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					                           Jeannine LaRocque, PhD.
Georgetown University Medical Center
School of Nursing and Health Studies
Department of Human Science
265 St. Mary’s Hall
3700 Reservoir Rd.                                            Office phone: (202) 687-2807
Washington, DC 20057                                          Email: jlk99@georgetown.edu

Education
  University of North Carolina, Chapel Hill, NC
  Doctorate of Philosophy, “DNA damage response in Drosophila: Orchestrating repair with
  cell cycle checkpoints"
  Department of Biology, 2002-2007

  South Carolina Honors College; University of South Carolina, Columbia, SC
  Bachelors of Science (magna cum laude), Biology, 1998-2002

Research and Professional Experience
  Georgetown University Medical Center; School of Nursing and Health Studies
  Department of Human Science
  Assistant Professor, 2011- present
  DNA damage and repair in Drosophila melanogaster

  Sloan-Kettering Institute for Cancer Research, Developmental Biology, New York, NY
  Research Fellow, 2007-2011
  Mechanisms of double strand break-induced homologous recombination repair in
  mammalian cells. Laboratory of Dr. Maria Jasin.

  University of North Carolina, Department of Biology, Chapel Hill, NC
  Graduate Fellow, 2002-2007
  Studied the role of cell cycle checkpoints in DNA repair in Drosophila melanogaster using
  molecular and genetic techniques. Laboratory of Dr. Jeff Sekelsky.

  University of South Carolina, Department of Biology, Columbia, SC
  Howard Hughes Fellow and research assistant, 1999-2002
  Completed Honors College Senior Thesis: “Molecular analysis of diazotrophic
  assemblages associated with the roots of Juncus roemerianus.” Studied the physiological
  response of diazotrophic bacteria to toxins. Laboratory of Dr. Rick Lovell.

  Medical University of South Carolina, Department of Pathology and Laboratory Medicine,
  Charleston, SC
  Summer Undergraduate Research Fellow and research assistant, 2000-2001
  Studied the Role of GTPase Activating (GAP) activity of Exoenzyme S in effects on
  epithelial cells. Laboratory of Dr. Joan Olson.

Teaching experience
  Georgetown University Medical Center; School of Nursing and Health Studies
  Department of Human Science
  Assistant Professor, 2011- present
                                                                                      Curriculum vitae
                                                                                          J. LaRocque

  Developed and taught HSCI-190, Introduction to Genomics and Genetics and HSCI-100
  Language of Health and Disease:
       Fall 2011: HSCI-190 (42 students; 2 credit lecture)
       Spring 2012: HSCI-190 (85 students; 2 credit lecture); HSCI-100 (30 students; 3 credit
       lecture)

  LaGuardia Community College (CUNY); Department of Natural and Applied Sciences, Long
  Island City, NY
  Course instructor, Fall 2010 Session I
  Developed and instructed lecture portion of SCB204, Fundamentals of Human Biology II.
  Duties include designing the course lectures, assignments, and exams. Incorporated unique
  teaching pedagogies to help master challenging subjects and topics. Topics included the
  nervous system, digestive system, endocrine system, and reproduction/development.

  LaGuardia Community College (CUNY); Department of Natural and Applied Sciences, Long
  Island City, NY
  Course instructor, Fall 2010 Session II and Spring 2010 Session I
  Developed and instructed lecture portion of SCB 115, Principles of Biology (for non-majors).
  Duties included designing the course lectures, assignments, and exams. Incorporated unique
  teaching pedagogies to help master challenging subjects and topics. Topics ranged from
  introduction to life and molecules to anatomy, with an emphasis on the human body and
  environment.

  Gerstner Sloan-Kettering Graduate Program, New York, NY
  Teaching assistant, 2008
  Assisted in focus group seminar series for graduate students in the Gerstner Sloan-Kettering
  (GSK) Graduate Program. Duties included moderating several discussions with class of 10
  graduate students focusing on molecular biology and genome instability.

  North Carolina DNA Day Ambassador, April 2007
  Participated in a community outreach program to local public high schools to teach students
  about genetics, molecular biology, and genomics. Duties included multiple course
  preparation sessions and teaching two modules focusing on forensics and molecular biology.

  University of North Carolina, Department of Biology, Chapel Hill, NC
  Teaching assistant, Genetics and Molecular Biology (undergraduate course), 2003
  Work included self-prepared independent instruction in 2 weekly recitation sections, tutoring
  and grading.

Research mentoring experience
  Georgetown University Medical Center; School of Nursing and Health Studies
  Department of Human Science
  Assistant Professor, 2011- present
  Advise undergraduate student(s) in independent research. Mentoring included
  scientific/laboratory training, data analysis, and assistance with scientific writing leading to
  fellowship applications.

  Weil-Cornell Graduate School, New York, NY
  Graduate student research mentor, 2008
  Advised one first-year rotating graduate student in independent research projects that lead to
  seminar presentations of the student’s work. Mentoring included scientific training, data


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                                                                                Curriculum vitae
                                                                                    J. LaRocque

  analysis and assistance with completion of the presentation.

