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Qiba-nxp-ProposedPhase1A-2008-11-13-v05.ppt - QIBA Wiki Powered By Docstoc
					                      QIBA
            Proposed Phase 1A Project
                      V5.0

             QIBA Phantom Subgroup



N Petrick           RSNA QIBA Phantom Group   November 13, 2008   1
Outline of proposal
 Modified 1A reader study
 Outstanding issues




                                                        2

  N Petrick   RSNA QIBA Phantom Group   November 13, 2008
Draft 1A: Study objective
 Measure intra- and inter reader bias
  and variability on phantom lesions
  for:
   Uni-dimensional size measurement
   Semi-automated 3D volumetric
          measure
 Compare with fully automated       Not going to size for specific effect or
                                     significance but just report as pilot
  algorithm?
                                                                     3

  N Petrick         RSNA QIBA Phantom Group          November 13, 2008
Draft 1A: Nodule/scan dataset
   Nodules (10 attached nodules)
           -10 & +100HU
           10, 20 mm spheres                                Okay
           10 mm ovoid, lobulated, spiculated
   Scanner
           Philips 16 slice
   Exposure (120 kVp):
                                     100 mAs okay
           100 mAs
   Slice thickness (50% overlap)
           0.75 & 5.0 mm slices
   Recon kernel                          0.75 mm slices okay
           Standard/medium (Still on table: Detail/Lung kernel)
   Pitch
           1.2
   2 repeat scans                           Okay
   40 segmentations in set

                                                                                    4

    N Petrick                      RSNA QIBA Phantom Group          November 13, 2008
Draft 1A: Study Protocol
 Reader:
     6 RadPharm radiologists
                         Need to determine this?
   Software:            Wendy will visit RadPharm and

     In-house review software (Siemens?)
                         provide more info next week.


               Semi-automated 3D volume software
               Uni-dimensional measure (RESIST)
     Which fully automated software?
                                                                   5

    N Petrick           RSNA QIBA Phantom Group    November 13, 2008
Draft 1A: Study Protocol
   Reading session:
           Readers read all cases in 2 different reading session
             Random ordering
                   One-dimensional measure
                   Semi-automated segmentation
               Session separated by 3 week?
               Include duplicate cases within each read session (1/3-1/2
                of cases for intra-reader estimates)
           Any time restrictions?
             Probably not
           Any specific instructions?
             Probably not
                                                                       6

    N Petrick                RSNA QIBA Phantom Group   November 13, 2008
Draft 1A: Analysis                        Okay



 Estimate intra- and inter-reader
    variability in the different volume
    estimate
     Estimate bias from known truth
     Estimate variability
   Compare the bias and variability with
    the different methods
                                                                 7

    N Petrick   RSNA QIBA Phantom Group          November 13, 2008
Draft 1A: Outstanding issues
   Objective-Okay
           This is pilot, no sizing will be done
             May want to at least look at this to see if we have a
                reasonable study design
   Data collection: Okay
     +100 HU (all 1A scanner settings)
             Acquired: 10 mm & 20 mm sphere, ovoid, spic, lob
           -10 HU (all 1A scanner settings)
             Acquired: 10 mm & 20 mm sphere
             Missing: 10 mm ovoid, spic, lob (Est: 12/01/08)
           10 mm aspherics okay
           100 mAs okay

                                                                       8

    N Petrick                RSNA QIBA Phantom Group   November 13, 2008
Draft 1A: Outstanding issues
   Readers-Okay
           6 okay (base on expected effect size?)
   Software-Open source option is available to use
           Need to finalize which software
           Contact Bob Ford to discuss
   Study Issues
           GUI
                 AVT designed interface?
                 Standard PACs interface?
           How will nodule locations be provided to readers?
                 Full scans with nodule centers
                 Extracted ROIs
           Can cases be directly uploading into PACs?
           How to randomize cases during reading sessions
           Data format for segmentations/measurements
           Truth/scoring format
           ROIs or full scans with lesion marked


                                                                                9

    N Petrick                       RSNA QIBA Phantom Group     November 13, 2008
Draft 1A: Pilot Study
 Study protocol
         9 nodules for segmentation
           2 slice thickness
           10 mm -10 HU, sphere, spiculated
           10 mm, +100 HU, lob., ovoid
           20 mm, +100 HU, sphere
         3 nodules with each segm. method
         2 readers
 Timeframe
         Needs to be determined

                                                                10

  N Petrick            RSNA QIBA Phantom Group   November 13, 2008
Draft 1A: Outstanding issues
 Statistical
   Can we measure intra-reader variance
          with only 2-4 repeat reads?
         What effect size can we distinguish?
             Again, may want to explore but this study
              will only measure as in a pilot



                                                                11

  N Petrick            RSNA QIBA Phantom Group   November 13, 2008
Draft 1A: Outstanding issues
 Other issues
   Need to define QIBA publication policy
   Determine research team makeup
             Lisa Kinnard & Marios Gavrielides from
              FDA lab
   Other Issues


                                                                12

  N Petrick            RSNA QIBA Phantom Group   November 13, 2008
Draft 1A: Submissions
   Conferences
           ASCO
             5/29-6/2/09 Orlando
             Abstract Deadline: 1/6/09
           RSNA
             End Nov, 2009, Chicago
             Abstract Deadline: 4/15/09
   Journal
     NEJM!
     Radiology
     Oncology journals?
                                                                    13

    N Petrick              RSNA QIBA Phantom Group   November 13, 2008
Action Items
 Rick Avila to follow-up with caBIG
    AVT group
   Rick Avila to lead effort of Lesion
    Ground Truth subgroup
   Reporting Mechanism to be
    discussed at later date

                                                         14

    N Petrick   RSNA QIBA Phantom Group   November 13, 2008
Work Items and workgroup
 ??




                                                      15

 N Petrick   RSNA QIBA Phantom Group   November 13, 2008

				
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