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							                                                           hormone
    Issue 9, April 2009

                                                           research
           in thi
       Mentio
                  s issu
              ns in th
                         e
                       e media
                                                           news
       Welcom
              e to ne
                                                                           Newsletter of the Centre for
                       w staff
        The He                                                             Hormone Research
                 alth an
        Unders           d                                                 Murdoch Childrens Research Insitute
                tanding
            project                                                        at The Royal Children’s Hospital




                                                                  staff achievements
Major research grant                                              •	 Ruki Guneratne was awarded
                                                                     the Yvonne Wagner Award in
Congratulations to Professor Andrew Sinclair, Theme director         November 2008.
Early Development & Disease, who was awarded a National
Health and Medical Research Council Program Grant of                Ruki has been a part of the Department of
$5 million for research into disorders of sexual development.       Endocrinology and Diabetes for 25 years and
                                                                    has been part of RCH for over 30 years.
Congratulations also to co-investigators Professor Peter
Koopman, Associate Professor Vincent Harley.                        As the senior administrative officer in the department Ruki is
                                                                    the glue that holds it all together. She is the calm and reassuring
Disorders of sexual development (DSDs) are surprisingly             face in the department and at the end of the phone. Ruki is equally
common, and often result in infertility, genital abnormalities,     adept dealing with anxious families as she is with a broad range
gender mis-assignment and long-term psychological trauma.           of clinicians both within the department and everyone across
In this program we will pool our expertise in human molecular       the hospital.
genetics, mouse developmental biology and protein chemistry
to identify genes important for sex determination and               Everyone in the department is indebted to Ruki and her
development of the gonads, and discover how they contribute         extraordinary capacities. Ruki is a very worthy winner of the
to DSD, in order to improve clinical care to patients with DSD.     Yvonne Wagner Award.
                                                                     I
                                                                  •	 	n	August	2008,	our	diabetes	researchers	won	the	best	oral	
                                                                     presentation at the International Society for Paediatric and
                                                                     Adolescent Diabetes Annual Scientific Meeting in Durban,
                                                                     South Africa. Congratulations to Ashleigh Lin.
                                                                    Diabetes research from MCRI was well represented at this
                                                                    meeting with five original papers and two plenary lectures
                                                                    given by A/Professor Lis Northam.
                                                                     F
                                                                  •	 	 ergus Cameron was appointed
                                                                     Senior Associate Editor of the Journal
                                                                     of Paediatric Endocrinology.
                                                                     A
                                                                  •	 	 ndrew Sinclair was appointed to the
                                                                     Australian Biotechnology Advisory Council.
                                                                     P
                                                                  •	 	 eter Simm won the Young Investigator
                                                                     Award at the Australasian Paediatric
                                                                     Endocrine Group Annual Scientific
                                                                     Meeting in Canberra.
                                                                  •	 	n	2008,	Dr Matt Sabin, RCH Foundation
                                                                     I                                                     Peter Simm
                                                                     Fellow, was awarded one of ten places at a
                                                                     Nobel Conference on Systems Biology and
                                                                     Child Health, organised through the Nobel Assembly and
Andrew Sinclair’s team. Clockwise from left: Kelly Roeszler,
Amanda Notini, Craig Smith, Andrew Sinclair, Thomas Ohnesorg,        the Karolinska Institute (Sweden). The aim of this conference
Sonja Gustin and Hinda Daggag. Absent: Stefan White.                 was to explore how novel approaches in systems biology and
                                                                     network medicine may be able to further our knowledge of
                                                                     disease mechanisms leading to childhood diabetes, obesity
                                                                     and growth problems. (Continued next page)
staff achievements                              (Continued)             new staff 2008
•	 	 nna Barton received the Dietitian Association of Australia
   A                                                                    Denisia Geladas – Diabetes
   Small Research Grant to conduct her study investigating the need     Denisia joined the diabetes team as a research coordinator
   for supper when using Lantus insulin. She also won a scholarship     in February 2008. She coordinates three research projects
   to attend the ISPAD Science School and attend                        including a clinical drug trial aimed at preventing type 1
   the ISPAD conference in 2008.                                        diabetes using an insulin nasal spray.

