"BIO 472H1S - COMPUTATIONAL GENOMICS AND BIOINFORMATICS - DOC - DOC"
CSB 472H1S - COMPUTATIONAL GENOMICS AND BIOINFORMATICS 24L, 12T Lecturers: Prof. N. Provart (Team Leader) email@example.com Prof. D. Guttman firstname.lastname@example.org Exclusion: BCH 441H1 Prerequisites: BIO 230H1/(240H1, 241H1)/250Y1/255H1/255Y1 Recommended preparation: BIO 260H1/HMB 265H1 Computational genomics and bioinformatics provide us with tools to extract biological information from complex genomic data. We are now able to produce vast amounts of genomic data, which are simply meaningless characters without sophisticated analysis methods. CSB472 will teach you the fundamentals of analyzing genomic data. This course emphasizes understanding how core bioinformatic analyses work, the strengths and weaknesses of related methods, and the important parameters embedded in these analyses. CSB472 is not an applied methods course, nor a course to for developing new bioinformatic tools. We will examine the fundamentals of pairwise and multiple sequence alignment, phylogenetic analyses, genome annotation, gene prediction, and gene expression data analysis. Theoretical, applied, and statistical issues will be addressed. An important component of this course involves learning introductory PERL scripting. A basic understanding of this very straightforward scripting language greatly facilitates bioinformatics analysis, and is an essential skill for anyone wishing to pursue work in this area. PERL scripting will be taught in a one hour tutorial / computer lab which follows each lecture. No prior programming experience is required. We will also devote some tutorials to hands-on analysis of genomic data. This is an advanced course with a strong genetics emphasis meant for Biology and Human Biology/GGB specialists/majors. Required text: Zvelebil & Baum 2008 Understanding Bioinformatics. Garland Science, New York. Evaluation: Four assignments (40%), midterm (30%), final (30%)