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TOBACCO CHEMISTS
RE SEARCH
CONFERENCE
4437728
OCTOBER 6-8, 197 1
EXECUTIVE INN • LOUISVILLE
http://legacy.library.ucsf.edu/tid/rmz71b00/pdf
MOST
Tobacco and Health Research Institut e
University of Kentucky
109 Kinkead Hall
Lexington, Kentucky 40506
http://legacy.library.ucsf.edu/tid/rmz71b00/pdf
GENERAL PROGRA M
25TH TOBACCO CHEMISTS RESEARCH CONFERENCE
EXECUTIVE INN,LOUISVILLE, KENTUCKY
OCTOBER 6-8,197 1
TUESDAY, OCTOBER 5, 1971
6 :009 :00 P . M . REGISTRATION - Lobb y
WEDNESDAY, OCTOBER 6, 1971
8 :00 A . M . - 4 :30 P. M . REGISTRATION - Lobby
Opening Remark s
Dr . R . B . Griffith, Chairman
Tobacco and Health Research Institute,
University of Kentuck y
Welcome
Dr . Alvin Morris, Vice President for Ad-
ministration, University of Kentuck y
TECHNICAL SESSION - Label and Patio
Rooms - Mr . H . F . D . Borowski, British-
American Tobacco Company, presidin g
TECHNICAL SESSION - Label and Patio
Rooms - Dr . I . W . Hughes, Brown and
Williamson Tobacco Corporation, presidin g
TECHNICAL SESSION - Label and Patio
Rooms - Mr . Frank E, Resnik, Philip
Morris, Incorporated, presiding
http://legacy.library.ucsf.edu/tid/rmz71b00/pdf
11 :50 A . M . LUNCH
2 :00 P . M . TECHNICAL SESSION - Label and Patio
Rooms - Dr . Roger A. Andersen, Agri-
cultural Experimental Station, University
of Kentucky, presiding
6 :30 P . M . SOCIAL HOUR -Crown, W ndsor, and
Yorkshire Room s
TECHNICAL SESSION - Label and Patio
Rooms - Mr . James H. Bell, Lorillard
Corporation, presiding
http://legacy.library.ucsf.edu/tid/rmz71b00/pdf
WEDNESDAY MORNING
9 :00 Opening Remarks
Wdcotne
9 :20 TECHNICAL SESSIO N
H . F . D . Borowski, Presiding
EFFECT OF ETHYLENE ON TOBACCO LEAVES . E. C. SWW,
Department of Biochemistry, North Carolina Sate University,
9:20 Raleigh, North Carolina 27607
It he been reported pravloudy that ethylene causes a rise in respiration of detach.
ad tobacco serves; (Sider, E. C. 23rd Tobacco Chemists Conference) . The nsplr•
aeon raw reaches a maximum in approximately 4 days and subsequently declines .
The ATP level oso Increases during this period and decline after 4 days . No
change we noted In cytochrome oxidasa peroxides, and odiphenol oxides
Womb during this perod . Reducing Milan do not differ signMkantly from the
central . Chlorophylls Increases upon exposure of the leaves to ethylene and
chlorophyll content declines. Pectlnesterase activity Increases in both [mated and
cenbol leave . The level of ethylene giving maximum response appears to W
pprmlmaety, 10 spin for both the ATP and chlorophyllase responses. Levels to
3000 ppm do not appear to be 1NJMtory .
Tabaca ems produce ethylene. Yourrpr leave produce more ethylene than
adder Wares These INMp W21 be discussed In relation to wring of tobacco
kw~
J-2 - THE NEUTRAL LIPID PROFILE OF RIPE AND CURED TO
MOOD LEAVES AND THE EFFECTS OF MOISTURE STRESS .
at B . H . woolen, W . I . Irvim, P. W . Brown and D . N. /ones, Research
DNWon, Camera Limited, Nendon Road, Basildon, Esex,
Englan d
.A •ky Of she pnW behavlow of the neutral nplds of tobacco during Rue-
w*g he been eanled out Nkotlaa ebecsan (var . White Gold) we grown In a
:-cent OW ambvunot d.ambw. Dried sample of rips, yellowed, and eared
tiara wee pound and axaacad with n•Wxane. The neutral BpWs (hexane sol-
obw wan stand Davlm .MWry after column chromatapphy on norw
asd aeo by tAolaya der, tmetry. The effects of "Ang on the allow neuval
3pM consent and warless Bpid components (Induding hydrocarbons, eolaryl
acrd Sheryl an, P UOgInone•A, sdarasol, carob, free fatty ,tide, ad ph'
arts) In lanes at aRerem stalk position will be dbcwsd . The effect of
acclaim sos coMtlem during growth On plant du, lee yl ld, and neubsi lipid
Oompadekn WIN be described.
Btsii tie cane of this Investigation . a erpenold ketorw (bombiprenane) has
beset Identified for the first time as a tobacco contltuent .
http://legacy.library.ucsf.edu/tid/rmz71b00/pdf
WEDNESDAY MORNIN G
-3- A METHOD AND APPARATUS FOR RAPID TURGOR CON-
DfTIONING OF TOBACCO PRIOR TO FREEZE DRYING . W. H.
10 :00 fohnon, Department of Bldodcal and Apkulwrai Endneering,
limit Carolma State Univsnity, Rakldt, North Carolina 2760 7
A method and apparatus have been developed which permits rapid and controlled
bnprepration of sobatco shnds or strips with water prior to freeze drylny The
method Imam vawum nmotal of air from within cells and intenallular spaces
f slowed by controlled movement of liquid water into the material .
Replicated experiments have ben Conducted to evaluate proolds Variables of
vrvem Urns and pranre, tur{or .candltloaln{ ratio, and "cam water removal on
specific volume, bcroate . Results dhow that uniform Impropation of tobacco
mats to mobtes kwb up an 600400% (dry Ma) can be accomplished within
taaw4, while minimizing I= of Sublet . Spedlk volume Intueases were found
to be related to the inipotca ndidrdn (TC) moo ; beaver optimal Insist .,
say be obtaNW st TC rado a low w4 :1 with 100%ormote Increase .
