Chapter 5: Biomembranes and Cell Architecture By: Anna Whiteshield Overview Lipid Composition Protein Components Organelles of Eukaryotic Cell Cytoskeleton Purification of Cells Visualizing Cell Architecture Overview of the cytoskeleton Three types of filaments in the cytosol Actin also known as Microfilaments Microtubules Intermediate filaments Organization of the filaments Bundles Filaments are closely packed in parallel arrays. Networks Filaments crisscross at right angles and loosely packed. Microfilaments Structural support and motility Actin Composed of polymerized α- and β-tubulin Membrane-microfilament binding proteins connect them to the membrane Intermediate Filaments Support for Nuclear membrane Lamins Cell adhesion Desmin, keratin, vimentin. Motility MSP Microtubules Structural support, motility, cell polarity α and β Tubulin Cell division (bacteria) Necessary for endoplasmic reticulum location and formation of mitotic apparatus Summary Cytoskeleton provides structural stability and movement for the cell. Microfilaments and their proteins form a skeleton underneath the plasma membrane Intermediate filaments mediate cell-cell adhesion and cell-matrix adhesion. Microtubules radiate from centrosome forming the MTOC. References: http://bio.winona.edu/bates/Bio241/cells.htm Lodish,H.,A. Berk, P. Matsudaira, C.A. Kaiser, M. Krieger, M.P. Scott, S.L. Zipursky, and J. Darnell. 2004. Biomembranes and Cell Architecture. P.174-178. Molecular Cell Biology. W.H. Freeman and Company, New York.
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