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					                                                                         Chemformation
                                                                                      The Newsletter of the MIT Department of Chemistry
                                                                                        Volume 28, Number 6, Thursday, June 16, 2011




DINCĂ RECEIVES DOE EARLY CAREER RESEARCH PROGRAM AWARD


                                   P
                                          rofessor Mircea Dincă has been selected by the Department of Energy Office of
                                          Science to receive a FY2011 Early Career Research Program Award. His proposal en-
                                          titled “ Electronic and Ionic Conductors from Ordered Microporous Materials” was se-
                                   lected by the Office of Basic Energy Sciences.

                  The Dincă Lab is focused on addressing research challenges related to the storage and con-
                  sumption of energy and global environmental concerns. Central to its efforts is the synthesis
                  of novel organic-inorganic hybrid materials and the manipulation of their electrochemical and
photophysical properties, with a current emphasis on microporous materials.


TWO CHAIRS FOR CHEMISTRY PROFESSORS


                                   P
                                          rofessors Alice Y. Ting and                                                                                  Professor Nolan has been a fac-
                                          Elizabeth M. Nolan have                                                                                      ulty member since July 2009.
                                          been appointed respective-                                                                                   Her current research interests
                                   ly to the Ellen Swallow Richards                                                                                    include synergies between metal ion
                                   Chair and the Pfizer Laubach Ca-                                                                                    homeostasis, innate immunity and
                                   reer Development Chair.                                                                                             the host/pathogen interaction, and
                                                                                                                                                       elucidating the roles of metallopro-
                   Professor Ting has been a faculty                                                                                                   teins in other biological phenomena.
Alice Y.Ting       member in the MIT Chemistry                                                               Elizabeth M. Nolan
                   Department since 2002. Her work
has been on the development of probes and reporters
for live cell imaging. To simultaneously harness the                                                           A Peek Inside!
power of genetics and the power of chemistry, Alice’s
                                                                                                               Hooding/Commencement.......................................................... 2
lab has frequently exploited enzymes that act on both                                                          What Lies Ahead for Seniors ..................................................... 4
protein and small-molecule substrates. Her lab has                                                             Brett Fors (the guy with the namesake ligand) ....................... 8
developed new technologies for imaging protein traf-                                                           Goreham and Rachupka Wed ..................................................................... 8
ficking, protein-protein interactions, and enzymatic                                                           Recent Publications ...................................................................................... 9
                                                                                                               ChemRefs Poster Competition ................................................................... 10
activity. Current research interests include imaging
                                                                                                               NRC Awards ................................................................................................. 11
studies of synapse formation/development, and in vi-                                                           Searle Scholars Program ........................................................................... 11
tro evolution of novel enzyme function.




Chemformation is published by Chemistry Headquarters. The next issue will be produced in September 2011. Please convey items of interest (or mailing list changes) to Liz McGrath, Communications and Development
Coordinator, Dept. of Chemistry, MIT, 18-393, Cambridge, MA 02139, 617/253-4080; 617/258-7500 (fax); e-mail: emg@ mit.edu. Current and back issues can be accessed on the Chemistry Dept. Web site http://web.mit.edu/
chemistry/

Chemformation, Vol 28, no.6                                                                                                                                                                            Page 1
L-R: Lisa Marshall, Scott Geyer, Insin Numpon (foreground), Brian Walker, Moungi Bawendi, Lesley-Ann Giddings, Timothy Swager, Stephen
Lippard, Christine Tinberg, Woon Ju Song, Do Loi, Jared Silvia, Christopher Cummins, Christopher Clough and Glen Alliger, Yogesh Surendranath,
Sylvia Ceyer, Brett Vanveller, Timothy Swager, Zhe Lu, Gregory Fu, Pamela Lundin, Catherine Drennan, Johnathan Cheng, Mohammad Movassaghi,
Omar Ahmed, Smaranda Marinescu, Brian Hanna, Richard Schrock, Meredith Hartley, Wendy Iskenderian-Epps, Barbara Imperiali, Angelyn Larkin,
Brenda Goguen, Emily McLaurin, Sylvia Ceyer, Brian Underwood, Omar Ahmed, Brett Fors, Stephen Buchwald, Yu-Tzu Li, Troy Van Voorhis, Lee-
Ping Wang, Rebecca Nicodemus, Anne Hudson Click here to view slideshow




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                                                                                                                                     Photography / Liz McGrath




Chemformation, Vol 28, no.6                                                                                               Page 2
CONGRATULATIONS GRADUATES!


