2012 Patient Impact Initiative Request for Proposal Packet by 5gO7r8

VIEWS: 6 PAGES: 16

									                      Letter of Intent Instructions
To have your Rediscovery Research Grant considered for the Patient Impact Initiative (PII), please complete
this Letter of Intent form and e-mail it to Partnership for Cures along with a Principal Investigator (PI)
Biosketch. We will review the Letter of Intent and contact you to complete a grant application if your project
fits our Rediscovery Research™ model.

ELIGIBILITY
The Patient Impact Initiative is open to all researchers and clinicians at or on staff at academic medical centers
and other research institutions that have agreed to become Partner Institutions in the Patient Impact Initiative. It
is also open to invited researchers at other institutions.

PLEASE REVIEW THE DESCRIPTION BELOW OF THE RESEARCH WE ARE REQUESTING.
The closer the research is to making a direct patient impact, the more likely it is to be highly ranked.
Pilot or other clinical trials are ideal. Cost effectiveness is a key ranking criterion.

AREAS OF FOCUS: We accept proposals in any disease and for any Rediscovery Research therapy. We
do have some committed funds for clinical trials in CLL ($30K/year for 2 years, to prolong remission),
myelodysplastic syndrome (RARS variant, up to $100K/year for 2 years) and lung cancer ($30K/year for
2 years.) We also have funders interested, but not committed to, pediatric cancer and rare disease
projects.

There is no fee to apply to the Patient Impact Initiative.

CHECKLIST
Please include:

      Completed Letter of Intent Form below, including the grant title/description (400 word max) of you
       proposed research project
      PI Biosketch or CV so your eligibility can be confirmed

PLEASE NOTE

      Letters of Intent must be submitted electronically to PII-LOI@4cures.org
      Letters of Intent are due not later than March 2, 2012 at 9:00 pm Central Time
      Required documents listed above must be submitted as a single Microsoft Word Document file (any
       version.) Submit only the Letter of Intent Form and PI Biosketch. Do not include the rest of the
       information in this document.
      The file should be named in the following format:

PII LOI Year-Month Institution First Name Last Name Project Title.doc

(Example - PII LOI 2012-1 UIC Bruce Bloom Repurposing Maddonic Acid for Rockitis.doc)
              Patient Impact Initiative Letter of Intent Form
Please complete the following Principal Investigator and Project information:

First Name
Last Name
Degree(s)
Dept/Division
Academic Title
Institution
Street Address
City
State
Country
Postal Code
Office Phone
Mobile Phone
E-Mail Address

Project type (Please         Lab Only      Lab/Animal Trial       Animal Trial
check all that apply)        Lab/Human Samples       Human Clinical Trial
Estimated project
length in months
Estimated project cost

Research Project Title:

Research Description (Please type here - Not more than 400 words describing the proposed research project.
The 400 words do not have to fit on this page only-they can continue onto a separate page.)




If you have any questions, please contact:
Dr. Bruce E. Bloom, Ashoka Fellow 2010-2012
President and Chief Science Officer, Partnership for Cures
585-542-8737 or Bruce@4cures.org


                       Rediscovery Research™ Description
The Patient Impact Initiative inspires scientists and clinicians (and interested parties outside of medicine) to create and
complete pilot clinical trials and other Rediscovery Research to directly impact patients. This “Rediscovery Research”
can impact patients by reusing, reconfiguring and combining already existing drugs and devices, modifying treatment
protocols and testing clinical observations. These 1-3 year Rediscovery Research Projects can focus on any disease, use
any therapy and impact any group of patients, as long as they meet the parameters of the Patient Impact Initiative, which
are to create better near term treatment options, improve early diagnosis and lengthen disease remission reusing science
and medicine that has already been discovered once.

What qualifies as Rediscovery Research?

The following are some examples of Rediscovery Research. It is likely that once the Patient Impact Initiative creates the
incentive for Rediscovery Research, bright minds will find new ways to use reuse, combine and newly apply already
available science and medicine to help patients.

