typically into the urinary tract by 5HzRgE5


									Complications of Synthetic mid-Urethral Slings
By Christian Twiss, MD and Shlomo Raz, MD

Issues in Incontinence: Spring/Summer 2008

Due to its efficacy, safety, and relative simplicity, the synthetic mid-urethral sling procedure has
emerged as one of the mainstays
of surgical therapy for female stress urinary incontinence. The transobturator approach to placing mid-
urethral slings has recently been marketed as safer than the retropubic approach due to avoidance of
entry into the retropubic space. However, accumulated experience has demonstrated that significant
complications are possible with both techniques. The purpose of this review is to summarize the rates,
etiology, and management of the most common complications encountered with synthetic mid-urethral
slings and to compare, based on recent evidence, complication rates of the retropubic and
transobturator approaches to sling placement.

One of the difficulties in assessing bleeding complications of synthetic sling placement is that “bleeding”
as a complication has no firm definition or criteria. There is great variability in the literature in reporting
and assessing the degree of bleeding, including intraoperative versus postoperative bleeding, bleeding
requiring reoperation, bleeding requiring transfusion, hematoma size, volume of blood loss, and major
vascular injury. Bleeding can occur from the vaginal incision, from the periurethral dissection, from
vessels in the retropubic space, or, in rare cases, from overt injury to the iliac or obturator vessels. When
placing retropubic slings, a common source of troublesome bleeding is inadvertent deviation of the
trocar within the retropubic space, either too close to the urethra, leading to bleeding from the
periurethral venous complex, or too lateral, leading to venous bleeding from vessels on the pelvic
sidewall. Careful control of trocar placement reduces the potential for bleeding from these sites.

One of the largest series to report bleeding after retropubic placement of syntheticslings is an Austrian
registry of 5578 tensionfree vaginal tape (TVT) procedures,1 which showed an overall 2.7% rate of
bleeding complications with 0.8% requiring reoperation, primarily via laparotomy. Other large TVT series
2-3 report similar rates of hemorrhage/hematoma, between 1.9% and 2.7%. However, when routine
pelvic magnetic resonance imaging (MRI) was performed after retropubic sling procedures, 25% of
patients were found to have clinically unsuspected retropubic hematomas.4 From these data we can
conclude that significant bleeding is possible after retropubic sling placement, albeit that the reported
rates in the large studies suggest that major, clinically overt bleeding is uncommon.

More recent evidence suggests that bleeding is significantly reduced with the transobturator approach
to mid-urethral sling placement. Several large series 5-8 fail to report any significant bleeding
complications with the technique. The meta-analysis by Sung et al 9 of randomized controlled trials
comparing retropubic with transobturator slings found that the rate of significant hematoma was 1.6%
for the retropubic approach compared to 0.08% for the transobturator approach. Similarly, in the recent
metaanalysis by Novara et al, 10
the odds ratio of pelvic hematoma was 4.83 for retropubic as compared to transobturator slings.
However, despite this evidence, significant bleeding, including iliac and obturator vessel injury, has been
reported 11-12 with use of the transobturator technique. Thus, although there is a consensus that
transobturator sling procedures carry significantly less bleeding risk compared to retropubic mid-
urethral sling procedures, transobturator sling placements are by no means immune to bleeding
complications, and careful attention must be paid to proper technique.

Perforations and erosions
Perforations occur when the surgeon inadvertently places the sling material into an unwanted
anatomical position, typically into the urinary tract (bladder, bladder neck, or urethra) or through the
vaginal wall. Perforations are typically considered an intraoperative complication, recognized and
corrected at the time of surgery. Erosions are typically detected in the postoperative period when sling
material is found in the urinary tract or noted to be exposed in the vagina. While erosions are often
considered a postoperative complication, it is important to be cognizant that many postoperative
“erosions” are actually the result of undetected perforations that occurred at the time of surgery.

