Antonis Makrigiannakis MD, PhD by 5gO7r8


									Antonis Makrigiannakis MD, PhD

Professor Ob/Gyn,
Director of Reprod Medicine
University of Crete, GR 71003
Heraklion, Crete, GREECE

Tel: 0030 2810 325656

Age: 46 years old
Married, two kids

Board Member of ESHRE
National Representative of Greece in ESHRE
Chairman elect of MSRM
Council Member of ESCI
Member of the American Association advancing the Science.

Total Citations: 34OO
Total Impact factor: 403
Total Number of Papers in Medline: 105
No of Grants: 4
No of International Awards: 10
Invited Speaker in International Conventions: 134 participations

Antonis Makrigiannakis obtained his medical degree from Athens University, Greece. He
completed his PhD thesis and post-doctoral studies on molecular pharmacology of hormones and
neuropeptides in the Medical School of the University of Crete Heraklion, Greece, in a combined
project with NIH,. Further training and specialization in infertility and reproductive medicine was
undertaken in the Division of Human Reproduction, Department of Obstetrics and Gynecology,
University of Pennsylvania, Philadelphia, USA. He then moved to London, UK where he worked at
the Hammersmith Hospital as a Senior Scientist in the IVF Unit and the Centre of Reproductive
Medicine. His research is focused on the molecular mechanisms of implantation and has led to
numerous publications in international journals. Particularly he has investigated the biological role
of corticotropin-releasing factor in human endometrium, highlighting its involvement in blastocyst
implantation and maternal immunotolerance.

Currently, Antonis Makrigiannakis holds the position of as Professor in Reproductive Medicine in
the University of Crete. He is the Director of the IVF unit of the University Hospital of Heraklion.
This unit operates for the first time in Heraklion and has been established under his directorate.
Furthermore, he is Director of the Laboratory of Human Reproduction, which occupies seven PhD
students, and two post Docs. The laboratory focuses primarily on basic research on the following
- Role of the Corticotropin Releasing Hormone in human implantation
- Role of granulosa cell adhesion molecules in corpus luteum formation

Antonis Makrigiannakis has received the following Grants/Scholarships

1. Scholarship from the scholarship foundation “Alexandros Onassis” for research in the USA
2. Research Grant from research programs of WYETH-USA (1999)
3. Scholarship from “Empirikio” Foundation (2000)
4. Scholarship for 2 years from scholarship foundation “Alexandros Onassis” for research in Greece
5. Scholarship from IKYDA program of the Greek Scholarship Foundation for promotion of co-
operation and basic research between Greece and Germany (2003-2005)
6. Funding from GLAXOSMITHKLINE for clinical protocol involving a phase III clinical trial of
the HPV-16/18, VLP/AS04 vaccine (2004-2005)
7. Funding from SHERRING for clinical protocol involving hormone replacement treatment
8. Funding from the Oncology Clinic of the University Hospital of Ioannina (Prof Foutzilas, Prof
Pavlidis) for basic research protocol entiteled “role of CRH in ovarian cancer” (2005-2006)
9. Funding from Greek State for basic research (PENED, 2006-2009)

Antonis Makrigiannakis has received the following International Awards

1. Award for clinical research (AACR-GLAXO WELCOME ONCOLOGY CLINICAL
RESEARCH SCHOLAR AWARD) from the American Association for research on Gynecological
Cancer. NEW ORLEANS, USA, 1998. Replication selective herpes simplex virus-1 in the treatment
of epithelial ovarian cancer. Coukos G, Caparelli D, Makrigiannakis A, Abbas A, Kaiser L, Rubin S,
Albelda SM, Molnar-Kimber KL.