    1. repurposing an FDA approved drug or drug combinations to treat "off label" diseases
    2. combining an older drug or a combination of older drugs with a newer drug to increase the newer drug
        effectiveness
    3. combining a drug with a non-drug treatment option, such as radiation, to make the non-drug treatment work better
    4. combining a non-drug treatment option with an available drug to make the drug work better
    5. testing combinations of available drugs that are not currently prescribed together but are already used in one
        specific disease to see if the combination works better in that disease
    6. scientifically testing combinations of vitamins, supplements and botanicals, that would be available to physicians
        and their patients, if efficacy can be proven
    7. in limited circumstances, human clinical testing of new compounds, in rare diseases for which there is no current
        treatment, and there is strong likelihood of efficacy and accelerated approval
    8. repurposing FDA approved devices to treat "off label" diseases
    9. modifying current treatment protocols to make them work better and help more patients for longer periods of
        time, such as modifying the time of day of drug administration, reducing drug doses while increasing the
        frequency of drug administration to reduce side effects, testing radically lower doses of effective medicines that
        patients refuse because of side effects
    10. scientifically testing clinical observations or sound clinical ideas, including those from integrative medicine or
        from other parts of the world
Examples of Rediscovery Research

       Repurposing of thalidomide for multiple myeloma, then other blood cancers, other cancers, and non-oncologic
        diseases, and the development of Revlimid (Repurposing Example 1 from above)
       Testing the addition of NK cells to autologous stem cell transplants to improve the remission rate in non-
        Hodgkin’s lymphoma (Repurposing Example 9 from above)
       Combining an old malaria drug with a new kinase inhibitor to help the kinase inhibitor work for more lung cancer
        patients for a longer period of time (Repurposing Example 2 from above)
       Creating life saving treatments for children with familial dysautonomia by screening and then proving that
        specific vitamins and botanical compounds increased the overall production of a critical protein (Repurposing
        Example 6 from above)
       Repurposing a device originally developed to help the blind “see” to significantly improve functional
        performance in multiple sclerosis and traumatic brain injury patients (Repurposing Example 8 from above)
       Repurposing a laser ablation device originally used to treat breast cancer to treat prostate cancer patients with a
        much low incidence of side effects such as incontinence and impotence (Repurposing Example 8 from above)
       Repurposing the pain medication buprenorphine for the interruption and maintenance of heroin and other opioid
        addictions (Repurposing Example 1 from above)
       Repositioning the anti-Parkinsonian drug Requip for the treatment of both Restless Legs Syndrome and SSRI-
        induced sexual dysfunction (Repurposing Example 1 from above)
       Repositioning anti-epileptics gabapentin and pregabalin for treating anxiety disorders and neuropathic pain.
        (Repurposing Example 1 from above)
       Proving that Hatha Yoga breathing and relaxation can be as effective a treatment for Generalized Anxiety
        Disorder as drugs or counseling (Repurposing Example 10 from above)

Why Rediscovery Research?

There are thousands of potential treatments waiting to be rediscovered in the medicine and science that already exists. Of
the top 50 selling pharmaceuticals in 2004, 84% have had additional indications approved since their initial US licensure
(http://www.msi.co.uk/drug-repurposing). This type of Rediscovery Research provides

       low research costs and fast delivery of “new” effective treatments to patients by leveraging knowledge, resources
        and regulatory approvals already paid for through past research and clinical experience
       treatments that typically use low cost drugs and devices with known safety profiles, following slightly modified
        treatment protocols with which clinicians are already familiar
       significantly reduced healthcare costs created in a fraction of the time and expense


The Patient Impact Initiative Rediscovery Research will take place at academic research Partner Institutions, biotechs,
pharmaceutical companies and large clinical practices. Administration will be centrally provided by the staff of the
Partnership for Cures. Project reviews will be conducted by independent volunteer clinicians, scientists and lay reviewers
using an electronic interface. Rediscovery Research Projects must be designed to make a direct impact on patients in 1-3
years and can cost $10,000-$100,000 per year, with an emphasis on funding frugal, cost-effective grants that impact
patients.