Bladder perforation is one of the more common intraoperative problems encountered with retropubic
midurethral sling placement, occurring in 2.7%–6% in large series. 2, 13-16 Bladder perforation during
retropubic sling placement occurs more commonly in patients with a history of anti-incontinence
procedures,13 likely due to scarring within the retropubic space. Bladder perforation occurs less
frequently with the transobturator approach compared to the retropubic approach, 9,10,17 with reported
rates of bladder perforation between 0% and 1.5% with this technique. 7,9,17,18

However, the majority of bladder perforations, when recognized intraoperatively, are relatively minor
complications and are often corrected intraoperatively by repositioning and re-passage of the trocar and
sling material,16 typically followed by a period of bladder drainage with a urethral catheter.

Urethral perforation remains rare for both retropubic and transobturator approaches, but it can occur
with either.2,7,16,19 As opposed to the case of bleeding and bladder perforation, the evidence does not
currently suggest that urethral perforation occurs less commonly with the transobturator approach
compared to the retropubic approach. Intraoperative urethral injury has been reported in 0.07%–0.2%
of retropubic sling cases 2,16 and 0.1%–2.5% of transobturator sling cases.7,20,21 Since the urethra is a
high-pressure system, this complication typically requires a formal repair of the damaged area and is
somewhat more serious than bladder perforation. After repair, the choice of placing or not placing a
sling depends upon the severity of the perforation and the comfort level and judgment of the surgeon.
Regardless, as with bladder injury, a period of urethral catheterization is recommended during the
healing period.

When sling material is found in the urethra in the postoperative period, it is termed a urethral erosion.
The risk factors for postoperative urethral erosion include undetected urethral perforation, excessive
sling tension, and postoperative urethral dilations.19 Treatment involves removal of the offending
material and formal urethral repair. Unfortunately, both in our experience and in that of others,
recurrent incontinence (stress and/or urge incontinence) is common after intervention in these

Bowel perforation is a potentially lethal complication that typically occurs when the retropubic approach
is utilized in patients with bowel adhesions in the retropubic space due to prior abdominal surgeries.
23,24 Bowel perforation is rare, reported to occur in 0.03%–0.7% of retropubic sling cases. 13,23,24 The
risk of this complication is greatly reduced with use of the transobturator approach because it
specifically avoids entry into the retropubic space. We agree with other authors that the transobturator
approach should be considered in patients who are at particularly high risk for bowel adhesions in the
retropubic space. Treatment for bowel perforations is directed at resolving associated sepsis, removal of
the sling, and resection and/or repair of the damaged segment of bowel.

Postoperative vaginal erosions are another problem with synthetic slings. Metaanalyses 10,17 of
randomized trials comparing retropubic with transobturator synthetic slings fail to demonstrate a
significant difference in vaginal erosion rates between the two techniques. Large case series 2,23,25,26 of
TVT and SPARC-sling procedures report that vaginal erosions are rare, occurring in 0.2%–1.8% of cases.
While some authors 27 have suggested slightly higher rates of vaginal erosions with transobturator
slings, this may reflect the high erosion rates (6.1%–20%) noted to occur with the Mentor ObTape kit, 28-
30 which has subsequently been removed from the market. More recently, a large French registry 20 of
984 TVT-O (inside-out transobturator approach for TVT) procedures reported a postoperative vaginal
erosion rate of 0.6%, a figure within the range found in the large TVT and SPARC series.

These results bring to light that the more important factor in preventing vaginal erosions appears to be
choice of synthetic sling material. Soft, woven, monofilament polypropylene mesh with large (> 75
microns) pore size appears to be the mesh of choice, as it allows proper incorporation of the mesh into
host tissue and facilitates immune surveillance. 31 Both multifilament meshes and monofilament
meshes with small pore sizes allow passage of microbes but not host macrophages, thereby promoting
infection and subsequent erosion. 31

Management of vaginal erosions consists of either complete excision of the mesh, excision of the
exposed portion of mesh, or observation. While several authors 32-34 have reported on their experience
with mesh erosions, there is currently no evidence-based consensus on the management of vaginal
erosions. We typically attempt complete mesh removal in cases where the mesh is infected or traverses
the urinary tract, the mesh composition (multifilament, small pore size) is unfavorable and likely to re-
erode or become infected, or the mesh is causing significant pain due to infection or its location. We
perform more conservative excision of the exposed area of mesh followed by closure of the vaginal wall
in cases where the mesh is uninfected, non-painful, and composed of favorable material. Others 35 have
adopted a similar management scheme for vaginal erosions. Some authors 34 have also reported
successful conservative observation and spontaneous healing of small, non-infected erosions.

