Free Mixing Insulin 1

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							   If you need to speak to one of the Diabetes Nurses about your
   diabetes, the address and telephone number are shown below.

Diabetes Centre
Kinsgate House, Wellington Road North,
Stockport, SK4 1LW

Diabetes Specialist Nurses
Jennefer Richmond, Andrea Urwin, Jane O’Brien,
Sheena Cottam, Julie Whitehead

                   Telephone: 0161 426 5408/5409
                 Doctor                  Practice Nurse
 Name
 Telephone No:


Reviewed 2004
This booklet aims to give you some general guidelines on how to adjust




                                                                                                                                                                                                                                 morning CLOUDY




                                                                                                                                                                                                                                                                           CLEAR insulin by
your insulin doses safely. There maybe a number of reasons why your




                                                                                                                                                                                                           insulin by 4 units.



                                                                                                                                                                                                                                 insulin by 4 units.
                                                                                                                                                                                          CLOUDY insulin



                                                                                                                                                                                                           morning CLEAR
                                                                                                                                    15 mmols/litre
blood glucose is unusually high or low on an occasion and these are listed




                                                                                                                                                                                          evening meal




                                                                                                                                                                                                                                                                           evening meal
below: -




                                                                                                                                                                      INCREASE evening INCREASE




                                                                                                                                                                                                           INCREASE



                                                                                                                                                                                                                                 INCREASE




                                                                                                                                                                                                                                                       INCREASE evening INCREASE
                                                                                                                                                                                          by 4 units.
                                                                                                                                    or Higher




                                                                                                                                                                                                                                                                           4 units.
     Possible reasons why your blood glucose is high:
        You have forgotten to take your insulin injection.
        You have taken a smaller insulin dose than usual.




                                                                                                                                                                                                                                 morning CLOUDY
                                                                                                                                 8 – 14 mmols/litre
        You have eaten a larger amount than usual.




                                                                                                                                                                      insulin by 2 units.




                                                                                                                                                                                                           insulin by 2 units.



                                                                                                                                                                                                                                 insulin by 2 units.




                                                                                                                                                                                                                                                       insulin by 2 units.
                                                                                                                                                                                                           morning CLEAR
                                                                                                                                                                      meal CLOUDY
        Stress/anxiety.




                                                                                                                                                                                                                                                       meal CLEAR
        Illness.




                                                                                                                                                                                                           INCREASE



                                                                                                                                                                                                                                 INCREASE
                                                                             Insulin Dosage Adjustments – Free Mixing Insulins
     Possible reasons why your blood glucose is low:
        You have taken a larger insulin dose by mistake.




                                                                                                                                 mmols/litre
        You have forgotten a meal.




                                                                                                                                                                      CONTROL




                                                                                                                                                                                                           CONTROL



                                                                                                                                                                                                                                 CONTROL




                                                                                                                                                                                                                                                       CONTROL
        You may have left a long gap between your insulin injection




                                                                                                                                                                      GOOD




                                                                                                                                                                                                           GOOD



                                                                                                                                                                                                                                 GOOD




                                                                                                                                                                                                                                                       GOOD
         and meal (particularly if you take Humalog or NovoRapid




                                                                                                                                 4–7
         insulin).
        You have only eaten a small amount of carbohydrate food.
        Very hot or cold weather.




                                                                                                                                                                                                           insulin by 2 units.
                                                                                                                                                                      CLOUDY insulin




                                                                                                                                                                                                                                 CLOUDY insulin
                                                                                                                                                                                                           morning CLEAR




                                                                                                                                                                                                                                                       CLEAR insulin
        Physical exercise.




                                                                                                                                    Blood Glucose

                                                                                                                                    mmols/litre or




                                                                                                                                                                      evening meal




                                                                                                                                                                                                                                                       evening meal
                                                                                                                                    Less Than 4
        Alcohol.




                                                                                                                                                                      by 2 units.




                                                                                                                                                                                                                                 by 2 units.




                                                                                                                                                                                                                                                       by 2 units.
                                                                                                                                                                      REDUCE




                                                                                                                                                                                                           REDUCE



                                                                                                                                                                                                                                 REDUCE




                                                                                                                                                                                                                                                       REDUCE
                                                                                                                                                                                                                                 morning
                                                                                                                                    Hypo
If your blood glucose level is consistently too high or too low at a
particular time of day on at least two occasions then you should consider
adjusting your dose of insulin. If after reading this booklet you would




                                                                                                                                                                                                                                                       Supper/bedtime
                                                                                                                                                                                                                                 Before Evening
like further advice on adjusting your insulin doses please feel free to

                                                                                                                                    Blood Glucose


                                                                                                                                                      Blood Testing




                                                                                                                                                                                                           Before Lunch
contact the Diabetes Specialist Nurses at Lime House, Stepping Hill
Hospital. Our telephone number and address are on the back page of this




                                                                                                                                                                      Breakfast
leaflet.




