Discovery and Analytical Sciences by jennyyingdi


									                                Discovery and Analytical Sciences

RTI	International	conducts	a	wide	range	of	research	in	the	life	sciences,	with	an	emphasis	
on	programs	in	human	health,	agriculture,	and	the	environment.	We	apply	interdisciplinary	
expertise	in	biological,	chemical,	environmental,	agricultural,	social,	and	forensic	sciences	to	
provide	solutions	to	societal	needs.
Researchers at RTI conduct basic,              Pharmaceutics and
applied, and translational research to         Biotechnology
support clients and address priorities         Drug discovery and development are
of funding agencies in government,             core research activities at RTI. Our team
academia, industry, and other sectors.         of medicinal chemists, pharmacologists,
Project teams are led by experienced           toxicologists, and other scientists work
principal investigators and other senior       with pharmaceutical companies and
scientists.                                    government agencies to bring new
                                               medicines to market. We develop new
  Expertise                                    processes—based on synthetic biology,
  •	 Analytical	and	bioanalytical	             for example—to exploit plants and
     chemistry                                 microorganisms for the production of          Pharmaceutical Research
  •	 Biorepository	operations
                                               high-value-added compounds.                   Programs
  •	 Pharmacology                              We provide targeted consultation to help      •	 Drug	discovery	and	development
  •	 Toxicology	(preclinical,	reproductive,	   clients understand the market potential       •	 In vitro	and	in vivo	pharmacology	and	
     and	developmental)                        of current intellectual property (IP)            assay	development
  •	 Neurotoxicology,	developmental	           assets and analyze existing assets or         •	 Neuropharmacology	
     neurotoxicology                           technologies for potential investment to      •	 Models	for	neurodegenerative	
  •	 Microscopy	and	microanalysis
                                               create additional IP to take the science to      diseases
                                               the next step.                                •	 Organic	synthesis,	medicinal	
  •	 Proteomics
                                                                                                chemistry,	and	lead	optimization	
  •	 Genomics	and	metagenomics
                                               Air Quality                                   •	 Preclinical	metabolism,	
  •	 Populomics                                We conduct basic and applied research            pharmacokinetic,	and	toxicology	
  •	 Behavior	science                          in support of air quality measurement            research
  •	 Neuroimaging                              and monitoring. We develop and                •	 Analytical,	bioanalytical,	and	
  •	 Waste	conversion                          evaluate methods for measuring and               pharmaceutical	sciences	
  •	 Microbiology
                                               analyzing particulate matter, asbestos,
                                               metals, bioaerosols, and organic
  •	 Proficiency	testing
                                               contaminants. Our microbiologists study
  •	 Biomarkers	and	systems	biology            environmental causes of allergy and           Air Quality Research Programs
  •	 Bio-	and	cheminformatics                  asthma, impacts of new technologies           •	 Air	sampling	and	speciation	of	
  •	 Micro-macro	plant	interactions            on the environment and human health,             particulate	matter
  •	 Plant	and	microbial	biotechnology         and bioterrorism-associated biological        •	 Organic	and	inorganic	analyses
  •	 Ethnobotany                               aerosols.                                     •	 Efficiency	testing	of	filtration	media
  •	 Computational	biology                     We are the sole contractor selected           •	 Bioaerosol	research
  •	 Pharmaceutical	sciences                   by the U.S. Environmental Protection          •	 Laboratory	proficiency	testing
  •	 Small	molecule	design	and	synthesis       Agency to perform chemical speciation         •	 Auditing	of	air	quality	monitoring	
                                               for the nationwide network of PM2.5              sites
  •	 Metallomics
                                               monitoring sites. Drawing on this             •	 Training,	capacity	building	in	air	
  •	 Environmental	sciences	and	ecology
                                               experience, we also advise national and          monitoring
  •	 Phytoremediation	and	site	                local governments seeking to establish        •	 Modeling	and	source	apportionment
     management	                               air quality monitoring programs and
                                               build capacity for environmental data
                                               collection and analysis around the world.
                                            Human Exposure
                                            RTI conducts numerous studies to help        Human Exposure Research
                                            understand the interaction between
                                            human health and exposures to                •	 Testing	toxicity	of	commodity	
                                                                                            chemicals	under	TSCA,	FIFRA,	or	
                                            natural and man-made environmental
                                            contaminants. We develop and apply
                                            methods for chemical analysis and            •	 Environmental	disease,	including	
                                                                                            allergy	and	asthma	
                                            toxicological testing in support of
                                            government and private-sector goals to       •	 Measurement	and	management	of	
                                            ensure the safety of chemicals used in          emissions	and	exposure	
                                            industrial and consumer products.            •	 Analyses	of	particulate	pollutants,	
                                                                                            aerosols,	biologicals,	bioaerosols	
Personalized Medicine                       Agriculture
                                                                                         •	 Laboratory	proficiency	testing	
At RTI we have integrated programs in
                                            We conduct basic and translational           •	 Aerosol	challenge	testing	for	
genetics, neurobiology, environmental
                                            research in the area of agricultural and        protective	garments
science, and human health to define
                                            environmental biotechnology. Our             •	 Health	effects	of	exposure	to	
disease states and states of wellness and
                                            experts study critical plant-microbe            commodity	chemicals	and	
susceptibility to disorders and disease.
                                            interactions, physiological processes,          environmental	contaminants
The goal of these programs is to devise
