BIOGRAPHICAL SKETCH

Document Sample
BIOGRAPHICAL SKETCH Powered By Docstoc
					                                                             BIOGRAPHICAL SKETCH
                                Provide the following information for the key personnel in the order listed on Form Page 2.
                                                 Photocopy this page or follow this format for each person.


 NAME                                                                           POSITION TITLE

                                                                                ASSOCIATE PROFESSOR, DEPT. BIOCHEMISTRY & MOLECULAR BIOLOGY
 Arrigo De Benedetti
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
                                                                                   DEGREE
                     INSTITUTION AND LOCATION                                                           YEAR(s)                  FIELD OF STUDY
                                                                                (if applicable)
 Bar Ilan University, Israel                                                     B.Sc.
                                                                             B.Sc.                     1979
                                                                                                    1979                   Biochemistry
                                                                                                                         Biochemistry
 State University of NY at Albany                                                M.S.
                                                                             M.Sc.                     1983
                                                                                                    1983                   Molec. Biol.
                                                                                                                         Molec. Biol.
 State University of NY at Albany                                            Ph.D.Ph.D.                1985
                                                                                                    1985                   Molec. Biol.
                                                                                                                         Molec. Biol.
 University of Chicago, IL                                                       Post-Doc
                                                                             Post-Doc                  1986-88
                                                                                                    1986-88                Molec. Gen.
                                                                                                                         Molec. Gen.
 Un. of Kentucky, Lexington                                                      B.Sc.
                                                                             Post-Doc                  1979
                                                                                                    1988-91                Biochemistry
                                                                                                                         Biochemistry
RESEARCH AND PROFESSIONAL EXPERIENCE: Concluding with present position, list, in chronological order, previous employment, experience,
and honors. Include present membership on any Federal Government public advisory committee. List, in chronological order, the titles, all authors, and
complete references to all publications during the past three years and to representative earlier publications pertinent to this application. If the list of
publications in the last three years exceeds two pages, select the most pertinent publications. DO NOT EXCEED TWO PAGES.

                                                                   EMPLOYMENT
1980-81              Laboratory Technician, Bacteriology/Hematology Tel Hashomer Hospital, Tel Aviv, Israel
1984-85              Instructor Introductory and Advanced Organic Chemistry, Empire State College, New York
1992-98              Assistant Professor, Biochemistry & Molec. Biology, LSU Medical Center, Shreveport, LA.
1998-                Associate Professor, Biochemistry & Molec. Biology, LSU Medical Center, Shreveport, LA.
                 RESEARCH PROJECTS ONGOING OR COMPLETED DURING THE LAST 3 YEARS
Agency: NSF (MCB-9513756).Total cost $500,000 . “Increase Translation Initiation at non-AUG codons by eIF-4E”.
(Investigates the role of the translation factor eIF4E in selection of the initiator codon on mRNAs, particularly those that
can be translated from alternative CUG codons.). Period: 5/1/96 to 4/30/99. Principal Investigator: Arrigo De Benedetti.

Agency: NIH/NCI (R29-CA69148). Total cost $500,000 . “The Proto-oncogene eIF-4E in Breast Cancer”. (Investigates
the expression and possible role of the translation factor eIF4E in the development breast cancer.). Period: 08/01/96 to
07/31/2001. Principal Investigator: Arrigo De Benedetti.

Agency: Susan G. Komen Foundation (BCTR0100512). Total cost $237,225. A Protein Kinase involved in Breast
Cancer Radioresistance. Period: 10/01/01 to 09/30/03. Principal Investigator: Arrigo De Benedetti.

