Neurobio of Trauma

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							      Creating a Culture of Care:
  Implementing Trauma-Informed
       Practices to Reduce
         Seclusion and Restraint
________________________
Neurobiological & Psychological
      Effects of Trauma

Module created by Glenn Saxe, MD: 2002, updated 2009, 2011
“Without understanding the basic
principles of how the brain develops
and changes, we cannot expect to
design and implement effective
interventions.”
                  Bruce Perry, M.D.

                                       2
                                                    Boston Medical Center
                                           Intensive Residential Treatment Program
                       80
                                         Total Seclusion, Restraint & Injury Episodes
                                                         09/00 - 01/08
                       70
                                                                                                                                                                                              SR Episodes

                       60                                                                                                                                                                     Kid Injury
SR & Injury Episodes




                       50                                                                                                                                                                     Staff Injury


                       40

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                       30


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                                                                                                                                                                                                                         Sep-07
                                                                                                             Significant Periods
Longitudinal Course of PTSD Symptoms
in Children with Burns
                          50



                          45



                          40



                          35
          PTSD-RI Score




                          30



                          25



                          20



                          15



                          10



                          5


                          0
                               Acute Assessment          3 Month Assessment

                                                  Time Period
Lateral Ventricles Measures in an 11 Year
Old Maltreated Male with Chronic PTSD,
Compared with a Healthy, Non-Maltreated
            Matched Control




                                 (De Bellis et al, 1999)
From Neurons to Neighborhoods:
    The Science of Early Child
          Development


Report from the Institute of Medicine/National
                 Academies
         National Research Council
           Trauma in U.S.A.
• 3 million children were suspected of being
victims of abuse and/or neglect      (Mazelis, 1999)


• 3.9 million adolescents have been victims of
serious physical assault, and almost 9 million
have witnessed an act of serious violence
                                     (Kilpatrick et al, 2001)


• In 1998, 92% of incarcerated girls reported
sexual, physical or severe emotional abuse in
childhood                       (Acoca & Dedel, 1998)
               PTSD in U.S.A.
• Over 50% of U.S. women & 60% of men report experiencing
at least 1 traumatic event at some point in their lives. But,
only a minority (10% of women & 5% of men) report
developing posttraumatic stress disorder, the most prominent
psychiatric disorder associated with traumatic events.
                            (Koenen, 2005; Kessler et al, 1995)

• More than 80% of those diagnosed with PTSD will suffer
from other psychiatric disorders. (Solomon & Davidson, 1997)

• For more than 1/3 with PTSD, it will be a persistent
condition and experienced for several years.
                                     (Solomon & Davidson, 1997)
           Impact of Adult PTSD
• Childhood trauma, compared to adult-onset trauma:
   • results in a greater probability of developing psychiatric
     disorders (particularly anxiety disorders and PTSD)
     throughout the lifetime (Zlotnick et al., 2008), and
   • is believed to have a long-term impact in the frontal,
     temporal and parietal regions of the brain and how
     information is processed (Cook et al., 2009)
• Studies have identified 4 main risk factors for PTSD in adults:
  1) a pre-existing psychiatric disorder; 2) a family history of
  disorders; 3) childhood trauma and 4) being female (Breslau, 2002)
• Late-onset PTSD is under recognized and undertreated in adults
  and creates greater probability of additional psychological
  difficulty and physical health symptoms later in life (Snyder, 2008)
Effective Treatment Must Account
               For:

 1) A dysregulated nervous
 system


 2) A social-environment that
 cannot contain this
 dysregulation
Core Concepts of Development

1) The development of children
unfolds along individual
pathways whose trajectories are
characterized by continuities
and discontinuities, as well as by
a series of significant transitions.
                        (Shonkoff & Phillips, 2000)
Longitudinal Course of PTSD Symptoms
in Children with Burns
                          50



                          45



                          40



                          35
          PTSD-RI Score




                          30



                          25



                          20



                          15



                          10



                          5


                          0
                               Acute Assessment          3 Month Assessment

                                                  Time Period
     309.81 PTSD Definition
The development of characteristic
 symptoms, following exposure to a
 traumatic stressor involving direct
 personal experience or witnessing
 another persons’ experience of:

  – Actual or threatened death
  – Actual or threatened serious injury
  – Threat to physical integrity
Post Traumatic Stress Disorder
• Characterized by:
  – Re-experiencing the event
     • Intrusive thoughts, nightmares, or
       flashbacks that recollect traumatic images
       and memories

  – Avoidance and emotional numbing
     • Flattening of affect, detachment from
       others, loss of interest, lack of motivation,
       and constant avoidance of any activity,
       place, person, or event associated with the
       traumatic experience
Core Concepts of Development


2) The growth of self regulation
is a cornerstone of early
development that cuts across all
behavioral domains.
                      (Shonkoff & Phillips, 2000)
State Change
Parameters that change between
             state

       •Affect
       •Thought
       •Behavior
       •Sense-of-self
       •Consciousness
Emotional States and Child Development
  • Discrete behavioral states are a central
  organizing experience of infancy