Apparatus dewteped pro, ltls fa strbmadc eequncRg of opradom for sumi-
ceArrmsa Row oparadon. M 1bb method, seebrd modification can be
scceiplYied with minimal less or eoAM a, fs►oo/t madMudan of lad cil .
btry sin be adtkvd thrar#i candled vurnwden Swing the bnprpsti n
:70 *a MISSION
.10
4. ;AN .INSTRUMENT FOR THE RAPID AND ACCURATE MEA-
J&PLEI6EMT OF FILLING POWER I. R. Wept, W. P . Kirsch-
. : •s, aid N . A. TbalpN, Latlard Research Canter, 420 En/Wt
_t
•3ric ri_E'rpa1. Gnrebvo, !earth Cyrafbsa
Am a)R,be Mn dadtsd to measure automasitelly On spec-ft volume of
.
oyNlmnDI coodlaom an ornate b dmu4t conditions axon N
~YY ee ~i'F+a~ln a Ptedc contaliw r'°`d Seined shape and cam
( asttro0ed,cslodtlore b tb~tpeciflod_Pedfk Volume ,
Al - gyn . . s+. a.s .: .r..-.~., .
. .
or ran be sempjeja4 Tar: temple An, sbpa,
1ta6 of oomprtadoq va" du, and mobbm
b o6sd20 shaves O a,~.t d sataEMh espwdiko n
M S been rend? * P ooeaiq wMW end the IMIWnm at
race type, s. at led and an aoMoeo and to fuWast Cigarett e
4 - ;4437733
http://legacy.library.ucsf.edu/tid/rmz71b00/pdf
WEDNESDAY MORNIN G
•6- AUTOMATED METHOD FOR THE DETERMINATION OF PLAS-
TICIZERS IN CIGARETTE FILTER ROD MATERIAL . A. J .
11 :10 Sauabaugh and Kwnsth L . Rutm, R. J . Reynolds Tobacco Com-
pany, Research Division, 115 Chestnut Street, Wlmton-Salem,
North Carolina 2710 1
An Automated method Is Pro pored for the calorimetric determination of triacetln
and ttethysne glycol dacetets plasticizers N Sluice acetate clprette fliter
rode.
Should the Identify of the pWdclau be unknown, Initial testing must Include a
simple qualitative Analysis by GC . Sample Prepared" combs of extraction of
Pladctra from the filter material with owsar,W . Than the reaction of the ex-
Endted acetep with bydroxylamlrr, followed by an addition of ferric chloride,
ykds a ferric hydroxamate complex produtlry a violet color. The absorption
mw[Wm of the complex Is at 500 rem and fotloM leers Law from 0400 uJml .
.
The aptcal density nrp b 0000.700 . . . .
The simplicity of Sib procWUn legs Reelf well to use with automated imw-
men4ten. It hi bon adpted for uA so Me Robot Chemist which permit the
performance of wlyae at a reA of 120 tw hair let the standards necessary for
v a eeuaaeadon one . The method has been drown to work equally well for
alts tta sdn or tiethylw glycol dlwteta after selection of the appropriate
sandard for use In construction of the sada,d cu m
a
-~- -- ON THE CORRELATION 'BE'TWEEN VARIOUS LEAF CON .
11 STTTVENTS AND SELECTED SMOKE COMPOUNDS . G. Resin
rp, T. C ia, Ted D. Hoafrname, American Health Foundation,
Nn Yak, her tat and Plat Scaaeoe Ressafl Division, A . R . S .,
V. S. Depatmat of Agrtwdtoe, RYavlle, Marys d
-laewdtaer 19 (O am) were math from leaves of eight stalk position of
Meer .Ruoeuwt emteda and ww amak'ad under Standard conditions . The main-
. : auean arks was qurgtatlnly analyzed for dry NOW pudcula mama (M),
'-~gbsda, CO, acrolaa, irytlN ,,4., bydc i cyaelh, phenol, aeeob, baea(a}
arrdraowa, and Wns(ej.ywne. Sans of thou quandtai date win correlated
5744 an easratcal prepaJBr of Si tabaca'rbN . Indude data for arpn, stares,
b ..
NBlarg'adidam, pheaatk.apdemal, St" piaM, aedn0 Wide, alkaloids, nlao
{Baueesss rsmpou!n4 ptry)poengle, 1d4 .ou r, Jat'v edit : ., ;
http://legacy.library.ucsf.edu/tid/rmz71b00/pdf
WEDNESDAY MORNING
11 :50 LUNCH
WEDNESDAY AFTERNOON
2:00 TECHNICAL SESSIO N
t
1. W . HuOrcs, Fitaif
.7 . THE RADIOCHEMICAL ANALYSIS OF PHOSPHORUS
CONTAINING RESIDUES IN TOBACCO FUMIGATED WIT H
Y~0 PHOSPHINE . I. G. Underwood, Rnsarch & Development 6tabllW
tact, MkisMAmsdcan Tobacco Co. Ltd ., Repns Park Road,
Southampton, Errand
Fwtsiptbn of RaAacco with phaaphine results In Its than 2 p-0 b . of the phos'
Online P rsrrWtk* in the --co . N., . ..., there Is a posiblliry that other
ruhdusl plwphorw compoudr may be pmsnL This has been inveWSated by a
radioch mIci "thod of analysis.
Eaperbnw d faatgdon of tobacco with radlamdlw plwaphtne has demonstrated
West the lard of taddrd phmphwm eempewWs afar hmiption wa lea than 5
p.p.m. In 1M 'about- This rake k dapa4..a on tobaao type (being lower for
.
Rtrrby Ilan tar TWecnS amass- a a row, mobmn ounant) and is incnasd
by a was In&AllUmm teams dS abbaoco. -
On aaeskktg 94PAMN Made kaa a06 At Om furnlpb0 aobaccaa, the mutual
r.-aaua we rraked admy lip des ais,-s being tramfemd to mainstnan
Tbare is r "Wa from dii week Of On pretence, after phaphae fumipdon,
:X tmy .pisa+issatQnpcorrm tab rm®a~g pment m "- " or ai .
' ,JRANSP R <. INTO THE MAINSTREAM AND
. . . . ;' 57 W40GARS . 1. H. NPrer and A. G.1rH-
irZ~ . ~s4aQtaawk'Dp+naaoL-Ittpsral Tobacco Group Ltd., Rank
4aaIAT . idtl_1isa iormiY D :D.E. i.D.E: D .D.M ., and tress
01, tifFgpj mes w. tVaurdln die radmicrearn as sldausim
i
V df Saar gSiS laarrarcd d The sloes wan smoked in a drau/s ►
fas III I$4bmaOaam MId:' ilmaam a,ob collected on Cambriolp
dbvlbutomWco
~ad .dayrLlaYr i1~011'imo &- =OAT . well nWSd ms
an deactlvaad draaina
.- ,Pt .St.-less tOpnastepyby .
lpcs- . . _ lS' Hilo Ltyar drlomaropaph{.'~lif''.
