"BM oore Seminar"
Department of Biochemistry and Biomedical Sciences SEMINAR SERIES Speaker: Bradley S. Moore, Scripps Institution of Oceanography & Skaggs School of Pharmacy and Pharmaceutical Sciences University of California at San Diego Title: "Genomics-inspired discovery and bioengineering of natural product drugs" Date: Tuesday May 10, 2011 Time: 11:30 am Place: HSC 4E20 Host: Justin Nodwell Abstract: The natural product discovery process has not fundamentally changed in decades in which new bioactive metabolites are identified through bioassay-guided isolation schemes. While this approach has been essential to the discovery and development of many important clinical agents that have helped shape modern medicine, it is hampered by its own success in which known agents are rediscovered at a higher frequency than new chemical entities. The genomics revolution has recently provided an orthogonal approach to the discovery of natural product drug leads in which sequenced genomes are “mined” for biosynthetic pathways. Not only does this method provide a rational basis for guiding the isolation of new chemical entities, it also enables synthetic biology platforms to genetically reengineer biosynthetic pathways to extend nature’s chemistry. While promising, this emerging technology faces its own challenges. This seminar will focus on the status, challenge and future potential of genome mining in the natural product discovery process. Website: http://moorelab.ucsd.edu Coffee and cookies available at 11:15am