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									                                                   Dr François Caya
                        OIE Regional Representation for the Americas

The OIE Reference Laboratories and Collaborating Centres and the
                                             concept of twinning

                                           Mazatlán, México, 11-12 February 2008
OIE Reference Laboratories
& Collaborating Centres
 Reference laboratories:

   designated to pursue all the scientific and technical items
   relating to a named disease on the OIE lists

 Collaborating centres:

   designated to pursue expertise in a specific sphere of
   competence relating to the management of general
   questions on animal health issues (e.g. epidemiology, risk
   analysis, etc.)

Reference Laboratories
 171 Reference Laboratories in 30 Countries covering
          68 terrestrial and 25 aquatic diseases:

    Function as expert centre for that specific disease
    Store and distribute reference reagents
    Conduct and validate diagnostic tests
    Gather, analyse and disseminate
     epizootiological data
    Provide training
    Place expert consultants
     at the disposal of the OIE

OIE Reference Laboratories 2007

Collaborating Centres
        24 Collaboration Centres in 14 Countries:
   Operate as a centre of research, expertise, standardisation and
    dissemination of technique
   Propose /develop procedures which will facilitate harmonisation
   Provide training to personnel from OIE Members
   Place expert consultants at the disposal of the OIE

    Animal welfare                                          Emerging
                                  Various                    diseases
                                  for CCs
 Surveillance                                             Training of
                         etc….          ELISA                           5
OIE Collaborating Centres 2007

Summary table of OIE Reference Laboratories
and Collaborating Centres 2007

             Reference       Collaborating
             Laboratories    Centres

Number            171               24

Countries          30               14
Diseases /         93               22
Experts           146               24
OIE Reference Laboratories in Americas
Fish Diseases - Americas

 Fish Disease               Country   Expert/Laboratory

 Infectious                   USA     Dr J. Winton
 haematopoietic necrosis              Western Fisheries Research Center,

 Infectious salmon           Canada   Dr Frederick Kibenge
 anaemia                              Atlantic Veterinary College, PEI

 Bacterial kidney disease     USA     Dr J. Winton
 (Renibacterium                       Western Fisheries Research Center,
 salmoninarum)                        Washington

 Channel catfish virus        USA     Dr L.A. Hanson
 disease and                          Fish Diagnostic Laboratory,
 Enteric septicaemia of               Mississippi
 catfish (E. ictaluri)
OIE Reference Laboratories in Americas
Mollusk Diseases - Americas

 Mollusk Disease             Country   Expert/Laboratory

 Infection with:               USA     Dr E.M. Burreson
 Perkinsus olseni;                     Virginia Institute of Marine Science,
 Perkinsus marinus                     Virginia

 Infection with                USA     Prof. Carolyn Friedman
 Xenohaliotis                          Friedman Shellfish Health Laboratory,
 californiensis                        Washington

 Infection with:               USA     Dr E.M. Burreson
 Haplosporidium costale                Virginia Institute of Marine Science,
 Haplosporidium nelsoni                Virginia

 Infection with Mikrocytos    Canada   Dr S. Bower
 mackini                               Pacific Biological Station,
                                       British Columbia                        9
OIE Reference Laboratories in Americas
Crustacean Diseases - Americas

 Crustacean                  Country   Expert/Laboratory
 Crustacean pathogens:         USA     Prof. D. Lightner
 •Infectious hypodermal                Department of Veterinary Science,
 and haematopoietic                    Arizona
 •Infectious myonecrosis;
 •Spherical baculovirosis;
 •Taura syndrome; and
 •White spot disease

Application procedures for
Reference Laboratories and Collaborating Centers

           OIE Delegates

                                 For Collaborating
          Director General
                                 Centers, relevant
      Specialists Commissions    Commission may
                                 also be involved.
     Administrative Commission

      International Committee
                                 Valid for 4 years
             approval                                11
Rights and obligations of
Reference laboratories and Collaborating Centres

                        Internal rules

  Article 5 allows:
     use of the title “OIE Reference Laboratory”
     put OIE emblem on documents
  Article 7 requires:
     submission of a brief annual report on
    the activities
The concept of Twinning

• Creating a link that facilitates the exchange of knowledge and
  experience between two laboratories

• Medium to long-term arrangement to establish diagnostic
  capacity for specific disease

• Not short-term training, must be sustainable

• Funding targeted in support of project proposal with identified

• Potential candidates for OIE Reference Laboratory

• No change in obligations of OIE RL’s and CC’s – TOR, funding,
  regional obligations – as agreed by CVO of country