  First Name                  Last Name            Advisor       Degree List   Degree

  Omar                        Ahmad                Movassaghi      11-Feb      PhD
  Glen                        Alliger              Nocera          10-Sep      PhD
  Trisha                      Andrew               Swager          11-Feb      PhD
  Alexander                   Barnes               Griffin         11-Jun      PhD
  Tsz Yan Clement             Chan                 Dedon           11-Jun      PhD
  Johnathan                   Cheng                O’Connor        11-Jun      PhD
  Christopher                 Clough               Cummins         11-Jun      PhD
  Eric                        Dane                 Swager          10-Sep      PhD
  Loi                         Do                   Lippard         11-Jun      PhD
  Jonathan                    Fischer              Ceyer           10-Sep      PhD
  Brett                       Fors                 Buchwald        11-Jun      PhD
  Jennifer                    Fortune Schefiliti   Klibanov        10-Sep      PhD
  Scott                       Geyer                Bawendi         10-Sep      PhD
  Lesley-Ann                  Giddings             O’Connor        11-Jun      PhD
  Brenda                      Goguen               Imperiali       11-Jun      PhD
  Brian                       Hanna                Schrock         11-Jun      PhD
  Meredith                    Hartley              Imperiali       11-Jun      PhD
  Bryan                       Hsu                  Hammond         11-Feb      SM
  Numpon                      Insin                Bawendi         11-Feb      PhD
  Wendy                       Iskenderian          Imperiali       11-Feb      PhD
  Yan                         Kung                 Drennan         11-Jun      PhD
  Angelyn                     Larkin               Imperiali       11-Feb      PhD
  Yu-Tzu                      Li                   Marzari         11-Jun      PhD
  Zhe                         Lu                   Fu              10-Sep      PhD
  Pamela                      Lundin               Fu              10-Sep      PhD
  Smaranda                    Marinescu            Schrock         11-Jun      PhD
  Lisa                        Marshall             Bawendi         11-Feb      PhD
  Emily                       McLaurin             Nocera          11-Feb      PhD
  Christopher                 Morten               Jamison         11-Jun      PhD
  Rebecca                     Nicodemus            Tokmakoff       11-Feb      PhD
  Julia                       Robinson - Surry     Danheiser       11-Jun      PhD
  Weerawat                    Runguphan            O’Connor        11-Jun      PhD
  Kristin                     Schleicher           Jamison         10-Sep      PhD
  Taeho                       Shin                 Nelson          10-Sep      PhD
  Jared                       Silvia               Cummins         11-Jun      PhD
  Sarah                       Slavoff              Ting            10-Sep      PhD
  Woon Ju                     Song                 Lippard         11-Jun      PhD
  Yogesh                      Surendranath         Nocera          11-Jun      PhD
  Christine                   Tinberg              Lippard         10-Sep      PhD
  Daniel                      Turner               Nelson          10-Sep      PhD
  Brian                       Underwood            Jamison         11-Feb      PhD
  Brett                       Vanveller            Swager          11-Jun      PhD
  Brian                       Walker               Bawendi         11-Jun      PhD
  Lee-Ping                    Wang                 Van Voorhis     11-Jun      PhD
  Cliff                       Wong                 Bawendi         11-Feb      PhD
  Nancy                       Yerkes               O’Connor        10-Sep      PhD



Chemformation, Vol 28, no.6                                                     Page 3
WHAT LIES AHEAD FOR OUR SENIORS


                                                                  L-R: Seniors: Back row (L-R): Ben Fosque,
                                                                  Andrew Mussachio, Victoria Wang, Jon Gunn,
                                                                  Jason Ashe, Katie Pullom

                                                                  Front row (L-R): Patricia Hagen,
                                                                  Jose Villa-Uribe, Mia Shandell, Julie Reardon