.
,.yapw =- . .up
. as Y gentee l d lbe ht cdclde pnaul 3
~~YY~,ta~iape %r VKIWft talpd horn less Ohm 1% to 1% Si she
;~lirma~l_ a('~'bw Stns Sde sum smoke . D.C.S. wa rat ,
` gw W6111 ib@W-Sa'arT a1 dies WPM, aid ON oat abundant pyrotyob -
'lrrdraa of ilea ands ItreaaRp6on no the olennic D .D .E well D.DAL
443773 5
"f=
I
http://legacy.library.ucsf.edu/tid/rmz71b00/pdf
WEDNESDAY AFTERNOO N
,p . THE TRANSFER OF RADIOLABELLED NICOTINE TO
CIGARETTE SMOKE. T. It Mouflon, Tobacco Research Council
2:40 Laboratories, OWy Road, Harlow HUI, Harropte, Yorkshire ,
EshMuM
A prolecW mdbbotoplc study of nicotine metabolism in human smokers no
necen head the development of sophisticated apparatus for production and c&F
WOW of hanaBmeohdy labelled dganon smoke. Sorted, Upped cipnias wire
each "Wkd" With S,CJ of 121-34 Clldcotlne di(pinluoyl tartrate), apecmc
activity 20 mCUm mok, ushm an apparatus in which a fixed volume of liquid is
dispensed from a pardAven bypodermk syringe along the axis of a cipretb s
..
ON ayrihye needle Is wbadnwn at a uniform rat DsVMbutlon of radioactive
maaerW along the axis of the tobacco rod after conditioning was chocked by
determining We tgcMc radioactivity of eleven weighed sections from each of
several cpntss akcad at random .
In each euolallment an elpnttas Wen smoked In a cylindrical glass smoking
cartl4s, using a stow pbmo-amcWN macrons having an adjustable puff volume .
Mainstream Pend- law smoke was collectad puff-by-puff an a arks of Cambridge
tn, tine a0psept90 IBM big used for equivalent puff of each dianete .
.MkeWa Is JpWenDy, oardwM to the particulate pine of Mainstream and
ddsoaaa 4SN.W rob In unafld tam, rdlolabelld alkaloid accounting
for appmsdmaply 15% of the total radioactivity recovered Iran T .P.M . Then an
ate cast a !fescue N go transfer behaviour of endogenous and added
.,
adlolabaaed nicer . . either puf 4y'puW or in local .
MENTHOL TRANSFER . T. F. RkM, L. L. SnocAMY, and M. L
• . tatnold4 Brown a Williamson Tobacco Corporation, Research f
`~wabpmwnt pep rwnn; ISM W . Hill Street, Louisville, Kentuck y
j iQUi b Mai stream snake of mandrel and nicotine has been studied . For
tf>► "tarVh?1e the squllbrium distribulion of menthol between the tobacco and
Ne awbabs aasuslBW matW hs beer stsmed, about an 4 .kd of Me tool
AiAgf k'lssa wu the IBW before Yr akin . 11'1N such cipnttes, the trsefr
was that of airatira
You b$,iadrr bee she been AOarnbsad for nmpuaibrium dbatbotoss of
"'ewe~ 7s te4coa cod 1M MM . Greatest nrwthd bandw Is Sand
baba essstbd b WdaIy M Vie sObr . Menthes aander k also power than
. 1ogUl salad cassette wtrn mot of the monad ben tihe tobacco TMs .
A . Yatiati sa'dtrouaed Is tars of mentld <Ra ttlon from the tobrce and
Ras tottbaeea Mad fbe f%ter by b sewoL .
4437736 .
http://legacy.library.ucsf.edu/tid/rmz71b00/pdf
WEDNESDAY AFTERNOON
3 :40 INTERMISSIO N
.11 . FATE OF COMPOUNDS IN THE BURNING CIGARETTE . POLY-
MERIC CARBOHYDRATES : PECTINS, STARCH, CELLULOSE .
3:50 .
Ma%vle P. Newell and Freddie W . Bat, Research Department, R. 1 .
Reynolds Industries, Inc ., Wlmmn'alem, North Caollna 27102
The peat falls of Poly metc wbohydrates In the burning dpuette we Investipe .
.
ad by Mcoepontng radloactive pectin, parch, or cellulose, all randomly labeled,
Into cigarettes. Ths cigarette were smoked under standard condition ; the
Various fractions were wtscted end assayed for radioactivity . A brief dbcuslon
of the methods and equipment b included . Results show that a definite difference
ebb Si the dbrrbutlen Pattern of ON combustion produces from these three
compmrAL However, in each cat the greater portion of radioactivity Is found In
the ddestreait smoke with sidesmeam carbon dioxide being the lariat single
traction for each of the compounds sdbd . The average contributions of each
erspasnd to the make tractors of a hypert flcal cigarette an calculated and
r empaed .
x:12 . MECIaP MS OF'TNE PYROLYSIS OF POLY (AMINO ACIDS) .
'W. It. -I&tmbn, I. W . Ne/ak and R. W. Halt, Philip Morris R*
search Cssr, ►.C . Box 36513, Richmond, Virginia 2326 1
lbyaws of 11ydueit ndte, Ldeodm, L'rollne, L.mpartc acid, and L .
Atrsok add win pytolyaad at S00, 700, $00, and 1000' in a helium flow of 75
WflMst, Frspnentabua Products wen alselynd by to chromatopaphy . Water
Jed olben dioxide wee the major vellift peoduct at 500' . Carbon monoxide
:aid l0'M~ cyailds Oetade anajor preducb a 700` . ►oly(L giu tantic acid) pmt
00-RAR catbea eareav s ads pelyrycse Be" the Isar Poly-Ldeucene and
.ltd1'L'PeeOte gam file gnat MCI at 7110' bred above . Yields of HCN were foun d
10.9 mender asdRks those obpkrd be= the free amino acids, although i t
Was found to pawed ihrou# similar Intermediates . Difkrmcas due to
add. wen-slot at psi i-thwe previously hued for the fre e
aA pa add ss we '..MJ d been palygiydne, and foamed residue s
IBSraa~MYaed free . Ody(Lmpartk red t-giu mk acks) . Free redkal mecha n
.ire 05 ♦Aaoed UNch tiab abiiSSms, vMalMxation, and product dbtDL
http://legacy.library.ucsf.edu/tid/rmz71b00/pdf
WEDNESDAY AFTERNOO N
-13- FORMATION TEMPERATURES OF SELECTED GA S PHAS E
PRODUCTS FROM THE PYROLYSIS OF TOBACCO . H. G .
