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									SPECT is used to diagnose head trauma, epilepsy, dementia , and cerebrovascular disease.
Development of a radiotracer called Tc99m label has increased the resolution of brain images
generated from SPECT. The images yield very accurate spatial and contrast resolutions. The
resulting sharp images enable the clinician to visualize very small structures within the brain.
The accuracy of SPECT brain images makes it a very useful clinical and research tool.

Clinically, SPECT is useful for diagnosing the following disease states:

      Cerebrovascular disease or stroke : SPECT is useful to detect ischemia (reduced blood
       flow), determination of stroke causes, evaluate transient ischemia, determine prognosis,
       and monitor treatment.
      Dementia such as in Alzheimer's disease: SPECT studies can be used effectively to rule
       out other medical causes of dementia.
      Head trauma: Evidence suggests that SPECT is useful to detect greater number of lesions
       following the period after head trauma. It seems that the high resolution and accurate
       brain images of SPECT can detect lesions in the brain that are not possible to visualize
       using other techniques such as positron emission tomography (PET) scanning. SPECT
       images can give clinicians important information concerning prognosis (also sometimes
       called outcome) and treatment of persons affected with head injury.
      Epilepsy: The radioactive material injected before SPECT imaging concentrates at the
       seizure locus (the region that contains nerve cells that generate an abnormal impulse).
       This can help identify the location of seizures and assist clinicians concerning
       management and outcomes.
      SPECT allows clinicians to visualize a specific area of the brain called the striatum,
       which contains a neurotransmitter (a chemical that communicates nerve impulse from
       one nerve cell to another) called dopamine. Circuitry in the striatum and interaction with
       dopamine can help provide valuable information concerning movement disorders ,
       schizophrenia , mood disorders, and hormone diseases (since hormones require control
       and regulation from the brain in structures called the pituitary gland and hypothalamus).

As a research tool, SPECT imaging seems to be sensitive tool to measure blood flow through the
brain (cerebral blood flow), in persons who have psychological disorder such as obsessive-
compulsive disorder (higher blood flow) and alcoholism (lower blood flow).

Other dianostic indications and procedures are similar to other imaging studies such as
computed tomography, magnetic resonance imaging , and PET.

Read more: Single photon emission computed tomography - causes, used, brain, mood,
Definition, Description

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