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					SORIN GROUP Presentation   May 2011   1
       A GLOBAL MEDICAL DEVICE COMPANY AND A LEADER
        IN THE TREATMENT OF CARDIOVASCULAR DISEASES




 3,700 employees in the world

 Over 5,000 hospitals served around the world

 One million patients treated with Sorin Group’s
  devices every year in over 80 countries

 Listed on the Milan Stock Exchange




                                       SORIN GROUP Presentation   May 2011   2
A GLOBAL REACH




      Focusing on 3 core Business Units

      The World Leader in Cardiopulmonary
       with a 35% market share worldwide

      A strong presence in Europe and in Japan
       in the Cardiac Rhythm Management market

      #2 Heart Valve Company in Europe




  SORIN GROUP Presentation                 May 2011   3
                                   SORIN GROUP SALES
                               BY THERAPEUTIC AREA - 2010


HEART VALVES
  € 120.5 million
   Tissue and mechanical valves,
                                              16%
   annuloplasty rings for heart valve                                          CARDIOPULMONARY
   replacement and repair
                                                                                 € 338 million
                                                                                  Heart-lung machines, oxygenators,
                                                                                  autotransfusion systems when
                                                                         46%      extracorporeal circulation is needed
                                                  € 746 million                   during prosthetic replacement, bypass,
CARDIAC RHYTHM                                                                    valve repair
                                        38%
MANAGEMENT (CRM)
  €285 million
   Implantable cardiac defibrillator (ICD)
   and pacemaker systems to restore normal
   cardiac rhythm, cardiac resynchronization
   therapy (CRT) systems to treat heart failure
   and Holter systems


                                                  SORIN GROUP Presentation                            May 2011     4
                      SORIN GROUP
 FOUNDED IN 1956 AS A JOINT VENTURE RESEARCH PROJECT

                                                             SORIN
                                                     MANUFACTURING FACILITIES



         FIAT
Automotive manufacturer
        (Turin)
                                                                         In The 60s
   MONTECATINI                                                           Today
  Chemical company
       (Milan)




                          SORIN GROUP Presentation                    May 2011   5
                             MAJOR MILESTONES (1)

   COMPANIES                    ENTERING                              LISTING ON
   FOUNDATION                  SORIN GROUP                      MILAN STOCK EXCHANGE

    40’s   70’s       80’s    ’92   ’99   ’01   ’03                January 2004



  Sorin Biomedica

 Stöckert / Dideco

Cobe Cardiovascular

   ELA Medical

   Carbomedics




                                     SORIN GROUP Presentation                     May 2011   6
                                                RECENT MILESTONES (2)




   FOCUSING ON                                   STREAMLINING
                                                                                     EXPANDING PRODUCT PORTFOLIO
  CORE ACTIVITIES                                ORGANIZATION

2008                                     2010    DISTRIBUTOR       2011            2009     ACQUISITIONS         2011
           DIVESTITURES                          ACQUISITIONS
                                                                                                 EVH
        Vascular Therapy                           Austria                                  (Endoscopic Vessel
                                                                                               Harvesting)

             Renal Care                                                                         Gish
                                                 Netherlands                                 (Oxygenators)


                Angel™                             Poland
       (Whole Blood Separation System)




                                                        SORIN GROUP Presentation                                 May 2011   7
              A PORTFOLIO OF INNOVATIVE PRODUCTS

                       Heart-Lung Machines           Oxygenators       Autotransfusion Systems




CARDIOPULMONARY    


                           Heart failure           Tachyarrhythmia        Bradyarrhythmia
                       Management Systems        Management Systems     Management Systems


  CARDIAC RHYTHM
MANAGEMENT (CRM)   


                          Tissue Valves            Mechanical Valves      Self-Anchoring,
                                                                          Sutureless Valve



    HEART VALVES   



                                   SORIN GROUP Presentation                             May 2011   8
               A TRADITION OF EXCELLENCE IN INNOVATION


 EUR 66.9 million dedicated to R&D
  i.e. 9% of sales revenues

 14% of employees work in R&D
  Over 500 people in North America, France, Italy
  and Germany

