)          26.67 (23.75, 29.76)     29.07 (25.79, 31.10)      25.95 (24.03, 29.73)      27.53 (25.26, 30.11)     0.14
History of Hypertension                                     53.6% (15/28)                   50.0% (13/26)          63.6% (14/22)             46.7% (14/30)             64.0% (32/50)         0.79
History of Hyperlipidemia                                   46.4% (13/28)                   46.2% (12/26)          45.5% (10/22)             46.7% (14/30)             54.0% (27/50)         0.98
Current Smoking                                             53.6% (15/28)                   46.2% (12/26)          61.9% (13/21)             76.7% (23/30)             62.0% (31/50)         0.19
History of diabetes mellitus                                 7.1% (2/28)                    15.4% (4/26)           45.5% (10/22)              13.3% (4/30)             22.0% (11/50)         0.01
 Insulin-treated                                             3.6% (1/28)                     7.7% (2/26)            31.8% (7/22)              10.0% (3/30)              8.0% (4/50)          0.02
History of prior myocardial infarction                      14.3% (4/28)                    11.5% (3/26)            4.5% (1/22)               20.0% (6/30)             22.0% (11/50)         0.37
History of prior percutaneous coronary intervention         14.3% (4/28)                    15.4% (4/26)            18.2% (4/22)              20.0% (6/30)             24.0% (12/50)         0.84
History of prior coronary artery bypass grafting             3.6% (1/28)                     0.0% (0/26)            0.0% (0/22)               3.3% (1/30)               0.0% (0/50)          0.49
History of congestive heart failure                          3.6% (1/28)                     3.8% (1/26)            9.1% (2/22)               0.0% (0/30)               8.0% (4/50)          0.49
History of peripheral vascular disease                       3.6% (1/28)                     3.8% (1/26)            13.6% (3/22)              13.3% (4/30)              2.0% (1/50)          0.16
History of renal insufficiency                               3.6% (1/28)                     7.7% (2/26)            9.1% (2/22)               0.0% (0/30)               6.0% (3/50)          0.57
 Current Dialysis                                            0.0% (0/28)                     3.8% (1/26)            4.5% (1/22)               0.0% (0/30)               2.0% (1/50)          0.65
 Creatinine Clearance <60                                   11.1% (3/27)                    21.7% (5/23)            27.3% (6/22)              8.3% (2/24)              15.2% (7/46)          0.39
Anemia                                                       3.6% (1/28)                    12.0% (3/25)            15.0% (3/20)              10.3% (3/29)             14.0% (6/43)          0.68
Thrombocytopenia*                                           23.1% (6/26)                    13.6% (3/22)            4.5% (1/22)               6.7% (2/30)               8.9% (4/45)          0.22
CPK at admission, U/l                                   92.00 (67.00, 218.00)        216.00 (120.00, 369.00)   208.82 (135.00, 445.50)   178.00 (87.50, 342.50)    125.00 (70.00, 194.00)   0.010
                                                                             2054.00 (1173.00,         2162.22 (1015.00,          1322.50 (540.00,          1173.50 (499.00,       0.036
CPK peak value during original STEMI, U/l     2217.50 (1406.50, 4146.50)
                                                                                 4831.00)                  4172.00)                  2352.00)                  2770.00)
Angiographic and procedural characteristics
Door to Balloon Time (minutes)                  77.00 (60.00, 126.00)      106.50 (72.50, 123.50)     95.00 (81.00, 130.00)     89.50 (65.00, 134.00)     89.00 (71.00, 122.00)     0.40
Symptom onset to Balloon Time (minutes)        175.00 (151.00, 242.00)     238.00 (189.00, 320.00)   241.00 (185.00, 643.00)   240.00 (149.00, 345.00)   217.00 (161.00, 330.00)    0.06
Left Ventricular Ejection Fraction               53.50 (50.00, 60.00)       45.00 (33.50, 59.00)      45.00 (37.00, 51.00)      45.00 (40.00, 55.00)      51.00 (42.00, 60.00)      0.10
Multivessel disease                                 57.1% (16/28)              57.7% (15/26)             59.1% (13/22)             46.7% (14/30)             66.0% (33/50)          0.57
Number of vessels treated                            1.00 ± 0.00                 1.16 ± 0.37               1.05 ± 0.21               1.03 ± 0.18               1.00 ± 0.00          0.01
Number of lesions treated                            0.0% (0/28)                16.0% (4/25)              4.5% (1/22)               3.3% (1/30)               0.0% (0/49)           0.01
Vessel treated
 Left anterior descending coronary artery           30.0% (9/30)               48.4% (15/31)              37.5% (9/24)             40.0% (12/30)             35.3% (18/51)          0.65
 Circumflex coronary artery                         20.0% (6/30)                22.6% (7/31)              20.8% (5/24)              10.0% (3/30)              7.8% (4/51)           0.26
 Right coronary artery                              46.7% (14/30)               29.0% (9/31)             41.7% (10/24)             46.7% (14/30)             56.9% (29/51)          0.18
