Rheumatoid arthritis MEF by jennyyingdi

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									Rheumatoid arthritis




                 Tena Trbojević
              Mentor: A. Žmegač Horvat
Rheumatoid arthritis
  chronic diesease

  inflammatory disease
 (inflammation of joint
 lining)


  autoimmune disease
 (immune reaction against
 joint tissues - synovial
 membrane)
Rheumatoid arthritis
 causes pain,
 swelling, stiffness,
 loss of function in
 the joints

 generally occurs in
 a symmetrical
 pattern

 may also attack
 tissue in the skin,
 lungs, eyes, and
 blood vessels
Rheumatoid arthritis




 small joints of hands and feet
 affected first, larger joints later
Rheumatoid arthritis
begins
during the
most
productive
years (30 –
60)

occurs much
more
frequently in
women than
in men
(w:m=3:1)
Rheumatoid arthritis

  specific agent or agents are not
  yet known

  infectious agents, such as
  viruses and bacteria, may
  trigger RA in people with an
  inherited tendency to develop
  the disease
Rheumatoid arthritis




 synovitis
 fibrous ankylosis
 bony ankylosis
 osteoporosis
Rheumatoid arthritis
 Rheumatoid arthritis - symptoms:

Around the joints
  warmth
  redness
  swelling
  pain
  limitations in joint
  motion

General
  sickness
  tiredness
  fever
Rheumatoid arthritis
 can be difficult to diagnose in its early stages

 Patient history
 - questions about the intensity of pain symptoms
 - frequency of symptoms
 - what makes the pain better or worse

 RTG, MRI, arthrography, arthroscopy

 Blood test (RF, CRP, SE)
   RF→ Waaler- Rose test
        1:32=normal
        1:64≤ pathological
Rheumatoid arthritis
              Treatments can:

               relieve pain
               reduce swelling
               slow down or help
               prevent joint damage
               increase ability to
               function
               improve sense of well-
               being
Rheumatoid arthritis – treatment
                       options:
 exercise
 medication
 stress reduction

 DMARDs (disease-modifying anti-
 rheumatic drugs): methotrexate,
 leflunomide, sulfasalazine,
 cyclosporine

 corticosteroids : cortisone,
 hydrocortisone, prednisone

 in some cases - surgery (joint
 replacement and tendon reconstruction
 - two types of surgery available to
 patients with severe joint damage )
Rheumatoid arthritis

 research efforts: focused on developing
 drugs that can reduce inflammation and
 slow or stop the disease with few side
 effects; investigators trying to identify
 the infectious agents and understand
 how they work → new therapies

 scientists are also examining why
 rheumatoid arthritis often improves
 during pregnancy
Rheumatoid arthritis

  http://www.medicinenet.com/rheumatoid_arthritis_pictures_slideshow/
  article.htm

  http://video.about.com/arthritis/Chronic-Rheumatism-Hand.htm

  http://nihseniorhealth.gov/videolist.html#rheumatoidarthritis
References:

http://nihseniorhealth.gov/videolist.html#rheumatoidarthritis

http://www.medicinenet.com/rheumatoid_arthritis_pictures_sl
ideshow/article.htm

http://video.about.com/arthritis/Chronic-Rheumatism-
Hand.htm

								
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