                                                                  Missing from photo: Chase Anderson,
                                                                  Bina Choi, Yieu Chyan, Caroline Hagerman,
                                                                  Marie Herring, Brian Lee, Peter Tieu, Alex Vai,
                                                                  Philip Vogel, Clifton Wagner



Chase Anderson

Chase Anderson is a founding brother of the Sigma Alpha Epsilon fraternity, author of one of the most thrilling
fantasy books that will be hitting the presses soon, is also the best catalyst for oxytocin that Course 5 has ever
seen. When he isn’t making chemistry (in the lab) or playing with balls on the varsity soccer team he is dancing
the night away with his posse in DanceTroupe. When not holding several positions in his fraternity or running
around being a social butterfly, he was continuing work on the nine volume series that is one of the highlights of
his life at MIT (besides deciding to become Course 5, naturally!) or writing the script for TechTheater or simply
walking around Boston with friends. His decision to become part of the 5 family came after falling in love with
5.12 and realizing that leaving the major was never an option. Even though 5.62 and a slew of other classes that
took sweat, tears, and even one occasion a little bit of blood, he has loved every moment of it. Chase would also
like to thank Dr. Mariusz Twardowski, Ms. Melinda Cerny, Professor Jamison, and all the TA’s and professors
who have helped him discover not only the joys of chemistry, but also of life at MIT. Next year, Chase will be
pursing a Master’s in Biological Engineering, working with Wogan Laboratories (where he has been since after
freshman year) on cancer research. He looks forward to the opportunity and is excited for the new opportunities
that will arise in the coming year.

Jason J. Ashe

Jason Ashe is from Strong Island, New York, where children are harvested to attend Ivy League schools to study
more liberal arts majors. Although he almost fell into that same trap, he made the decision to study Physics and
Pre-med at MIT. Well, obviously, we’re here at the Course-5 Senior Banquet so the Physics thing didn’t work
out all that well. After going through course 12, 4, and 8, Jason finally declared course 5, while still trying to be
‘premed.’ While at MIT, he’s kept himself busy while essentially double-majoring in Chemistry and the MIT
Logarhythms, the all-male a cappella group on campus that meets at least 8 hours per week. As both President
and Tour Manager for 3 semesters, Jason hasn’t been able to do much outside of the Logs. He managed to join
Phi Kappa Theta Fraternity his sophomore year. Other than that, Jason’s enjoyed his time at MIT with the Logs,
his close group of friends on campus and within his brotherhood. Next year, Jason will be attending Duke Divin-
ity School to pursue a Master’s of Divinity (~0.001% of MIT graduates go to Divinity School every year). What
happened to Pre-med? Well, Jason’s going to take the dreaded Mentally Crucifying Assassination Test this sum-
mer and then after Duke, he’ll venture off into the medical field to hopefully become an Ob/Gyn. A minister who
will eventually specialize in the female reproductive system? Yeah, he’s weird, don’t ask.
                                                                                                      Continued on Page 3
Chemformation, Vol 28, no.6                                                                          Page 4
Bina Y. Choi

Bina Choi is a chemistry major from Houston, TX, where the humidity reaches 99%, the rush-hour traf-
fic never ends, and barbeque is done right. She came to MIT thinking about majoring in courses 5 and
9, dropped the 9 after a brain neurology course her first IAP, and then spent a frazzled period in her
sophomore year seriously considering switching into 2, 3, 4, back to 9, or 20. But molecular studies and
chemical reactions eventually won her back over, and she hasn’t looked back since. Outside of academics,
Bina has spent much of her MIT career getting to know her sisters in Sigma Kappa, managing and editing
Komaza magazine, and playing cello as an Emerson Fellow. She also enjoys photography, traveling (she
went to Tanzania and Italy through D-Lab and MISTI), and delicious coffee (shoutout to the lovely ladies
at Peet’s). She is planning on working after graduation for a year, before attending medical school.