    Rationale for twinning

•      Uneven geographical spread – mostly northern

•      More than 70% of the 172 OIE Members are
       developing/transitional countries

•      Need for better access to scientific expertise for
       negotiations, certifications, justification of
       standard setting

•      To increase global laboratory/diagnostic capacity
       and expertise                                        14
Twinning among OIE Reference Laboratories

     Countries with six or more OIE Reference Laboratories

                                     Number of Reference
                Country                 Laboratories
               Australia                     8
                Canada                       15
                 France                      16
               Germany                       12
                  Italy                      9
                 Japan                       13
             South Africa                    6
           United Kingdom                    30
           United States of                  25
               America                                       15
Resolution No.XXI in 2002:
The Role of OIE RLs and CCs in Capacity Building for Developing

  RLs and CCs shall be encouraged to:
   enter into partnerships with developing countries
   share scientific knowledge / provide training to
   laboratories in developing countries
   provide expertise in producing vaccines especially
   those not requiring a cold chain.
   provide technical assistance to develop surveillance
   programmes for disease control

                        2002           2006

                        Little progress                           16
       Acceleration of “twinning concept”

 1st International Conference of OIE Reference
  Laboratories: December 2006, in Brazil
       Members agreed the networking and the twinning
        incentive for laboratories would lead to a more even
        geographical distribution of veterinary scientific

 75th General Session in May 2007
       New Resolution: “The Role of RLs and CCs in Providing
        Permanent Support for the Objectives and Mandates of
        the OIE” was adopted

                                       OIE should continue to
                                         develop its twinning
                                             initiatives..      17
 Role players

   – Support in coordinating project
   – Funding – World Animal Welfare Fund and
     donor countries
   – Facilitate negotiations
   – Finalise contract and budget
• OIE Reference Laboratory (Parent lab)
   – Driving force
   – Expert from PL is driver/project leader
   – Management of budget
• Candidate laboratory
   – Fully committed
   – Agree to go all the way with partnership
   – Not a disguise for obtaining funding

Twinning process

                     OIE REF.          APPLICANT
                       LAB                LAB

   ID possible            DISEASE/TOPIC
   Reg. office            HEADS OF BOTH LABS
                          OFFICIAL DELEGATES
                                               •Regional needs
                                               •Managing expert
                                PROJECT        •Budget
                                PROPOSAL       •Work plan

            BIOLOGICAL             OIE         DONOUR FUNDING
            STANDARDS               DG         EVALUATION BUDGET
            COMMISSION          S & T DEPT
Principles for selecting Parent and Candidate Laboratories

 • Must be supported by Veterinary Service
 • Must be related to national/regional need
 • Parent laboratory must have required level of
 • Candidate laboratory should have potential to make
   significant improvements
 • Location must not affect mutual cooperation
 • Goals must be realistic
 • Sustainability – human and financial resources –
   commitment of Government via CVO – can not be
   indefinitely donor dependant.

Project proposal

• Proposal to OIE signed by both CVO’s and Directors

• Details of team leader and participating experts

• CV’s of experts of Parent and Candidate Laboratories

• Project plan and timetable (3 year project)

• Budget proposal

Budget allocation

• Exclude equipment

• Travel costs and per diem

• Laboratory reagents linked to twinning project

• Shipping of diagnostic specimens

• Training activities and workshops related to
  twinning project

 Project risks

• Before starting and during project:

   – Identify project risks

   – Consider impact on project should they occur

   – Consider likelihood of occurrence

   – Consider mitigation actions

   – Documented contingency plan

(Disease outbreaks, change in management, CVO change, budget cuts)
Monitoring performance

• Stages/phases approach –
  reporting during intervals of

• Interim report – every 4 months

• Annual reports

• Final report

• Post-project review

 Twinning Guide and Project Template/Contract
 • Background
 • How to apply/proposal
 • Basic project
 • Project plan (objectives,
 • Regular monitoring
 • Facilitates efficient
 • Formalizes agreement                        25
OIE potential twinning projects

• Several proposals already
• Eleven proposals formally
• Candidate laboratories
  mostly from Middle and
  South Asia, Russia, Africa
• Most favored diseases. AI,
  NCD, FMD, Brucellosis
• Needs: RVF, Aquatic, AI
  (Africa, South America)

The way forward

• Expansion of initiative

• Funding

• Coordination with other
  initiatives for laboratory
  improvement and capacity
     World Organisation for
         Animal Health

• Acknowledgement:
 – Dr. Keith Hamilton
 – Dr. Tomoko Ishibashi
 – Sara Linnane

• Many thanks !


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