What is the Patient Impact Initiative Grant Process?

The Patient Impact Initiative has a two-step Grant Process. Step one is the completion and submission of a very short
Letter of Intent (LOI) form. This enables our scientific and lay reviewers to determine if the project is likely to meet our
Patient Impact Initiative parameters.

You will be informed within 2 weeks of your LOI submission whether or not to submit a full Grant Proposal. If you are
invited to submit a full proposal, we will send you a form to complete that will include:
       A description of the proposed research (1600 word max)
       A budget and timeline
       A description of how/when your Rediscovery Research idea will impact patients
       The NIH Biosketch of the PI and full PI contact information
       Names of three scientists and/or clinicians you feel are qualified to review your project who have no conflict of
        interest

Grants will be reviewed and ranked by scientific and lay reviewers. The closer the research is to making a direct patient
impact, the more likely it is to be highly ranked. Pilot or other clinical trials are ideal. Cost effectiveness is also a key
ranking criterion.

All LOIs and Grant Proposals should be sent as Microsoft Word documents via e-mail. Instructions are included on the
LOI and Grant Proposal forms.



Mission: The mission of the Patient Impact Initiative is to secure funds to improve healthcare outcomes and reduce
patient healthcare costs worldwide by financing, facilitating, and publicizing Rediscovery Research solutions that
repurpose drugs, test clinical observations, and modify treatment protocols.



Vision: To create and manage a global collaboration of philanthropists, disease specific non-profits, research
institutions, researchers, clinicians, industry, media and the lay public that raises and deploys funds to drive the
development Rediscovery Research solutions to patients that quickly improve quality and length of life.
         Patient Impact Initiative Rediscovery Research Proposal



                                            APPLICATION
                                            GRANTEE INFORMATION
Sponsoring Institution Name                 Peotone State University

Grantee's First Name                        Bruce
Grantee's Last Name                         Bloom
Link to Grantee’s research/profile          http://www.4cures.org/home/meet_the_staff
website
Grantee's Institutional Address, line 1     70 West Madison Street
Address, line 2                             Suite 1500
Address, line 3
City                                        Chicago
State                                       IL
Zip code                                    60602
Grantee’s Email address                     bruce@4cures.org
Home phone                                  847-948-7004
Office phone                                312-696-1366
Cell phone                                  847-529-6888
Fax number                                  312-263-0939
Current academic title and degrees          Assistant Professor, MD, JD
Current academic department(s)              Clinical Research
                                            RESEARCH PROPOSAL
Title of research proposal                  Pilot human clinical trial to determine the effectiveness of a three
                                            different olfactory trained service dogs in the early detection of lung
                                            cancer
Estimated total budget                      $28,000
Estimated length of research (in            18 months (2 months for IRB approval and dog training and validation,
months)                                     12 months for enrollment of subjects and collection of data, 1 month for
                                            data processing and statistical analysis, 3 months for preparation,
                                            submission and acceptance of manuscript)
Indicate whether this is lab research,      Human clinical trial
animal study, human clinical trial, other
(if other, describe)
Number of human subjects (If                300
applicable)
Age range of human subjects (if             21-49
applicable)
Primary disease(s) research could           Lung cancer
impact
Secondary disease(s) research could         Other cancers that have metastasized to the lung; TB, other
impact                                      inflammatory lung diseases
Key words (as many as possible)             Service dog, expired breath, lung cancer, spiral CT, early detection,
(Examples: stem cell, gene therapy,         smokers, smoking, x-ray, screening
sRNA, diagnostic, prevention,
treatment, consortium, anti-viral,
botanical, translational, multiple
sclerosis, cancer, pediatric, geriatric,
etc.)
                                               INSTITUTIONAL OFFICER CONTACT INFORMATION
Institutional Officer Contact Name             Jerry Paris
Contact Title                                  Department Chair
Address, line 1                                70 West Madison Street
Address, line 2                                Suite 1500
Address, line 3
City                                           Chicago
State                                          IL
Zip code                                       60602
Email address                                  bruce@4cures.org
Office phone                                   312-696-1368
Fax number                                     312-263-0939
                                               PUBLICATION AND DISCLOSURE
Publication-has there been any public          Yes, see http://www.pinestreetfoundation.org/articles/ICT.pdf
disclosure of this idea, either by you or
some other party (Yes/No/I don’t know?)
If Yes, when and by who?
Disclosure- Have you disclosed this            Yes
concept to your institution, and, if not, is
there a plan for disclosing
                                               CONTACT INFORMATION FOR SCIENTISTS QUALIFIED TO REVIEW
                                               YOUR GRANT (AFTER THEY SIGN A NON-DISCLOSURE
                                               AGREEMENT.) THEY MUST BE FROM OUTSIDE OF YOUR
                                               INSTITUTION AND NOT INVOLVED IN ANY OF YOUR RESEARCH.