•	 	 eather Gilbertson received a DART grant to conduct her
   H                                                                    Denisia has worked in the hospital for over 18 years as a
   study investigating what proportion of a meal needs to be low        paediatric registered nurse. She has been a clinical nurse
   glycaemic index to get the best blood glucose level outcomes.        specialist, educator and a university paediatric lecturer for
                                                                        five years. Currently she liaises with scientists, clinicians,
   Recruitment for this study has just begun. If your child is over 8
                                                                        coordinators and executives, both on site, interstate and with
   years of age, using an insulin pump and are interested in finding
                                                                        highly respectable research Institutes, such as the Garvan in
   out more information, please contact Heather directly on
                                                                        Sydney and the Walter and Eliza Institute in Melbourne.
   9345 5663 or speak to her during clinic.
                                                                        Catherine Prochilo – Diabetes
                                                                        Catherine Prochilo, diabetes educator, joined the diabetes
FOXteL Lap 2008                                                         team in October 2008 and is job sharing with Rebecca Gebert.
                                                                        Catherine has been an ‘adult’ educator for seven years and also
In 2008 the FOXTEL Lap was held in Melbourne, Sydney, Adelaide,
                                                                        works at Diabetes Australia-Victoria.
Brisbane and Perth to raise funds for MCRI and the Centre for
Hormone Research.                                                       Janne Pitkin
Corporate teams and celebrities competed alongside each other           Janne is a research nurse who is working with A/Professor
                                                                        Margaret Zacharin on two studies – Preterm Infant Hormone
to run as many 100m laps as they could.
                                                                        study and a Head Injury study.
In 2008 the Centre for Hormone Research entered a team
and raised over $4,000, with one of our Development Board               Janne has worked over the years as a midwife, radiotherapy/
                                                                        oncology nurse, and enjoyed completing an Anthropology
members, Bryce Cameron, raising a quarter of the funds,
                                                                        degree in Perth.
congratulations Bryce!
If you would like to be involved in the 2009 event please contact       Most recently Janne was at the Austin which was to do with
Alyssa Jones, PR & Development Manager, email: pr@mcri.edu.au           sleep studies and respiratory clinical trials.
                                                                        Juliet Jennings – Diabetes
                                                                        Juliet took up the position as a clinical research fellow in
                                                                        May 2008 after completing her specialist training in general
                                                                        paediatrics with an interest in diabetes and endocrinology in
                                                                        Belfast. Juliet has worked in both Ireland and the UK. Juliet
                                                                        hopes to complete a MD studying the impact of coeliac disease
                                                                        on type 1 diabetes and its complications. She is currently
                                                                        working on a study which aims to provide insight into the link
                                                                        between the pathophysiological changes in brain function and
                                                                        neuropsychological impairment which occur in children and
                                                                        adolescents diagnosed with type 1 diabetes mellitus.

                                                                        Anna Serlachius
                                                                        Anna Serlachius is a PhD student from Finland, whose research
                                                                        aims to implement and evaluate a coping skills training program
                                                                        for adolescents with type 1 diabetes. Anna has a Masters
                                                                        degree in health psychology and has a longstanding interest
                                                                        in stress and coping in chronic illness.




                                                                        new board member
                                                                        Bryce Cameron
                                                                        Bryce is a type 1 insulin dependant diabetic diagnosed at the age
                                                                        of four. Bryce has been a patient of both Professor George Werther
                                                                        and Associate Professor Fergus Cameron during the 12 years spent
Diabetes Ball 2008                                                      at The Royal Children’s Hospital.

The 12th Annual Dinner Dance and Auction organised                      Becoming involved with the Centre for Hormone Research will
by Kerrie Beauglehall was held in July 2008 and raised                  hopefully give Bryce the opportunity to get more involved in
                                                                        promoting awareness, aid and prevention of disease, as well as
over $30,000 in support of the diabetes complications
                                                                        giving his knowledge through personal experiences he has had
screening program and several diabetes research projects.
                                                                        throughout his life.
The Ball is the sole source of funding for the vital program
                                                                        Bryce is passionate about preventing issues before they arise rather
and without the dedication of the volunteer organisers,
                                                                        than taking the band aid approach.
children with insulin dependent diabetes would be at
risk of complications during their teenage years, such as               Bryce is currently working full-time in the composites & reinforcement
blindness, heart attack, and dialysis or limb amputation.               industry and takes up part-time studies in engineering.
       ns
   ntioe
 Me th
  in dia
  me

The Centre has been
recognised in the media,
focusing on diabetes,
growth and obesity issues.