4:30 Oryw4 Jr. and R. G . Honeyain, Rewach Depatnent Liam and
Myers Incorponbd, Durtian, Harty CroOn ; 27707
A bchsque capabie of quantitatively mwwrbrg an yields of selected gwacus
product from the pyrolysis of tobacco e e funcdoo of pyrolysis bmprawre has
Now dated . A t ermopa+imebb "yaw has low coupled to a q cnromato•
Qaph by a dosed sampling system, permltt sag an efficient collecdon . of Yu
pyrolydc product ad a abeeauent Irrlwtbn Into the chromatwtphk can's,
q sawn . The product ban the TGA pyrolysis of tobacco sample were col-
lected am I@CC bmpensra naenrels from ambient cadldom to a Mal
somprawn at 600'C . AN the pyrplysr were pttonned In a mean, of Mtropn,
with the flow rat . adjusted to dmutata ctpretb puffing condltlrts The concen-
aid.,t of tlM q phre ccmprmrmIs in the 7GA effluent wen observed to be
wry dependent apps den pytolylk bmpenara The yields from each sample
were wmmed oar 12 No awsprabrre ntenab, and total yield was comparable
to that obtained by a opnbnobn rdtectuo oar the entire temperature rope .
Tae t senate IN piss of ipodten of On weal yield was esandaily Identical
10 ttea fa nd In nmrotmrs pgekerb.n, sad dpretbs of the same
lobamn
.-~~ . . . CHANGES IN nODIXTION ARDTDXCIT/ OF AFLATOXINS
4'50 PRODUCED TEMPERATURE,
- -- :w. PYROLY&M a CO-PYROLYSIS WITH TOBACCO . CYarws V.
VAV W V. &W Cahn, Iidwafty of Kentucky, Lexington,
PIs'i4y.4W eplb,rse Mrftper+CMt*s Uslk rcMdse, whkh had been Vows in
a soft VIES liquid ieti, wwicwkard at 25', 40', W, BO, and 1 OO'C
far 74 bamte so dtwmbse - r teat cased duels M atahdn p oduction .
.Tams mate .enfrmdd r 1M _mowlm and Ibaawe of to Gamma nadkim . UV
'pecbpkowmaVy and td Open thru nata'pky assn of Move fungal extinct
If d Na pamr Wmab at' 11 amxym'i .0* adry furl 'ear wmre
Fradrwd bale is deSc d "gum at 2S' W WC than from Nose of O N
lw tn.a - M'"/wlpamW M O," wy~ 7MF'C, Mawxtn was Stir
Pi 0 at wall law ._ .,&4 ! tome et er.ttabpwnd k) a Is production
!altentwil[raYii ten"-i."~iay~r'e" •». .
/X1t'br w a3" MW `*da`tbtl C ift tlltbx0nt4MiW masew of A .
I owe nwtr wsposioce tebuc=r dais ails, in crablmtan, wave
. S ta'bieSJY rest Ipfsbodra-'certd be detected In O n
rifetffa -' 1j iwibba T[cSaf W ley ieatts ni dtaweA, as tecc .rw
either Plm'm1j1b at 700•C, ra dam matt twaviii it 40O sr IOC Psrtnsa,
a
lrriv Vi S-Ced' tl f' JIY .rs 1t~rpll~rlr larpentntl r so 4n b
.~aeiilG6+~ rr daee.Bn~rwtRnrr :' --a-- - .. p.- -.
http://legacy.library.ucsf.edu/tid/rmz71b00/pdf
. ~{ . AN AUTOMATED PROCEDURE FOR THE DETERMINATION
a 1OF AMMONIA IN TOBACCO . P. F. Coll/m, W. W. Lawience,1 . F .
William. Research Deparmrest, UMeu and Myer, Incorporated,
Durham, North Caetlna 2770 2
An autemaad peemdure Is decrlbed Which has been developed for the deter-
mhtetlon of anuomla in esbacco . The procedure employs a Technic= Auto-
ArWymr with a pecWly defpwd distillation unit apmtlns at a sampling mu of
30 per bout. Water Wa found to be an adequate Swat for the attraction of
ammonia fmm tobacco. Separetlom of the ammonia from interferences Is accom-
plished by voladliutbn at 9YC from ectracb buffeted at pH 9 . The separation is
erffklnt to pamlt ewrma colorlmstrk mesa meat of the ammona by use of
the PbauselrypoWplta reaction. The procedure ha been applied to a variety of
106eoaOf with anmonla caviare revile fresh em b 0 .3%, with an overall
latatiee standard deviation of 2% a .dead from Ouplicae wWym The accuracy
of the procedure a pdpd by compaben with a previously described manual
dbctade rSthydrin a cafteule esaerad deal &Y jecowwy seems is considered
aWAaeeey.