2. 1st award for study on gene therapy of epithelial cancer of the ovaries. 23rd INTERNATIONAL
HERPESVIRUS WORKSHOP. YORK, UK. 1998. Replication selective herpes simplex virus-1 and
the use of a producer cell line in the treatment of epithelial ovarian cancer. Coukos G, Caparelli D,
Makrigiannakis A, Abbas A, Kaiser L, Rubin S, Molnar-Kimber KL

3. PRESIDENT’S PRESENTER AWARD for research on Reproductive Gynecology from the
American Association of Gynecologic research. SOCIETY OF GYNECOLOGIC
INVESTIGATION, ATLANTA, USA, 1999. Vascular endothelial growth factor (VEGF) and its
receptor (flt-1) mediates the hCG-induced expression of fibronectin (FN) and its a5β1-integrin
receptor during corpus luteum formation and luteolysis. Makrigiannakis A, Coukos G, Koi H,
Montas S, Coutifaris C.

MEDICAL CENTER, PHILADELPHIA USA, for the participation in the study entitled ‘Producer
cells enhance the oncolytic activity of a replication-selective Herpes Simplex Virus-1 mutant in
epithelial ovarian cancer in vivo’, which was the basis for PATENT (L1929)/1999.
5. HONOURS AWARD from the Ob/Gyn Association of the State of Maryland, USA for the
supervising of resident in Ob/Gyn Dr. Denise Wallinsky, who received the 2nd award of the
Association for the study ‘Expression of integrins ανβ3 and ανβ5 and ligands OPN and FN in the
fallopian tube epithelium’.

6. Award at the 39th Annual European Congress of European Society for Clinical Research (39th
Annual Meeting of ESCI, Athens, Greece, 2005), for the study “Urocortin is expressed at the
implantation site of the human blastocyst”.

Representative publications:

1.     Bamberger AM, Minas V, Kalantaridou SN, Radde J, Sadeghian H, Loning T,
Charalampopoulos I, Brummer J, Wagener C, Bamberger CM, Schulte HM, Chrousos GP,
Makrigiannakis A. Am J Pathol 2006, 168:141-150
2.    Zhang L, Conejo-Garcia JR, Katsaros D, Gimotty PA, Massobrio M, Regnani G,
Makrigiannakis A, Gray H, Schlienger K, Liebman MN, Rubin SC, Coukos G. N Engl J Med 2003,
3. Makrigiannakis A, Coukos G, Mantani A, Prokopakis P, Trew G, Margara R, Winston R,
White J. J Clin Endocrinol Metab 2001, 86:5964-5972
4. Makrigiannakis A, Zoumakis E, Kalantaridou S, Coutifaris C, Margioris AN, Coukos G, Rice
KC, Gravanis A, Chrousos GP. Nature Immunol 2001, 2:1018-1024
5. Bamberger AM, Sudahl S, Loning T, Wagener C, Bamberger CM, Drakakis P, Coutifaris C,
Makrigiannakis A. Am J Pathol 2000, 156:1165-1170
6. Makrigiannakis A, Amin K, Coukos G, Tilly JL, Coutifaris C. J Clin Endocrinol Metab 2000,
7. Kohen P, Castro A, Caballero-Campo P, Castro O, Vega M, Makrigiannakis A, Simon C,
Carvallo P, Devoto L. J Clin Endocrinol Metab 1999, 84:4239-4245
8. Makrigiannakis A, Coukos G, Christofidou-Solomidou M, Gour BJ, Radice GL, Blaschuk O,
Coutifaris C. Am J Pathol 1999, 154:1391-1406
9. Makrigiannakis A, Zoumakis E, Margioris AN, Stournaras C, Chrousos GP, Gravanis A.
Neuroendocrinology 1996, 64:85-92
10. Makrigiannakis A, Zoumakis E, Margioris AN, Theodoropoulos P, Stournaras C, Gravanis A.
J Clin Endocrinol Metab 1995, 80:185-189
11.   Makrigiannakis A, Margioris A, Markogiannakis E, Stournaras C, Gravanis A. J Clin
Endocrinol Metab 1992, 75:584-589
12. Margioris AN, Markogiannakis E, Makrigiannakis A, Gravanis A. Endocrinology 1992,

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