                                               Potential Reviewer #1
Name                                           Steve Brown
Institution                                    University of Chicago
Email address                                  SBrown@uchicago.edu
Office phone                                   312-555-1212
                                               Potential Reviewer #2
Name                                           Doug George
Institution                                    University of Southern California
Email address                                  DougG@uic.edu
Office phone                                   773-555-1212
                                               Potential Reviewer #3
Name                                           Jeff Smith
Institution                                    Rush University Medical Center
Email address                                  JSmith@rush.edu
Office phone                                   708-555-1212
                                               Now Please Complete Grant Proposal Information Below
                                                Please type in 11 point Arial font-Thank you!

Principal                PI-Bruce Bloom, DDS, JD, Chief of Pulmonary Oncology, Peotone State University,
Investigator and co-     Peotone ,IL
investigators,           Coordinator-Kathy Knorr, MS, BSN, Peotone State University, Peotone ,IL
including affiliations   Dog Safety-John Smith, DVM, PhD, Head of Animal Sciences, Floosmor Veterinary
                         College
                         Dog-Trainer-Ron Pace, Owner, Dog Training International, Chicago, IL
                         Dog Handlers-Graduate students John Jones, Tom Brown, Laura White from Floosmor
                         Veterinary College
                         Statistician-Monty Pythagoras, University of Chicago
Narrative Title of       A pilot human clinical trial to determine the effectiveness of olfactory trained service
Proposal                 dogs in the early detection of lung cancer by screening smokers with a cough of 30+
                         days who have been seen by an MD and referred for a spiral CT scan
Rationale: What is       There are several very small studies and many anecdotal observations that the superior
the clinical problem     olfactory ability of dogs can be used to detect cancer and other disease states. Ron
that creates a need      Pace at DTI has now trained over 30 service dogs to detect blood glucose changes in
for this research        exhaled breath, and data collected using his dogs has shown a 99.5% accuracy at
                         determining blood glucose below 80 or over 180. The service training has now been
Identify the challenge   extended to lung cancer, and his trained dogs are over 98% accurate in lab tests
and opportunity          distinguishing breath samples from smokers with lung cancer and without lung cancer.
                         There is no cost effective screening for lung cancer at this time, and no machine is as
(No more than 200        sensitive as a dog’s nose. Testing three different dogs will help us to determine whether
words)                   this could be a widely used method of screening.

