2302523 Bioinorganic Chemistry

							Electron Transfer and
  Catalysis Process
Electron Transfer
       •Energy can be considered in electro-
       chemical terms.

       Fuels: sugar, fats, H2
       Oxidants: O2, H+
       •Oxidation of sugar by O2 provides a
       lot of energy (4 eV per O2 molecule).

       •Electron flow along electron-transport
       chains is coupled to chemical process
       such as ion transfer.
Electron Transfer in Mitochrondia
Electron Transfer Cytochromes
Biomolecular Electron Transfer
                  Copper ET Centers




Plastocyanin is a small electron carrier protein. The blue copper center is
well suited to undergo fast and efficient electron transfer because the
reorganize is very small.
Cytochrome c oxidase
                    Catalytic Cycle
4 electrons are required to break O-O bonds, eventually producing two H2O.
Heme–Copper/Dioxygen
      Adducts




           Karlin et al. Acc. Chem. Res. 2007, 40, 563.
    Zinc Enzyme: Carbonic Anhydrase




Zinc is suited for catalyzing acid-base reactions as it is abundant and redox
inactive.
Coenzyme B12: Cobalamin