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DEPT Spectra COSY Spectra HETCOR Spectra

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DEPT Spectra COSY Spectra HETCOR Spectra Powered By Docstoc
					 DEPT Spectra
 COSY Spectra
HETCOR Spectra
          DEPT-90, DEPT-135
 Distortionless Enhancement by Polarization
                    Transfer
• Preferred procedure for determining # protons
  attached to carbons
• Variable proton pulse angle q is set at 90o and
  135o
• In DEPT-90, only CH shows. In DEPT-135,
  CH2’s are phased down, CH and CH3 are
  phased up
Adjustment of 1H pulse angle
Avoids overlapping multiplets
                  CH


                       CH3



                CH2
2-Heptanone, CPD and DEPT-35
6-Methyl-5-hepten-2-ol
 Standard CPD Spectrum
DEPT-90
DEPT-135

           OH
DEPT-90

DEPT-135

           O
               CH3
    <




>
Limonene
               Ipsenol
        CPD, DEPT-135, DEPT 90




    7              4           2 1
         8,10          5   3
6                                9
90
              CO 2CH3



      CH3CO
        O

135
Correlated Spectroscopy
FT of the t1 domain, acetone
                              FT in t1 will give 2D frequency spectrum
                       FT of t2
2D Exchange NMR
                  t2




                                                                         
                                                              
                                                     
                                            
                                   
                       
           t1
15 l N•Ndimethylacetamide in 700 l d-chloroform at 29° C
A-B coupling in COSY Spectrum
     O
CH3CH2CCH3
CH2CH3
Isobutyl Alcohol

 OH
O

    O
1H   NMR Spectrum of Ipsenol
COSY Spectra of Ipsenol
             9

     5   6           7
     4
HO               8
         3
             2
                 1
HETCOR Spctrum of Ipsenol
Exercise 5.6, p. 291

     H      O
H           COCH2CH3


H    N      H
Exercise 5.6, p. 292

     H      O
H           COCH2CH3


H    N      H
O
    CH3

				
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posted:8/9/2012
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