 Numerous partnerships with cardiology specialists
  and cardiac surgeons as well as world-renowned
  universities and research centers

 Relying on “engineer-physician intelligence networks”
  to develop innovative therapeutic solutions

 A portfolio of 2,200 patents




                                          SORIN GROUP Presentation   May 2011   9
               40 YEARS
   OF BREAKTHROUGHS & HISTORIC FIRSTS
2011     Launch of the FIRST Self-Anchoring & Sutureless Heart Valve : PERCEVAL S ™
2010     XTRA New Sorin Group Autrotransfusion machine
2008     World’s FIRST CRT-D with hemodynamic sensors: PARADYM™
2006     FIRST semi rigid ring with unique 3D motion (Memo 3D™)
2002     First oxygenator with integrated arterial filter – SORIN* Synthesis™
         World’s FIRST sensor to optimize patient hemodynamics
1998     First dual chamber adult oxygenator – DIDECO* Avant™
1995     World’s FIRST dual-chamber ICD implant: ELA Medical* DEFENDER™
1994     World’s FIRST implant of a bi-ventricular pacing system (ELA Medical)
1993     First newborn oxygenator – DIDECO Lilliput™
1982     FIRST implant of a biological stented heart valve (MITROFLOW*™)
1981     World’s FIRST microcomputer within an ELA Medical’s pacemaker
1973     FIRST modular heart lung machine by STOECKERT*
       * These companies were gradually merged to build the strong unified brand that Sorin Group represents today



                                         SORIN GROUP Presentation                                                    May 2011   10
                                                    A GLOBAL PRESENCE

                       Sales By Geography                                         Current R&D and Manufacturing Locations

            RoW
                         15%
                                          15%
 Japan
                 9%                               9%
               48%                                       48% Europe
                              €746 million

 North                28%                     28%
America


 CARDIOPULMONARY                                           CARDIAC RHYTHM MANAGEMENT (CRM)                           HEART VALVES




 Mirandola (Italy)     Munich (Germany)   Denver (USA)      Clamart (France)   Minneapolis (USA)   Meylan (France)    Saluggia (Italy)   Vancouver (Canada)


                                                              SORIN GROUP Presentation                                               May 2011      11
      TECHNOLOGICAL LEADERSHIP - SOME EXAMPLES

                                      PROJECT               HIGHLIGHTS


                       LinOx                             Technological and
CARDIOPULMONARY       (Leadership in Oxygenation)      industrial innovation




 CARDIAC RHYTHM        Remote                                 First pilot
    MANAGEMENT        Monitoring                            system trial




                                                           Self-Anchoring
                                                        Sutureless Heart Valve
    HEART VALVES      Perceval STM
                                                          Strong customer
                                                         Support (surgeons)


                             SORIN GROUP Presentation               May 2011     12
                                   EXECUTIVE LEADERSHIP TEAM



                                                    André-Michel BALLESTER
                                                      Chief Executive Officer

                                Davide BIANCHI                                       Stefano DI LULLO
                                  Heart Valves                                  Cardiac Rhythm Management


Michel DARNAUD
Cardiopulmonary
& Intercontinental

                                                                                                               Kieran TUITE
                                                                                                            Corporate Operations

                  Edward ANDRLE
                      Strategy
               & Business Development                                                Brian SHERIDAN
                                                                                           Legal

                                        Stéphane BESSETTE
                                                                  Demetrio MAURO
                                          Human Resources
                                                                    Finance & IT
                                          & Communication

                                                    SORIN GROUP Presentation                                    May 2011     13
                                 SORIN GROUP VISION


            A global leader innovating in the attractive
             €20 billion Cardiovascular Market

            The market leader in Cardiopulmonary

WE ARE…     A growing player in the Heart Valves
             and Cardiac Rhythm Management arenas,
             with a strong European franchise

            A company with a multi-cultural management
             team and a simplified organization


WE WILL…    Continue to invest in technological innovation,
             for sustainable, profitable long-term growth




                                        SORIN GROUP Presentation   May 2011   14
Cos’è Perceval S?



      Perceval è un sistema innovativo per il
        trattamento della stenosi aortica.