Goals, Aims and/or       This study will test if olfactory trained service dog screening is sensitive and reliable for
Objectives (No more      the early detection of lung cancer in smokers with a cough. Our goal is to screen 300
than 300 words)          subjects in a 12 month period of time and correlate the three dog screening data with
                         the CT scan and biopsy data. Long term 2 and 5 year follow-up of subjects will also be
                         done in order to determine if the dogs detected lung cancer not detected by CT scan.
                         Aim 1-receive IRB approval to add the dog screening to an IRB approved project
                         Aim 2-to train 3 service dogs to detect lung cancer from test samples of smokers who
                         have and have not been diagnosed with lung cancer
                         Aim 3-to screen at least 10 subjects per day over a 36 week period at the weekly
                         screening day at the Peotone State University pulmonary clinic. That clinic sees, on
                         average, 60 smokers with persistent cough per screening day. The three dogs will each
                         be in a separate room for screening, and the dog handlers will be rotated among the
                         dogs at different weeks.
                         Aim 4-to correlate the data with the results of the spiral CT scans and any f/u biopsies to
                         determine who well each individual dog did in early detection, and how the dogs
                         compared to each other and to their lab successes
                         Aim 5-to publish the data in the Journal of Pulmonary Oncology
Background, basic       Please write on a separate document and attach as a Microsoft Word document to the
study design and        proposal.
narrative (No more
than 1600 words         PLEASE NOTE-AN EXAMPLE OF THIS IS NOT ATTACHED
and 4 figures/
diagrams, in no         Suggested format
more than 3 total       A-Background and preliminary studies
pages. Please write     B-Study Design
on a separate           C-Evaluation of results
document and            D-Statistical methods, if any
attach as a
Microsoft Word
Document to the         Please type in 11 point Arial font and use margins no narrower than 0.5”
proposal.)
                       Thank you!
Potential clinical     There is no accurate and cost effective method of screening for the early detection of
impact and what        lung cancer in smokers with a persistent cough. If the data show that olfactory trained
would be the potential service dog screening is an accurate lung cancer screening tool, we will
next steps (No more        1) Begin using the service dog screening at Peotone State University on a regular
than 300 words)                basis
                           2) Secure funds for training service dogs to be used in three different institutions to
                               validate these early findings within 2 years
                           3) Begin an aggressive dog and physician/nurse or tech handler training program at
                               Peotone State University
                           4) Secure funds to do a wider screening of non-smokers with persistent cough and
                               smokers with no symptoms to see if dog screening is reliable and verifiable in
                               those groups
                           5) Develop a service dog olfactory training program and certification program from
                               dog trainers so that more dogs can be appropriately trained using the Dog
                               Training International techniques. Ron Pace has agreed to create and provide
                               this training for no charge.
                           6) Begin working with the government and other payers to secure health care
                               coverage for olfactory trained service dog screening visits, which we have
                               calculated to cost no more than $3.00 per visit.
Publication: Where     We will publish this in the Journal of Pulmonary Oncology. We also expect to get
and how do you         significant service dog trade publication exposure, as well as national press coverage.
expect to present the We also expect to publish an editorial in the Journal of Applied Veterinary Medicine, and
data you gather from have ample opportunity to present the results of this research at various meetings of
this research?         pulmonologist, veterinarians and dog trainers.
Narrative budget           Please note: There will be no indirect costs allowed for these Patient Impact Initiative
                           Rediscovery Research grants. However, administrative personnel costs of up to 10% of
                           the budget or 10% total effort of named administrators, whichever is less, can be added
                           to the direct costs budget but only if specifically justified.

                           Most Clinical Projects will not be approved with PI salaries, and overall cost-
                           effectiveness is a critical criterion in our decision-making process. Be as frugal
                           as you can and still accomplish your goals. We are mostly interested in projects
                           that show clinically significant difference between control and test groups, or
                           where a test group shows clinically significant differences from the normal
                           course of the disease where there is no control group.

