Bioscience Community of Learners

Bioscience Community of Learners Innovative Pipeline Partnering PANEL Timothy D. Nolan, Director, Greater Cinti Tech Prep Bill Tacon, Sr. Director Workforce Development, BioOhio Mike Deperro, Director of Manufacturing, Alkermes Inc. Suzanne Bradshaw, Associate Prof, Biotechnology UC RWC Jamie Allison, Biotech Science Teacher, Loveland High School Greater Cincinnati Tech Prep Consortium Consortium Services • Curriculum Collaboration & Articulation • Professional Development • Academic Enrichment • Student Support • Program Review STEM Careers • • • • Science Technology (Information Technology) Engineering and STEM Educators Mathematics and Medical BioOhio • Founded in 1987 as the Edison BioTechnology Center, BioOhio (formerly Omeris) is a non-profit organization designed to build and accelerate bioscience industry, research, and education in Ohio • Headquartered in Columbus, with affiliates around the state • Workforce is one of our 4 strategic focus areas Total economic impact of the bioscience/healthcare industry in Ohio ($146 billion = 17% of Ohio‟s economy) Bio-in-Ohio by the numbers, then & now Year 2001 2006/2007 Number of bio entities in Ohio University R&D expenditures New Company starts 352 $481 million 12 818 (2.3X) $1.1 billion (2.3X) 58 (4.8X) Average „04‟06 $261 million (18.6X) Thru Q3 2007 44 (5.5X) 235 (2.7X) Private capital raised for new starts $14 million Bioscience Capital sources (in State) BioOhio (EBTC) 8 86 An Expanding Ohio Bioscience Industry! • Ohio‟s manufacturing industry base is repositioning! • Traditional heavy industry based manufacturing moving to one which embraces high technology • Significant bioscience expansion in manufacturing • Alkermes, Amylin, Ben Venue, Eurand, Meridian……….. • $500 million investment, adding 700 new jobs in 2 years • Shortage of trained workforce • Workforce survey – first state-wide survey of Ohio‟s bioscience industry • Employment Needs: Educational Credentials You don‟t need an advanced degree to work in the Biosciences! Respons e Count 65 What educational credentials are considered for your workforce (where applicable)? High School Diploma R&D 1.5% (1) Two Year Degree 4.6% (3) Four Year Degree 46.2% (30) Advanced Degree 47.7% (31) Manufacturing (Line) Manufacturing (Supervisor) QA & Regulatory Senior Management Management Administration Marketing/Sales IT/Computing 40.6% (13) 8.6% (3) 2.0% (1) 0.0% (0) 2.0% (1) 24.5% (12) 7.7% (4) 2.4% (1) 31.3% (10) 28.6% (10) 4.1% (2) 0.0% (0) 0.0% (0) 40.8% (20) 7.7% (4) 16.7% (7) 28.1% (9) 51.4% (18) 69.4% (34) 48.1% (25) 67.3% (33) 28.6% (14) 67.3% (35) 71.4% (30) 0.0% (0) 11.4% (4) 24.5% (12) 51.9% (27) 30.6% (15) 6.1% (3) 17.3% (9) 9.5% (4) 32 35 49 52 49 49 52 42 51 answered question Alkermes, Inc. Wilmington, OH Michael R. Deperro Director of Manufacturing 13 Alkermes: Patient inspired • Biotechnology Industry • Founded in 1987 • Publicly Traded (NASDAQ): ALKS • Over 800 employees across 3 domestic locations • Headquarters in Cambridge, MA • Manufacturing facilities in – Wilmington, OH (Medisorb Technology) – Chelsea, MA (AIR Technology) WILMINGTON MANUFACTURING SITE STRUCTURE Total Headcount (Ohio)   Site Operations Manufacturing  Engineering  Maintenance  Metrology Process Development Regulatory Affairs Quality Assurance  QA Operations  QA Compliance  QA Validation Quality Control  QC Chemistry  QC Microbiology  QC Technical Service Supply Chain General & Administrative ~400 62 146    15 2 69  62   21 23 ALKERMES DELIVERY PLATFORMS Injectable Pulmonary Medisorb® AIR® Wilmington, OH Boston, MA 2007 Clinical Development Programs Preclinical Phase I Phase II Phase III Regulatory Review Approved RISPERDAL® CONSTA® (Schizophrenia) VIVITROL® (Alcohol Dependence) AIR® Insulin (Diabetes) Exenatide LAR (Diabetes) ALKS 29 (Alcohol Dependence) ALKS 27 (COPD) AIR® PTH (Osteoporosis) NCEs (Addiction/CNS) Other (Various) Medisorb Technology • • Patented and Commercialized in Ohio Drug delivery platform for injectable sustained-release formulations lasting from days to months – Provides consistent levels of medication to patients without daily dosing requirements – Process designed for the encapsulation of peptides and water- and organic-soluble small molecules – Composed of bioactive small molecule or peptide incorporated into a matrix of poly(d,l-lactide-co-glycolide) [PLGA] polymer – Release of bioactive component controlled by drug diffusion and biodegradation of polymer matrix in vivo Partnerships – Johnson & Johnson (Janssen) – Risperdal® Consta® – Cephalon – Vivitrol® – Amylin Pharmaceuticals – Exenatide LAR • www.alkermes.com COPYRIGHT © 2008 ALKERMES, INC. University of Cincinnati Blue Ash/Raymond Walters College History • RWC -- open access regional branch campus of the University of Cincinnati • Laboratory Technology – 2 year AAS degree (since 1986) • Biotech option (since Sept 2001) – Emphasis on development of hands-on technical lab skills Where do AAS Biotech students go? • Bachelor‟s degree program – UC College of Allied Health (CAHS) • Clinical Lab Science – UC College of Applied Science (CAS) • Chemical Technology • Biotechnician Job – Mostly R&D and academic jobs – Exploring curricular changes to prepare graduates for biomanufacturing jobs Where do we get students? • Need strong math and science background • Most current students have switched from other majors • Many students are returning to college • 1 year Certificate option for bachelor‟s degree holders • Tech Prep Biotech students from high schools • Can receive credit for 6 quarter hours at RWC • Orientation to Lab Technology • Laboratory Safety • Biotech Seminar Current Biotech Pathway High School Tech Prep 2 year AAS degree: UC RWC 2-3 years BS degree: UC CAHS or UC CAS Biotechnician employment Employers of RWC Biotech Graduates • • • • • • • UC Medical School UC Genome Research Institute UC Raymond Walters College Children‟s Hospital Research Foundation Meridian Bioscience P&G Various small bioscience companies, clinical labs, and chemistry companies Laboratory Technology: Biotech • Articulation agreement with HS Tech Prep Biotech programs: – Credit for 6 quarter hours • Orientation to Lab Technology • Laboratory Safety • Biotech Seminar Loveland High School • State-rated “Excellent” school 5 years in a row • District has portions in three counties • 1,322 students total enrollment • Block schedule • Colors: Orange & black • Mascot: Tiger • Student - Teacher ratio 19.1:1 (classroom only) How to make this work… • You must have 110% support and cooperation with the following people: – – – – – – – Building Principal Guidance Counselors District Treasurer District Superintendent School Board College Teachers Tech Prep Consortium Smooth Running Initial Pathway Results Class of ‟07 Ten graduates $cholar$hip$ $7,000 As of Feb 15 Class of ‟08 Seventeen graduates $6,000