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									Author(s): Lin, CY (Lin, Chia-Yu); Huang, CS (Huang, Chin-Shiu); Huang, CY (Huang,
Chun-Yin); Yin, MC (Yin, Mei-Chin)

Title: Anticoagulatory, Antiinflammatory, and Antioxidative Effects of Protocatechuic Acid in
Diabetic Mice

Source: JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 57 (15): 6661-6667 AUG
12 2009

Language: English

Document Type: Article

Author Keywords: Protocatechuic acid; diabetes; monocyte chemoattractant protein-1;
coagulation

KeyWords Plus: OXIDATIVE STRESS; IN-VITRO; PROINFLAMMATORY CYTOKINES;
EXTRACTS; HEPATOTOXICITY; HYPERGLYCEMIA; COAGULATION; MELLITUS;
ENZYMES; SERUM

Abstract: Content of protocatechuic acid (PA) in eight locally available fresh fruits was
analyzed, and the protective effects of this compound in diabetic mice were examined. PA at
1%, 2%, and 4% was supplied to diabetic mice for 8 weeks. PA treatments significantly
lowered plasma glucose and increased insulin levels. PA treatments at 2% and 4%
significantly lowered plasminogen activator inhibitor-1 activity and fibrinogen level; increased
plasma activity of antithrombin-III and protein C; decreased triglyceride content in plasma,
heart, and liver; elevated glutathione level and the retention of glutathione peroxidase and
catalase activities in heart and kidney. PA treatments at 2% and 4% also significantly lowered
plasma C-reactive protein and von Willebrand factor levels and reduced interleukin-6, tumor
necrosis factor-alpha, and monocyte chemoattractant protein-1 levels in heart and kidney.
These results support that protocatechuic acid could attenuate diabetic complications via its
triglyceride-lowering, anticoagulatory, antioxidative, and antiinflammatory effects.

Addresses: [Huang, Chun-Yin; Yin, Mei-Chin] China Med Univ, Dept Nutr, Taichung, Taiwan;
[Lin, Chia-Yu; Huang, Chin-Shiu] Asia Univ, Dept Hlth & Nutr Biotechnol, Taichung, Taiwan

Reprint Address: Yin, MC, China Med Univ, Dept Nutr, Taichung, Taiwan.

E-mail Address: mcyin@mail.cmu.edu.tw

Cited References: ASAKAWA H, 2000, J DIABETES COMPLICAT, V14, P121.
ASO Y, 2003, DIABETIC MED, V20, P930.
BIGGS HG, 1975, CLIN CHEM, V21, P437.
BROWNLEE M, 2001, NATURE, V414, P813.
CAI L, 2006, J AM COLL CARDIOL, V48, P1688, DOI 10.1016/j.jacc.2006.07.022.
CAO YG, 2009, BIOCHEM PHARMACOL, V77, P1096, DOI 10.1016/j.bcp.2008.11.029.
CERIELLO A, 1995, DIABETES, V44, P924.
CHAO CY, 2009, FOODBORNE PATHOG DIS, V6, P201, DOI 10.1089/fpd.2008.0187.
DRIMAL J, 2008, ENDOCR REGUL, V42, P129.
GEERLINGS SE, 2000, EUR J CLIN INVEST, V30, P995.
GOLDBERG RB, 2003, CARDIOL CLIN, V21, P399.
HATANAKA E, 2006, CLIN EXP IMMUNOL, V146, P443, DOI
10.1111/j.1365-2249.2006.03229.x.
HSU CC, 2006, FOOD CHEM TOXICOL, V44, P393, DOI 10.1016/j.fct.2005.08.012.
KWON YII, 2006, ASIA PAC J CLIN NUTR, V15, P107.
LIMAYE PV, 2003, MOL CELL BIOCHEM, V243, P147.
LIU CL, 2002, FOOD CHEM TOXICOL, V40, P635.
LIU HH, 2003, ROBOT AUTON SYST, V42, P47.
LIU WH, 2008, PHYTOTHER RES, V22, P53, DOI 10.1002/ptr.2259.
LOWRY OH, 1951, J BIOL CHEM, V193, P265.
MA HL, 2007, BIOMED CHROMATOGR, V21, P931, DOI 10.1002/bmc.836.
MARTINOVIC I, 2005, CIRC J, V69, P1484.
MASELLA R, 2004, J NUTR, V134, P785.
MCCUE P, 2004, ASIA PAC J CLIN NUTR, V13, P401.
MOHAMEDALI V, 2001, J INTERN MED, V250, P415.
MYRUP B, 1995, DIABETOLOGIA, V38, P73.
NAKAMURA Y, 2001, J AGR FOOD CHEM, V49, P5674.
PACHECOPALENCIA LA, 2008, J AGR FOOD CHEM, V56, P4631, DOI 10.1021/jf800161u.
RUDEL LL, 1973, J LIPID RES, V14, P164.
SHI GF, 2006, NEUROSCI LETT, V403, P206, DOI 10.1016/j.neulet.2006.02.057.
STAGOS D, 2006, MUTAT RES-GEN TOX EN, V609, P165, DOI
10.1016/j.mrgentox.2006.06.032.
URANO T, 2000, SEMIN THROMB HEMOST, V26, P39.
YAMADA T, 2000, DIABETES RES CLIN PR, V49, P23.
YEN GC, 2000, J AGR FOOD CHEM, V48, P3431.

Cited Reference Count: 33

Times Cited: 0

Publisher: AMER CHEMICAL SOC

Publisher Address: 1155 16TH ST, NW, WASHINGTON, DC 20036 USA

ISSN: 0021-8561

DOI: 10.1021/jf9015202

29-char Source Abbrev.: J AGR FOOD CHEM

ISO Source Abbrev.: J. Agric. Food Chem.

Source Item Page Count: 7
Subject Category: Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
Technology

ISI Document Delivery No.: 477RW

								
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