Jonathon T. Gunn

Jon Gunn is a double chemistry and biology major from St. Louis, MO. He began as a chemistry major
before deciding to switch to biology, but couldn’t break it to Melinda he was leaving so he chose just to
double major instead. Since becoming a major, Jon has been a tutor for almost every class possible, and
was a TA for 5.111. He also worked in the Buchwald group for a year and a half, during the last half of
which he was known as the “mysterious elusive undergrad” because of his insanely busy schedule. Out-
side of lab, Jon played on his dorm’s IM tennis team, and worked backstage on numerous theater produc-
tions for Next Act, Dramashop, and the Boston Conservatory. Next year, he will be heading to an as-of-
yet-undetermined medical school to pursue a career in an as-of-yet-undetermined specialty. Jon would like
to wish his entire class the best of luck, and thank the Chemistry Department faculty and staff (especially
Melinda and Mary) for their wisdom and support. And for the letters of recommendation.

Patricia Anne Hagen

Patricia is a chemistry major from southern California. She has enjoyed learning about all things chemis-
try while here at MIT. She spent her junior year at the University of Cambridge with her good friend Car-
rie, where they spent a good deal of time comparing the teaching styles in America and Britain. She still
misses the delicious sandwiches and yoghurts, but plans to visit Carrie in England to relive their tastiness.
Besides studying chemistry, Patricia played intramural flag football, and was the president of the Baptist
Student Fellowship. After she graduates, she will pursue her M.Ed with Boston Teacher Residency so that
she can show high school students how cool chemistry is!

Caroline E. Hagerman

Carrie is from Milwaukee, WI, where she grew up with her wonderful parents, lovely younger sister Nora,
and an array of poodles. She has spent her time at MIT UROPing in the Essigmann lab at MIT and the
Schreiber lab at the Broad Institute, attempting to get pre-meds excited about organic chemistry while
tutoring 5.12 and 5.13, serving on the exec committee of the MIT Undergraduate Biochemistry Associa-
tion, and playing a multitude of intramural and club sports terribly. During her third year, she studied at
Cambridge University, where she learned the bizarre ways that Brits pronounce molecule names, wan-
dered around Europe, and added netball to the list of sports she plays terribly. She is looking forward to
returning to Cambridge in the fall to start a PhD in medicinal chemistry in Dr. David Spring’s lab. Carrie
would like to thank her family and friends for everything they have done for her as well as everyone who
mentored and advised her over the years.




Chemformation, Vol 28, no.6                                                                          Page 5
Marie K. Herring

Marie has been a Course 5 major since 8th grade, though the distance from Idaho Falls, ID to 11-120 prevented
her from declaring her major for 5 years. Once here, she jumped right in, getting involved with ClubChem and
their magic shows her freshman year and overloading on classes her sophomore year. Summers spent working
in the Hammond Lab, Bayer (MISTI-Germany), and the Ceyer Lab cemented her interest in research, though
the exact sub-field remained a mystery. Her other passion, dance, kept her free time pretty well occupied, as did
being an Associate Advisor, O-Leader, REX chair, DanceTroupe officer, SWE Board member, HSSP instructor,
PSC volunteer 5.111/5.12 Tutor, and ClubChem officer. She will be working for a start-up, Soane Energy, in the
fall, after a (probably uncomfortably hot) summer teaching for a high school science camp at KAUST in Saudi
Arabia. She would like to thank the chemistry department for all of the guidance it has offered, particularly from
Professor Ceyer, Professor Bawendi, and Melinda Cerny. Thanks also to her fellow students and lab partners. It’s
been an awesome 4 years.

Brian K. Lee

Brian is Course 5 with a minor in 21M from New Jersey. He came into MIT bright and starry-eyed, and leaves..
well, still bright and starry-eyed. Mostly. He used to think that a certain other university down the street was over-
rated, but now that he’s going there next year for graduate school, it gets some grudging respect. In his spare time,
he plays Go, the best board game that nobody has heard of. He also sings with the MIT Concert Choir, and plays
piano. He tutored 5.13, and loves teaching for ESP. Brian would like to thank Professors Buchwald and Swager
for his UROP experiences, and Professor Jamison for helping him make some important decisions. He wishes the
best to the many other MIT students he’s met.