                               Beyondblue
                                          grant
                                Congratulati
                                              ons to Fergus
                                Lis Nor tham                   C ameron an
                                              (in collaborat                d
                               Universit y) w                 ion with Swin
                                              ho won a gra                  burne
                               the Beyondb                   nt of $80,00
                                             lue Vic torian               0 from
                              (bbVCoE) for                   Centre of E xc
                                              research.                     ellence
                              Type 1 diabet
                                              es as a risk fa
                             and other ad                     ctor for dep
                                            verse outcom                   ression
                             in rural Austr                 es for young
                                            alia.                          people
M_POWR and                                                                                                              MCRi
Biorepository                                                                                                           Centre for
The Murdoch Childrens Research Institute                                                                                hormone
(MCRI) has named childhood obesity as                                                                                   Research
one of its priorityresearch areas.
In line with this, the Multidisciplinary Paediatric                                                                     Patron
Obesity and Weight Research Group (M_POWR)                                                                              Professor David de Kretser,
was formed in 2008 and has brought together                                                                             AC, Governor of Victoria
a full range of specialists to determine how to
tackle this problem. It links obesity researchers
                                                                                                                        Executive
across the Institute with clinicians throughout
The Royal Children’s Hospital.                                                                                          Professor George Werther,
M_POWR’s vision is to conduct                                       health and                                          (Director)
cutting-edge research to:
   P
•	 	 revent	child	and	adolescent	
                                                                    understanding                                       Professor Andrew Sinclair
                                                                                                                        Associate Professor
   obesity                                                          Health and Understanding is a project we            Fergus Cameron
                                                                    have been working on for over two years
   U
•	 	 nderstand	the	risks	for	child	                                                                                     Dr Vincenzo Russo
                                                                    with UC Publishing and Blake Education.
   obesity including environmental,
                                                                    We asked various children’s authors to write
   genetic and lifestyle factors          Dr Matt Sabin
                                                                    educational magazine-style books on the             Development Board
   F
•	 	 ind	out	who	develops	early	                                    areas of research within the Centre for             David N Galbally, QC
   complications and why                                            Hormone Research including obesity,                 (Chairman)
•	 	 reat	obesity	effectively	and	
   T                                                                diabetes, growth and development.                   Bryce Cameron
   prevent its complications.                                       Health and Understanding is a literacy-based        Vince Comito
Investigators coordinating the group                                series written for students in the last three
are Dr Matt Sabin, Professor Melissa                                                                                    Anne Cronin
                                                                    years of primary school. It provides teachers
Wake and Dr Richard Saffery.                                        and students with the opportunity to explore        Katie Finney
One of the central research projects                                a range of health topics that are involved          Philippa Finney
is the construction of a large-scale         Professor              in and required for a healthy lifestyle. This
                                            Melissa Wake                                                                David J Galbally
biorepository of information and                                    series looks at our need for an active lifestyle,
samples from overweight and                                         how health needs change as people grow,             Stefan Hnativ
obese children. The biorepository                                   how we can develop and build relationships          Alyssa Jones
aims to identify how environmental,                                 with others, and the personal health choices
genetic and metabolic parameters                                                                                        Adrian King
                                                                    students must make for themselves in order to
come together to influence disease                                  enjoy good health.                                  Raoul Salter
development and progression.
                                                                    The main aim of this project is to raise the       Ian Solomon
It is only through large-scale                                      profile of the Centre for Hormone Research
initiatives like this, that we will be                              and educate primary school students, parents,
able to fully understand the different Dr Richard Saffery           teachers and friends. Currently we have raised over
roles of environment and genetics in                                $4,000 from royalties.
the development of obesity-related diseases
like Type 2 diabetes. Dr Matt Sabin is a lead                       There are 24 student books, three teacher guides and three big
investigator on this project with input from the                    books. If you are interested in the series, the books are available
wider M_POWR collaboration.                                         from Blake Education website at www.blake.com.au or for any
                                                                    queries please contact Lee-Ann Jones: leeann.jones@mcri.edu.au




Who’s afraid of Virginia Woolf?                                               thank you
                                                                              We would like to say thank you to everyone who supported our
starring Professor George Werther                                             Special Preview Screening of The Boy in the Striped Pyjamas
                                                                              on Monday 23 March at the Rivoli Cinema. The evening was very
By Edward Albee, Directed by John Keogh                                       successful and we collected over $2,000 in donations on the
                                                                              night towards diabetes research.
24 April to 9 May, 2009                                                       Special mentions to the following people for their contributions
If you would like to join the Centre for Hormone Research                     in making the night such a success:
team in a group booking on Wednesday 6 May 2009 to see
Professor George Werther in the production of ‘Who’s Afraid of                •	 Philippa	and	Alan	Finney,	CHR	Development	Board
Virginia Woolf?’, please contact Lee-Ann Jones on (03) 9345 7057              •	 Liam	McIntyre,	Rivoli	Cinemas
or leeann.jones@mcri.edu.au.                                                  •	 Walt	Disney	Studios	Motion	Pictures,	Australia
Tickets are $15.                                                              •	 Yasmine	McCafferty,	Carey	Baptist	Grammar	School
                                                                              •	 Kathy	Kaplan	and	Karen	Silver,	Bialik	College
RSVP no later than Monday 13 April 2009.
                                                                              •	 Jody	Goddard,	Huntingtower	School
If you would like to attend the production on another date please             •	 Margot	Thompson,	Loreto	Mandeville	Hall
contact the ticket booking line on 1300 131 552.

         The Centre for Hormone Research is within the Murdoch Childrens Research Institute at The Royal Children’s Hospital, Melbourne

						
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