  University of North Carolina, Department of Biology, Chapel Hill, NC
  Undergraduate research mentor, 2003-2007
  Advised 3 undergraduate students in independent research. Mentoring included scientific
  training, data analysis and assistance with writing of assignments required for either
  coursework or senior thesis completion.

  University of North Carolina, Department of Biology, Chapel Hill, NC
  Graduate student research mentor, 2006
  Advised two first-year rotating graduate students in independent research projects that lead
  to seminar presentations of their work. Mentoring included scientific training, data analysis
  and assistance with completion of the presentation.

Academic advising/mentoring experience
  Georgetown University Medical Center; School of Nursing and Health Studies
  Department of Human Science
  Assistant Professor, 2011- present
       Faculty advisor to 12 undergraduate Human Science students. Mentoring included
       coursework and career advisement.
       Honors Thesis Committees. Served as Honors Thesis Committee co-chair (1 student)
       and committee member (2 students) to Human Science students during their completion
       of requirements to earn Honors from the Department of Human Science. Mentored
       during various stages of Honors Thesis process, including written proposals, written
       theses, advice on experiment design/implementation (where applicable), and research
       presentations.

Grants and fellowships awarded
   Ruth L. Kirschstein National Research Service Award funded by the NIGMS of the NIH (F32
     NRSA; 2008-2011); “Gene conversion and end processing mechanisms during double-
     strand break repair;” score of 117 on first submission; total of $142,000 in stipend and
     reagent support
   MSKCC-CCNY Partnership for Cancer Research, Prevention, and Community Outreach
     pilot grant (U54; 2010-2011); “Role of RECQ1 in Homologous Recombination Repair of
     DNA Double Strand Breaks”; written with M. Jasin (MSKCC) and collaborator S. Sharma
     (City College of New York); total of $50,000 in stipend and reagent support
  NSF Pre-doctoral Graduate Fellowship (2003-2006)
  Graduate Mentor Support Grant (2006)
  Keystone Symposium Travel Award (2005)
  Howard Hughes Undergraduate Research Fellow (2001-2002)
  South Carolina Honors College Research Assistantship (2000-2001)
  MUSC Summer Undergraduate Research Fellow (2000)

Departmental committee and community service
  Member of the Nursing and Health Studies Green Team (2011-present)
  Sloan-Kettering Cancer Center Postdoc Association Secretary (2010-2011)
  MSKCC Research Faculty Advisory Committee member (2010-present)
  Sloan-Kettering Cancer Center Postdoc Association executive council member (2008-2010)
  MSKCC Diversity Communication Committee (2009); participated in committee to help launch
     the diversity website to the MSKCC community


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                                                                               Curriculum vitae
                                                                                   J. LaRocque

  CUNY College Now, Department of Academic Affairs; reviewed applications for New York
    City Science and Engineering Fair (NYCSEF) (2009)
  University of North Carolina Biology Graduate Student Association (2003-2005)

Awards, honors, and society memberships
  New York Academy of Sciences (2007-present)
  Future Science Educators (2009-present)
  Sloan-Kettering Cancer Center Postdoc Association member (2008-2011)
  National Postdoc Association member (2007-2011)
  Genetics Society of America
  University of North Carolina Biology Graduate Student Association (2003-2005)
  Phi Beta Kappa National Academic Honor Society
  United States Academic All-American Society
  Golden Key National Honor Society
  Phi Mu Epsilon National Mathematics Honor Society
  Alpha Lamda Delta Honor Society
  T. L. McMeekin Award for superior undergraduate Biology Major (2001)
  National Dean’s List (2000)
  Dean’s List (1998, 1999)
  President’s List (1999-2002)

Publications
  LaRocque, JR, E Avdievich, K Wei, W Edelman, M Jasin. “Exo1 suppresses double-strand
  break induced recombination between identical and diverged sequences in mammalian
  cells.” In preparation.
  Sharma, S, P Phatak, A Stortchevoi, M Jasin, JR LaRocque. 2012. “RecQ1 plays a distinct
  role in cellular response to oxidative DNA damage.” DNA Repair, accepted.

  LaRocque, JR, JM Stark, J Oh, , K Yusa, K Horie, J Takeda, M Jasin. 2011. “Inter-homolog
  recombination and loss of heterozygosity in wild-type and BLM-deficient mammalian cells.”
  PNAS 108(29): 11971-11976.

  LaRocque, JR, M Jasin. 2010. “Mechanisms of recombination between diverged sequences
  in wild-type and BLM-deficient mouse and human cells.” Mol Cell Biol 30(8): 1887-1897.

  Anderson, SL, DT Bergstralh, KP Kohl, JR LaRocque, CB Moore, JJ Sekelsky. 2009.
  “Drosophila MUS312 and the vertebrate ortholog, BTB12, interact with DNA structure-specific
  endonucleases in DNA repair and recombination.” Mol Cell 35:128-135.