Groin and thigh complications
Groin and thigh complications are significantly more prevalent with transobturator slings than
retropubic slings and can be lifethreatening in some cases. A meta-analysis 17 of randomized controlled
trials comparing retropubic with transobturator slings found that the odds ratio of groin/thigh pain was
8.3 for transobturator as compared to retropubic slings, and the large French registry of TVT-O
procedures 20 reported a 2.7% rate of residual pain lasting greater than 4 weeks duration. In our
experience and in that recently published by others, 36 the groin and thigh pain encountered after
transobturator sling placement can in some cases be unrelenting and require sling removal, a
challenging task. Such pain can result from the passage of the sling through the adductor brevis,
adductor magnus, and gracilis muscles (with subsequent myositis); infection and/or abscess; hematoma;
or, rarely, obturator nerve entrapment. 12,37 More significant is that serious infectious complications
resulting from transobturator slings have been reported,38 including groin and thigh abscesses, sepsis,
and gangrene.

Managing groin and thigh complications raises the important issue of “invasiveness” with regard to
transobturator slings. While transobturator sling procedures are often marketed as “less invasive” due
to avoidance of the retropubic space, one must be cognizant that transobturator slings are placed into
an anatomic region that is very difficult to access after the sling is placed. Removal of retropubic slings
remains relatively straightforward, especially because urologists and gynecologists are familiar with the
anatomy of the retropubic space and urethra. Conversely, removal of a transobturator sling remains
challenging because it occupies a deeptissue space that is difficult to access, and the anatomy of this
region is far less familiar to pelvic surgeons. Thus, both retropubic and transobturator sling procedures
are “invasive,” and each sling carries its own set of problems associated with the anatomic region that it

Postoperative voiding dysfunction
Voiding dysfunction after sling placement typically includes postoperative urgency/urge incontinence
symptoms and/ or obstructive symptoms. The occurrence of voiding difficulties in the postoperative
period highlights the importance of determining and documenting the patient’s voiding pattern prior to
surgical intervention. For example, persistent urinary urgency after sling placement is typically not
considered a complication whereas de-novo urgency symptoms are considered a complication of the
surgical intervention.

Recent evidence 17,39 suggests that de-novo urgency after sling placement is relatively common,
occurring in 10%–15% of cases; however, the range in the literature 40-43 spans a tenfold difference,
from 3.1% to 32%. Recent meta-analyses of randomized trials comparing retropubic to transobturator
slings are conflicting. The meta-analysis of Latthe et al 17 suggests that there is no significant difference
in de-novo urgency rates with respect to the retropubic as compared to the transobturator approach,
whereas the study by Novara et al
 suggests fewer storage-related lower urinary tract symptoms with the transobturator technique
compared to the retropubic. A recent study by Botros et al 42 suggests that transobturator slings may
carry a lower rate of de-novo urge incontinence when compared to retropubic slings.

One hypothesis 42,44 for this difference in postoperative urgency symptoms is that transobturator slings
occupy a more horizontal plane as compared to the U-shape of retropubic slings, thereby making less
contact with the urethra, resulting in a reduced incidence of de-novo urgency symptoms; however, the
evidence supporting this hypothesis is preliminary.