. 18 . . . . :-E1l.ECTRON CAPTURE GLC ASSAYSOF LEAF POLYPHENOLS
AND ►NENYLALAMINE AWR)NIA LYASE . R . A . Andrus and
940 T.41. wa afta, P1apt Sala ce Raesarb ebWon, United Sates
-4-pauses of -AfloStn, Aertcdhrrel Research Service, and
"-•= Seprmewit I Aaarsy, ttoNadty of Karacky, Lexington,
9uarwaaes taaeabatoa at-wA pelMM, ns at, Well warutln motetas
am'paIelsd da top WemaaQapb a ,ed with a aeherrfoll eleaen
a+eta 4rdaa . Raal6fesCook at lead quer,etln cai paranfy be afar
vied sp40vrara_gaai dYgyaMC add beetas and vin corrana, rapecdnly,
U60 mbm for aoulamm Maroc the auarety of brio compound punt a fine
sapeomb we the 11 a Impda .-The pfypbwdb an dbecdy attracted
fl . Vd- ,U " .S : Aglbpala aid fi► acad be a trwesMAllcdon
hydnih 4ma"'apre6ea M a/ycea obis She came of caook at, an
Spam sac- peWp! - SyaW .file a d nmatogmphy. About S
IOWA* aaeabr ft r w , . - n dsgm fak ad the tower in of
Mcoow*im[a e $ so aeppdaati 30 as cask U, and 300 r% wiw=CK
XjMiMaw admatMy!►)A14'amitt in abate ad
w lbti S eta %S * tar opnerq cadltlo a
PAL i s i siMrrie e/t*ee i to frumm-krnaak ofd, IN
`bapesia I-pesyt_ of -1 11 pdyphumb aJ dsne polymer, much a tar'
Barr a*?#*& Melbodoler ad petRmaay bpd lc cm Cif be dbased . -
http://legacy.library.ucsf.edu/tid/rmz71b00/pdf
THURSDAY MORNIN G
-17- THE STRUCTURE OF A NEW SESOUrrERPENE-1-KETOs
CYPERONE-ISOLATED FROM TOBACCO. D. L Robert,
9:40 Rasarch Department, R . J . Reynolds Industries, Inc, Wiroton-
Saim, North Carolina 27102
A nee, and tm ssS aeqularpwre, d+3b,7, toanydro -1,4SImeNyldlrydroay-
7-bo-propenyl-2(6N)naphdidenaro (1iew-o-cyperane), he been Iodated from
Mwwnd and burley tobaccos It mpnrnn the first Idendfkadon of a ruder
manrtyp Imps In tobacco leciatlon of lietoo-cypetone(I) from burley
nbacco Wa ac I Wharf by chlotofoen ettnctlon of acidified casdanate from
the naanMg of burley tobacco. The drlordonn esci was dxomatographed
OW dbdllsd to give several tractors The iiato-ocyperone was crystallized from
oce of than fractlar Mid ncrpRallizsd from pentane a gIve a melting point of
76 .765 .
The mvwm W I I. beat irdd ad from lnhw , ulmaMolst, eW nuclear
n.caDc rent tpoct& lute m d from the damk l degradation of the
tobatse bdaw to tudslea CwA4wa a, of the structure vas obtained by zinc
due raduedad of l b (e)oc,pew aM idtydrmyaeyperone . The formation of
ON fssat pnduct also aatafMM V es swoodrnbtry of I e the same a to
foots in ( .$cypeaae. - .
An MI 11 to the rybNaY of l4xta, cypanne MI also be dbcuead .
•-~$ . , ;~: •A MEW TOBACCO SMOKE ANALYSIS FACILITY . N. A . Guerin,
: .Sob Rf4t Naran(Liboearory, on RIp, Teonmae 37230
10 :00
A am aabsea matte aedytls tflty ba been a tablislrd wl hls an Analytical
4ualsWy 1100lsWrof Oak RWP MMkvW Laboratory . The primary ogecUw of
*a faaApr l .a Fswl6e 4aelcal MarcarKelou of dpema aW daanro
aoob ONANNala be mom by Afat NMI oevacbc tarusrmentador, and aaN-
-aalalaMall}wdbpM~t Bee taboatsy Sr .nova purport an arrnyed a
V@Nm t Roptaaabs be SW AWMW ohaatci dtarwarizadon of mnoka . The
darii4 rats RWM i aRaboe n blolag/ealifsemfcal *"Ws of mobse
pltls 00 tsaaary In as SOMW a arras that the bblogcal sbrdle bdude
. b
TbaFmwpoaaals-asatswRy ldaralss ens -la sampt resat as
snday,dlad also Mi=d agM Is Almant Gar S Ion evhan dwaak ►
I+M~tdl~lA~>titYfaM .oaebaaotvapow2frt . andyab, eN pars
aatltati~ :d♦gtyda aw itaad - .aeatg t e apsclal fagsdm dlrepaaa• a
.w6lcrlsabRrth r*SS *n wtauoa U onto -
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THURSDAY MORNING
10 :20 INTERMISSIO N
-19 . SULFUR-CONTAINING COMPOUNDS IN THE GAS PHASE OF
'O, CIGARETTE SMOKES . A . D. Norton, M . t Gwrin, G . Olerich ,
Oak Ridge National Laboratory, Oak Ridge, Tennessee 3783 0
TM r of P chromatography with Name photometric deacbon prorMea a
comraWt meaee at detecting wlfurcontalning compounds In amokat A chram-
atepen of the wtfuncontalnlng compounds of the smoke b obtained when the
Mbcbr Is operated In the wlfurweclfk mode and the props chromatographic
cabman Is in Picas The aaddvlty of the detector Is such as to allow analyses to
be made on fmcdow of a puff . Specillchy Is such as to mini nice interferences
frowntbe compounds The method Is both rapid and convenien t
TM wffur dNvele of filter and n n4lim dpntta an qualitatively compared .
The of scdwr of dunoal In reducing the quantity of Ht S delivered Is dramat-
ically vbualbad. Preliminary quwtltatlw data generated by the technique for
M' gift specks are premed . - , . .
1.'x .';., ; POLAR APIEZONS FOR THE GAS CHROMATOGRAPHIC DE-
TERMINATIONS OF IPHENANTHRENE AND BENZ(A)ANTH-
--- -tACENE IN SMOKE OONDENSATES . N. Kubota, M. R. Goenn ,
-P J A. Altbard, CA MLdge Piatlenal Laboratory, Oak Ridge ,
.
1RbtH Berea vow a - *awn tw) .-we8 -beito($pymn* (W) an deter .
abrilb. lk eta snabr cortdaumes A mtadwly standard proadun b employ-
aM as pte►/rs S. appepdeo tub*aclSt'A MOOHCydohexane, cyciohexan a
pd flIrLO: M Ocydohaxae extraction nuance provide an aromati c
Whim. The arwnal c fraction Is subjected to a rapid fkmW
taf; idvid III 1011VA rK'his's arfavd to SwM nor wum n
:'Ib't'~Iwrrantiuere, iMAn sae IS anbhacCern from the alundr s
-RtrOw ahlorWTM proosdum it atandad use n-
" W adbhaclals k Wood to furNe pwet dmereaoe
MY 1140 determined $0 ChrOMANVaphiCally In
aTBt tertg,il/~7flideapymaaats '-
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THURSDAY MORNIN G
-21- "CARSON-14 AND NEUTRON IRRADIATED CIGARETTES FOR
ANIMAL LUNG DEPOSITION EXPERIMENTS . M. L . NSdox, R .
