"Epidemiology and Biostatistics 679:"
Epidemiology and Biostatistics 679: Clinical Epidemiology June 6-29, 2005 Instructors: Dr. Jean Bourbeau (email@example.com) Dr. Dick Menzies (firstname.lastname@example.org) Dr. Kevin Schwartzman (course coordinator; email@example.com) Research Offices: Respiratory Epidemiology and Clinical Research Unit Montreal Chest Institute K1 3650 St. Urbain Objectives: The general objective of this 3-credit course is to provide students with a basic understanding of the methods of epidemiology, as applied to clinical practice and clinical research. Specifically, we will address key principles of testing and measurement in the clinical context, as well as study design, analysis, and inference in the clinical research setting. Students will be encouraged to apply concepts covered in the course to their own areas of interest. Prerequisites: All students should have a strong clinical background in medicine or an allied health profession. Preference will be given to residents and fellows enrolled in postgraduate medical training programs at McGill University. Previous course work in epidemiology or research experience is not required. Textbook: Fletcher, Clinical Epidemiology: The Essentials, 3rd edition, available at the McGill University bookstore. Students will also need to purchase a course pack containing additional readings. Lecture notes, assignments, and links to articles will be available from the course website. Format: Ten classroom sessions, from 1:30-4:45 Mondays, Wednesdays, and Fridays from June 6 through June 29 inclusively. Attendance at all sessions is mandatory. Each session will include 1) didactic lecture material, and 2) student presentations. A written final examination will be administered during the last session (see below). Student Teams: Students will be divided into teams of 2-3, for purposes of assignments and presentations. Assignments and Presentations: 1. Before each lecture, an assignment addressing key points of that day’s lecture will be distributed. This must be handed in (1 per team) at the beginning of the next lecture. In addition, during each class session, one team will give an oral presentation outlining its answers to the assignment for that day’s lecture. Over the month, all students will be expected to present in this fashion. 2. The assignments will include questions about papers from the medical literature, which reflect issues addressed in the lectures. These papers will be selected by the group responsible for each oral presentation, and identified ahead of time so that all students in the class use the same paper. For example, the students responsible for the oral presentation on cohort studies will select a paper reporting a cohort study of interest to them. 3. For the final assignment, each team will hand in a summary (maximum 2 pages double- spaced) of an original proposed research protocol, addressing a clinical research question which team members consider relevant. Further details on content and format will be provided in class. These summaries will be presented by the teams in class on Monday, June 27 and handed in that day. Final Exam: A written final exam, in short-answer format, will be administered in class on Wednesday, June 29. Evaluation: Written homework assignments: 20% Oral presentation of homework assignment: 10% Written protocol summary: 20% Oral presentation of protocol summary: 10% Final exam: 30% Class participation: 10% TOTAL 100% Notice Regarding Academic Integrity and Plagiarism: The Department of Epidemiology and Biostatistics has asked instructors to remind students of McGill University regulations regarding academic integrity and plagiarism. These are excerpted below. It is understood that assignments submitted by groups of students will include contributions of all group members; for such assignments, a single copy submitted with all group members’ names will be sufficient. However, we expect that each group will submit its own assignment, written separately from those of other groups. The same holds true for the protocol summaries. Where assignments cite others’ research work, appropriate references must be provided. Direct quotes from other writers should be indicated by quotation marks. The usual McGill University regulations will pertain to the final exam on June 29, 2005. III. ACADEMIC OFFENCES The integrity of University academic life and of the degrees the University confers is dependent upon the honesty and soundness of the teacher- student learning relationship and, as well, that of the evaluation process. Conduct by any member of the University community that adversely affects this relationship or this process must, therefore, be considered a serious offence. 15 Plagiarism (a) No student shall, with intent to deceive, represent the work of another person as his or her own in any academic writing, essay, thesis, research report, project or assignment submitted in a course or program of study or represent as his or her own an entire essay or work of another, whether the material so represented constitutes a part or the entirety of the work submitted. (b) Upon demonstration that the student has represented and submitted another person’s work as his or her own, it shall be presumed that the student intended to deceive; the student shall bear the burden of rebutting this presumption by evidence satisfying the person or body hearing the case that no such intent existed, notwithstanding Article 22 of the Charter of Student Rights. (c) No student shall contribute any work to another student with the knowledge that the latter may submit the work in part or whole as his or her own. Receipt of payment for work contributed shall be cause for presumption that the student had such knowledge; the student shall bear the burden of rebutting this presumption by evidence satisfying the person or body hearing the case that no such intent existed (notwithstanding Article 22 of the Charter of Students’ Rights). Downloaded and excerpted from A Handbook on Student Rights and Responsibilities, 2003, p. 17. Available on-line at http://upload.mcgill.ca/secretariat/greenbookenglish.pdf Additional information is available at www.mcgill.ca/integrity/ Course Outline: EPIB-679, June 6-29, 2005 Meeting # Date Topics Instructor(s) 1 Mon Introduction, course overview Schwartzman June 6 Bourbeau Menzies Diagnostic tests, screening, prevention Schwartzman 2 Wed Measurement issues: precision, validity, Bourbeau June 8 responsiveness; clinical scales/scores 3 Fri From clinical observations to research: Menzies June 10 Hierarchy of study designs Planning and designing a first study Guest lecturer: Dr. Sandra Dial, MUHC 4 Mon Measures of disease occurrence and Menzies June 13 association Descriptive, cross-sectional, ecologic studies 5 Wed Cohort studies Menzies June 15 Survival analysis Selection bias 6 Fri Clinical trials Bourbeau June 17 7 Mon Case-control studies Schwartzman June 20 Beginning your own clinical research: Schwartzman research questions, scope of work, pilot Menzies studies, ethical considerations Description of protocol summary assignment; Schwartzman the peer-review process 8 Wed Confounding, matching, related issues in Schwartzman June 22 analysis Inference and hypothesis testing Fri HOLIDAY—NO CLASS June 24 9 Mon Student presentations of protocol summaries Bourbeau June 27 Exam review Menzies Schwartzman 10 Wed Final exam Bourbeau June 29 Menzies Schwartzman