Treatment of de-novo urgency after sling surgery is first directed at ruling out sling erosion into the
urinary tract, followed by treatment of urge symptoms including first-line pharmacologic therapy
(antimuscarinics) followed by possible second-line therapies (neuromodulation, botulinum toxin) for
failures. One must also be mindful that partial obstruction resulting from the sling placement can also
result in de-novo urgency symptoms. Thus, a careful history assessing for simultaneous obstructive
symptoms (straining, hesitancy, positional voiding, incomplete emptying), examination of the urethra
and sling (for evidence of excessive tension or malposition), and urodynamic assessment are important
in the evaluation of de-novo urgency symptoms. 45

In cases where obstruction is determined to be the likely cause of de-novo urgency symptoms,
intervention to loosen or incise the sling or formal urethrolysis may be required. Success rates for
storage-symptom resolution after sling de-obstructing procedures vary widely from 12%–100%, but
most studies report success rates in the 75%–85% range. 46 The wide range of success rates may result
from the timing of surgical intervention on the obstructing sling; there is evidence 47,48 suggesting that
longer periods of obstruction are associated with higher rates of persistent storage symptoms.

Postoperative urinary obstruction can be a serious complication after sling surgery, and the incidence
remains difficult to assess primarily due to the fact that the diagnosis is not always straightforward.
While complete urinary obstruction requiring indwelling or intermittent catheterization is obvious, the
diagnosis of partial obstruction can be problematic because obstructive symptoms are often
accompanied by urgency symptoms, making the clinical assessment difficult, and because there are no
firm urodynamic criteria for diagnosing urinary obstruction in women. We agree with other authors 49
that the single most important element in making the diagnosis is the temporal relationship between
the onset of new obstructive voiding symptoms and the sling surgery. These symptoms may or may not
be accompanied by some objective evidence of partial obstruction such as elevated postvoiding residual
volume. This highlights the importance of defining the patient’s voiding pattern prior to surgery so that
postoperative alterations can be recognized.

A recent review 39 of the Medicare data on 1356 sling procedures found that within the first
postoperative year there was a new diagnosis of obstruction in 7% of cases and treatment for
obstruction in 8% of cases. The AUA Female Stress Urinary Incontinence Clinical Guidelines Panel
estimated 50 the overall risk of permanent and temporary (< 5 weeks) postoperative urinary retention
after sling surgery to be 5% and 8%, respectively. A recent study by Morey et al 51 and two recent meta-
analyses 10,17 suggest that obstructive complications are more common after retropubic as compared to
transobturator sling procedures; this may reflect the difference in shape of the two types of slings, as
discussed above, but this concept is currently unproven.

There are multiple etiologies for postoperative urinary obstruction after sling surgery, including
excessive sling tension, urethral or bladder-neck perforation, urethral fibrosis, and cystocele with
subsequent urethral kinking. Thus, initial management includes careful physical examination of the
urethra and vagina, including diagnostic cystoscopy and assessment of urethral mobility and vaginal
support. Urinary erosions and vaginal prolapse require appropriate corrective surgery; in patients
without these findings, the decision to perform surgical intervention on the sling must next be made.

Urodynamic evaluation of cases of suspected obstruction after sling surgery remains controversial, as
preoperative urodynamic parameters do not correlate with results of urethrolysis surgery for
postoperative obstruction following sling surgery, 52 and there are no firm urodynamic criteria for
diagnosing female urinary obstruction. Nonetheless, a high-pressure low-flow pattern noted on
urodynamic testing, when coupled with corroborating symptoms, can be invaluable in such cases.
Therefore, we routinely perform urodynamic evaluation when assessing suspected post-sling
Initial management is often conservative, consisting of intermittent self-catheterization and possible
alpha-blocker therapy. There is little evidence to guide duration of this treatment, but we agree with
other authors 47,48 that early intervention should be undertaken not only due to the distress caused to
the patient but also because prolonged obstruction after sling surgery may be associated with increased
rates of permanent voiding dysfunction. In our experience and that of others,45 operative intervention
is typically required on the sling when urinary retention and/or obstructive symptoms do not resolve
within approximately 4 weeks after sling placement; however, other authors 46 suggest a longer waiting
period of 12 weeks.