           Sorin Group propone al cardiochirurgo:
            • Innovazione
            • Una nuova terapia
            • Un nuovo sistema curativo


                       SORIN GROUP Presentation     May 2011   15
Perceval S: Progettata attorno ad una valvola comprovata
                  Valvola di Pericardio
                  Bovino
                  •Disegno a doppio foglio di
                  pericardio con
                      >20 anni di esperienza
                  •   Fissaggio del tessuto
                  •   Trattamento detossificante



                  Dispositivo di
                  ancoraggio
                  • Lega auto-espandibile
                  • Geometria “Double ring”
                                                      PERCEVAL S
                  • Design speciale del supporto
                  • Ricoperto di Carbofilm


                           SORIN GROUP Presentation     May 2011   16
Perceval S: piattaforma provata clinicamente

                   Valvola in Pericardio Bovino
                   > 20 ANNI DI ESPERIENZA
                   • Disegno valvola
                    - doppio foglio di Pericardio
                    - cross stitches
                    - Performance eccellenti
                   Tessuto Valvola
                    - Pericardio Bovino
                    - detossificazione




                   Dispositivo di Ancoraggio
                   •   Disegno speciale Montanti

                   •   Geometria a doppio anello

                   •   Lega ad auto Espansione

                   •   Rivestimento in Carbofilm



                            SORIN GROUP Presentation   May 2011   17
Componente Pericardica :
Struttura a Doppio Foglio
La configurazione finale è ottenuta da un unico foglio composto da due: un foglio di pericardio a
forma di tricuspide è suturato ad un secondo usando fili rivestiti di Carbonio
turbostratico(CarbofilmTM).


                                              Foglio Funzionale interno




    Foglio interno Funzionale                                               Foglio esterno di supporto




  Beneficio: apertura cilindrica con bassi gradienti pressori e meno turbolenze


                                         SORIN GROUP Presentation                           May 2011     18
Il dispositivo di ancoraggio:
Sistema Auto-Ancorante

                                                        Anello outflow
      ANELLO OUTFLOW
      (Livello giunzione                                smussato
         Sinotubulare)




                                                               Montanti Sinusoidali
                                                               (Seni di Valsalva)



                                                                 Montanti
                                                                 commissurali
   IANELLO INFLOW RING
        (Livello annulare)




                             SORIN GROUP Presentation                    May 2011     19
Il dispositivo di ancoraggio:
 Montanti Auto-Ancoranti

                                 Montanti Commissurali           Supporto alla Valvola

                                   Montanti Sinusoidali          • Ancoraggio
                                                                 • Adatta con diverse
                                                                   anatomie del seno di
                                                                   Valsalva , no lrigurgiti
    Lega auto-espansione                                           paravalvolari
                           Adattamento alla Radice Aortica       • Previene Migrazioni




              Beneficio: auto-ancorante, stabile, senza suture

                                      SORIN GROUP Presentation                        May 2011   20
Il dispositivo di ancoraggio :Carbofilm




                                                                              Physical Vapour Deposition


                                                            High Vacuum
                                                                Chamber
                                                       (room temperature)




                                                             Electric Field




                                                  spessore
                                                  0.5µm



         Beneficio: Carbofilm ottimizza emocompatibilità e biocompatibilità



                            SORIN GROUP Presentation                                      May 2011         21
                                  Perceval S

   Impiantata con Tecnica                   Pericardio Bovino per performance di durata
    Chirurgica Standard a cuore               ed emodinamica
    aperto                                   Derivata da esperienza 20 anni Tecnologia
   Adatta per MICS                           Pericarbon Freedom Sorin
                                             Tecnologia Lega Superelastica ad Auto –
                                              Espansione
                                             Curativa –rimozione valvola calcifica
                                             Anatomica –adatta all’anatomia del paziente
                                             Senza fili di sutura
                                             Collassabile
                                             Reduce tempi di X-clamping & procedurali
                                             Eccellente performance Emodinamica




                                  SORIN GROUP Presentation                   May 2011
Sorin S.p.A.
Via Benigno Crespi, 17
20159 Milano – Italy

www.sorin.com




                         SORIN GROUP Presentation   May 2011   23

				
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