Andrew J. Musacchio

Andrew Musacchio is a double major in Course 5 and 7A from Acton, MA. Once at MIT he realized chemistry
was just as fun as he had hoped, and declared as a chem major as early as was possible. He decided that just doing
classwork wasn’t quite exciting enough so he started UROPing in the Buchwald lab the summer after his sopho-
more year and has remained working in that lab ever since. While not in the lab or at class Andrew kept busy by
hurdling for the MIT Indoor and Outdoor Track teams and spending time with his fraternity Chi Phi. Next year
he is looking forward to moving to pursuing his Ph.D at Princeton even though it means he will have to move to
New Jersey.

Juliann L. Reardon

Julie is a double major in 5 and Women’s and Gender Studies (yes, that major does exist…) from Uxbridge, MA.
Originally, Julie was course 7, but she found that even through her cursed 5.12 exams with pages sticking together
that she really did love chemistry and changed her major. And while she hasn’t had any formal chemistry UROPs
(except for interning a summer at AstraZeneca), she makes up for it by tutoring 5.12 and 5.13 and also living in TA
and professor office hours. Aside from the academics, Julie has kept busy as an Addir Fellow, Burchard Scholar,
researching at Mass Eye and Ear, and by serving as choir director and piano accompanist for the Tech Catholic
Community. Julie’s looking forward to moving on to medical school at Brown University in the fall and is greatly
appreciative of the fact that she doesn’t have to go to medical school in the evil empire (NY) and can remain a
loyal Sox, Celts, Bruins, and Pats fan worry-free. Julie wishes her chemistry class the very best, and would like
to thank the Chemistry department faculty and staff for their support and encouragement over the past four years.

Mia A. Shandell

Mia is an actress/singer/dancer/chemistry major from Boca Raton, Florida. On a freshman-year whim, more or
less, she declared Course 10B as a major and after 2.5 years of disinterest in her classes remembered her initial

Chemformation, Vol 28, no.6                                                                           Page 6
love of 5.12 and switched to Course 5 even though it would take an extra year to finish the degree. She is thankful
she did because getting a degree in a subject she likes has been well worth the time. She UROP’d her freshman
year at the Media Lab and then in Michael Strano’s research group in the ChemE department where she still works
on all things carbon nanotubes. When not in lab or class, she was on stage - first in Musical Theater Guild produc-
tions then Dramashop. However, her major theatrical accomplishment has been co-founding and performing in
the alternative theater group, Present Simple, which has performed five plays, including original and translated
works, in the last 2.5 years at MIT and in Budapest, Hungary. Her near-future plans are to move to NYC for gradu-
ate school in Pharmacology at Columbia University and simultaneously become a Broadway star. Wish her luck
in both.

Peter P. Tieu

Peter Tieu came to MIT from Long Beach, CA, trading the warmth and sun for wind and snow. He decided to
major in chemistry because he knew that engineering is not his forte. Having played badminton in high school,
he continued to do so here with MIT’s badminton club, eventually becoming the president of the club for a year.
After Melinda explained the course 5 structure, a general timeline for classes formed. He realized that a Spanish
language concentration would conflict with lab classes so the result with a semester of only Hass classes after lab
classes were done. Thanks to Dale Robinson, class of 2010, Peter was able to avoid purchasing tomes for many
classes. Finally, senior year has allowed the time to resume cooking which had to be halted after freshman year
due to time constraints. After senior year is still a large question mark but graduate school is most certainly not
in the near future.