  Gamble, MD, CE Bagwell, JR LaRocque, PW Bergholz, CR Lovell. 2009. “Seasonal
  variability of diazotroph assemblages associated with the rhizosphere of the salt marsh
  cordgrass, Spartina alterniflora.” Microb Ecol 59: 253-265.

  LaRocque, JR, DL Dougherty, S Hussain, JJ Sekelsky. 2007. “Reducing DNA polymerase α
  in the absence of Drosophila ATR leads to P53-dependent apoptosis and developmental
  defects.” Genetics 176: 1441–1451.

  LaRocque, JR, B Jaklevic, TT Su, JJ Sekelsky. 2007. “Drosophila ATR in double-strand
  break repair.” Genetics 175(3): 1023-1033.




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                                                                                 Curriculum vitae
                                                                                     J. LaRocque

  McVey, M*, LaRocque, JR*, MD Adams, JJ Sekelsky. 2004. “Formation of deletions during
  double-strand break repair in Drosophila DmBlm mutants occurs after strand invasion.”
  PNAS 101(44):15694-15699. *These authors contributed equally

  LaRocque, JR., C.E. Bagwell, P.W. Bergholz, and C.R. Lovell. 2004. Influence of Host Plant-
  Derived and Abiotic Environmental Parameters on the Composition of the Diazotroph
  Assemblage Associated with Roots of Juncus roemerianus. Antonie van Leeuwenhoek
  International Journal of General and Molecular Microbiology 86:249-261.

  Bagwell, C.E., J.R. La Rocque, G.W. Smith, M. Friez, J. Longshore, and C.R. Lovell. 2002.
  "Molecular diversity of diazotrophs in oligotrophic tropical seagrass bed communities." FEMS
  Microbial Ecology 39:113-119.

  Fraylick, J.E., J.R. La Rocque, T.S. Vincent, J.C. Olson. 2001. “The independent and
  coordinate role of the ADP-ribosyltransferase and GTPase activating activities of exoenzyme
  S on HT-29 epithelial cell function.” Infection and Immunity. 69(9):5318-28.


Platform presentations and invited seminars and lectures
   LaRocque, JR. “If it’s broken, fix it! Mechanisms of double-strand break repair.” Department
   of Biology; Georgetown University. Washington, DC 20057. March 2012.
  LaRocque, JR. “Cancer in Society: DNA Damage and Repair.” MSKCC/CCNY Partnership
  for Cancer Research; City College High School Program. New York, NY 10031. March 2011.

  LaRocque, JR. “The Role of Drosophila ATR in double-strand break repair.” Drosophila Cell
  Cycle Conference. Porto, Portugal. June 2006.

  LaRocque, JR. “Double strand break repair in mei-41 mutants.” Checkpoint workshop. 45th
  Annual Drosophila Research Conference. Washington, DC. March 2004.

Poster presentations
  LaRocque, JR, J Stark, M Jasin. “Interhomolog recombination and loss of heterozygosity in
  wild-type and BLM-deficient mammalian cells.” Keystone Symposia: DNA Replication and
  Recombination. Keystone, CO. March 2011

  LaRocque, JR, J Stark, M Jasin. “Interhomolog recombination and loss of heterozygosity in
  wild-type and BLM-deficient mammalian cells.” NYAS Genome Integrity Discussion Group.
  July 2010.

  LaRocque, JR, M Jasin. “Recombination between diverged sequences in mammalian cells.”
  FASEB Summer Research Conference: Genome Integrity. August 2009.

  LaRocque, JR, M Jasin. “Mechanisms of homeologous recombination in wild-type and
  Blm-/- ES cells.” Keystone Symposia: Genome Instability and Repair. Taos, NM. March 2009.

  LaRocque, JR, M Jasin. “Mechanisms of gene conversion in wild-type and Msh2 mutant
  mammalian cells.” Molecular and Clinical Mechanisms in Bloom’s Syndrome and Related
  Disorders. Chicago, IL. May 2008.

  LaRocque, JR, DL Dougherty, S Hussain, JJ Sekelsky. “The Role of Drosophila ATR in



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                                                                          Curriculum vitae
                                                                              J. LaRocque

Response to Endogenous Damage.” Keystone Symposia: Genome Instability and Repair.
Breckinridge, CO. January 2007.

LaRocque, JR, JJ Sekelsky. “The Role of Drosophila ATR in Double-strand break repair.”
Keystone Symposia: Genome Instability and Repair. Taos, New Mexico. March 2005.

Fraylick J.E., J.R. La Rocque, C.L. Rocha, D.W. Frank, T.S. Vincent, J.C. Olson.
“Independent and Coordinate Effects of ExoS GAP and ADP-ribosyltransferase Activities on
Epithelial Cell Function.” 101st Annual Meeting of the American Society of Microbiology,
Orlando, FL. May 2001.




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