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Aspirin Preparation by ewghwehws

VIEWS: 24 PAGES: 29

									  Can you draw

2-hydroxybenzoic acid?
Set up the apparatus needed
          for reflux
Today

               Aspirin – coursework briefing




        Homework
Background reading and questions
              1-5
                                     Challenge Question
                                   Predict and draw the nmr, ir and mass
                                         spec for aspirin, and oil of
                                                wintergreen
              Aims

    To recap how to set up reflux
    apparatus and understand the
coursework requirements and practice
         % yield calculations
What are the similarities between
    these two compounds?




Oil of wintergreen    aspirin
• Nearly everyone has used aspirin at
  sometime in our lives, but few know that a
  related compound derived from willow
  bark has been used to relieve pain and
  treat fevers for over 2,000 years.
                 Aspirin
• Aspirin is described as having analgesic
  (pain killing), anti-inflammatory and
  antipyretic (fever reducing) actions.

• Oil of wintergreen has the same properties
  and is applied as an ointment for relief of
  pain in lumbago, sciatica and rheumatism,
  as the oil is readily absorbed through the
  skin
2-hydroxybenzoic acid (salicylic acid) can be converted into
                         aspirin




                                    O       O                    O                   O

                OH    + CH3         C   O   C   CH3          O   C   CH3   +   CH3   C   O   H


            COOH                                        COOH

2-hydr oxybenzenecar boxylic acid                     aspir in




                  How will we do this?
Stage 1
               Let’s see this in action




You will need to click on the video link on the wiki to see this in action
  Draw and fully label the
apparatus needed for reflux

 What is the purpose of each part?
How can we calculate the yield of 2-hydroxybenzoic acid?
How will you get full marks for the table?
              How can we calculate the yield of aspirin?


What is the theoretical yield if I start with 2g of 2-hydroxybenzoic acid?
How will you get full marks for the table?
Practice yield


  How can you
  practice your
  calculations?
        Obtaining the aspirin
• Ordinary filtration can be very slow.

• Suction (or vacuum) filtration uses a side
  arm conical flask called a Buchner flask
  and a porcelain, flat bottomed perforated
  funnel.



                             Dries solid too
   Checking the purity

Remember – melting points occur over
 a range, the narrower the range the
        purer the compound
Timetable
      Lesson 1




At this point stopper your flask, make sure it is labelled
and leave in a safe place until next lesson
      Lesson 2




Make sure it is labelled and leave in a safe place until
next lesson
  Lesson 3




Then ……
Lesson 4
             You will also need to




And complete the revision task booklet provided ready for week beginning 13th
December


Assessment written paper Tuesday 14th December
Name it
     Can you…

 Explain the purpose of the
        coursework?
  Set up reflux apparatus?
Carry out yield calculations?
              Challenge Question
            Predict and draw the nmr, ir and mass
                  spec for aspirin, and oil of
                         wintergreen




        Homework
Background reading and questions
              1-5

								
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