Maternity Cover Marais lab by HC120727023519


									                         THE INSTITUTE OF CANCER RESEARCH

                           Section of Cell and Molecular Biology
                                     Chelsea, London

                            Higher Scientific Officer (REF: C357)


                                 Closing date: 24 June 2010

                         THE INSTITUTE OF CANCER RESEARCH

               Cancer Research UK Centre for Cell and Molecular Biology
                                 Chelsea, London

                                    Higher Scientific Officer

The Institute of Cancer Research (a College of the University of London) is a world-class
cancer research organisation. In the 2008 Higher Education Funding Councils' Research
Assessment Exercise, The ICR received the highest percentage of research assessed as
four stars, world leading, in the areas of biological sciences and cancer studies. We came
top of the Times Higher Education overall table of HEIs that submitted to more than one
UoA - ranking it as the UK's leading academic research centre, with 37% of activity ranked
4* (world leading) and 42% ranked 3* (internationally excellent). In partnership with The
Royal Marsden NHS Foundation Trust, we form the largest comprehensive cancer centre in
Europe, dedicated to research that extends from epidemiology, genetics and molecular
biology, through drug discovery and development, to cancer diagnosis and patient
A 12-month position is available for a higher scientific officer to provide maternity cover for a
biochemist/molecular biologist to join a research group that is developing novel therapeutic
agents for cancer. The successful applicant will develop and run biochemical, cell-based and
in vivo assays to test the efficacy of new compounds that will be synthesized in-house. This
is an opportunity to join an established and successful team with a proven record in
biological and small molecule drug discovery [Cancer Research (2005) 65: 5003-5008;
Journal of Medicinal Chemistry (2009), 52: 3881-1891; Journal of Medicinal Chemistry
(2009), 52: 2255-2264; Cancer Research 65: 5003-5008.]. The post will be based in
Chelsea, but will involve strong collaborations with the Sutton Campus.

Applicants will hold a BSc in Genetics, Molecular Biology or a relevant field, have good
laboratory and analytical skills and experience of preparing data for presentation. Experience
in cell culture, invasion assays and in vivo models of cancer will be an advantage as will a
demonstrable knowledge of drug discovery processes.
The position will be offered on a fixed-term contract of up to 12 months for maternity cover to
commence August 2010 with a salary in the range £28,966 - £32,512 p.a. inclusive based on
previous experience.

Informal enquiries may be made to Dr Richard Marais on +44 20 7153 5171; email Please DO NOT send your application to Dr. Marais; CVs must
be submitted in line with the instructions below.

To apply please email your CV and covering letter (addressing where you meet the
person specification and incl. the names and addresses of two referees), to:, quoting job reference number C357.

In a separate email, please send your completed equal opportunities monitoring form to the same email address
quoting the job reference number above.

Closing date:                 24th June 2010

Interviews will be held:      week commencing 5th July 2010
                        THE INSTITUTE OF CANCER RESEARCH

                                    JOB DESCRIPTION

JOB TITLE                    Higher Scientific Officer

SECTION/TEAM                 CMB/ Signal Transduction

GRADE                        HSO

RESPONSIBLE TO               Dr Richard Marais (Team Leader)


To work on Wellcome Trust funded position to develop new drugs for cancer treatment. To
develop, implement and run new assays to test novel compounds as they are synthesised in-


Experimental laboratory work

To design and execute experiments appropriate for the project. To work semi-independently
to drive the project forward. To work as part of a team to pursue a program of work agreed
with the project managers.

Use established procedures within the research project and to establish new approaches
where appropriate.

To maintain accurate records of experiments and reagent descriptions in laboratory

General Laboratory Management

To provide support to the research team and to assist in maintenance of the laboratory and
with ordering. To perform other functions as determined by the Team Leader and consistent
with the position.

To ensure that work conforms to the requirements of COSHH, Local Rules for use of
radioactivity and other Codes of Practice as required by the Institute Safety Policy.


To work in a flexible but organised manner in close collaboration with the Project Team.

To meet objectives within pre-determined timescales.

To communicate effectively with other members of the Team, Centre and where necessary
the Institute and outside organisations.
To prepare reports of results for oral and written presentations at internal and external
meetings for publication.

To take an interest in the relevant literature.

Any other duties that may be required which are consistent with the nature and grade of the

This job description is a reflection of the present position and is subject to review and
alteration in detail and emphasis in the light of future changes or development.
                          THE INSTITUTE OF CANCER RESEARCH

                                   PERSON SPECIFICATION

     Job Title:                 Higher Scientific Officer

     Section / Team:            CMB / Signal Transduction

                                Criteria                                      or
Education & Knowledge
BSc, MSc or PhD in Genetics/ Molecular Biology or related subject             E
Demonstrable knowledge of the process of drug discovery,                      D
particularly in cancer
Previous experience in the development of cell-based assays                   E
2 or more years of professional laboartory experience                         D
Biochemistry/ molecular biology/enzyme assays                                 D
Experience with in vivo tumour models                                         D
Good laboratory and analytical skills                                         E
Proficient use of PC and databases                                            D
Excellent interpersonal skills with the ability to work flexibly and to       E
establish effective working relationships
Good organisational skills                                                    E
Ability to plan, organise & prioritise a busy workload                        E
Ability to work effectively & efficiently, both independently & as part       E
of a team.

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