                                         SELECTED ARTICLES IN REFEREED JOURNALS
     1. De Benedetti, A. and Graff, J. (2004) eIF-4E expression and its role in malignancies and metastases
          Oncogene 23: 3189-3199.
     2. Sunavala-Dossabhoy, G., Fowler, M., and De Benedetti, A. (2004) Translation of the radioresistance
          kinase TLK1B is induced by -irradiation through activation of mTOR and phosphorylation of 4E-BP1.
          BMC Molecular Biology 5: 1-10.
     3. Norton, K.S., McClusky, D., Sen, S., Yu, H., Meschonat, C., De Benedetti, A., Li, B. D. L. (2004) TLK1B Is
        Elevated With eIF4E Overexpression in Breast Cancer. J Surg Res 116: 98-103.
     4. Sunavala-Dossabhoy, G., Li, Y. Williams, B., and De Benedetti, A. (2003) A dominant negative mutant of TLK1
        causes chromosome missegregation and aneuploidy in normal breast epithelial cells. BMC Cell Biol. 4(1): 16-28.
     5. DeFatta, R., and De Benedetti, A. (2003) Translational upregulation of yes accompanies eIF4E-mediated
        oncogenic transformation. Int.J.Oncology 23: 1709-1714.
     6. Mathews-Greer, J., De Benedetti, A.; Tucker, A.; Dempsey, S.; Black, D.; Turbat-Herrera, E. (2002) A Model
        for Angiogenesis in HPV-Mediated Cervical Neoplasia The Journal of Applied Research 2(1):77-86
7. Li BD, Gruner JS, Abreo F, Johnson LW, Yu H, Nawas S, McDonald JC, DeBenedetti A. (2002) Prospective
   study of eukaryotic initiation factor 4E protein elevation and breast cancer outcome. Ann Surg. 235(5):732-738.
8. DeFatta, RJ, Li, Y., and De Benedetti, A. (2002) Selective killing of cancer cells based on translational control of
   a suicide gene. Cancer Gene Therapy 9: 573-578.
9. DeFatta, RJ., Chervenak, RP., and De Benedetti, A. (2002) A cancer gene therapy approach through translational
   control of a suicide gene. Cancer Gene Therapy 9: 505-512
10. Li, Y., DeFatta, R.J, Sunavala, G., Anthony, C., and De Benedetti, A. (2001). A translationally regulated Tousled
    kinase phosphorylates histone H3 and confers radioresistance when overexpressed. Oncogene 20: 726-738.
11. Berkel, HJ., Turbat-Herrera, EA., Shi, R., and De Benedetti, A. (2001) Expression of the translation initiation
    factor eIF4E in the polyp-cancer sequence in the colon. Cancer Epidem. Biomarkers & Prevention 10: 663-666.
12. Anthony, C., Zong, Q., and De Benedetti, A. (2001) Overexpression of eIF4E in S. cerevisiae causes slow growth
    and decreased -factor response through alterations in Cln3 expression. J. Biol. Chem. 276: 39645-39652
13. Zimmer, S.G., De Benedetti, A., Graff, J.R. (2000) Translational control of malignancy: the mRNA cap-binding
    protein, eIF4E, as a central regulator of tumor formation, growth, invasion and metastasis. Anticancer Res. 20:
    1343-1351.
14. Crew JP, Fuggle S, Bicknell R, Cranston DW, De Benedetti A, Harris AL. (2000) Eukaryotic initiation factor-4E
    in superficial and muscle invasive bladder cancer and its correlation with vascular endothelial growth factor
    expression and tumour progression. Br. J. Cancer 82: 161-166.
15. DeFatta, RJ, Nathan, CO, and De Benedetti A. (2000) Antisense RNA to eIF4E suppresses oncogenic properties
    of a HNSCC cell line. The laryngoscope 110: 928-933.
16. De Benedetti, A. and Harris, A.L. (1999) eIF4E expression in tumors: its possible role in progression of
    malignancies. Int.J.Biochem.Mol.Biol. 31: 59-72.
