Final Presentation - PowerPoint by Ptcu8g

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									         Graduation Project I
   Device for controllable administration
               of drug dosage
Prepared By:
              - Mona Ibrahim          200002091
              - Azza Al Hassani       200002019
              - Asma Ahmed            200002020
              - Hamda Al Ketbi        199902209
              - Moza Al Shamsi        199908356
Adviser’s name:
                  - Dr. Yousef Haik
              Outline

o Introduction
o Background Theory
o Methods and Techniques
o Results and Discussions
o Conclusion
Introduction
  Project Description



                 Physician




                             Dispensing Device
Testing Device

                 Patient
           Objectives

o Design a blood testing mechanism

o Design a drug dispensing mechanism

o Design and construct a working
  prototype of the system
                  Motivation

o   Frequent Monitoring
o   Dose adjustment
o   Reduce patient error
o   Time saving
o   Availability of a patient medical history
o   Minimizing potential risks and liability
o   Reduce visiting appointments which will
    reduce insurance payments.
Background Theory
      Blood Clotting
o A natural process in which blood
  cells and fibrin strands clump
  together to stop bleeding
Blood Coagulation Mechanism
o There are two well-recognized coagulation
  pathways:
   o Extrinsic (thromboplastin)
   o Intrinsic (prothrombin/fibrongen)
       Prothrombine Time PT


o The time it takes plasma to clot.
o PT is reported in seconds
International Normalization Ratio

o The ratio of the patient's clotting time to the
  mean reference value.


                      PTtest
             INR  (          )
                     PTnormal
               Anticoagulants

o Medications that delay the coagulation of
  blood
o Some of these are:
  o Heparin
  o Argatroban
  o Hirudin
  o Warfarin
                 Warfarin
o Warfarin is probably the best known and

  most widely used oral anticoagulant. It is a
  non-habit forming medication used to limit
  the size of existing blood clots and to
  prevent formation of new blood clots in
  high-risk patients
Methods and Techniques
Design Process
            Market Analysis
o   The ProTime System-PT-INR Testing
o   The Harmony INR Monitoring System
o   Coaguchek System
o   INRatio®PT Monitoring System
              Function Structure

Global device
function                                   Blood             System       Drug
                                           sample                         dose




   Blood
  Sample                                             Drug
            Hold          Testing     Dispenser
                                                                      Overall
                                                    Dosage
           Sample         Device

                    INR value              Dose                       function
                                Computer                              structure
          Specifications


o Measuring System



o Dispensing System
             Measuring system
Small sample volume: 20 µL


Disposable sample holder

Measuring time is less than one minute

Made of biocompatible materials

Sensitive: can measure less than 1 mg/ mL of Prothrombin

Meet the International Biomedical Instrumentation standards
         Measuring system
Portable and easy to use

Touch button operation

Large, easy to read reporting screen


Perform measurement automatically as soon as
  the sample is applied

Durable, Repeatable and Cost effective meter and test strip
           Dispensing system
Store medicine       Cost effective   Durable


Loading medicine dump


Dispense one tablet at the time


Patient interference to the device is negligible


Time for dispensing to be less than 2 minutes
Developing concepts
Testing Morphological Chart
Hold
Sample


Testing       1.RLC        4. Plasma
                           profile
                                          7. Shear stress   10.Cantilever
                                                            beam

methods       2. Protein
              separation   5. Viscosity
                                          8.Charged
                                          Particle          11.Piezoelectric

              3. Contact   6. Light       9.Elisa           12. Blood layer
              angle        intensity                        thickness

Display INR   Digital      Printer        LED               LCD
              display                     monitor
Testing Methods
RLC Testing Method
Protein Separation Method
Cantilever Beam Method
Plasma Profile
Measuring the distance moved
Shear Stress
Light Intensity
Blood layer Thickness
Contact Angle
Flow in Pipes
Piezoelectric
Elisa
Viscosity
The charged Particle method
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           Function Generator
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                                         6rd
                                                     3
Resistance Measurement using Y tube
Drug Dispensing Device
Dispensing Morphological Chart
Tablet
Holder



Mover    Belt    Gear      Manual    Piston




         Shaft
                 Pulleys   Rollers
Dispensing Morphological Chart
Actuator   Dc         pneumatic hydraulic Step
           motor                          motor


count      IR         Laser       Distance Sensor
           sensor     Sensor


Lock       solenoid   Worm gear   Spring
                                  damping
                                            Spring
                                            solenoid arm
                                            locking
                                            (hook)
Dispensing Morphological Chart
Cutter    cutter              Paper cutter
                   Scissors                  Utility Knife
                   (Sharp)




Ejector
Dispensing Concept 1
Dispensing Concept 2
Dispensing Concept 3
Communication Part
Communication Morphological Chart


  Sending   Wire    Sound         Laser

  signals

                                  transmitter
            modem   Fiber optic
Results and Discussions
          Feasibility study

o Cantilever beam method

o Light Intensity and plasma profile

o Measuring the distance moved
                      Feasibility study

o Capacitance measurements
  o Procedure 1: Measuring the voltage across the copper plates
                                           with time

                                          Voltage vrs Time
                    900
                    880
                    860
                    840
                    820
           V (mV)




                    800
                    780
                    760
                    740
                    720
                    700
                          0   1   2   3    4    5    6       7   8   9   10   11   12

                                                 Time (min)
                               Feasibility study
o Procedure 2: Measuring the capacitance across the copper
                                           plates with time


                                   Capacitance vrs Time        Series1
       C (Micro Farad)




                         2.4
                         2.3
                         2.2
                         2.1
                          2
                               0   5      10      15      20   25

                                          Time (sec)
                                 Feasibility study
o Procedure 2: Measuring the capacitance across the copper
                                                 plates with time for different INR values

                                                                                        INR =1
                                       Capacitance vs time                              INR =1.7
                                                                                        INR =2.4
                       1.4
                       1.2
    Capacitance (µF)




                        1
                       0.8
                       0.6
                       0.4
                       0.2
                        0
                             0   0.5   1   1.5   2       2.5        3   3.5   4   4.5   5
                                                     Tim e (m in)
          Feasibility study
o Contact angle measurements


                                Syringe

       camera

                sample stage
                                   light source




     Captive Bubble Contact Angle apparatus
        Feasibility study
o Surface Area method
         Feasibility study

o Protein Separation method
Conclusion
         Future work

o Resuming investigating the testing
  methods
o Evaluating testing methods
o Selecting the proper and suitable
  testing method
o Selecting appropriate design for
  dispenser
o Building a prototype for the whole
  device

								
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