Understanding SNPs and Cancer

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Understanding SNPs and Cancer Powered By Docstoc
					  Understanding Cancer and Related Topics
Understanding SNPs and Cancer
Cancer – Different Fates
 Cancer – A Complex Disease



Normal lung cell                      Normal islet cell



                   Many years later




Lung cancer cell                      Diabetic islet cell
SNPs May Be the Solution




     SNPs A    SNPs B




     SNPs C    SNPs D
What Is the Human Genome?




Human Cell
                      Nucleus




                      Chromosomes
DNA and Chromosome Structure




                     Chemical
 DNA molecule        bases
(chromosome)
                     A

                     T

                     G
                     C
         The Genome Contains Genes




Gene 1 Coding region          Protein 1


                              Noncoding region


Gene 2 Coding region          Protein 2


                              Noncoding region
Variation in the Human Genome
 Person 1                          Person 2




             = Variations in DNA
What Is Variation in the Genome?
Common Sequence



       Variations


                    Polymorphism




                    Deletions




                    Insertions

                           Chromosome




                    Translocations
Variations Causing No Changes




         = Variations in DNA that cause no changes
Variations Causing Harmless Changes




          = Variations in DNA that cause harmless changes
Variations Causing Harmful Changes
             No Disease               Hemophilia




     No Disease           = Variation in DNA that
                          causes harmful change
Variations Causing Latent Changes




        = Variations in DNA that cause latent effects
        Many years later            Many years later

				
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