THE NOBEL PRIZE IN PHYSIOLOGY OR MEDICINE 1947

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					THE NOBEL PRIZE IN PHYSIOLOGY OR
           MEDICINE


             1947
 The Nobel Prize in Physics 1947

• "for his investigations of the physics of the upper
  atmosphere especially for the discovery of the
  so-called Appleton layer"




       Sir Edward Victor Appleton (United Kingdom)
   The Nobel Prize in Chemistry
              1947

• "for his investigations on plant products of
  biological importance, especially the alkaloids"




        Sir Robert Robinson (United Kingdom)
   The Nobel Prize in Literature
              1947
• "for his comprehensive and artistically significant
  writings, in which human problems and
  conditions have been presented with a fearless
  love of truth and keen psychological insight"




        André Paul Guillaume Gide (France)
 The Nobel Peace Prize 1947




Friends Service Council (The   American Friends
Quakers)                       Service Committee (The
                               Quakers)
London, United Kingdom
                               Washington, DC, USA
THE NOBEL PRIZE IN PHYSIOLOGY OR MEDICINE 1947




CARL FERDINAND CORI          GERTY THERESA CORI, NÉE RADNITZ
            USA                                  USA
         (1896-1984)                         (1896-1957)
                                   3rd woman to win the Noble prize.



• "for their discovery of the course of the catalytic
  conversion of glycogen"
                        CORI CYCLE




The Cori cycle is their explanation for the movement of energy in the body—
from muscle, to the liver, and back to muscle.
     Bernardo Alberto Houssay
                        (Argentina)




           (April 10, 1887 – September 21,1971)




• "for his discovery of the part played by the
  hormone of the anterior pituitary lobe in the
  metabolism of sugar"
• Carbohydrates produced from food or liver
• Used by muscles
• Production and consumption of
  carbohydrates-Constant blood sugar level
• The liver
• Hypoglycemia when liver is removed
• Hyperglycemia-the liver diminishes or
  ceases the production of sugar, and stores
  it.
• The pancreas secretes insulin in adequate
  quantities so as to maintain a normal
  blood sugar level, and the blood sugar
  level regulates the amount of insulin
  secreted. Thus hyperglycemia increases
  the secretion of insulin and hypoglycemia
  diminishes or completely inhibits it.
• He found that hypophysectomized dogs
  were hypersensitive to the toxic and
  hypoglycemic action of insulin
• These discoveries stimulated the study of
  harmonal feedback control mechanisms
  which are central to all aspects of modern
  endocrinology.
                 Outline
• Carbohydrate metabolism and other
  metabolic processes are regulated by the
  balance maintained between the secretion
  of several endocrine glands.
• Diabetes and other metabolic diseases are
  a disturbance in this endocrine equilibrium.
FIGURE SHOWING THE ANTERIOR PITUTARY LOBE
• Due to the body's ability to hold no more
  than around 2,000 kcal of glycogen,
  marathon runners commonly experience a
  phenomenon referred to as "hitting the
  wall" around the 20 mile (32 km) point of a
  marathon. (Approximately 100 kcal are
  utilized per mile, depending on the size of
  the runner and the race course.) When
  experiencing glycogen debt, runners many
  times experience fatigue.
              References
• http://nobelprize.org/
• http://en.wikipedia.org/wiki/Main_Page

				
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