THE NOBEL PRIZE IN PHYSIOLOGY OR
The Nobel Prize in Physics 1947
• "for his investigations of the physics of the upper
atmosphere especially for the discovery of the
so-called Appleton layer"
Sir Edward Victor Appleton (United Kingdom)
The Nobel Prize in Chemistry
• "for his investigations on plant products of
biological importance, especially the alkaloids"
Sir Robert Robinson (United Kingdom)
The Nobel Prize in Literature
• "for his comprehensive and artistically significant
writings, in which human problems and
conditions have been presented with a fearless
love of truth and keen psychological insight"
André Paul Guillaume Gide (France)
The Nobel Peace Prize 1947
Friends Service Council (The American Friends
Quakers) Service Committee (The
London, United Kingdom
Washington, DC, USA
THE NOBEL PRIZE IN PHYSIOLOGY OR MEDICINE 1947
CARL FERDINAND CORI GERTY THERESA CORI, NÉE RADNITZ
3rd woman to win the Noble prize.
• "for their discovery of the course of the catalytic
conversion of glycogen"
The Cori cycle is their explanation for the movement of energy in the body—
from muscle, to the liver, and back to muscle.
Bernardo Alberto Houssay
(April 10, 1887 – September 21,1971)
• "for his discovery of the part played by the
hormone of the anterior pituitary lobe in the
metabolism of sugar"
• Carbohydrates produced from food or liver
• Used by muscles
• Production and consumption of
carbohydrates-Constant blood sugar level
• The liver
• Hypoglycemia when liver is removed
• Hyperglycemia-the liver diminishes or
ceases the production of sugar, and stores
• The pancreas secretes insulin in adequate
quantities so as to maintain a normal
blood sugar level, and the blood sugar
level regulates the amount of insulin
secreted. Thus hyperglycemia increases
the secretion of insulin and hypoglycemia
diminishes or completely inhibits it.
• He found that hypophysectomized dogs
were hypersensitive to the toxic and
hypoglycemic action of insulin
• These discoveries stimulated the study of
harmonal feedback control mechanisms
which are central to all aspects of modern
• Carbohydrate metabolism and other
metabolic processes are regulated by the
balance maintained between the secretion
of several endocrine glands.
• Diabetes and other metabolic diseases are
a disturbance in this endocrine equilibrium.
FIGURE SHOWING THE ANTERIOR PITUTARY LOBE
• Due to the body's ability to hold no more
than around 2,000 kcal of glycogen,
marathon runners commonly experience a
phenomenon referred to as "hitting the
wall" around the 20 mile (32 km) point of a
marathon. (Approximately 100 kcal are
utilized per mile, depending on the size of
the runner and the race course.) When
experiencing glycogen debt, runners many
times experience fatigue.