17. Sorells, DL,Gahli, EG., Meschonat, C., DeFatta, RJ., Black, D.,Li, L., De Benedetti, A., Nathan, CA, and Li,
    BDL. (1999) Competitive PCR to detect eIF4E gene amplification in Head and Neck cancers. Head & Neck 21:
    60-65.
18. DeFatta, R.J., Turbat-Herrera, E.A., Li, B.D.L., Anderson, W., and De Benedetti, A. (1999) Elevated Expression
    of eIF4E in Confined Early Breast Cancer Lesions: Possible Role of Hypoxia. Int. J. Cancer. 80: 518-522.
19. Carter, P.S., Jarquin, M., and De Benedetti, A.(1999) Differential expression of Myc1 and Myc2 isoforms in cells
    transformed by eIF4E: evidence for internal ribosome repositioning in the human c-myc 5’UTR. Oncogene 18:
    4326-4335.
20. Franklin S., Pho T., Abreo F., Nassar R., DeBenedetti A., Stucker F., Nathan C.O. (1999) mmunohistochemical
    Detection of the Proto-Oncogene eIF4E in Larynx and Hypopharynx Cancers. Archives of Otolaryngology/Head
    & Neck Surgery 125: 177-182.
21. Sorrells DL Jr. Ghali GE. De Benedetti A. Nathan CA. Li BD. (1999) Progressive amplification and
    overexpression of the eukaryotic initiation factor 4E gene in different zones of head and neck cancers. Journal of
    Oral & Maxillofacial Surgery. 57: 294-299.
22. Nathan, CO., Franklin, S., Abreo, F., Nassar R., De Fatta, R., De Benedetti A., Stucker, FJ, Glass, J. (1999)
    Analysis of Surgical Margins with the Molecular Marker eIF4E: A prognostic factor in patients with Head &
    Neck cancer. J. Clin. Oncology 17: 1-6.
23. Franklin, S., Pho, T., Abreo, F., Nassar, R., De Benedetti, A., Stucker, F., and Nathan, CA. (1999) Detection of
    the proto-oncogene eIF4E in larynx and hypopharynx cancers. Arch. Otolaryng. Head Neck Surg. 125: 117-182.
24. Nathan, CO., Franklin, S., Abreo, F., Nassar R., De Benedetti A., Williams, J. Stucker, F. (1999) Expression of
    eIF4E during Head and Neck tumorigenesis: Possible role in angiogenesis. The laryngoscope 109: 1253-1258.
25. Abid, R., Li, Y., and De Benedetti, A. (1999) Translational regulation of ribonucleotide reductase by eIF4E links
    protein synthesis to the control of DNA replication. J. Biol. Chem. 274: 35991-35998.
26. Li, BDL, McDonald, J., Nassar, R., and De Benedetti A. (1998) Clinical outcome in stage 1 to 3 breast
    carcinomas and eIF4E overexpression. Annals of Surg.Soc. 227: 756-763.
27. Scott, P.A.E., Smith, K., Poulsom, R., De Benedetti, A., Bicknell, R., and Harris, A.L. (1998) Differential
    expression of vascular endothelial growth factor mRNA versus protein isoforms expression in human breast
    cancer and relationship to eIF4E. Brit. J. Cancer 77: 2120-2128.
28. Li, BDL, Liu, L., Dawson, M., and De Benedetti, A. (1997). Overexpression of eukaryotic initiation factor 4E
    (eIF4E) in Breast Carcinoma. Cancer 79: 2385-2389.
29. Graff, J.R., De Benedetti, A., Olson, J.W., Tamez, P., Casero, RA, and Zimmer, S.G. (1997) Translation of ODC
    mRNA and polyamine transport are suppressed in ras-transformed CREF cells by depleting translation initiation
    factor 4E. BBRC 240: 15-20.
30. Nathan, C.A., Carter, P., Liu, L., Li, BDL., Abreo, F., Tudor, A., Zimmer, S. and De Benedetti, A. (1997).
    Elevated Expression of eIF-4E and FGF-2 isoforms During Vascularization of Breast Carcinomas. Oncogene 15:
    1087-1095.
31. Nathan C.A., Liu, L., Li, BDL, Abreo, F., Nandy, I., and De Benedetti, A (1997). Detection of the proto-
