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KERATIN RABBIT ANTIBODY

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					                                                                                 SPECIFICATION SHEET
                                                                                                 Rev 50217A




KERATIN 5 RABBIT ANTIBODY
CATALOG:                    E13821
PRESENTATION:               7.0ml prediluted antibody which is ready-to-use for staining of
                            formalin-fixed, paraffin-embedded tissues.
IMMUNOGEN:                  Synthetic peptide corresponding to C-terminal of human keratin 5.
SPECIES REACTIVITY:         Human. Others-not known.
DESCRIPTION:                Twenty human keratins are divided into acidic (pI <5.7) and basic (pI
                            >6.0) subfamilies. Members of the acidic and basic subfamilies are
                            found together in pairs. The composition of keratin pairs varies with
                            the epithelial cell type, stage of differentiation, cellular growth
                            environment, and disease state. Many studies have shown the
                            usefulness of keratins as markers in cancer research and tumor
                            identification. Point mutations in cytokeratin5 gene can cause various
                            types of epidermolysis bullosa simplex. It is expressed in most
                            epithelial and biphasic mesotheliomas.
APPLICATION AND SUGGESTED DILUTIONS:
                     • Immunohistochemistry (Formalin/paraffin)
                                  - Working dilution: Ready-to-use for 30 min at RT
                             Staining of formalin-fixed tissues requires boiling tissue sections in 10mM
                             citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.
                            The optimal dilution for a specific application should be determined by
                            the investigator.
MOLECULAR WEIGHT:              58kDa
POSITIVE CONTROL:             Mesothelioma
CELLULAR LOCALIZATION:          Cytoplasmic
STORAGE & STABILITY:          Ab with sodium azide is stable for 24 months when stored at 2-80C.
LEGAL CONSIDERATION:          This product is recommended FOR RESEARCH USE ONLY.




                           Human mesothelioma stained with
                           Anti-keratin 5, cat# E13821




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