                                                                                                                                                                      Before




                                                                                                                                                                                                                                                       Before
                                                                                                                                    Levels


                                                                                                                                                      Times




                                                                                                                                                                                                                                 Meal
Before Evening Meal Injection                                                Listed below are some ‘golden rules’ to guide you in adjusting your
Cloudy insulin - Isophane                                                    insulin doses.

Main action between bedtime and breakfast which is reflected in blood test      Increasing the dose of insulin will lower your blood glucose level.
results before breakfast the following morning.

   If your blood glucose is high (8 mmols/l or more) before breakfast              Insulin         =       Blood
    on at least two occasions, INCREASE your cloudy insulin before your                                     Glucose
    evening meal.
                                                                                Reducing the dose of insulin will increase your blood glucose level.
   If your blood glucose is low (less than 4 mmols/l) before breakfast
    on at least two occasions, REDUCE your cloudy insulin before your
    evening meal. However, if you have a severe hypoglycaemic reaction              Insulin         =       Blood
    reduce this insulin dose the following day.                                                             Glucose

                                                                                If your blood glucose has been 8 mmols/l or higher for at least two
If you are at all unsure about adjusting your insulin doses, please do           days, refer to the insulin dose adjustment chart at the back of this
not hesitate to contact the Diabetes Nurses.                                     leaflet.

                                                                                Wait at least two days before altering an insulin dose to ensure this
                                                                                  adjustment is necessary.
                                                                                       ONCE is an INCIDENCE TWICE is a COINCIDENCE
                                                                                                       THREE TIMES is a PATTERN
                                                                                If your blood glucose level is very high or very low at a particular time
                                                                                  of day, it is the insulin injection you gave before this reading that you
                                                                                  need to alter. For example:
                                                                                       Your breakfast time insulin affects your blood sugar levels
                                                                                         before lunch and before tea.
                                                                                       Your teatime insulin affects your blood sugar levels before bed
                                                                                         and before breakfast.
                                                                                If your blood glucose level is very high or very low do not be tempted
                                                                                  to alter the insulin dose you are about to give.

                                                                                Aim to keep your blood glucose levels between 4 and 7 mmols before
                                                                                 meals.
                FREE – MIXING INSULIN REGIMEN
                                                                                  If your blood glucose is low (less than 4 mmols/l) before lunch on at
Clear insulins (fast and rapid acting)                                             least 2 occasions, REDUCE your clear insulin before breakfast.
Humalog (Lispro)                                                                   However, if you have a severe hypoglycaemic reaction reduce this
NovoRapid (Aspart)                                                                 insulin dose the following day.
Human Actrapid
Humulin Soluble                                                                Before Breakfast Injection
Human Velosulin                                                                Cloudy insulin - Isophane
Pork Actrapid                                                                  Main action between lunch and evening meal which is reflected in blood
Hypurin Porcine Neutral                                                        test results before the evening meal.
Hypurin Bovine Neutral
Insuman Rapid                                                                     If your blood glucose is high (8mmols/l or more) before your
                                                                                   evening meal on at least 2 occasions, INCREASE your cloudy insulin
Cloudy insulins (Isophane - intermediate acting)                                   before breakfast.
Human Insulatard
Pork Insulatard                                                                   If your blood glucose is low (less than 4 mmols/l) before your
Humulin Isophane                                                                   evening meal on at least 2 occasions, REDUCE your cloudy insulin
Hypurin Porcine Isophane                                                           before breakfast. However, if you have a severe hypoglycaemic
Hypurin Bovine Isophane                                                            reaction reduce this insulin dose the following day.
Insuman Basal
                                                                               Before Evening Meal Injection
This insulin regimen involves mixing two different insulins together and       Clear insulin - Soluble, fast or rapid acting
giving them in one injection. It gives the flexibility of being able to        Main action between evening meal and bedtime which is reflected in
adjust either a clear insulin or a cloudy insulin according to blood glucose   blood test results before bed.
readings at particular times of the day.
                                                                                  If your blood glucose is high (8mmols/l or more) before bed on at
If you are mixing a rapid acting insulin with a cloudy insulin, you should         least 2 occasions, INCREASE your clear insulin before your evening
inject immediately before the meal. If you leave a gap between an                  meal.
injection of rapid acting insulin and your meal, you may risk going hypo.
                                                                                  If your blood glucose is low (less than 4 mmols/l) before bed on at
Before Breakfast Injection                                                         least 2 occasions, REDUCE your clear insulin before your evening
Clear insulin - Soluble, fast or rapid acting                                      meal. However, if you have a severe hypoglycaemic reaction reduce
Main action between breakfast and lunch that is reflected in blood test            this insulin dose the following day.
results before lunch.
 If your blood glucose is high (8mmols/l or more) before lunch on at
    least 2 occasions, INCREASE your clear insulin before breakfast.

						
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