    oncogene eIF4E in surgical margins may predict recurrence in head and neck cancer. Oncogene 15: 579-584.
32. Kevil, C., De Benedetti, A., Payne, K.D., Coe, L.L., Laroux, S., and Alexander, S. (1996). Translational
    regulation of Vascular Permeability Factor by eukaryotic initiation factor 4E: Implications for tumor
    angiogenesis. Int. J. Cancer 65: 785-790.
33. Anthony, B., Carter, P., and De Benedetti, A. (1996). Overexpression of the protooncogene/translation factor
    eIF-4E in breast carcinoma cell lines. Int. J. Cancer 65: 858-863.
34. Kevil C., Carter, P., Hu, B., and De Benedetti, A. (1995). Translational enhancement of FGF-2 by eIF-4 factors,
    and alternate utilization of CUG and AUG codons for translation initiation. Oncogene 11: 2339-2348.
35. Bommer, U.A., Lazaris-Karatzas, A., De Benedetti, A., Nurenberg, P., Benndorf, R., Bielka, H., & Sonenberg, N.
    (1995). Translational regulation of the mammalian growth-related protein P23: Involvement of eIF-4E
    phosphorylation. Cell. Mol. Biol. Res. 40: 633-641.
36. Kerekatte, V., Smiley, K., Hu, B., Smith, A., Gelder, F., and De Benedetti, A.(1995). The
    Protooncogene/Translation Factor eIF-4E - A Survey of its Expression in Breast Carcinomas. Int. J. Cancer 64:
    27-31.
37. Graff, J.R., Boghaert, E.R., De Benedetti, A., Tudor, D.M., and Zimmer, S.G. (1995). Reduction of translation
    initiation factor 4E reduces tumor growth, invasion and metastasis of ras-transformed cloned rat embryo
    fibroblast. Int. J. Cancer 60: 255-263.
38. De Benedetti, A., Joshi, B., Graff, J.R., Zimmer, S.G. (1994). CHO cells transformed by the translation factor
    eIF-4E display increased c-myc expression, but require overexpression of Max for tumorigenicity. Mol. Cell. Diff.
    2: 347-371.
39. Barve, S.S., Cohen, D.A., De Benedetti, A., Rhoads, R.E., and Kaplan, A.M. (1994). Induction of IL-2
    transcription in Th2 cells by upregulation of transcription factors with the protein synthesis initiation factor 4E. J.
    Immunology 152:1171-1181.
40. Rinker-Schaeffer, C.W., Graff, J.R., De Benedetti, A., Zimmer, S.G., and Rhoads, R.E. (1993). Decreasing the
    level of translation initiation factor 4E with antisense RNA causes reversal of ras-mediated transformation and
    tumorigenesis of cloned Rat Embryo Fibroblasts. Int. J. Cancer 55:841-847.
41. Joshi-Barve, S., De Benedetti, A., and Rhoads, R.E. (1992). Preferential translation of heat shock mRNAs in
    HeLa cells deficient in protein synthesis initiation factor eIF-4E and eIF-4G. J. Biol. Chem. 267:21038-21043.
42. De Benedetti, A., Joshi-Barve, S., Rinker-Schaeffer, C.W., and Rhoads, R.E. (1991). Expression of antisense
    RNA against initiation factor eIF-4E mRNA in HeLa cells results in lengthened cell division times, diminished
    translation rates, and reduced levels of both eIF-4E and the P220 component of eIF-4F. Mol. Cell. Biol. 11:5435-
    5445.
43. De Benedetti, A. and Rhoads, R.E. (1991) A novel BK virus-based episomal vector for the expression of foreign
    genes in mammalian cells. Nucl. Acid Res. 19:1925-1931.
44. De Benedetti, A. and Rhoads, R.E. (1990) Overexpression of eukaryotic protein synthesis initiation factor 4E in
    HeLa cells results in aberrant growth and morphology. Proc. Natl. Acad. Sci. USA 87:8212-8216.

				
DOCUMENT INFO
Shared By:
Categories:
Tags:
Stats:
views:6
posted:7/27/2012
language:
pages:3