Narrative budget           Peotone State University just received a 18 months federal grant to screen 300 smokers
small description plus     with a history of persistent cough of 30-60 days using spiral CT scans and follow-up
a listing                  biopsies, when necessary. All costs associated with enrollment and management of the
A-personnel                subjects in this study will be covered by the federal grant. Only the costs associated
B-animals                  with training and managing the dogs, IRB approval, statistical evaluation and
C-patient costs            publication/presentation are required for this project. The training of the dogs takes only
D-core facilities and      about a month, and they can screen hundreds of subjects per day for less than $0.50
services                   per subject! The PI and collaborators are receiving no support for this project.
E-supplies
F-other                    $28,000 Overall Budget
(Approximately 300         $14,350 A-personnel-$8,350 for Ron Pace dog training, $2000 per grad student stipend
words plus budget          for dog handler training and being present at the Saturday research dates
figures )                  $10,950 B-animals-training, housing, vet care, food for 12 months equals $10/dog/day X
                           365
                           $0 C-patient costs-all covered by other grants
                           $1200 D-core facilities and services-data processing, videography, manuscript
                           submission support
                           $1500 E-supplies-purchase of three different 2-3 year old dogs of different breeds for
                           training
                           $0 F-other
Conflicts-Please list      Ron Pace also trains for-profit blood glucose olfactory service dogs for type 1 diabetics,
any conflicts or           and will begin to train dogs to detect lung cancer, so any notoriety from this project may
potential conflicts that   have a positive (or negative) financial impact for him.
could arise or are
clearly present as a       We have applied for funds for this research to the LUNGevity Foundation and to the
result of this research    Peotone Rotary Club, but have not received a response.

                           We are aware of no other conflicts.
Supporting                 Paper 1 shows that there is anecdotal support for the reliable and verifiable use of
literature-You are         olfactory trained service dogs for lung cancer screening.
welcome to provide
citations and short        Paper 2 details the successful training methods of Ron Pace and Dog Training
explanations to as         International for olfactory trained blood glucose monitoring service dogs.
many as three
publications that          Paper 3 describes successes reduced mortality, morbidity and healthcare costs
provide a scientific       associated with the use of olfactory trained blood glucose monitoring service dogs over
and/or clinical            a ten year period of time.
foundation for why
this work is important
and can make a
patient impact
                                                            Please Sign Below


The PI and the institution are willing and able to support all aspects of these
studies, including IRB and other approvals, and the PI is a person who is eligible to
receive Federal Grants.




PI Signature

Date 3-21-2012



Institutional Officer (listed above) Signature

Date 3-22-2012

      Send completed application and grant proposal as a Microsoft Word document (any version) via e-mail to:

                                                PII-Grant@4cures.org
             Dr. Bruce E. Bloom, President and Chief Science Officer, Partnership for Cures 312-696-1366


    Grant Proposals are due no later than 9:00
   p.m. Central time on Thursday April 12, 2012
                                               Please label as follows:
                           2012 PII GPP Institution Firstname Lastname Research title.doc
                         (e.g 2012 PII GPP UIC Bruce Bloom Silencic Acid for Babbloritis.doc)
             Patient Impact Initiative Rediscovery Research Proposal


                                            APPLICATION
                                            GRANTEE INFORMATION
Sponsoring Institution Name
Grantee's First Name
Grantee's Last Name
Link to Grantee’s research/profile
website
Grantee's Institutional Address, line 1
Address, line 2
Address, line 3
City
State
Zip code
Grantee’s Email address
Home phone
Office phone
Cell phone
Fax number
Current academic title and degrees
Current academic department(s)
                                            RESEARCH PROPOSAL
Title of research proposal
Estimated total budget
Estimated length of research (in
months)
Indicate whether this is lab research,
animal study, human clinical trial, other
(if other, describe)
Number of human subjects (If
applicable)
Age range of human subjects (if
applicable)
Primary disease(s) research could
impact
Secondary disease(s) research could
impact
Key words (as many as possible)
(Examples: stem cell, gene therapy,
sRNA, diagnostic, prevention,
treatment, consortium, anti-viral,
botanical, translational, multiple
sclerosis, cancer, pediatric, geriatric,
etc.)
                                               INSTITUTIONAL OFFICER CONTACT INFORMATION
Institutional Officer Contact Name
Contact Title
Address, line 1
Address, line 2
Address, line 3
City
State
Zip code
Email address
Office phone
Fax number
                                               PUBLICATION AND DISCLOSURE
Publication-has there been any public
disclosure of this idea, either by you or
some other party (Yes/No/I don’t know?)
If Yes, when and by who?
Disclosure- Have you disclosed this
concept to your institution, and, if not, is
there a plan for disclosing
                                               CONTACT INFORMATION FOR SCIENTISTS QUALIFIED TO REVIEW
                                               YOUR GRANT (AFTER THEY SIGN A NON-DISCLOSURE
                                               AGREEMENT.) THEY MUST BE FROM OUTSIDE OF YOUR
                                               INSTITUTION AND NOT INVOLVED IN ANY OF YOUR RESEARCH.

