Benha M. J.
Vol. 21 No 1 Jan. 2004
SERUM FERRITIN; A NOVEL CORONARY
ARTERY DISEASE RISK FACTOR
Ayman Abd Al-Samad MD, Mahmoud M. A. Yossof MD*.
Ahmad Wafa Soliman MD, Ay-maa Abd Alaziz MD,
Nader Alshahat MD. Sahar El-Gharabawy MD*
and Araal Selem MD**
Departments of Cardiology, Internal Medicine", Biochemistry'"',
Mansoura Faculty of Medicine. Egypt.
Strong epidemiological evidence is available that iron. is an importan;
factor in the process of atherosclerosis. Therefore, it has been hypouv
esized that the assessment of novel markers help to identify persons
prone to premature CAD.
Purpose: The aim of the study is to assess the potential role offemtir as
an independent risk factor promoting atherosclerosis.
Subjects cr-id methods: 45 patients u-'itn. CAD were studied and sub-
di uided into 3 main groups; group 1: patients with chronic.. stable angi-
na group 2: patients with unstable angina, group 3: patients with acute
myo cardial tnfarction and additional group 4 of 15 subjects as a control.
All patients and control were subjected to accurate history taking, dim
cal examination and a variety of laboratory investigations in associatior
with s.ferritin and plasma malondialdehyde level (MDA).
Results: It was found that patients with, CAD whether chronic stable
angina, unstable angina, or acute myocardial infarctton had a significani-
ly higher serum ferritin level than the control subjects: mean s. ferriti:
702.46 + 211.36 ng/L versus 195.66 + 41.46 ng/L, P-value 0.001 also
the CAD patients had a higher oxidative stress represented by lipic perox-
idation product MDA (Malondiaidehyde): mean MDA in umol/L 0.780 +
0.213versus 0.375 + 0.198 µmol/Lfor the control subjects. P-value 0.01.
Conclusion: Serum femtin could be considered a novel, and indeper,
dent CAD risk factor associated with increased oxidative stress in the
form of increased lipid peroxidation and hence MDA.