                                            and metabolomic modeling, and                •	 Facility,	systems,	and	instrument	
medical, psychosocial, and public health
                                            exploit these interactions to address           auditing	for	environmental	quality	
interventions and policies that promote
                                            pressing issues in food production,             assurance
the implementation of personalized and
                                            such as efficiency of water and fertilizer   •	 Human	neurotoxicity	and	health	
preventive medicine.
                                            utilization, to improve national and            outcomes
                                            global food security while helping
  Personalized Medicine Research            promote sustainable agriculture.
  Programs                                                                               Agriculture Research Programs
                                            We also study the scientific and public
  •	 Genomics                                                                            •	 Agricultural	enhancement
                                            policy aspects of environmental
  •	 Proteomics                                                                          •	 Environmental	biotechnology
                                            contamination and bioremediation as
  •	 Transdisciplinary	science	and	         part of integrated land management           •	 Agricultural	waste	conversion
     translational	prevention               strategies. Our work seeks to advance        •	 Ethnobotany
  •	 Metabolomics	and	obesity	research      the understanding of the benefits and        •	 Food	diagnostics	
  •	 Biomarkers	and	systems	biology         potential environmental challenges
                                                                                         •	 Alternative	crop	use
  •	 Human	microbiome                       presented by nanotechnology, biofuels,
                                                                                         •	 Global	climate	change
  •	 Populomics,	spatial,	and	systems	      and other new technologies.
  •	 Risk	behaviors	and	addiction	
  •	 Environmental	genomics
                                                                                                      Clients and Funding Agencies
                                                                                                      •	 National	Institute	of	Environmental	
                                                                                                         Health	Sciences
                                                                                                      •	 National	Institute	on	Drug	Abuse
                                                                                                      •	 Environmental	Protection	Agency	
                                                                                                         and	state	agencies
                                                                                                      •	 Substance	Abuse	and	Mental	Health	
                                                                                                         Services	Administration
                                                                                                      •	 National	Institute	of	Mental	Health
                                                                                                      •	 National	Institute	of	Neurological	
                                                                                                         Disorders	and	Stroke
                                                                                                      •	 Department	of	Defense
                                                                                                      •	 Department	of	Justice
                                                                                                      •	 National	Cancer	Institute
                                                                                                      •	 Commercial	and	international	clients
Forensics                                            training courses for forensic scientists in
                                                     the United States and internationally. By
Our forensic scientists use rigorous,                                                               More information
                                                     reducing time and cost commitments,
transdisciplinary approaches to advance                                                             Jennie Hunter-Cevera
                                                     our courses allow laboratory managers
basic and applied knowledge and inform                                                              Executive Vice President
                                                     to more efficiently meet continuing
national and international policy,                                                                  Discovery and Analytical Sciences
                                                     education requirements.                        919.541.6466
practice, and programs.
We develop and evaluate methods to                      Forensics Research Programs                 Elizabeth Hill
improve practice in postmortem forensic                 •	 Proficiency	testing                      Vice President
toxicology, forensic operations and                     •	 Reference	standards	                     Discovery and Analytical Sciences
reporting systems, and data collection                                                              919.541.6747
                                                        •	 Oversight	of	accreditation	and	
and analysis. We also provide reference
                                                           certification	programs
materials and conduct performance                                                                   RTI International
                                                        •	 Education	and	training                   PO Box 12194, 3040 Cornwallis Road
testing to verify the performance of
                                                        •	 Microbial	forensics                      Research Triangle Park, NC 27709-2194 USA
drug testing laboratories across the
                                                                                                                                        RTI 7633-2 0911
United States.                                          •	 Development	of	analytical	
                                                           techniques	for	testing	for	controlled	
Under a contract with the Department                       substances
of Justice, RTI develops web-based

                        RTI International is one of the world’s leading research institutes, dedicated to improving the human condition
                        by turning knowledge into practice. Our staff of more than 2,800 provides research and technical services to
                        governments and businesses in more than 40 countries in the areas of health and pharmaceuticals, education and
                        training, surveys and statistics, advanced technology, international development, economic and social policy, energy
                        and the environment, and laboratory testing and chemical analysis. For more information, visit
                        RTI International is a trade name of Research Triangle Institute.

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