Telemedicine and Advanced Technology Research Center (TATRC

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Telemedicine and Advanced Technology Research Center (TATRC Powered By Docstoc
					            ABFI 2004
   Cellular/Molecular Biosciences
          Kenneth C. Curley, M.D.
          Robert Read, LTC (Ret) USA

      Medical Research & Materiel Command
Telemedicine & Advanced Technology Research Center
                  Ft Detrick, MD
                      The Portfolio
   Initially small number of Congressionally directed
    research projects expanded to include:
    –   Gene Therapy
    –   Tissue Engineering
    –   Immunotherapy
    –   Pharmacology
   Basic science research is part of the Army Science and
    Technology Master Plan-a flow of knowledge and
    materiel that will drive the development of future
    diagnostic tools and therapies
   In 2003 TATRC managed nearly $10M in such
    research.
                     Tissue Engineering
   Mass transport problem as tissue structure becomes more
    massive
   Key to engineering vital organs: build vasculature directly into
    scaffold
   Semiconductor fabrication techniques utilized
   Ability to etch channels into silicon and pyrex wafers
    demonstrated




                                    Cell growth on a pyrex wafer with
                                        25micron etched channels
(CIMIT)
                    Tissue Engineering
                                   Ability to seed and liftoff
                                    hepatocytes and endothelial cells
                                    demonstrated

                                   Novel approaches for growing
                                    engineered cells into organs
                                    developed


Tissue Engineered Ear from Human Cartilage




                                                    Liver Scaffolding



 (CIMIT)          Artificial Blood Vessel
 Implantation of Stromal Cells Expressing BMP-4
  Completely Heals Critical Size Calvaria Defect




              Control Stromal Cells            BMP-4 Stromal Cells

Dr. David Baylink, Loma Linda VA Healthcare System
Dr. David Baylink, Loma Linda VA Healthcare System
          Future of the Portfolio
 With the increasing pace of discovery it is
  anticipated that the portfolio will continue to
  increase in funding
 As an organization, we will be developing
  molecular biology-related R&D roadmaps that
  address Army science and technology goals
 Molecular biology, in many guises, will become
  more closely connected to the patient
Questions: See Mr. Read
or feel free to email or call
        Dr. Curley at
       301-696-9240
              or
     curley@tatrc.org

				
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