  • Infants experiential world is divided into
  separate and definable emotional/behavioral
  states

  • Critical task of early child development is to
  build smooth transitions/bridges between states

  • Regulation of emotion is initially contingent on
  caregivers facilitating these transitions (Wolff, 1987)
 Goal of Treatment
• Maintain Calm/ Continuous/
  Engaged State

• Prevent Discontinuous States

• Build Cognitive Structures
  that allow Choices
Between Stimulus and Response


         Stimulus

      Traumatic           COGNITION!!!
      Reminder
                                         Response

                                         Traumatic State
             Social-
          environmental                Neuro-
           Intervention              regulatory
                                    Intervention




                     Intervention
 Core Concepts of Development


3) Human development is shaped
by a dynamic and continuous
interplay between biology and
experience.


                    (Shonkoff & Phillips, 2000)
Emotional Brain




              (Restak, 1988)
Between Stimulus and Response

                           Cortex



                           Hippocampus
                                         Slower


        Sensory Thalamus   Very Fast      Amygdala


 S Stimulus
                                                  Response

                                                             (LeDoux, 1996)
Between Stimulus and Response

                           Cortex


                           Hippocampus
                                         Slower


        Sensory Thalamus   Very Fast      Amygdala


 S Stimulus
                                                  Response

                                                             (LeDoux, 1996)
Between Stimulus and Response

      Social                                             Neuroregulatory
   Environmental             Cortex         Psychotherapy Intervention
    Intervention



                             Hippocampus                  Psychopharmacology
                                           Slower


          Sensory Thalamus   Very Fast      Amygdala


 S Stimulus
                                                    Response

                                                                 (LeDoux, 1996)
Play




       (Panksepp, 1998)
Play and Fear




                (Panksepp, 1998)
Social-Ecological Model
         Culture
        Neighborhood   Individual
           School
         Peer Group
           Family

        Individual
Core Concepts of Development


4) Human relationships, and the
effects of relationships on
relationships, are the building
blocks of healthy development.
                     (Shonkoff & Phillips, 2000)
         Attachment
• Earliest relationships critical for
  capacity to regulate state

• Early traumatic relationships set up
  person to respond with state
  dysregulation to interpersonal cues in
  subsequent relationships
Attachment & Relational Deficits

 •Appear guarded & anxious
 •Difficult to re-direct, reject support
 •Highly emotionally reactive
 •Hold on to grievances
 •Do not take responsibility for behavior
 •Make the same mistakes over and over
 •Repetition compulsion / traumatic re-
 enactment                 (Hodas, 2004)
     Traumatic Relationships
• Emotions expressed in interpersonal
relationships can be extremely painful and can
be related to trauma experience
• These trauma-based emotions (e.g. anger,
fear, hopelessness, sexual arousal) can be very
hard for clinicians to tolerate
• Clinicians must be mindful about their
experience of trauma-based emotion so that
this emotion is not enacted in the clinical
relationship
 Core Concepts of Development


5) Children are active
participants in their own
development, reflecting the
intrinsic human drive to explore
and master one’s environment.
                      (Shonkoff & Phillips, 2000)
           Traumatic Mastery
• Many children have primarily experienced abusive
and neglectful relationships
• Extreme behaviors within relationships can be seen
as defensive or self-protective
• Traumatized children respond to their trauma
history in the present. They are not able to discern
that the context has changed
• This behavior must be seen as an attempt to master
extremely difficult environments. In this way,
traumatized children are “doing the best that they
can”
Core Concepts of Development

6) The course of development can
be altered…by effective
interventions that change the
balance between risk and
protection, thereby shifting the
odds in favor of more adaptive
outcomes.
                      (Shonkoff & Phillips, 2000)
         Recovery from Trauma
• Brain plasticity & traumatic brain injury
• Promote neurogenesis
   • Exercise and gross motor movement
      • Increased V02, increased blood flow x 2 to
        hippocampus, new blood vessels, strengthens
        neural connections
                           (Pereira et al., 2007; Snyder & Cameron, 2011)

   • Use of anti-depressant medications (Surget et al., 2011)
   • Cognitive stimulation
• Procedural learning              (Grigsby & Stevens, 2002)
   • Deconstruct behavioral sequence
   • Teach new patterns of response
              CONCLUSIONS
• Response to traumatic stress is learned behavior,
  mediated by the brain & the social environment
• Traumatic stress brings the past to the present
• The survival response impacts the mind, body,
  behavior & speech “… the amygdala leads a hostile
  takeover of consciousness by emotion.” (LeDoux, 2002 )
• To change the response, create new learning & skills:
   – Analyze & adapt
   – Buffer & bolster
   – Teach, support, & build that “cognitive wedge”
“Cowardice asks the question – is it safe?
Expediency asks the question – is it politic?
Vanity asks the question – is it popular?
But conscience asks the question – is it right?
And there comes a time when one must take
the position that is neither safe, nor politic,
nor popular. But one must do it because
it is right…”
                      Martin Luther King, Jr.

						
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