Alex T. Vai

Alex T. Vai grew up in the Eastern Massachusetts towns of Framingham and Sudbury. His decision to study at
MIT only cemented his status as a crusty, life-long Bay Stater. During his freshman year, he worked with Profes-
sor Don Sadoway in Course III studying the formation of oxygen by direct electrolysis of molten lunar regolith.
It was during this work that Alex first developed his relationship with molybdenum - affectionately known as
“Moly” - that has followed him through his undergrad years. He joined the Cummins Group partially to escape
from the many hours spent using a razor blade to scrape the oxidized remains of Moly electrodes from the inside
of furnace tubes. Only later did he discover that Moly was also a centerpiece of the transition metal chemistry
studied by his new group. Nevertheless, he stayed on and has learned a great deal exploring the organometallic
chemistry of nitrile oxides. The summer before his senior year, Alex also had a close encounter with Moly in her
radioactive forms, doing radiochemistry research at the University of Nevada, Las Vegas. Besides playing with
Moly, Alex also spends quite a bit of time playing his violin, Sally, both independently and as a member of the
MIT Symphony Orchestra. Alex has also served as an officer of the MIT Archery Club and MIT MedLinks. Next
fall, Alex plans to matriculate at the University of Oxford (his only grad school option with worse weather than
MIT) and study for a DPhil in Inorganic Chemistry. There has been no mention of any molybdenum chemistry.
Yet.
Jose L. Villa-Uribe

Jose hails from the wonderful city of Santa Marta, on the Caribbean coast of Colombia. He moved north to
Houston, Texas in 2002, and because that did not have the snow he was promised, moved even further north to
Cambridge in 2007. At MIT he has spent his time being a Resident Associate Advisor to the confused freshmen
of Next House, seeing (and treating) cool injuries as an EMT with the campus ambulance, pushing tiny volumes
of liquid inside microchannels over at HST, and most recently, approving your degrees as a student representative
to the CAP. After almost not being Course 5 twice, Jose saw the light and decided to join the cool kids; now he’ll
be leaving MIT with degrees in Chemistry and Biology before once again moving to a new city to begin medical
school.



Chemformation, Vol 28, no.6                                                                        Page 7
Victoria Wang

Victoria is a black belt in Tae Kwon Do and cat-lover from central Illinois who came to MIT enamored with
chemistry. She discovered that, yes, chemistry could in fact explain life from the electron transport chain to semi-
conductors. In four semesters of undergraduate lab, Victoria has learned about the rigors of laboratory technique
but also the fun times to be had on the fourth floor of building four and remembers, fondly, when her lab partner
accidentally ripped the drying oven out of the wall. Outside of chemistry, her UROP focused on mental disorders
and behavioral studies at the McGovern Institute. She also traded in martial arts for rowing on the Charles River
and savors the hours she has spent exploring the world of rowing. At the end of it all, Victoria would like to thank
everyone for their support and guidance during her undergraduate years.




BRETT FORS
The Guy With The Namesake Ligand



                  D
                          r. Brett Fors, a 2011 PhD graduate from the Buchwald Group, was recently featured in
                          “The Haystack,” a C&EN blog written by Associate Editor of Chemical and Engineer-
                          ing News, Carmen Drahl. Dhral covers the science and business of the pharmaceutical
                  and biotech industries. Her blog features Brett’s namesake ligand, “BrettPhos” and is in the
                  June 8th edition of C&EN, To read the blog click here




GORHAM AND RACHUPKA WED



O
         n May 22, 2011, Anne Gorham, Manager of Operations
         in the Department of Chemistry’s Instrumentation Facil-
         ity, married Tony Rachupka. The ceremony took place
in Rindge, New Hampshire. Tony is a Coordinator, Sequenom &
Sample Manager” in the Genetic Analysis Platform at the Broad
Institute. The couple met at MIT.

Anne and Tony are ardent hikers, campers, and backpackers (all 4 sea-
sons) in and around New England. Tony recently finished his New Hamp-
shire 48 4K peaks (there is an AMC list of all official peaks in NH that
are above 4,000 feet). Anne is on 34, and hopes to finish the 48th by the
end of this summer.

They have two cats, Omar and Oscar.



