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Discovery and Analytical Sciences RTI International conducts a wide range of research in the life sciences, with an emphasis on programs in human health, agriculture, and the environment. We apply interdisciplinary expertise in biological, chemical, environmental, agricultural, social, and forensic sciences to provide solutions to societal needs. Researchers at RTI conduct basic, Pharmaceutics and applied, and translational research to Biotechnology support clients and address priorities Drug discovery and development are of funding agencies in government, core research activities at RTI. Our team academia, industry, and other sectors. of medicinal chemists, pharmacologists, Project teams are led by experienced toxicologists, and other scientists work principal investigators and other senior with pharmaceutical companies and scientists. government agencies to bring new medicines to market. We develop new Expertise processes—based on synthetic biology, • Analytical and bioanalytical for example—to exploit plants and chemistry microorganisms for the production of Pharmaceutical Research • Biorepository operations high-value-added compounds. Programs • Pharmacology We provide targeted consultation to help • Drug discovery and development • Toxicology (preclinical, reproductive, clients understand the market potential • In vitro and in vivo pharmacology and and developmental) of current intellectual property (IP) assay development • Neurotoxicology, developmental assets and analyze existing assets or • Neuropharmacology neurotoxicology technologies for potential investment to • Models for neurodegenerative • Microscopy and microanalysis create additional IP to take the science to diseases the next step. • Organic synthesis, medicinal • Proteomics chemistry, and lead optimization • Genomics and metagenomics Air Quality • Preclinical metabolism, • Populomics We conduct basic and applied research pharmacokinetic, and toxicology • Behavior science in support of air quality measurement research • Neuroimaging and monitoring. We develop and • Analytical, bioanalytical, and • Waste conversion evaluate methods for measuring and pharmaceutical sciences • Microbiology analyzing particulate matter, asbestos, metals, bioaerosols, and organic • Proficiency testing contaminants. Our microbiologists study • Biomarkers and systems biology environmental causes of allergy and Air Quality Research Programs • Bio- and cheminformatics asthma, impacts of new technologies • Air sampling and speciation of • Micro-macro plant interactions on the environment and human health, particulate matter • Plant and microbial biotechnology and bioterrorism-associated biological • Organic and inorganic analyses • Ethnobotany aerosols. • Efficiency testing of filtration media • Computational biology We are the sole contractor selected • Bioaerosol research • Pharmaceutical sciences by the U.S. Environmental Protection • Laboratory proficiency testing • Small molecule design and synthesis Agency to perform chemical speciation • Auditing of air quality monitoring for the nationwide network of PM2.5 sites • Metallomics monitoring sites. Drawing on this • Training, capacity building in air • Environmental sciences and ecology experience, we also advise national and monitoring • Phytoremediation and site local governments seeking to establish • Modeling and source apportionment management air quality monitoring programs and build capacity for environmental data collection and analysis around the world. Human Exposure RTI conducts numerous studies to help Human Exposure Research Programs understand the interaction between human health and exposures to • Testing toxicity of commodity chemicals under TSCA, FIFRA, or natural and man-made environmental OECD contaminants. We develop and apply methods for chemical analysis and • Environmental disease, including allergy and asthma toxicological testing in support of government and private-sector goals to • Measurement and management of ensure the safety of chemicals used in emissions and exposure industrial and consumer products. • Analyses of particulate pollutants, aerosols, biologicals, bioaerosols Personalized Medicine Agriculture • Laboratory proficiency testing At RTI we have integrated programs in We conduct basic and translational • Aerosol challenge testing for genetics, neurobiology, environmental research in the area of agricultural and protective garments science, and human health to define environmental biotechnology. Our • Health effects of exposure to disease states and states of wellness and experts study critical plant-microbe commodity chemicals and susceptibility to disorders and disease. interactions, physiological processes, environmental contaminants The goal of these programs is to devise and metabolomic modeling, and • Facility, systems, and instrument medical, psychosocial, and public health exploit these interactions to address auditing for environmental quality interventions and policies that promote pressing issues in food production, assurance the implementation of personalized and such as efficiency of water and fertilizer • Human neurotoxicity and health preventive medicine. utilization, to improve national and outcomes global food security while helping Personalized Medicine Research promote sustainable agriculture. Programs Agriculture Research Programs We also study the scientific and public • Genomics • Agricultural enhancement policy aspects of environmental • Proteomics • Environmental biotechnology contamination and bioremediation as • Transdisciplinary science and part of integrated land management • Agricultural waste conversion translational prevention strategies. Our work seeks to advance • Ethnobotany • Metabolomics and obesity research the understanding of the benefits and • Food diagnostics • Biomarkers and systems biology potential environmental challenges • Alternative crop use • Human microbiome presented by nanotechnology, biofuels, • Global climate change • Populomics, spatial, and systems and other new technologies. sciences • Risk behaviors and addiction research • Environmental genomics Clients and Funding Agencies • National Institute of Environmental Health Sciences • National Institute on Drug Abuse • Environmental Protection Agency and state agencies • Substance Abuse and Mental Health Services Administration • National Institute of Mental Health • National Institute of Neurological Disorders and Stroke • Department of Defense • Department of Justice • National Cancer Institute • Commercial and international clients Forensics training courses for forensic scientists in the United States and internationally. By Our forensic scientists use rigorous, More information reducing time and cost commitments, transdisciplinary approaches to advance Jennie Hunter-Cevera our courses allow laboratory managers basic and applied knowledge and inform Executive Vice President to more efficiently meet continuing national and international policy, Discovery and Analytical Sciences education requirements. 919.541.6466 practice, and programs. email@example.com We develop and evaluate methods to Forensics Research Programs Elizabeth Hill improve practice in postmortem forensic • Proficiency testing Vice President toxicology, forensic operations and • Reference standards Discovery and Analytical Sciences reporting systems, and data collection 919.541.6747 • Oversight of accreditation and firstname.lastname@example.org and analysis. We also provide reference certification programs materials and conduct performance RTI International • Education and training PO Box 12194, 3040 Cornwallis Road testing to verify the performance of • Microbial forensics Research Triangle Park, NC 27709-2194 USA drug testing laboratories across the RTI 7633-2 0911 United States. • Development of analytical techniques for testing for controlled Under a contract with the Department substances of Justice, RTI develops web-based RTI International is one of the world’s leading research institutes, dedicated to improving the human condition by turning knowledge into practice. Our staff of more than 2,800 provides research and technical services to governments and businesses in more than 40 countries in the areas of health and pharmaceuticals, education and training, surveys and statistics, advanced technology, international development, economic and social policy, energy and the environment, and laboratory testing and chemical analysis. For more information, visit www.rti.org. RTI International is a trade name of Research Triangle Institute.
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