Number of stents implanted                           1.85 ± 1.05                 1.67 ± 0.92               1.48 ± 1.03               1.55 ± 0.91               1.70 ± 1.20          0.77
Total stent length implanted                     30.00 (20.00, 44.00)       24.00 (20.00, 46.00)      23.00 (20.00, 32.00)      26.00 (18.00, 45.00)      28.00 (20.00, 40.00)      0.81
Post-stent dilatation balloon used                  44.4% (12/27)               34.6% (9/26)             47.6% (10/21)             69.0% (20/29)             44.9% (22/49)          0.12
Direct stenting                                     26.9% (7/26)                29.2% (7/24)              42.9% (9/21)             34.5% (10/29)             40.0% (20/50)          0.70
Any drug-eluting stent implanted                    80.8% (21/26)              61.5% (16/26)             61.9% (13/21)             79.3% (23/29)             72.0% (36/50)          0.38
Side Branch Lesion Treated                           7.1% (2/28)                0.0% (0/26)               4.5% (1/22)               10.0% (3/30)              6.0% (3/50)           0.60
Aspiration catheter used                            10.7% (3/28)                7.7% (2/26)               0.0% (0/22)               30.0% (9/30)              10.0% (5/50)          0.01
Pre-PCI flow TIMI 0/1                               92.9% (26/28)              91.7% (22/24)             68.2% (15/22)             65.5% (19/29)             52.0% (26/50)         0.0004
Final post-PCI flow TIMI 3                          78.6% (22/28)              75.0% (18/24)             68.2% (15/22)             86.2% (25/29)             94.0% (47/50)         0.051
Post-PCI Myocardial Blush Grade (Dynamic)                                                                                                                                          0.063
 Blush 0/1                                          14.3% (4/28)                39.1% (9/23)              22.7% (5/22)              20.7% (6/29)              8.0% (4/50)
 Blush 2                                            35.7% (10/28)               13.0% (3/23)              27.3% (6/22)              13.8% (4/29)             28.0% (14/50)
 Blush 3                                            50.0% (14/28)              47.8% (11/23)             50.0% (11/22)             65.5% (19/29)             64.0% (32/50)
Randomized to bivalirudin                           85.7% (24/28)              42.3% (11/26)              36.4% (8/22)             46.7% (14/30)             36.0% (18/50)         0.0004
Pre-randomization Heparin                           35.7% (10/28)              53.8% (14/26)             68.2% (15/22)             56.7% (17/30)             68.0% (34/50)          0.06
Pre-PCI clopidogrel loading dose given             89.3% (25/28)    100.0% (26/26)   100.0% (22/22)   96.7% (29/30)    96.0% (48/50)     0.24
 600 mg                                            64.0% (16/25)    46.2% (12/26)    50.0% (11/22)    65.5% (19/29)    58.3% (28/48)     0.20
 300 mg                                             36.0% (9/25)    53.8% (14/26)    50.0% (11/22)    34.5% (10/29)    39.6% (19/48)     0.20
Dissection                                          3.6% (1/28)      4.2% (1/24)      0.0% (0/22)      0.0% (0/29)      4.0% (2/50)      0.72
Thienopyridine prescribed at discharge             96.2% (25/26)    100.0% (14/14)   95.5% (21/22)    100.0% (30/30)   100.0% (50/50)    0.40
Aspirin prescribed at discharge                    100.0% (26/26)   92.9% (13/14)    90.9% (20/22)    100.0% (30/30)   100.0% (50/50)    0.06
Clinical Outcomes at one year after the ST event
Death                                                 7.1% (2)        50.0% (13)       27.6% (6)         3.3% (1)         8.0% (4)      <.0001
 Cardiac                                              7.1% (2)        50.0% (13)       22.7% (5)         3.3% (1)         8.0% (4)      <.0001
 Non-cardiac                                          0.0% (0)         0.0% (0)         6.3% (1)         0.0% (0)         0.0% (0)       0.14
Reinfarction                                         57.1% (16)       58.3% (14)       59.1% (13)       76.7% (23)       86.0% (43)      0.01
 Q Wave                                              53.6% (15)       46.4% (11)       54.5% (12)       53.3% (16)       68.0% (34)      0.30
 Non-Q Wave                                           3.6% (1)        23.8% (5)         4.5% (1)        31.0% (9)        22.0% (11)      0.04
Death or reinfarction                                64.3% (18)       84.6% (22)       81.8% (18)       80.0% (24)       86.0% (43)      0.23
Stroke                                                7.7% (2)         7.7% (1)         9.1% (2)         0.0% (0)         0.0% (0)       0.11
Target lesion revascularization                      96.4% (27)       69.2% (18)       68.2% (15)       76.7% (23)       78.0% (39)      0.05
Target vessel revascularization                      96.4% (27)       69.2% (18)       68.2% (15)       86.7% (26)       82.0% (41)      0.03
Non-target vessel revascularization                  18.7% (5)        26.9% (7)        13.6% (3)        27.6% (8)        18.0% (9)       0.57
Major Bleeding (non-CABG related)                    26.7% (7)        11.5% (3)         9.1% (2)         3.7% (1)         6.0% (3)       0.05
Major Bleeding (including CABG related)              26.7% (7)        15.4% (4)         9.1% (2)         7.3% (2)         6.0% (3)       0.07

				
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