Many techniques have been described for treatment of post-sling obstruction. These include sling-
loosening procedures, midline sling incision, segmental sling excision, and formal urethrolysis. Formal
transvaginal or retropubic urethrolysis remains the definitive treatment for sling obstruction, with
reported 46 success rates of 65%–93%, and relatively low rates of recurrent stress urinary incontinence
in the 0%–19% range.45 A detailed discussion of these techniques is beyond the scope of this review,
but the topic has recently been comprehensively reviewed. 46

Recurrent stress incontinence: treatment failure
There is currently a paucity of literature on the management of failed suburethral sling procedures.
Treatment failures can arise from a number of problems, including technical problems with the sling
placement, or from patient-oriented factors such as persistently high intra-abdominal pressures
(obesity) or poor urethral tissue quality (radiation, aging). Technical problems with the surgery include
sling laxity, poor sling placement (either proximal to the bladder neck or too distally near the meatus), or
sling placement into the urethra, which can sometimes lead to simultaneous recurrent stress
incontinence and obstructive/irritative symptoms.

The first steps in management remain a vaginal exam and cystoscopic evaluation to rule out a major
complication (perforation or erosion) and urodynamic evaluation to objectively define the patient’s
current voiding pattern as best as possible. Treatment of major complications necessitates appropriate
corrective surgery, often involving removal of the sling followed by a period of recovery and re-
evaluation prior to re-intervention. Options for re-intervention include adjusting (within a few days of
original surgery) tension of slings judged to be too lax, performing a tandem sling placement, removing a
malpositioned or failed sling with simultaneous placement of a new sling, or using adjuvant urethral
injectable therapy. 53,54 The selected option should be based on the suspected cause of the recurrent
incontinence; for example, when the urethra appears well supported, we typically administer a urethral
bulking agent to augment urethral coaptation, whereas in cases of persistent hypermobility due to sling
laxity or poor position, we will perform a secondary sling procedure with or without removal of the
extant sling (depending upon its position and composition).

Some authors 55 report decreased overall efficacy with a secondary sling as compared to a primary one
while others 56 report equivalent efficacy. There is some evidence 55 that, after failure of the primary
sling, a secondary retropubic sling may be more efficacious than a secondary transobturator sling. Other
authors 54 have reported successful management of failed sling surgery with the use of periurethral
bulking agents, but poor durability and incomplete symptom resolution remain problematic with this
modality. In our experience, bulking agents are most effective in cases where recurrent incontinence is
relatively mild and there is evidence of good urethral support. However, in cases of moderate to severe
recurrent incontinence, we typically place either a retropubic polypropylene sling or the UCLA spiral
sling with simultaneous transvaginal urethrolysis, as first described by our institution. 57 The latter
procedure is especially effective in salvage therapy for patients who have developed a fixed, fibrotic
(“pipestem”) urethra after multiple failed procedures, radiation, and/or other major insults to the

Under-reporting of complications
Despite that many series report complications with synthetic mid-urethral slings, there is compelling
evidence that these complications remain under-reported in the literature. Deng et al 58 recently
reviewed the MAUDE (Manufacturer and User Facility Device Experience) database and identified 161
major complications that included 39 vascular injuries, 38 bowel injuries, and 10 deaths due to surgical
complications of synthetic sling placement. In the same study, the ratio of major to total complications
in the MAUDE database as compared to literature review suggested significant under-reporting of major
complications resulting from synthetic sling placement. Another recent review 11 of the MAUDE
database found similar underreporting of complications of transobturator sling placement.

Synthetic mid-urethral slings have become mainstream therapy for female stress urinary incontinence.
Collective experience has revealed overall good safety and efficacy when proper attention is paid to
technique and selection of sling material. However, clinicians must remain aware that significant and
even lethal complications are possible despite the minimally invasive nature of synthetic mid-urethral
sling placement and that complications of these procedures remain underreported in the literature.
While the transobturator approach causes fewer bleeding and visceral perforation complications due to
avoidance of the retropubic space, it carries its own set of complications associated with placement into
the obturator space, which can pose challenging management problems. Thus, the “best” sling
procedure is that which works best in the hands of the individual surgeon, based upon accumulated
experience and familiarity with anatomy such that complications can be avoided. While complications
are preventable, the recognition that complications can occur even when the procedure is performed by
the most experienced hands, coupled with appropriate surveillance and recognition of intraoperative
and postoperative complications, is paramount for both patient safety and the ultimate achievement of
good surgical outcomes of synthetic midurethral sling procedures.


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