11 :30 a. Quincy, H . H . Roe, G . Oerich, M. R . Gwwrin, Oak Rddp Na,
tiaui Laboratory, Oak Rtdp, Tonne. 1787 0
A stay of the utility of IntntrachW devices In clpntte make Inhalation bb
away mwtiwdoiodae Is bSn1 conducted by members at the ORNL Biology
DWIslor. As the primary potential utility of such a device Is to Incrw the
Rainey of ammMM.Zeachk g the lure, a reliable technique for determinft lung
.-Carbon-14 Maadecane, carbon-14 dobIcontan, and as .
depoddon Is required
bon IrtadaW Upreuss have bean ewdled a depoaltlon measurement took . The
- at otban14 Skins theoretically allow Ow determination of localized
/apellUan because the alkans do not migrate rapidly from the Sa of deposition .
1Wtemn bradWW cipretta may prove more awful for the determination of
fetal dapodd(n .
,Dap are, peaaewed an the delhala of the radtoactlve Skates resulting from
Sprier sipteta preparation pnoa .ota Toad ptculate matter activity Is
•aantpeed mesh activity deheed pa puff . The I top of the acovtty In the
ft view b Uewaed . A aethod of recomrla{ dw radloactlve Skanw from
as llud bdr • Powers" Meobmm Irradiated efprettea an compared to the
s weem-144bow etpem a
oltrbab ba" been MeotlMdbi to wkly acidic iietwee c)
M1e pM*aSla 08"a at Spam ooke . 4-N'P mpyaMnopnm " C
aem a as ketaruS sbdard for an qurwatir aSyt t
on peered lure 2N-NAH. Afar alter :radon of 00 maetlml
fl . e aaweaa lay- tee &SBW Sal laoee .lUy woom S . sit
You ps sctrmcad uW. NS4 , aelu an and copow e"pi .
10-1ka >d raSW In fractions w%IA 4waiie w
Ten are ppaaad by in deoewtows0w la •
bya aewomst y . QuaRtDn and quw,tlat a dear a48 beywwmmd•
http://legacy.library.ucsf.edu/tid/rmz71b00/pdf
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THURSDAY AFTERNOO N
DETERMINATION OF CYANIDE IN CIGARETTE SMOKE BY A
CYANIDE ION4ELECTIVE ELECTRODE . David G. Vlctroy end
3:00 Gary L . Gwnt, Jr. COWAN FRan Csnpaty, ►. O. Bow 1414,
Chariots . North C"Ina 2620 1
A cyalNe selectlw Wcvods has been used for the deLmtlnadon of cyanide In
alpnm roke . HydroBn cyanide Is trapped by pain clprets smoke throush
an Aacarkbald /aa lubs. Tb Acata trap are darn emptied Into a known
aalurta o rater conslnMg NaON and Pb (MOO 4 . The cyslde concenvadon of
two ddutad satnpb Is tin matured with an loneescdn escvode .
The Sat poandomeak method dtords a dnnpBfed ad mon rapid analysis of
Iydropn cyanide with a mtlmum of laboratory a ulpment. Analysis of txmr
Nadal elpretsn dall .arbq from 150 to 1150 d cyaide per clpnva flee mutts
wnparaba to Pie obskrd by lb pyAdkr.batddins colorimavk method .
The ,Narks of alb art ha been determined with sand ad domgdc blend
spwtia. Stood" ohm c1gamst pa vc ssdsdnl nalyab on data from
-taalse VMS Be" a standard OevSdob of $1 far a ass ddhrry of 306 pg cyanide
per cbram .
avg . AN AUTOMATED METHOD FOR THE DETERMINATION OF
.-NICOTNJE ALKALOtfS IN .CIGARETTE SMOKE USING
~w CYANOGEN IROLNDE .4mbtr L DIni aid May L Sheppard, R
I. Rayndb Industries, Is. aseaach Dapabrnt, I IS Chestnut
SL, S. E. Wk sn-Sdsy Nwith QnNas 27102
new btota d, PICK) plcierrs Sr On hamenarad gectroplwkaoetri c
Vskiradludw of nsaltoe AU" hen Nat meillfbd and adapted to On analysis
NF taketaa alkyslw ! e j, arr. aatoba . a datirminas Is cried wt on an
70k diaeaardwrir worst a a'Glabddp IBSr pad containing snake
iaj Jar. maim . Caw de dojmaat 1?Siait Seat by mlxbq an aliquot of
. ttt Isaac sad tatlfau~ OW Cain,, RmrabY tabtdai, foboaad by
Rise l~s Of OAWkSt lbvl pn sea ft 1w Iwo ae}tatre a
t
w, bpibeljelpRakod • Ira cola datdopwwd
. J.iiplRrr dpC-43¢ calpriqpb at Wave, "4 ;;
ItailSa fal~d leis of iarf itaa Aa`ed by aka
FTC rear it Vie? Fie gtad a in to eves
wpertrSsM vtpka win am S N abape d
fbtaOsyf . z' 1p iTw
KrirffM ~ bAt o®r 1ht s type
_t, ~.,.~ran,r-- ac~setyp~ttt~ r ^ T ale .
~" ii► .lre . ..S4 pr tarpN`.R 7 ad'fiil`~v lase tr . p .. al . a ago-
y" ':s . 'IS d ace n ma.mawss for alb aaw.awlMn nt mead. mown of She
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MO
4
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FRIDAY MORNING
990 TECHNICAL SESSIO N
Aa m Bd6 Praldbtg
.29 . A NEW CHROMATOGRAPHIC METHOD FOR PREPARATIVE
.~ FRACTIONATION OF CIGARETTE SMOKE CONDENSATE FO R
9 BIOLOGICAL EXPERIMENTS . N. /. Klimiscn, FonchunRlnstltut
der ClgarstbMndustrk e.V., Hamburg Sa, Gadlenkatnp 38, West
Gemtan y
A new apmdan technique for pmpariWe production of dpntte snoke ca
darns friction Is deilbed employing IM methods of fldbeibudon
dnamatopaphy and plyernwation chrm i topaphy . A nines thaw friction V,
bbokwd by Ilul4IQuld dUOlbutbn, was spirited with a blphwc pair of
sdvante (sntbtwry phase : 85% methanol, mobile phase : henna) Into S7 .2% low
polar (heacr .e phase VII) aid 423% polar (methanol'phaae) wbstances The .