Chemformation, Vol 28, no.6                                                                         Page 8
  Recent Publications

                                                           Light-induced water oxidation at silicon
                                                       electrodes functionalized with a cobalt oxygen-
                                                                      evolving catalyst

                                                           Joep J. H. Pijpersa, Mark T. Winklerc, Yogesh
                                                              Surendranatha, Tonio Buonassisic, and




                                            I
                                                                          Daniel G. Nocera
                                                 ntegrating a silicon solar cell with a recently developed cobalt-
                                                 based water-splitting catalyst (Co-Pi) yields a robust, mono-
                                                 lithic, photo-assisted anode for the solar fuels process of water
splitting to O2 at neutral pH. Deposition of the Co-Pi catalyst on the Indium Tin Oxide (ITO)-passivated p-side
of a np-Si junction enables the majority of the voltage generated by the solar cell to be utilized for driving the
water-splitting reaction. Operation under neutral pH conditions fosters enhanced stability of the anode as com-
pared to operation under alkaline conditions (pH 14) for which long-term stability is much more problematic.
This demonstration of a simple, robust construct for photo-assisted water splitting is an important step towards
the development of inexpensive direct solar-to-fuel energy conversion technologies. Click here to read the MIT
News Story by David L. Chandler




B
       rian Walker, August Dorn, and Professor Moungi
       Bawendi--in collaboration with Professor Vladimir
       Bulovic in Electrical Engineering and Computer
Science--have reported the fabrication of composite pho-
todetectors consisting of J-aggregates conjugated to semi-
conductor nanowires in Nano Letters.




                                          Mechanistic Studies of Reactions of Peroxodiiron(III)
                                          Intermediates in T201 Variants of Toluene o-Xylene
                                                     Monooxygenase Hydroxylase

                                                      Woon Ju Song and Stephen J. Lippard
                                                         Biochemistry (2011), online




T
        he Lippard group reports kinetic studies of aromatic hydroxylation by an oxygenated intermediate
        (T201peroxo) of toluene/o-xylene monooxygenase hydroxylase. Decay rates of T201peroxo were monitored in
        the absence and presence of external (phenol) or internal (tryptophan residue in an I100W variant) sub-
strates by stopped-flow spectrophotometry under pre-steady-state conditions. Three possible reaction pathways
were evaluated and only one is consistent with the experimental results. It requires that two oxygenated interme-
diates, T201peroxo and ToMOHperoxo, be in equilibrium, with the latter dominating subsequent reactivity with arenes.

Chemformation, Vol 28, no.6                                                                         Page 9
 	
  

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  submissions	
  to	
  alyssa1@mit.edu	
  by	
  July	
  1st.	
  

              So	
  what	
  are	
  you	
  waiting	
  for?	
  Help	
  us	
  help	
  you!	
  


 	
  




Chemformation, Vol 28, no.6                                                                                    Page 10
NATIONAL RESEARCH COUNCIL OF THE NATIONAL ACADEMIES

The National Research Council of the National Academies sponsors a number of awards for graduate, postdoctoral
and senior researchers at federal laboratories and affiliated institutions. These awards provide generous stipends
($30,000 - $35,000 for graduate students, $42,000 - $75,000 per year for recent Ph.D. recipients and higher for
additional experience), and the opportunity to do independent research in some of the best-equipped and staffed
laboratories in the U.S. Research opportunities are open to U.S. citizens, permanent residents, and for some of
the laboratories, foreign nationals. Detailed program information, including instructions on how to apply online
and a list of participating laboratories, is available on the NRC Research Associateship Programs Web site at:
www.national-academies.org/rap
Questions should be directed to the NRC at
202-334-2760 (phone) or rap@nas.edu.
There is one remaining review cycles.
Upcoming deadline
August 1, 2011

Applicants should begin a dialogue with prospective Advisors at the lab(s) as early as possible, before their
anticipated application deadline.



  Details on all positions are on file and can be obtained from Liz McGrath, Room 18-388


 Institution/Company               #    Level of Hire        Area                                                     Tenure
                                                                                                                      Track
 Northern Arizona University       1    Full-time Lecturer   Organic and and General Chemistry                        No
 University of Michigan            1    Postdoc              Global carbon cycle, basic energy sciences and in        N/A
 (Steve Ragsdale Lab)                                        biomedical problems
 Center for Petroleum & Minerals   >1   PhD                  Research Scientist                                       N/A
 King Fahd University of Petro-
 leum & Minerals, Dhahran, Saudi
 Arabia




 Visit the Chemistry Department Events Calendar by clicking here to see all upcoming
 seminars and other events. ICal drop installed!




Chemformation, Vol 28, no.6                                                                                      Page 11

				
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