FRAX and risk of Vertebral Fractures: the Fracture Intervention Trial - PowerPoint

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FRAX and risk of Vertebral Fractures: the Fracture Intervention Trial - PowerPoint Powered By Docstoc
					 PTH deletion ameliorates the anomalies
 of FGF23-deficient mice by suppressing
the elevated vitamin D and calcium levels




Osteoscoop - Issue N°209 - November 2011
           FGF23


        FGFR1c     Klotho

                  -
            PTH secretion
                   +
- Vitamin D (1,25(OH)2D)
  Ca2+ serum level
                                                  1

                                           FGF23


                                          FGR1c       Klotho

                                                  -
                                            PTH secretion
                                               Low1
                                                  +
                                - Vitamin D (1,25(OH)2D)
                                  Ca2+ serum level
                                  High1


              Kidney             Spleen

1- Fgf23-/-     Soft tissue alteration     Skeleton alteration   Bad general health
                                                   2

                                           FGF23


                                           FGR1c       Klotho

                                                  -
                                            PTH2 secretion
                                                       +
                               - Vitamin D (1,25(OH)2D)
                                 Ca2+ serum level
                                 Lower2


              Kidney            Spleen

1- Fgf23-/-       Soft tissue alteration   Skeletal alteration    Bad general health

                  Partial amelioration      Partial rescue of     Larger and healthier
2- PTH-/- Fgf23-/- of tissue atrophy       skeletal anomalities         mouse
                                                     3

                                             FGF23


                                             FGR1c       Klotho

                                                     -
                                                                    +PTH3
                                               PTH secretion
                                                         +
                                 - Vitamin D (1,25(OH)2D)
                                   Ca2+ serum level
                                   Higher3


              Kidney              Spleen

1- Fgf23-/-         Soft tissue alteration   Skeletal alteration     Bad general health

                  Partial amelioration        Partial rescue of     Larger and healthier
2- PTH-/- Fgf23-/- of tissue atrophy         skeletal anomalities         mouse

3- Fgf23-/- + PTH                            Decreased trabecular     30% mice died
                                                bone volume          during experiment

				
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