Inca pbm VII free of Neat ns alkSoldz, containing the polycydic aromatic
hydrocarbons, was wbagurrdy espaated bib friction of defined molecule size
araasrdkc to plchromampsphk pdncfpia The separation system with the
cambmaVen pelystyrenepltlo4eads .5X 3J0u2hydrofuran u thoroughly
Ian goad with tepid to now. ion 'Mckrwy, stability In the Sudan volume,
letting capacty, rid nprdoeOfly. In canpa$ng the Sudan volumes of
ownpounds of the urns mSsaue she but at different polarity, It caild be proved
Las aaleot r Sevkig apraOM effeq and Spdflcant Influence, while ate
vptietr we not sI . After aftallr% S. odumn with dnen(i, h)pyrsn
and steams the pwilled baimis freeborn VII eras separated into three Inc .
dar.'Ota Of Ohm fria%a ewlglW .H% of do whale condensate and ca t-
0
eWwd an 34 ems po ycyd is aaadb kydroaabes a
•' flACTOk1ATION OF WHOLE SMOKE CONDENSATE . K. Roth-
leW a d J . K Walrad, Tobacco ite earch Council Laboratories,
-Oltey Reed. Mass. 191 , Mrropte, Vatddre , ErErd
fen arias m AN cacbtlpelc activity of omens role, by cell kinetic, tlna
!>•tol%a favasaeMO kSSeen adwdpa, It Is ianmry to casemate S .
/W~CiY atd/a a mmoom bf loaf . ceerItetette into mW Tract 0
"F06081111160 b ale alas-, MptMry Is adsteapb to Identify Owe cm .
l drier wok we bare are sot it m poodle a conantna mat
! • sib zw*Aom No ne'hattate wing ea vent prodw tech Squ a
Jasaslr ateamtt t811p9s&w % tea aim been fetid thrash Ow womb-
sans. f►MM$ hsive ebamed by dime .toad
and for la Some an prter of Or at bW
taseMan `f>ja bee869Ty that ML .aeySRe
tiMifVMi 7AM SWss be brprms mamuan led m o n
i Risk pa8l aid nkcden of all S . o t
IirBiTbaT~ed ebndamte . IMO err rteoweet
hu fiaOribed iris Ow a ire aced ne ata
t
Rtlatan ~ilTh,'malery osrbM!~tti' .
Rl- b1MW- ON deOr am bad r M'rt pr,
faai sin to of tM eatdviaa are steamed. at
Bless r r-'- . pas !t Mdl , -Ry ac*a component re apaaae8
M ► amcatraaTtaaetea -
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25th TOBACCO CHEMISTS
RESEARCH CONFERENC E
LOUISVILLE, KENTUCKY
OCTOBER 6-8,197 1
Local Arrangements Commikae
Charles Bortner, Choirtnan
Robert Johnson
John Benner
Lawrence Westbroo k
Program Editorial Commltte
R . C . Benedict, Chairma n
F . J . Schultz
R . S . Wade
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http://legacy.library.ucsf.edu/tid/rmz71b00/pdf
25th TOBACCO CHEMISTS RESEARCH CONFERENC E
Executive Inn Louisville, Kentucky October 6-8, 197 1
Technical Progra m
Wednesday, October 6
9 :00 Opening Remark s
9 :20 #1 EFFECT OF ETHYLENE ON TOBACCO LEAVES . E . C . Sisler, Department o f
Biochemistry, North Carolina State University, Raleigh, Nort h
Carolina 27607 .
9 :40 #2 THE NEUTRAL LIPID PROFILE OF RIPE AND CURED TOBACCO LEAVES AN D
THE EFFECTS OF MOISTURE STRESS . B . H . Woollen, W . J . Irvine ,
P . W . Brown and D . H . Jones, Research Division, Carreras Limited ,
Nevendon Road, Basildon, Essex, England .
10 :00 #3 A METHOD AND APPARATUS FOR RAPID .TURGOR CONDITIONING OF TOBACCO PRIO R
TO FREEZE DRYING . W . H . Johnson, Department of Biological an d
Agricultural Engineering, North Carolina State University ,
Raleigh, N . C . 27607 .
10 :20 INTERMISSIO N
10 :50 #4 AN INSTRUMENT FOR THE RAPID AND ACCURATE MEASUREMENT OF FILLIN G
POWER . J . R . Wagner, W . P . Kirschstein, and N . A . Thaggard .
Lorillard Research Center, 420 English . Street, Greensboro, N . C .
11 :10 #5 AUTOMATED METHOD FOR THE DETERMINASION . ..OF PLASTICIZERS IN
CIGARETTE FILTER ROD MATERIAL .. A . J . Sensabaugh and Kenneth L . Rush ,
R . J . Reynolds Tobacco Company, Research Division, 115 Chestnu t
Street, Winston-Salem, North Carolina 27101 .
11 :30 #6 ON THE CORRELATION BETWEEN VARIOUS TRAP CONSTITUENTS AND SELECTE D
SMOKE COMPOUNDS . G . Rathkamp, T . C . Teo, and D . Hoffman, American
Health Foundation, New York, New York and Crops Division, A .R .S . ,
U . S . Department of Agriculture, Beltsville, Maryland .
11 :50 LUNCH
2 :00 #7 THE RADIOCHEMICAL ANALYSIS OF PHOSPHORUS-CONTAINING RESIDUES I N
TOBACCO FUMIGATED WITH PHOSPHIDE . J . G . Underwood, Research &
Development Establishment, British-American Tobacco Co . Ltd . ,
Regents Park Road, Southampton .
2 :20 #8 THE TRANSFER OF D .D .T . INTO THE MAINSTREAM AND SIDESTREAM SMOKE
OF CIGARS . J . H . Bugler and A . G . Britton, Research Department ,
Imperial Tobacco Group Ltd ., Raleigh Road, Bristol, England .
2 :40 #9 THE TRANSFER OF RADIOLABELLED NICOTINE TO CIGARETTE SMOKE .
T . H . Houseman, Tobacco Research Council Laboratories, Utley Road ,
Harlow Hill, Harrogate, Yorkshire, England .
4437750
http://legacy.library.ucsf.edu/tid/rmz71b00/pdf
3 :00 I/10 MENTHOL TRANSFER . T . F . Riehl, L . L . Shockley, M . L . Reynolds,
Brown & Williamson Tobacco Corporation, Research & Development
Department, 1600 W . Hill Street, Louisville, Kentucky 40201 .
3 :20 INTERMISSIO N
3 :50 #11 FATE OF COMPOUNDS IN THE BURNING CIGARETTE . POLYMERIC CARBOHYDRATES :
PECTINS, STARCH, CELLULOSE . Marjorie P . Newell and Freddie W . Best,
Research Department, R . J . Reynolds Industries, Inc ., Winston-
Salem, North Carolina 27102 .