                                               Potential Reviewer #1
Name
Institution
Email address
Office phone
                                               Potential Reviewer #2
Name
Institution
Email address
Office phone
                                               Potential Reviewer #3
Name
Institution
Email address
Office phone
                                               Now Please Complete Grant Pre-Proposal Information Below
                                                          GRANT PROPOSAL
                                               Please type in 11 point Arial font-Thank you!

Principal
Investigator and co-
investigators,
including affiliations

Narrative Title of
Proposal

Rationale: What is
the clinical problem
that creates a need
for this research

Identify the challenge
and opportunity

(No more than 200
words)
Goals, Aims and/or
Objectives (No more
than 300 words)

Background, basic        Please write on a separate document and attach as a .pdf to the proposal.
study design and
narrative (No more       Suggested format
than 1600 words          A-Background and preliminary studies
and 4 figures/           B-Study Design
diagrams, in no          C-Evaluation of results
more than 3 total        D-Statistical methods, if any
pages. Please write
on a separate
document and             Please type in 11 point Arial font and use margins no narrower than 0.5”
attach as a .pdf to
the proposal.)           Thank you!

Potential clinical
impact and what
would be the potential
next steps (No more
than 300 words)

Publication: Where
and how do you
expect to present the
data you gather from
this research?
Narrative budget         Please note: There will be no indirect costs allowed for these Patient Impact Initiative
                         Rediscovery Research grants. However, administrative personnel costs of up to 10% of
                         the budget or 10% total effort of named administrators, whichever is less, can be added
                           to the direct costs budget but only if specifically justified. Well-justified budgets are
                           important, insofar as cost-effectiveness will be used as a key scoring criterion.

Narrative budget
small description plus
a listing

A-personnel
B-animals
C-patient costs
D-core facilities and
services
E-supplies
F-other
(Approximately 300
words-ok to provide
some narrative)

Conflicts-Please list
any conflicts or
potential conflicts that
could arise or are
clearly present as a
result of this research

Supporting
literature-You are
welcome to provide
citations and short
explanations to as
many as three
publications that
provide a scientific
and/or clinical
foundation for why
this work is important
and can make a
patient impact
                                                                Please Sign Below




The PI and the institution are willing and able to support all aspects of these
studies, including IRB and other approvals, and the PI is a person who is eligible to
receive Federal Grants.


PI Signature __________________________
Date _____________



Institutional Officer (listed above) Signature ______________________

Date _____________

                                Send completed Grant Proposals via e-mail to:

                                             PII-Grant@4cures.org
          Dr. Bruce E. Bloom, President and Chief Science Officer, Partnership for Cures 312-696-1366


  Grant Proposals are due no later than 9:00
 p.m. Central time on Thursday April 12, 2012
                                             Please label as follows:
                   PII Grant Year-Month Institution First Name Last Name Research Title.doc
                      (e.g PII GPP 2012-3 UIC Bruce Bloom Silencic Acid for Babbloritis.doc)

								
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