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Moducren® - You are taking medicines for a heart condition, such as 'Digoxin'. - You have a condition known as 'systemic lupus (hydrochlorothiazide, amiloride hydrochloride, erythematosus'. - You have gout. and timolol maleate, MSD) PLEASE READ BOTH SIDES OF THIS LEAFLET CAREFULLY BEFORE Your doctor may have asked you to change your diet YOU START TO TAKE YOUR TABLETS. slightly, to avoid eating foods which contain a lot of potassium. These foods include milk, bananas, raisins, Keep this leaflet. You may want to read it again. prunes. Your doctor will know which foods you should What is in your tablets? avoid. Your doctor may also need to carry out simple Active ingredients blood tests while you are taking Moducren, to monitor There are three active ingredients in Moducren: the level of potassium in your blood. Hydrochlorothiazide EP, amiloride hydrochloride EP, and In addition, if you are planning to have an operation, or timolol maleate EP. undergo an emergency operation (including at the Moducren Tablets are only available in one strength. dentist), you should tell the doctor treating you that you Each tablet contains 25 mg hydrochlorothiazide EP, 2.5 are or have been taking Moducren Tablets. mg amiloride hydrochloride EP, and 10 mg timolol What about alcohol? maleate EP. Your doctor may have told you that you should always Moducren Tablets are available in packs of 14, 28 or 1 keep your alcohol intake to a minimum because it may 00 tablets. affect the activity of Moducren and cause a decrease in Other ingredients blood pressure accompanied by a feeling of dizziness or Indigo carmine E132, industrial methylated spirit 740P lightheadedness when standing up quickly. BP, magnesium stearate EP, microcrystalline cellulose If you are concerned about how much alcohol you can EP, pregelatinised maize starch BP, purified water BP. drink while you are taking Moducren, discuss this with How do your tablets work ? your doctor. The active ingredients in your tablets are Can you take Moducren with other medicines? hydrochlorothiazide, amiloride hydrochloride, and timolol Moducren can occasionally interfere with a few other maleate: the first and second ingredients belong to a medicines that you may be taking, so it is important that group of medicines known as 'diuretics', the third you tell your doctor about all the medicines you are belongs to a group of medicines known as beta-blockers. taking, including those obtained without a doctor's These medicines act together to lower your blood prescription . pressure. If you are taking any of the following medicines you Who makes your tablets? should talk to your doctor before taking Moducren: Your tablets are made by Merck Sharp & Dohme - Medicines for diabetes. Limited, Shotton Lane, Cramlington, Northumberland, for - Other medicines to treat high blood pressure or a Merck Sharp & Dohme Limited, Hoddesdon, heart condition (such as Digoxin). Hertfordshire, UK, who hold the Product Licence in the - Medicines known as 'non-steroidal anti-inflammatory UK and Product Authorisation in Ireland. drugs' (NSAIDs), such as aspirin, ibuprofen. - Steroids or a medicine called ACTH. Why do you need to take these tablets? - Sympathomimetics, such as adrenaline. Your doctor has prescribed Moducren for you because - A medicine called lithium (a drug used to treat a you have high blood pressure. Although you may not feel certain kind of depression). unwell, high blood pressure can increase your risk of - Certain muscle relaxants. heart disease or stroke, if left untreated. - Barbiturates or narcotics. Are there patients who should not take these How should you take Moducren? tablets? You should take your tablets exactly as advised by your Yes; do not take the tablets if: doctor or pharmacist. The number of tablets you take 1. You are or think you may be pregnant. each day will depend upon your condition and whether 2. You are planning to become pregnant. you are taking other medicines. For most people this is 3. You are breast-feeding. either 1 or 2 tablets taken once a day, usually swallowed 4. You have asthma or other lung disease, such as with a glass of water. bronchitis or emphysema. Take Moducren exactly as your doctor has instructed. 5. You have a problem with your heart, such as heart It is very important to continue taking Moducren for as failure. long as your doctor prescribes. Do not take more tablets 6. You have a high level of a naturally occurring than the prescribed dose. chemical called potassium in your blood; or you are currently taking medicines which make your body What if you forget to take a tablet or take too many? retain this chemical, such as potassium supplements If you miss a dose, just carry on with the next one as or some types of water tablets. Your doctor will know normal. Do not take an extra one to make up. which medicines these are. In case of an overdose, contact your doctor 7. You have kidney or liver problems. immediately so that medical attention may be given 8. You are a diabetic or have been diagnosed as promptly. subject to spontaneous hypoglycaemia. What unwanted effects could your tablets have? 9. You are allergic to any of the ingredients. Like all medicines, Moducren may occasionally cause 10. You are allergic to any sulphonamide-derived drugs. side effects in some patients. These may include the (Ask your doctor if you are not sure which ones these following: Dizziness; tiredness; headache; a slow pulse are.) rate; cold feeling in your fingers or toes; If you think any of these apply to you, do not take the light-headedness due to a drop in blood pressure, tablets, go and talk to your doctor first and follow his fainting, angina; irregular heart beats; wheezing; difficulty advice. in breathing; stomach upsets (such as nausea, Use in children: Safety and effectiveness in children indigestion, constipation, diarrhoea, vomiting, stomach have not been established. pain); jaundice; lack or loss of appetite; thirst and a dry mouth; sore mouth; impotence; tingling sensations; rash; What else should you know about taking your dry eyes; sweating; shaking; muscle cramps; changes in tablets? your vision; disturbed sleep; depression, nervousness, You should check with your doctor before taking vertigo (spinning sensation); reduced bone marrow 'Moducren' if: activity; changes in the levels of blood and urine - You have angina or have had a heart attack in the chemicals (such as sodium, potassium, chloride and past. magnesium [your doctor can tell you more about these]) . Tell your doctor or pharmacist promptly about any of Remember, this medicine is for you. Do not share it with these or any unusual symptoms. anyone else. It may not suit them. How should your tablets be kept? How can you obtain more information about Keep your tablets out of the reach of children. Keep Moducren? them out of direct sunlight and in a dry place. This leaflet gives you only some of the most important Do not put them into another container as they might patient information about Moducren. If you have any get mixed up. If you have any tablets left over when your questions after you have read it, ask your doctor or doctor tells you to stop taking them, then return them to pharmacist, who will give you further information. your doctor or pharmacist. Do not take them past the expiry date which is clearly ® denotes registered trademark of Merck & Co., Inc., marked on the pack. Whitehouse Station, NJ, USA.
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