4 :10 #12 MECHANISMS OF THE PYROLYSIS OF POLY(AMINO ACIDS) . W . R . Johnson,
J . W . Nedlock and R . W . Hale, Philip Morris Research Center ,
P . 0 . Box 26583, Richmond, Virginia 23261 .
4 :30 #13 FORMATION TEMPERATURES OF SELECTED GAS PHASE PRODUCTS FROM THE
PYROLYSIS OF TOBACCO . H . G . Bryant, Jr . and R . G . Honeycutt,
Research Department, Liggett and Myers Incorporated, Durham,
N . C . 27702 .
4 :50 #14 CHANGES IN PRODUCTION AND TOXICITY OF .AFLATOXINS PRODUCED BY
DESSICATION, INCREASED TEMPERATURE, PYROLYSIS AND CO-PYROLYSIS
WITH TOBACCO . Charles Y . Yang and V . Cathryn Dohm, University
of Kentucky, Lexington, Ky . 40506 USA .
Thursday, October 7
9 :00 #15 AN AUTOMATED PROCEDURE FOR THE DETERMINATION OF AMMONIA IN TOBACCO .
P . F . Collins, W . W . Lawrence, J . F . Williams, Research Department,
Liggett and Myers Incorporated, Durham, North Carolina 27702 .
9 :20 #16 ELECTRON CAPTURE GLC ASSAYS OF LEAF POLYPHENOLS AND PHENYLALANINE
AMMONIA LYASE . R . A . Andersen and T . H . Vaughn . Plant Science
Research Division, United States Department of Agriculture,
Agricultural Research Service, and Department of Agronomy,
University of Kentucky, Lexington, Kentucky 40506 .
9 :40 017 THE STRUCTURE OP A NEW SESQUITERPENE - 1-KETO-(-CYPERONE -
ISOLATED FROM TOBACCO . D . L . Roberts, Research Department, R . J .
Reynolds Industries, Inc ., Winston-Salem, N . C . 27102 .
10 :00 1/18 A NEW TOBACCO SMOKE ANALYSIS FACILITY . M . R . Guerin, Oak Ridge
National Laboratory, Oak Ridge, Tennessee 37830 .
10 :20 INTERMISSION
10 :50 #19 SULFUR-CONTAINING COMPOUNDS IN THE GAS PHASE OF CIGARETTE SMOKES .
A . D . Horton, M . R . Guerin, G . Olerich, Oak Ridge National
Laboratory, Oak Ridge, Tennessee 37830 .
4437751
http://legacy.library.ucsf.edu/tid/rmz71b00/pdf
11 :10 #20 POLAR APIEZONS FOR THE GAS CHROMATOGRAPHIC DETERMINATIONS OF PHENAN-
THRENE AND BENZ(A)ANTHRACENE IN SMOKE CONDENSATES . H . Kubota ,
M . R . Guerin, C . A . Pritchard, Oak Ridge National Laboratory,
Oak Ridge, Tennessee 37830 .
11 :30 #21 CARBON-14 AND NEUTRON IRRADIATED CIGARETTES FOR ANIMAL LUNG
DEPOSITION EXPERIMENTS . W . L . Maddox, R . B . Quincy, H . H . Ross ,
G . Olerich, M . R . Guerin, Oak Ridge National Laboratory, Oak Ridge,
Tennessee 37830 .
11 :50 LUNCH
2 :00 #22 4-N-ALKYLAMINOPHE'NOLS IN CIGARETTE SMOKE . G . Singer an d
D . Hoffmann, Division of Environmental Carcinogenesis, American
Health Foundation, New York, New York .
2 :20 #23 ANALYSIS OF VOLATILE N-NITROSAMINES IN UNAGED MAINSTREAM SMOKE OF
CIGARETTES . D . Hoffmann and J . Vais, Division of Environmental
Carcinogenesis, American Health Foundation, New York, New York .
2 :40 #24 ALIPHATIC AMIDES IN CIGARETTE SMOKE . W . R . Johnson, R . W . Hale
and J . W . Nedlock, Philip Morris Research Center, P . 0 . Box 26583,
Richmond, Virginia 23261 .
3 :00 #25 DETERMINATION OF CYANIDE IN CIGARETTE SMOKE BY A CYANIDE ION-SELECTIVE
ELECTRODE . David G . Vickroy and George L . Gaunt, Jr ., Celanes e
Fibers Company, P . 0 . Box 1414, Charlotte, North Carolina 28201 .
3 :20 INTERMISSION
3 :50 026 AN AUTOMATED METHOD FOR THE DETERMINATION OF NICOTINE ALKALOIDS
IN CIGARETTE SMOKE USING CYANOGEN BROMIDE . John T . Diffee and
Mary E . Sheppard, R . J . Reynolds Industries, Inc ., Research
Department, 115 Chestnut St ., S .E ., Winston-Salem, N . C . 27102 .
4 :10 #27 PHOTOSENSITIZED OXIDATION OF TOBACCO SMOKE CONDENSATES . M . A . Nisbet
and S . Schmeller, Research Laboratory, Imperial Tobacco Products ,
P . 0 . Box 6500, Montreal, P . Q .
4 :30 #28 COAGULATION RATE OF UNDILUTED CIGARETTE SMOKE, Ray E . Leonard and
John E . Kiefer, Research Laboratories, Tennessee Eastman Company,
Division of Eastman Kodak Company, Kingsport, Tennessee 37662 .
Friday, October 8
9 :00 029 A NEW CHROMATOGRAPHIC METHOD FOR PREPARATIVE FRACTIONATION OF
CIGARETTE SMOKE CONDENSATE FOR BIOLOGICAL EXPERIMENTS . H . J . Klimisch,
Forschungsinstitut der Cigarettenindustrie e .V ., 2 Hamburg 54,
Gazellenkamp 38, West-Germany .
4437752
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9 :20 #30 FRACTIONATION OF WHOLE SMOKE CONDENSATE . K, Rothwell and J . K .
Whitehead, Tobacco Research Council Laboratories, Otley Road ,
Harlow Hill, Harrogate, Yorkshire, England .
9 :40 1131 THE USE OF GRAS-SUBSTANCES IN TOBACCO FLAVORS . Frank Szpak ,
Firmenich, 277 Park Avenue, N . Y ., N . Y . 10017 , and Dr . Pau l
Dietrich, Firmenich, Geneva, Switzerland .
10 :00 INTERMISSION
10 :30 Business Meeting
4437753
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